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Clinical context remains essential
Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.
Adult 450 mg tablet source. No pediatric solution or institutional HD regimen is inferred.
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VALCYTE: adult renal tablet table and hemodialysis restriction
Product / population
Adult VALCYTE 450 mg tablets; induction versus maintenance/prevention. Pediatric equations are not substituted.
Renal method
Cockcroft-Gault CrCl in mL/min.
Source revision
December 2025
Retrieved
2026-09-07
Local review status
Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.
Documented differences and cautions on this drug
All record notes are retained here, including notes about sources not selected in this review.
Adult tablet label versus UCSF intermittent-HD practice
The VALCYTE label provides no adult tablet dose for hemodialysis and says those tablets should not be used. UCSF lists institutional oral treatment and prophylaxis schedules in intermittent HD. This is a real label-versus-institution difference, not two independently agreeing labels.
What to reconcile: Confirm CMV indication, transplant context, formulation, dialysis schedule, cytopenias and infectious-disease input. The institutional regimen is not labeled approval; IV ganciclovir is preferred by UCSF for initiation in unstable renal function or dialysis.
Continuous-HD prophylaxis: institutional interval versus small PK study
UCSF lists prophylaxis every 48 hours during continuous HD. The Jarrell primary abstract studied daily enteral dosing in ten ICU transplant recipients on CVVHD and found that most reached a proposed trough target. These sources differ, but the study is not a comparative clinical-outcomes trial.
What to reconcile: Reconcile the actual dialysis modality and clearance, absorption, CMV risk, counts and monitoring. Full-text flow-rate details were not reviewed; no universal CRRT dose is derived or automatically preferred.
DailyMed / Genentech · Adult VALCYTE 450 mg tablets; induction versus maintenance/prevention. Pediatric equations are not substituted.
Renal method: Cockcroft-Gault CrCl in mL/min. Source date: December 2025 Retrieved: 2026-09-07
Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.
Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.
Renal dosing, restrictions and evidence limits
For CrCl >=60, induction is 900 mg twice daily and maintenance/prevention 900 mg daily. At 40-59, use 450 mg twice daily or 450 mg daily, respectively. At 25-39, use 450 mg daily or every two days. At 10-24, use 450 mg every two days or twice weekly. Below 10 on hemodialysis, the label provides no tablet dose and says the tablets should not be used; it directs clinicians to appropriately adjusted ganciclovir. Monitor kidney function and blood counts. Take with food and do not crush or split tablets. Institutional dialysis regimens are displayed separately, not called label-approved.
This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.
GlobalRPh v6.6 | RDM66-DIRECT-PHP-20260911 | Local library date 2026-09-11. Selected-card identity does not imply clinical verification.