GlobalRPh Renal Dosing Masterv6.6
Source review / handoff

Cefotaxime

One or two intact local summaries. No averaged regimen, patient-specific dose or automatic source preference.

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Clinical context remains essential

Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.

The source phrase most recent refers to November 2012. This historical source has not been relabeled as current FDA or Stanford guidance.

Current-source disagreement: the selected U.S. label suggests dose reduction below an indexed CrCl of 20; the older handbook table reduces below 5. Both are attributed below; this is not a single reconciled threshold.

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Cefotaxime for injection, USP

Product / population
Adult IV/IM cefotaxime sodium; not ceftriaxone.
Renal method
Not specified
Source revision
Retrieved
2026-09-05
Local review status
Source-read local summary; source-specific recommendations are not automatically interchangeable.
Official

Cefotaxime for injection, USP

Open original reference

NIH/NLM DailyMed - U.S. prescribing information · Adult IV/IM cefotaxime sodium; not ceftriaxone.

Renal method: Not specified in this summary.
Source date:
Retrieved: 2026-09-05

Source-read local summary; source-specific recommendations are not automatically interchangeable.

Baseline adult infection doses

Uncomplicated infection: 1 g every 12 hours IM/IV. Moderate/severe infection: 1-2 g every 8 hours IM/IV. Higher-dose infections such as septicemia: 2 g IV every 6-8 hours. Life-threatening infection: 2 g IV every 4 hours; maximum 12 g/day.

cefotaxime:dm-ed23b6bc-32c7-4c50-a53d-313ae78e5623-1 · Source locator: Dosage and Administration: adult guideline table

Renal adjustment and method caution

The label suggests halving the dose below estimated CrCl 20 mL/min/1.73 m2. It also presents the Cockcroft-Gault formula and requires steady-state serum creatinine. Preserve this indexed threshold as written; do not assume an unindexed estimate and indexed value are numerically identical. Individualize for infection severity and clinical course.

cefotaxime:dm-ed23b6bc-32c7-4c50-a53d-313ae78e5623-2 · Source locator: Precautions: General

Source identity and provenance
Source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ed23b6bc-32c7-4c50-a53d-313ae78e5623
Retrieved
2026-09-05
Exact label title
Cefotaxime for injection, USP
DailyMed Set ID
ed23b6bc-32c7-4c50-a53d-313ae78e5623
Labeler
Hikma Pharmaceuticals USA Inc.
DailyMed page updated
2024-04-11
FDA application
Abbreviated New Drug Application
U.S. product identity basis
Exact named product and route appear in the selected U.S. prescription label; current retail availability was not independently assessed.
Hash meaning
Locally authored source summary, not original SPL/XML/PDF bytes
Local summary SHA-256
ad3a73753cd3b96cff0af18a590cd1d1ea21dc8e2b0ddccfc7dd6b4e083b6afc

Document the clinical decision separately

This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.

GlobalRPh v6.6 | RDM66-DIRECT-PHP-20260911 | Local library date 2026-09-11. Selected-card identity does not imply clinical verification.

Pinned reference: https://globalrph.com/blogCalcs/renal-dosing-master/compare.php?id=cefotaxime&s1=dm-ed23b6bc-32c7-4c50-a53d-313ae78e5623&h1=37e47ad0b53b84d42c75974d4f07084506395846d839da63c981b2b8f2da8447