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1 local source card selected. Local card fingerprints checked where supplied. This is not an original-document hash, source-currency guarantee or clinical approval. Record-level cautions below are the current library's cautions, not a frozen prior version.
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Clinical context remains essential
Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.
An RX mirror and its underlying label are not independent clinical confirmations.
Check source scope before reading a dose
IQIRVO: selected RX renal passage
Product / population
Adult oral IQIRVO for labeled primary biliary cholangitis; baseline renal guidance is distinct from treatment-emergent muscle/kidney toxicity.
Renal method
Renal categories; severe-renal PK study used indexed MDRD eGFR and excluded dialysis
Source revision
Revision date not established in reviewed mirror passage.
Retrieved
2026-11-07
Local review status
Selected sections checked against the identified source; not a complete monograph or independent clinician approval.
Documented differences and cautions on this drug
All record notes are retained here, including notes about sources not selected in this review.
IQIRVO: source applicability and renal evidence limits
Baseline no-adjustment guidance does not clear on-treatment rhabdomyolysis/AKI. The non-dialysis severe-renal study must not be relabeled as dialysis validation.
What to reconcile: Assess muscle symptoms and myopathy/CPK risk; AKI can accompany rhabdomyolysis.
GlobalRPh RX List / label mirror · Adult oral IQIRVO for labeled primary biliary cholangitis; baseline renal guidance is distinct from treatment-emergent muscle/kidney toxicity.
Renal method: Renal categories; severe-renal PK study used indexed MDRD eGFR and excluded dialysis Source date: Revision date not established in reviewed mirror passage. Retrieved: 2026-11-07
Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.
Qualified no-adjustment statement. Apply only to the population, product and renal range described in this source.
Before using this finding
Severe-renal PK study excluded dialysis; no dialysis regimen established.
Dialysis evidence: No dialysis regimen established in selected content
Selected sections checked against the identified source; not a complete monograph or independent clinician approval.
Sections 8.6, 12.3 and 5.1
The mirror gives the same dose in mild/moderate/severe impairment. Its severe-renal PK description excludes dialysis. This does not negate the muscle-injury and kidney-injury warning.
RDM72-elafibranor-iqirvo-rx-1 · Source locator: Sections 8.6, 12.3 and 5.1
Source-specific limits
Selected renal section, not a complete prescribing monograph. A label and its mirror are not independent evidence.
This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.
GlobalRPh Renal Dosing Master v7.4. Review the retrieval and revision dates attached to each source. Selecting a reference does not imply clinical verification.
