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Daptomycin for injection - Fresenius Kabi USA 500 mg vial
Product / population
Adult intravenous daptomycin. Product preparation, infection indication and institution-specific higher-dose regimens must remain separately attributed.
Renal method
CrCl in mL/min; Cockcroft-Gault with actual body weight in the selected PK table
Source revision
5/2022
Retrieved
2026-09-10
Local review status
Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.
Documented differences and cautions on this drug
All record notes are retained here, including notes about sources not selected in this review.
Do not merge label and higher-dose institutional dialysis protocols
The label includes CrCl exactly 30 in its >=30 band. UCSF prints >30 and <30, omitting exactly 30, and uses higher doses and different HD scheduling.
What to reconcile: Keep source-specific dose, interval, indication, weight basis and modality together. The official threshold is explicit; seek institutional clarification rather than silently changing its headings.
DailyMed / Fresenius Kabi USA, LLC · Adult intravenous daptomycin. Product preparation, infection indication and institution-specific higher-dose regimens must remain separately attributed.
Renal method: CrCl in mL/min; Cockcroft-Gault with actual body weight in the selected PK table Source date: 5/2022 Retrieved: 2026-09-10
Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.
Before using this finding
The source explicitly includes exactly CrCl 30; do not silently repair a different institutional heading.
Dialysis evidence: A regimen is reported in selected content
Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.
Renal dosing, restrictions and evidence limits
The Fresenius Kabi label places CrCl exactly 30 mL/min in the at-least-30 category. Adult cSSSI uses 4 mg/kg every 24 hours and S. aureus bloodstream infection 6 mg/kg every 24 hours. Below 30, including HD/CAPD, the respective doses are every 48 hours, after HD when possible. Renal function and CPK require monitoring more often than once weekly in renal impairment. Pediatric renal regimens are unestablished. Reconstitution and storage differ among daptomycin formulations; this source does not establish interchangeability of preparation instructions.
Selected named sections only; not a complete monograph or independent clinical approval.
Selected exact-product labeling sections read. Original-source bytes and complete revision histories were not retained or reconciled; retrieval does not establish current product availability.
This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.
GlobalRPh v6.6 | RDM66-DIRECT-PHP-20260911 | Local library date 2026-09-11. Selected-card identity does not imply clinical verification.