GlobalRPh Renal Dosing Masterv6.6
Source review / handoff

Gabapentin immediate-release (Neurontin)

One or two intact local summaries. No averaged regimen, patient-specific dose or automatic source preference.

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1 local source card selected. Local card fingerprints checked where supplied. This is not an original-document hash, source-currency guarantee or clinical approval. Record-level cautions below are the current library's cautions, not a frozen prior version.

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Clinical context remains essential

Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.

Immediate-release gabapentin only. Do not apply this table to Horizant or Gralise. Source summary and reproduced table use different boundary notation.

Check source scope before reading a dose

Renal Drug Handbook, fifth edition

Product / population
Historical 2019 reference; renal bands retain the book's own method labels.
Renal method
Not specified
Source revision
Not established
Retrieved
2026-09-05
Local review status
Historical handbook facts locally summarized; not a current U.S. label or a modern CRRT protocol.

Documented differences and cautions on this drug

All record notes are retained here, including notes about sources not selected in this review.

Gabapentin formulations have different renal rules

Immediate-release gabapentin, GRALISE and HORIZANT are not interchangeable renal protocols. HORIZANT also has indication-specific schedules.

What to reconcile: Select the actual formulation and indication before using a dose or dialysis instruction.

Source difference identified; final patient-specific adjudication required.

Open this note and its source references

Exact-30 boundary not resolved by RX table wording

The RX table prints greater-than-30 to 59 and greater-than-15 to 29 bands; dialysis supplements are paired to maintenance regimens.

What to reconcile: Confirm the exact boundary and matched supplement in the complete current product table; no automatic dose calculation is provided.

Source difference identified; final patient-specific adjudication required.

Open this note and its source references

NEURONTIN: printed renal bands leave a boundary unclear

The RX table prints >30 to 59 and >15 to 29; exactly 30 is not clearly assigned. The hemodialysis supplement also belongs with a selected maintenance regimen.

What to reconcile: Verify the current table rather than silently rounding into a band. Do not select a supplement without its corresponding maintenance context.

Source-specific interpretation; independent clinician adjudication pending.

Open this note and its source references
Handbook

Renal Drug Handbook, fifth edition

UK Renal Pharmacy Group / Ashley and Dunleavy / CRC Press · Historical 2019 reference; renal bands retain the book's own method labels.

Renal method: Not specified in this summary.
Source date: Not established
Retrieved: 2026-09-05

Historical handbook facts locally summarized; not a current U.S. label or a modern CRRT protocol.

Historical renal bands

At GFR 30-60 and 15-30 mL/min the handbook advises starting low and titrating to response. Below 15 it lists 300 mg on alternate days or 100 mg nightly initially. For neuropathic pain or restless legs in moderate/severe impairment it separately suggests starting 100 mg daily; it advises no loading dose for neuropathic pain in renal patients.

gabapentin:rdh5-471-1 · Source locator: Renal impairment; Other information

Historical replacement-therapy protocol

For HD/high-flux treatment it describes a 300-400 mg load in previously untreated patients, then 200-300 mg after each HD session, titrated to tolerability. The neuropathic-pain no-load exception still applies. APD/CAPD follows the <15 band; continuous therapy follows the 15-30 band.

gabapentin:rdh5-471-2 · Source locator: Renal replacement; Other information

Source-specific limits

The handbook HD-only approach and the label maintenance-plus-supplement approach are distinct. Do not add their doses together. The book's general gabapentin recommendations do not establish dosing for GRALISE or the enacarbil prodrug.

Source identity and provenance
Retrieved
2026-09-05
Handbook page
Printed page 471; PDF page 490
Hash meaning
Locally authored source summary, not original SPL/XML/PDF bytes
Local summary SHA-256
ac66ac0bd02a14a2d0578cd85c97a9339d4f3e2c67d8836edb98ed9fb680f2db

Document the clinical decision separately

This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.

GlobalRPh v6.6 | RDM66-DIRECT-PHP-20260911 | Local library date 2026-09-11. Selected-card identity does not imply clinical verification.

Pinned reference: https://globalrph.com/blogCalcs/renal-dosing-master/compare.php?id=gabapentin&s1=rdh5-471&h1=16427eb122e65ee0d26d735f1a3d681674e45c73df027867859f6eabb913e143