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Clinical context remains essential
Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.
The current selected U.S. label and historical handbook differ in administration and available renal evidence. Immune-mediated nephritis requires toxicity management, not an automatic routine renal-dose reduction.
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Renal Drug Handbook, 5th edition - Ipilimumab
Product / population
Historical adult renal/RRT summary. U.S. product identity anchored to the separate locally included DailyMed label. This is not a current U.S. product label.
Renal method
Book table headed GFR (mL/min); its preface states renal adjustments generally derive from Cockcroft-Gault CrCl. Do not silently relabel as indexed eGFR.
Source revision
5th edition; 2019 copyright; historical reference
Retrieved
2026-09-05
Local review status
Historical handbook cross-check; not a current U.S. protocol
Documented differences and cautions on this drug
All record notes are retained here, including notes about sources not selected in this review.
Immune nephritis requires toxicity management, not a calculated dose reduction
The new RX section describes withholding or stopping treatment for immune-mediated creatinine toxicity. These CTCAE grades are not the baseline kidney-function categories used in pharmacokinetic assessment.
What to reconcile: Use the oncology toxicity-management protocol for treatment-emergent nephritis, including the combination-treatment rules. Do not reinterpret a baseline no-adjustment statement as permission to continue through significant immune toxicity.
UK Renal Pharmacy Group / CRC Press · Historical adult renal/RRT summary. U.S. product identity anchored to the separate locally included DailyMed label. This is not a current U.S. product label.
Renal method: Book table headed GFR (mL/min); its preface states renal adjustments generally derive from Cockcroft-Gault CrCl. Do not silently relabel as indexed eGFR. Source date: 5th edition; 2019 copyright; historical reference Retrieved: 2026-09-05
Historical handbook cross-check; not a current U.S. protocol
Historical renal / replacement-therapy guidance
At 20-50 mL/min the historical book retains the usual dose; 10-20 and <10 add caution. RRT removal is considered unlikely, with the lower renal band used. It notes lack of studies below 22 mL/min. This does not establish dialysis outcomes. Its older 90-minute infusion is not the selected current U.S. label administration, which is shown separately; no historical infusion instruction is promoted as current.
HB30-ipilimumab-1 · Source locator: Printed page 535: renal impairment, RRT and other information
Source-specific limits
Separate source recommendation, not proof of agreement or contemporary clinical validation. Dialysis predictions are retained with their original certainty.
Source identity and provenance
Retrieved
2026-09-05
Handbook page
5th edition, printed p. 535; uploaded PDF p. 554
Renal-function method
Book table headed GFR (mL/min); its preface states renal adjustments generally derive from Cockcroft-Gault CrCl. Do not silently relabel as indexed eGFR.
This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.
GlobalRPh v6.6 | RDM66-DIRECT-PHP-20260911 | Local library date 2026-09-11. Selected-card identity does not imply clinical verification.