GlobalRPh Renal Dosing Masterv7.4
Renal Dosing Master: fast drug lookup
Source review / handoff

Elbasvir and grazoprevir (Zepatier), oral tablet

One or two intact local summaries. No averaged regimen, patient-specific dose or automatic source preference.

Selecting here opens the current stored cards. The pinned link below records their fingerprints. Do not enter patient information in links or searches.

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1 local source card selected. Local card fingerprints checked where supplied. This is not an original-document hash, source-currency guarantee or clinical approval. Record-level cautions below are the current library's cautions, not a frozen prior version.

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Clinical context remains essential

Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.

Check source scope before reading a dose

Zepatier - labeled renal guidance

Product / population
Elbasvir and grazoprevir (Zepatier), oral tablet
Renal method
Creatinine clearance (CrCl), mL/min
Source revision
DailyMed SPL version 22, posted Mar 23, 2026
Retrieved
2026-11-07
Local review status
Selected renal passages reviewed; independent clinician adjudication pending.

Documented differences and cautions on this drug

All record notes are retained here, including notes about sources not selected in this review.

Zepatier - product and source limitations

Confirm HCV genotype, indication and hepatic eligibility for the combination.

What to reconcile: Apply only to the stated formulation, indication and renal population.

Selected renal passages reviewed; independent clinician adjudication pending.

Open this note and its source references
Official

Zepatier - labeled renal guidance

Open original reference

DailyMed / product prescribing information · Elbasvir and grazoprevir (Zepatier), oral tablet

Renal method: Creatinine clearance (CrCl), mL/min
Source date: DailyMed SPL version 22, posted Mar 23, 2026
Retrieved: 2026-11-07

Qualified no-adjustment statement. Apply only to the population, product and renal range described in this source.

Selected renal passages reviewed; independent clinician adjudication pending.

Renal guidance: 2.3 Renal Impairment / 8.8 Renal Impairment

The elbasvir/grazoprevir dose does not change in renal impairment or hemodialysis. If ribavirin is required and CrCl is 50 mL/min or lower, use ribavirin-specific dosing. Confirm HCV genotype, indication and hepatic eligibility for the combination.

RDM74-zepatier-official-1 · Source locator: Renal guidance: 2.3 Renal Impairment / 8.8 Renal Impairment

Source identity and provenance
Source family
product_label
Source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=164dc02a-9180-426a-b8b5-04ab39d2bbd4
Retrieved
2026-11-07
Renal-function method
Creatinine clearance (CrCl), mL/min
Source date/version
DailyMed SPL version 22, posted Mar 23, 2026
Hash meaning
SHA-256 of the local selected-source summary
Local summary SHA-256
7f7c7e343e2194d30180d66f83e5f53bdc94ba2e6513ae90bed1572c0aa36714

Document the clinical decision separately

This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.

GlobalRPh Renal Dosing Master v7.4. Review the retrieval and revision dates attached to each source. Selecting a reference does not imply clinical verification.

Pinned reference: https://globalrph.com/blogCalcs/renal-dosing-master/compare.php?id=rx-zepatier&s1=RDM74-zepatier-official&h1=36d71a015d6a77ffebf806dbd9e5094df4569eca5d68e7f1dad0c94ca15e65e0

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