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Clinical context remains essential
Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.
Adult 450 mg tablet source. No pediatric solution or institutional HD regimen is inferred.
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UCSF: valganciclovir in intermittent and continuous hemodialysis
Product / population
UCSF adult institutional CMV treatment/prophylaxis; dialysis regimens differ from the product label.
Renal method
Intermittent versus continuous hemodialysis; not automatically every CRRT modality.
Source revision
Source revision date not established in selected retrieval.
Retrieved
2026-09-07
Local review status
Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.
Documented differences and cautions on this drug
All record notes are retained here, including notes about sources not selected in this review.
Adult tablet label versus UCSF intermittent-HD practice
The VALCYTE label provides no adult tablet dose for hemodialysis and says those tablets should not be used. UCSF lists institutional oral treatment and prophylaxis schedules in intermittent HD. This is a real label-versus-institution difference, not two independently agreeing labels.
What to reconcile: Confirm CMV indication, transplant context, formulation, dialysis schedule, cytopenias and infectious-disease input. The institutional regimen is not labeled approval; IV ganciclovir is preferred by UCSF for initiation in unstable renal function or dialysis.
Continuous-HD prophylaxis: institutional interval versus small PK study
UCSF lists prophylaxis every 48 hours during continuous HD. The Jarrell primary abstract studied daily enteral dosing in ten ICU transplant recipients on CVVHD and found that most reached a proposed trough target. These sources differ, but the study is not a comparative clinical-outcomes trial.
What to reconcile: Reconcile the actual dialysis modality and clearance, absorption, CMV risk, counts and monitoring. Full-text flow-rate details were not reviewed; no universal CRRT dose is derived or automatically preferred.
UCSF Infectious Diseases Management Program · UCSF adult institutional CMV treatment/prophylaxis; dialysis regimens differ from the product label.
Renal method: Intermittent versus continuous hemodialysis; not automatically every CRRT modality. Source date: Source revision date not established in selected retrieval. Retrieved: 2026-09-07
Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.
Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.
Renal dosing, restrictions and evidence limits
For intermittent HD, UCSF lists CMV treatment as 450 mg orally once now and after HD; prophylaxis is 450 mg twice weekly. For continuous HD it lists treatment 450 mg daily and prophylaxis 450 mg every 48 hours. IV ganciclovir is preferred when initiating treatment during unstable renal function or dialysis. Give with food. These are institution-specific regimens outside the label's adult tablet-HD recommendation. Confirm actual dialysis settings and specialist monitoring rather than treating continuous HD and intermittent HD as interchangeable.
RDM40-professional-valganciclovir-81c34aacfb-C1 · Source locator: Adult dialysis table and dialysis notes
This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.
GlobalRPh v6.6 | RDM66-DIRECT-PHP-20260911 | Local library date 2026-09-11. Selected-card identity does not imply clinical verification.