GlobalRPh Renal Dosing Masterv6.6
Source review / handoff

Cefepime

One or two intact local summaries. No averaged regimen, patient-specific dose or automatic source preference.

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1 local source card selected. Local card fingerprints checked where supplied. This is not an original-document hash, source-currency guarantee or clinical approval. Record-level cautions below are the current library's cautions, not a frozen prior version.

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Clinical context remains essential

Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.

The source introductory threshold is rendered =60; the source table is preserved separately. This is not a newly verified label transcription.

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Nebraska Medicine - cefepime by CVVHD dialysate flow

Product / population
Adults; CVVHD only. Source PDF page 5.
Renal method
Dialysate flow in L/hour, not a generic CrCl band.
Source revision
2023 CRRT/PIRRT reference.
Retrieved
2026-09-05
Local review status
Locally included source-specific summary. Regimen differences are not automatically resolved.

Documented differences and cautions on this drug

All record notes are retained here, including notes about sources not selected in this review.

Daily post-HD timing is not the same as post-HD-only dosing

Label and institutional sources include daily dosing and post-dialysis-only schedules. Their indication, dialysis frequency, infusion, and exposure assumptions differ.

What to reconcile: Select one complete locally approved regimen; do not add a daily dose on top of a post-HD-only schedule.

Source difference identified; final patient-specific adjudication required.

Open this note and its source references

Different HD schedules remain source-specific, not interchangeable

The MAXIPIME mirror uses daily maintenance; UCSF describes a post-HD strategy and a separate unstable-schedule alternative.

What to reconcile: Resolve indication, dialysis timing and local specialist protocol before selecting a regimen; do not average or mix schedules.

Source-specific interpretation; independent clinician adjudication pending.

Open this note and its source references
Professional

Nebraska Medicine - cefepime by CVVHD dialysate flow

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University of Nebraska Medical Center / Nebraska Medicine · Adults; CVVHD only. Source PDF page 5.

Renal method: Dialysate flow in L/hour, not a generic CrCl band.
Source date: 2023 CRRT/PIRRT reference.
Retrieved: 2026-09-05

Locally included source-specific summary. Regimen differences are not automatically resolved.

Dosing / renal protocol and limits

After a 2 g IV load, standard-infection CVVHD dosing is 1 g every 8 hours at 1 L/hour; 1 g every 6 hours at 2 L/hour; and 1 g every 6 hours or 2 g every 8 hours at 3-4 L/hour. The neutropenic-fever row instead lists 2 g every 12 hours at 1-2 L/hour and 2 g every 8 hours at 3-4 L/hour. Reassess when therapy stops.

RDM30-062-cefepime-1 · Source locator: Nebraska Medicine - cefepime by CVVHD dialysate flow; renal/dosing sections and stated qualifiers

Source identity and provenance
Source
https://www.unmc.edu/intmed/_documents/id/asp/final_crrt_pirrt_abxrecommendations_2023.pdf
Retrieved
2026-09-05
Renal-function method
Dialysate flow in L/hour, not a generic CrCl band.
Source date/version
2023 CRRT/PIRRT reference.
Hash meaning
Locally authored summary text; not original SPL, HTML or PDF bytes
Local summary SHA-256
28eb23684864d4cd1bbe46a3d0f2995640b73193a7d12cbec869e0598f0693f0

Document the clinical decision separately

This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.

GlobalRPh v6.6 | RDM66-DIRECT-PHP-20260911 | Local library date 2026-09-11. Selected-card identity does not imply clinical verification.

Pinned reference: https://globalrph.com/blogCalcs/renal-dosing-master/compare.php?id=cefepime&s1=RDM30-062-cefepime&h1=376de4381f4df9af53465eab1ef89dbdaa246d903d2df12f70368e73bb440f85