GlobalRPh Renal Dosing Masterv6.6
Source review / handoff

Ampicillin/Sulbactam

One or two intact local summaries. No averaged regimen, patient-specific dose or automatic source preference.

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1 local source card selected. Local card fingerprints checked where supplied. This is not an original-document hash, source-currency guarantee or clinical approval. Record-level cautions below are the current library's cautions, not a frozen prior version.

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Clinical context remains essential

Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.

The source summary and source table use slightly different boundary notation at CrCl 30. The original indexed table heading and accompanying Cockcroft-Gault formula are retained; renal-function normalization must be confirmed before prescribing.

Check source scope before reading a dose

UCSF - ampicillin/sulbactam

Product / population
Adults; source-specific institutional guidance. Match route, indication and renal replacement modality.
Renal method
CrCl in mL/min where specified; no equation inferred.
Source revision
Revision date not stated in the reviewed page.
Retrieved
2026-09-05
Local review status
Locally included source-specific summary. Regimen differences are not automatically resolved.

Documented differences and cautions on this drug

All record notes are retained here, including notes about sources not selected in this review.

UNASYN label and UCSF do not use identical renal bands

At the printed value 30, the RX label table places patients in its at-least-30 row, whereas UCSF standard dosing places 30 in its 15-30 row. The RX heading also prints indexed clearance while UCSF uses mL/min.

What to reconcile: Reconcile the renal metric and endpoint before selecting an interval. Do not choose whichever row is more convenient or merge the label dose range with an institutional interval.

Source-specific interpretation; independent clinician adjudication pending.

Open this note and its source references

High-dose CRAB treatment is not the routine label regimen

The ID-directed UCSF CRAB regimen can exceed the routine labeled sulbactam exposure. It has different infusion duration and renal eligibility, and its printed extended-infusion columns leave exactly 60 unassigned.

What to reconcile: Use infectious-disease/antimicrobial-stewardship oversight and the exact infection context. Do not extrapolate this row into unlisted renal or dialysis settings. Keep total combination grams distinct from sulbactam grams.

Source-specific interpretation; independent clinician adjudication pending.

Open this note and its source references
Professional

UCSF - ampicillin/sulbactam

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UCSF Infectious Diseases Management Program · Adults; source-specific institutional guidance. Match route, indication and renal replacement modality.

Renal method: CrCl in mL/min where specified; no equation inferred.
Source date: Revision date not stated in the reviewed page.
Retrieved: 2026-09-05

Locally included source-specific summary. Regimen differences are not automatically resolved.

Dosing / renal protocol and limits

Standard adult IV dosing: CrCl >30 mL/min, 3 g every 6 hours; 15-30, 3 g every 12 hours; <15, 3 g daily. Intermittent HD: 3 g every 12 hours. Continuous HD: 3 g every 6 hours.

For carbapenem-resistant A. baumannii at CrCl >60, the specialist extended-infusion regimen is 9 g every 8 hours over 4 hours. The source requires ID/pharmacy advice for lower renal function or dialysis in that indication rather than applying the standard-infection table. Exactly 60 is not assigned in the CRAB row.

RDM30-054-ampicillin-sulb-1 · Source locator: UCSF - ampicillin/sulbactam; renal/dosing sections and stated qualifiers

Source identity and provenance
Source
https://idmp.ucsf.edu/content/ampicillin-sulbactam-unasyn
Retrieved
2026-09-05
Renal-function method
CrCl in mL/min where specified; no equation inferred.
Source date/version
Revision date not stated in the reviewed page.
Hash meaning
Locally authored summary text; not original SPL, HTML or PDF bytes
Local summary SHA-256
f577ec3943fdc1568b47035fcd93e59e91ee62d0b6fe68c2af6be17731b6535f

Document the clinical decision separately

This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.

GlobalRPh v6.6 | RDM66-DIRECT-PHP-20260911 | Local library date 2026-09-11. Selected-card identity does not imply clinical verification.

Pinned reference: https://globalrph.com/blogCalcs/renal-dosing-master/compare.php?id=ampicillin-sulb&s1=RDM30-054-ampicillin-sulb&h1=346a5372f620ab876c802baa965fdc69ebe1640517145dc910dbb9a6ee4d4bbf