GlobalRPh Renal Dosing Masterv6.6
Source review / handoff

Memantine

One or two intact local summaries. No averaged regimen, patient-specific dose or automatic source preference.

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1 local source card selected. Local card fingerprints checked where supplied. This is not an original-document hash, source-currency guarantee or clinical approval. Record-level cautions below are the current library's cautions, not a frozen prior version.

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Clinical context remains essential

Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.

Immediate-release scope. Do not apply this target or titration to extended-release memantine.

Check source scope before reading a dose

Memantine - immediate-release tablets

Product / population
Adults with moderate-to-severe Alzheimer-type dementia; exact release formulation.
Renal method
Cockcroft-Gault creatinine clearance, mL/min.
Source revision
09/2021
Retrieved
2026-09-10
Local review status
Selected source sections stored locally. Not a complete monograph or independent clinical approval.

Documented differences and cautions on this drug

All record notes are retained here, including notes about sources not selected in this review.

Before use: Memantine

Selected IR renal target agrees; this does not validate the full dated mirror or imply equivalence to ER.

What to reconcile: Use the release-specific maintenance limit and review initial/restart titration.

Source-specific interpretation; independent clinician adjudication pending.

Open this note and its source references
Official

Memantine - immediate-release tablets

Open original reference

DailyMed / NLM exact product labeling · Adults with moderate-to-severe Alzheimer-type dementia; exact release formulation.

Renal method: Cockcroft-Gault creatinine clearance, mL/min.
Source date: 09/2021
Retrieved: 2026-09-10

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.
Before using this finding

Confirm IR, ER or fixed combination; keep the maintenance limit separate from titration and restart instructions.

Selected source sections stored locally. Not a complete monograph or independent clinical approval.

Renal guidance and important limits

Limits that apply to these rows

These are maintenance limits, not initial titration doses. Do not extrapolate below CrCl 5 or create a dialysis replacement regimen.

Alkaline urine can reduce elimination. Reinitiation after several missed days may require retitration. Fixed memantine/donepezil is a separate product.

Memantine IR - renal maintenance target
Cockcroft-Gault CrCl (mL/min)Source-specific instruction
5-29Target 5 mg twice daily
Mild/moderate renal impairmentNo renal adjustment recommended in selected labeling
Read the retained text before reformatting

Memantine IR - renal maintenance target

Cockcroft-Gault CrCl (mL/min)Source-specific instruction
5-29Target 5 mg twice daily
Mild/moderate renal impairmentNo renal adjustment recommended in selected labeling

These are maintenance limits, not initial titration doses. Do not extrapolate below CrCl 5 or create a dialysis replacement regimen.

Alkaline urine can reduce elimination. Reinitiation after several missed days may require retitration. Fixed memantine/donepezil is a separate product.

RDM64-official-memantine-fe42767bfe-C1 · Source locator: Dosage renal impairment; Clinical Pharmacology; genitourinary/urine-pH and missed-dose instructions.

Source-specific limits

These are maintenance limits, not initial titration doses. Do not extrapolate below CrCl 5 or create a dialysis replacement regimen.

Alkaline urine can reduce elimination. Reinitiation after several missed days may require retitration. Fixed memantine/donepezil is a separate product.

Source identity and provenance
Source family
product_label
Source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=af2b73da-1be4-4b7f-929b-acb3b9a10f78
Retrieved
2026-09-10
Exact label title
Memantine - immediate-release tablets
DailyMed Set ID
af2b73da-1be4-4b7f-929b-acb3b9a10f78
Label revision
09/2021
Renal-function method
Cockcroft-Gault creatinine clearance, mL/min.
Source date/version
09/2021
Hash meaning
Local authored summary, not source HTML/XML/PDF bytes
Local summary SHA-256
8aa9da188916545d32cc3cfae9bdf5c6d3841f5ff6bcd6dc8ac9643e74f59bcc

Document the clinical decision separately

This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.

GlobalRPh v6.6 | RDM66-DIRECT-PHP-20260911 | Local library date 2026-09-11. Selected-card identity does not imply clinical verification.

Pinned reference: https://globalrph.com/blogCalcs/renal-dosing-master/compare.php?id=memantine&s1=RDM64-official-memantine-fe42767bfe&h1=5594aaae9b284e2a859e49e7d97b04027b1538e8cf020241ba96e779868d05a8