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Preparation. Administration. Evidence.

IV Dilution &
Medication Reference

Search 255 medications, read preserved historical references, and inspect separately reviewed preparation statements. Full monograph updates remain pending.

Version 6.4Release date 2026-11-04For healthcare professionals
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Medication reference

Hydromorphone

Monograph awaiting updateThis monograph will be updated in the future.

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Historical source. Current clinical review is incomplete. This monograph will be updated in the future.

Hydromorphone - Dilaudid ® (opens in a new tab)Original source URL: https://globalrph.com/dilution/hydromorphone-dilaudid/ | Retrieved 2026-11-04

Source dates, location and integrity

This historical article is separate from the reviewed claim cards. Product formulations and source dates may differ.

Original source URL
https://globalrph.com/dilution/hydromorphone-dilaudid/ (opens in a new tab)
Source date
Not established in the retrieved source
Retrieved
2026-11-04T19:46:38.187016+00:00
Source location
div.post-content
Packaged content SHA-256
0262312780e116315d904e9cdbe137ed413d394c309b0a2b468de6a48d8354b8
Original response SHA-256
11a022a127483eee72ac01840fb10327186b8b155750ef001581f14829b73743
Source body SHA-256
e4074684b49d3ee853966bba4ab83cb2068c24d108e9d61ebf08323d9ae6de6d

HYDROMORPHONE (DILAUDID ®)
The authors make no claims of the accuracy of the information contained herein; and these suggested doses and/or guidelines are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this document shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material. PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.

Usual Diluents
D5W, NS

Standard Dilutions [Amount of drug] [Infusion volume] [Infusion rate]
[ 20 mg ] [100 ml ] [ Titrate ]
[ 50 mg ] [100 ml ] [ Titrate ]
[0 - 100 mg] [100 ml] [Titrate]EXP: 24 hours RT/REF.
Usual rate: 0.2 to 2 mg/hr.

Stability / Miscellaneous

Stability data:
Drug Stability
Refrigerated		 Stability
Room Temp.		 Reconstituted
Vial/Powder		 Notes
Dilaudid - Hydromorphone Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F)

Stable for at least 24 hours at 25°C, protected from light in most common large-volume parenteral solutions

 Solution Inspect parenteral drug products visually for particulate matter and discoloration prior to administration, whenever solution and container permit. A slight yellowish discoloration may develop. No loss of potency has been demonstrated.

Protect from light.

Keep covered in carton until time of use.

WARNINGS

Drug Dependence
Hydromorphone Hydrochloride Injection can produce drug dependence of the morphine type and therefore has the potential for being abused. Psychic dependence, physical dependence and tolerance may develop upon repeated administration of Hydromorphone Hydrochloride Injection and it should be prescribed and administered with the same degree of caution appropriate for the use of morphine. Since Hydromorphone Hydrochloride Injection is indicated for use in patients who are already tolerant to and hence physically dependent on narcotics, abrupt discontinuance in the administration of Hydromorphone Hydrochloride Injection is likely to result in a withdrawal syndrome.

Infants born to mothers physically dependent on Hydromorphone Hydrochloride Injection will also be physically dependent and may exhibit respiratory difficulties and withdrawal symptoms.

Impaired Respiration
Respiratory depression is the chief hazard of Hydromorphone Hydrochloride Injection. Respiratory depression occurs most frequently in the elderly, in the debilitated, and in those suffering from conditions accompanied by hypoxia or hypercapnia when even moderate therapeutic doses may dangerously decrease pulmonary ventilation.
Hydromorphone Hydrochloride Injection should be used with extreme caution in patients with chronic obstructive pulmonary disease or cor pulmonale, patients having a substantially decreased respiratory reserve, hypoxia, hypercapnia, or preexisting respiratory depression. In such patients even usual therapeutic doses of narcotic analgesics may decrease respiratory drive while simultaneously increasing airway resistance to the point of apnea.

Head Injury and Increased Intracranial Pressure
The respiratory depressant effects of Hydromorphone Hydrochloride Injection with carbon dioxide retention and secondary elevation of cerebrospinal fluid pressure may be markedly exaggerated in the presence of head injury, other intracranial lesions, or preexisting increase in intracranial pressure. Narcotic analgesics including Hydromorphone Hydrochloride Injection may produce effects which can obscure the clinical course and neurologic signs of further increase in pressure in patients with head injuries.

Hypotensive Effect
Narcotic analgesics, including Hydromorphone Hydrochloride Injection, may cause severe hypotension in an individual whose ability to maintain his blood pressure has already been compromised by a depleted blood volume, or a concurrent administration of drugs such as phenothiazines or general anesthetics (see also Precautions - Drug Interactions). Hydromorphone Hydrochloride Injection may produce orthostatic hypotension in ambulatory patients.

Hydromorphone Hydrochloride Injection should be administered with caution to patients in circulatory shock, since vasodilation produced by the drug may further reduce cardiac output and blood pressure.

Pharmacokinetics
In normal human volunteers hydromorphone is metabolized primarily in the liver. It is excreted primarily as the glucuronidated conjugate, with small amounts of parent drug and minor amounts of 6-hydroxy reduction metabolites.

Following intravenous administration of Hydromorphone Hydrochloride Injection to normal volunteers, the mean half-life of elimination was 2.64 ± 0.88 hours. The mean volume of distribution was 91.5 liters, suggesting extensive tissue uptake. Hydromorphone Hydrochloride Injection is rapidly removed from the blood stream and distributed to skeletal muscle, kidneys, liver, intestinal tract, lungs, spleen and brain. Hydromorphone Hydrochloride Injection also crosses the placental membranes.

In terms of area under the analgesic time-effect curve, hydromorphone is approximately 8 times more potent than morphine (i.e., 1.3 mg of hydromorphone produces analgesia equal to that produced by 10 mg of morphine). After intramuscular administration, hydromorphone has a slightly more rapid onset and slightly shorter duration of action than morphine. The duration of Hydromorphone Hydrochloride Injection analgesia in the non-tolerant patient with usual doses may be up to 4 to 5 hours. However, in tolerant subjects, duration will vary substantially depending on tolerance and dose. Dose should be adjusted so that 3 to 4 hours of pain relief may be achieved.

Source: [package insert]

Dosing:
IV: (opiate naive) Start: 0.2 - 0.6 mg q2-3h prn. Pain, acute: 1-2 mg IV (slow - over 2-3 min) q3h prn.

Mechanically-ventilated pts: 0.7 - 2 mg q1-2h prn or start infusion: 0.5 - 1 mg/hr.

PCA: Usual concentration: 0.2 mg/ml. Demand dose (usual): 0.1 - 0.2 mg (range: 0.05 - 0.5mg). Lockout: 5-15 min. 4 hour limit: 4-6 mg.

Epidural: Bolus: 0.4-1.5 mg. Infusion conc: 0.05 - 0.075 mg/ml. Infusion rate: 0.04 - 0.4 mg/hr. Demand dose: 0.15mg. Lockout: 30 minutes. Alternatively (per Lexi-drugs 2012): Bolus: 0.4 -1 mg. Infusion rate: 0.03 - 0.3 mg/hour. Demand dose: 0.02 - 0.05mg. Lockout: 10-15 minutes.

IM/SC: (opiate naive) Start: 0.8 - 1 mg q4-6h prn. Usual range: 1-2 mg q3-6h prn.
Acute pain: 1-2 mg IM/SC q4-6h prn.

Additional Pain Management / Palliative Care resources

Pain Management: Its various aspects

Drug Tables and Calculators

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Open this historical article on its own

Product identifiers and clinical review status

This monograph will be updated in the future. Historical material is available where present in the original sources; full current exact-product and claim-level review remains pending.

Exact formulation, concentration, container, manufacturer, regulatory identifiers, and a reproducible label snapshot have not all been reconciled.

What remains to be completed
  • Retrievable exact-product SPL XML with version, revision, retrieval date and reproducible hash
  • Clinically reviewed, individually identified statements with two exact source mappings
  • Exact formulation, strength, container, manufacturer/labeler, application and NDC reconciliation
  • Renal-function methods and dialysis/CRRT modality review where applicable
  • Mechanism provenance, clinical source disagreements and full medication-specific safety reconciliation

Supplemental historical fields

Restored-data provenance and review notes

Source release: 2026-08-31. Current clinical review is incomplete. Original uses of current, verified, or normalized describe the historical source. They do not inherit the status of separately reviewed statements. Product formulations and source dates can differ.

Current review annotations for historical renal, dialysis, mechanism, and product fieldsSeparate renal reference: Open Renal Dosing Master (opens in a new tab)
Renal
Status
not_locally_normalized
Original classification
renal_review_flagged
Entries
    General note
    Preserve the source-specific renal-function basis. An indexed CrCl table is not interchangeable with unindexed CrCl or eGFR. Generic advice to check a method does not identify the equation for a dose row.
    Dialysis
    Status
    no_local_structured_regimen
    Entries
      General note
      Named modality alone does not establish applicability. CRRT subtype, effluent rate, residual renal function, timing and interruptions require review. Historical absence is not evidence that no guidance exists.
      Mechanisms
      • Source kind
        first_look
        Local pointer
        /mechanism
        Original level
        drug_specific
        Provenance classification
        historical_drug_specific_uncorroborated
        Label derived verified
        false
        Independently corroborated
        false
        Exact label section
        Not recorded
        Original source note
        Not recorded
        Review status
        historical_unverified
        Note
        Drug-specific wording in the old file is not proof of independent corroboration or an exact label locator. Consult separately published current mechanism claims where present.
      Future update
      Status
      pending_review
      Message
      This monograph will be updated in the future as current exact-product and claim-level review is completed.
      Source unavailable
      false
      Reason
      The historical content is restored; comprehensive contemporary verification remains incomplete.
      Historical first look: uses, mechanism, dosing context, and administration

      Recovered v5.1 source content; historical, awaiting current review.

      Id
      hydromorphone
      Source IDH51-FBBA06EAF5310210738EE473
      Generic name
      Hydromorphone
      Source IDH51-92EDC586AD0B706E18FE1D8F
      Class
      Sedation, analgesia, and anesthesia
      Source IDH51-E160E4AB62E5986206DFD446
      Subclass
      Opioid analgesic
      Source IDH51-108D210FF8DFB2882E172F26
      Primary uses
      1. Severe pain
        Source IDH51-307F122DCA1041D21712D9D7
      2. Palliative symptom control
        Source IDH51-27989651F01A1886B9115D00
      Mechanism
      Agonizes mu-opioid receptors and suppresses nociceptive neurotransmission while depressing respiratory drive.
      Source IDH51-281E0D7413C4ADB2C9D104CE
      Mechanism level
      drug_specific
      Source IDH51-E73CA76B75111F33776BBA3D
      Basic dosing orientation
      Adult infusion | Existing preparation record; use current package insert for indication-specific selection | Patient-specific dose | Not normalized in the preparation record | See current package insert and professional guidance | IV infusion; Adult | Common incremental dose 0.2 to 1 mg | Common incremental dose 0.2 to 1 mg | Patient- and indication-specific | See current package insert | IV push
      Source IDH51-03286D5D2E11D26D29AB1485
      Administration orientation
      Titrate by mg/hour; Over at least 2 to 3 minutes; 0.2 to 1 mg/mL; Over at least 2 to 3 minutes
      Source IDH51-A8400E54C76F823C1BF86B55
      Renal and population orientation
      Separate renal reference: Open Renal Dosing Master (opens in a new tab)The existing monograph contains a renal or nephrotoxicity signal; verify exact adjustment and monitoring in the current label.
      Source IDH51-B91665AFD8A6A59B38C6D0A6
      Key safety orientation
      1. Respiratory depression and hypotension.
        Source IDH51-4680BE733886F9330299C8CE
      2. Look-alike/sound-alike and potency confusion with morphine.
        Source IDH51-88A7B48F1411AF551B840259
      Coverage path
      structured_local_snapshot
      Source IDH51-120D6961779CD97D6074D735
      Coverage path label
      Structured GlobalRPh route snapshot
      Source IDH51-98D599D9B64BAA4389F0A8C0
      Legacy title
      Hydromorphone
      Source IDH51-747122356875EE293FE8D365
      Review note
      First-look orientation only. Verify indication, patient population, weight basis, organ function, exact IV product, dose, concentration, compatibility, rate, and current labeling before use.
      Source IDH51-41464386473AC90E673D98AA
      Search text
      Hydromorphone Sedation, analgesia, and anesthesia Opioid analgesic Severe pain Palliative symptom control Agonizes mu-opioid receptors and suppresses nociceptive neurotransmission while depressing respiratory drive. Adult infusion | Existing preparation record; use current package insert for indication-specific selection | Patient-specific dose | Not normalized in the preparation record | See current package insert and professional guidance | IV infusion; Adult | Common incremental dose 0.2 to 1 mg | Common incremental dose 0.2 to 1 mg | Patient- and indication-specific | See current package insert | IV push Titrate by mg/hour; Over at least 2 to 3 minutes; 0.2 to 1 mg/mL; Over at least 2 to 3 minutes The existing monograph contains a renal or nephrotoxicity signal; verify exact adjustment and monitoring in the current label. Respiratory depression and hypotension. Look-alike/sound-alike and potency confusion with morphine. Structured GlobalRPh route snapshot
      Source IDH51-4680C12D3600C08248B1062F
      Official access mode
      search
      Source IDH51-B66041D72DAF84FDA6F26C96
      Official search query
      Hydromorphone
      Source IDH51-2BE37B4D91E751B4DE23AE18
      Official access reason
      A source-backed DailyMed search is available; select and confirm the exact IV product.
      Source IDH51-6BEFAD3692202E1F043CA755

      No separate structured rows were bundled for dialysis, CRRT. Historical article content and source links may cover these topics.

      Historical dilution and intermittent infusion preparation

      Recovered v5.1 source content; historical, awaiting current review.

      PopulationAmountReconstitutionDiluentFinal volumeConcentrationRateStabilityNotes
      Source IDH51-C7F5E8C3E5A7D0FB0D8B5518
      Adult infusion
      Source IDH51-F9B179D8BFB27B1D7A5076FA
      		Patient-specific dose
      Source IDH51-90D4A4D0E6B4018EA0C3117E
      		Dilute concentrate or use premix.
      Source IDH51-7FB2FACD20AB8EB229B046B8
      		NS or D5W
      Source IDH51-5E495E0B024180BB9C8A2026
      		50 to 100 mL
      Source IDH51-0D6CF15680A6E0533419C93A
      		Commonly 0.2 to 1 mg/mL
      Source IDH51-B0B65E144EA4F635CE8F6CF5
      		Titrate by mg/hour
      Source IDH51-BBB3C173348E55C4975648C8
      		Use the shorter of current product labeling, validated stability data, and the applicable USP <797> sterility-based BUD ceiling.
      Source IDH51-E39E56577B616E859D93BE19
      		Standardize concentration and account for opioid tolerance.
      Source IDH51-6E7993B4B7B1CC01037097FA

      Historical IV-push guidance

      Recovered v5.1 source content; historical, awaiting current review.

      PopulationDose scopeConcentrationRateStatus
      Source IDH51-3F3AE4E4945BACFDD0CF68A0
      Adult
      Source IDH51-BE595EC292A5A4CD30EDDD56
      		Common incremental dose 0.2 to 1 mg
      Source IDH51-6BFAD725949168A1576CEAE1
      		0.2 to 1 mg/mL
      Source IDH51-6AE81047D4BE13FE7DE812BC
      		Over at least 2 to 3 minutes
      Source IDH51-3FE7F630FDE3CD3949BABB7A
      		Allowed with opioid monitoring
      Source IDH51-0BBD9C657E3847FFEA3FA031
      Source IDH51-0FAFF4B33FC8795F951F3408
      Pediatric
      Source IDH51-D09460470B6F40259D5D0145
      		Weight-based dose
      Source IDH51-FFC57F5666EB65CDACA6E7E1
      		Diluted per pediatric policy
      Source IDH51-24BD39309DD69502B51CAC85
      		Slow IV over 2 to 3 minutes
      Source IDH51-72BD7C75EC653B8AF87812D4
      		Pediatric protocol required
      Source IDH51-50B19E9D9E8C65CCB0472F08

      Historical continuous-infusion guidance

      Recovered v5.1 source content; historical, awaiting current review.

      PopulationStandard concentrationInitial rateTitrationMaximumNotes
      Source IDH51-E04379CE33D45F626E675051
      Adult
      Source IDH51-D445EB4637862945C9C0A21A
      		0.2 to 1 mg/mL standardized concentration
      Source IDH51-D3428871F1182C80D9A8F637
      		Patient-specific
      Source IDH51-D6ED2EAECDBC692A7F420528
      		Titrate to pain and adverse effects
      Source IDH51-5ABDD09EBD0D0C8BAC037B4F
      		Protocol-specific
      Source IDH51-33F31A859EDA0E85F2A51FD7
      		Confirm units and opioid-equivalent assumptions.
      Source IDH51-6D604924605CAD55523B4740

      Historical indication and population dosing

      Recovered tables and source-separated snapshots; full clinical revalidation remains pending.

      Existing dose and route snapshots

      RoutePopulationIndicationDoseIntervalDurationAdministrationSource levelNotes
      Source IDH51-9B7AADB76CF6110E1F2D56B9
      IV infusion
      Source IDH51-41D94F81E6FD656622C7DFB1
      		Adult infusion
      Source IDH51-B20ABADB2D3469B05BF211A4
      		Existing preparation record; use current package insert for indication-specific selection
      Source IDH51-A12C5672741731E2A512BF12
      		Patient-specific dose
      Source IDH51-B916D287637819420E3F5F07
      		Not normalized in the preparation record
      Source IDH51-B9CE134C90C0040A51883EB1
      		See current package insert and professional guidance
      Source IDH51-D4E0A23928F8F38512DDBEC4
      		Titrate by mg/hour
      Source IDH51-35C009B8AEA6AC2CC54FAC23
      		Existing GlobalRPh structured preparation snapshot
      Source IDH51-EBD046D84F237F590C4436AE
      		Standardize concentration and account for opioid tolerance.
      Source IDH51-9268996245AB2F11C3F59A9A
      Source IDH51-5863CFCC44C44BEE503A70C5
      IV push
      Source IDH51-AEF5B69A3E622CAB89DE6D7F
      		Adult
      Source IDH51-A100C373A5F9A4D98E5FF1F1
      		Common incremental dose 0.2 to 1 mg
      Source IDH51-467C520F71CA46069818462E
      		Common incremental dose 0.2 to 1 mg
      Source IDH51-2E949DF8498F67E6DA8E3F0A
      		Patient- and indication-specific
      Source IDH51-0BC4D06F389DDF85522753DE
      		See current package insert
      Source IDH51-942A5C1A540D38E4213D3987
      		Over at least 2 to 3 minutes
      Source IDH51-81FF5E0EEA28314F56FF276B
      		Existing GlobalRPh IV push snapshot
      Source IDH51-E9D3539FB1481305CA00917B
      		Allowed with opioid monitoring
      Source IDH51-80966F21776A880DCF6661A0
      Source IDH51-8E99DAB91F41D9419EB2E27E
      IV push
      Source IDH51-47EA0C62E30081A0941DB392
      		Pediatric
      Source IDH51-884A1AD3F12E6D08CC92F8A3
      		Weight-based dose
      Source IDH51-78439630EBBC0F023AB84135
      		Weight-based dose
      Source IDH51-23EB2449AF02E7784F946A98
      		Patient- and indication-specific
      Source IDH51-001525895E1C389430A281A1
      		See current package insert
      Source IDH51-D1518F4FD6D05D51AF3E0278
      		Slow IV over 2 to 3 minutes
      Source IDH51-F5628B6FAA8B5378CBA31C02
      		Existing GlobalRPh IV push snapshot
      Source IDH51-5836B4C5180147D1EC35E166
      		Pediatric protocol required
      Source IDH51-795E166A69E6567B5D7FCC6A
      Source IDH51-B07C7D58613451598C8D2C7B
      Continuous IV infusion
      Source IDH51-44FC7A7D4E46D2166B7FF51E
      		Adult
      Source IDH51-E4CF74711179F6204F3C914F
      		Existing continuous-infusion record
      Source IDH51-F3DE227BF8C38BA5E2B24292
      		Patient-specific
      Source IDH51-52F879E19FD9291216ACB3B7
      		Continuous infusion; titration-specific
      Source IDH51-58CEAF5392F82D067ECC73CF
      		Clinical-response dependent
      Source IDH51-EA4BB8CC5094D01472932C5D
      		Titrate to pain and adverse effects
      Source IDH51-E72180867573DB125C8D0FCB
      		Existing GlobalRPh continuous-infusion snapshot
      Source IDH51-47D82637327CEBAAB281FCD2
      		Protocol-specific Confirm units and opioid-equivalent assumptions.
      Source IDH51-BDB073EBB418F31DBE98EDC9

      Historical renal-function guidance

      Recovered v5.1 source content; historical, awaiting current review.

      Separate renal reference: Open Renal Dosing Master (opens in a new tab)
      Classification
      renal_review_flagged
      Source IDH51-5E9DE10D7AE7212AE5F897A5
      Summary
      The existing monograph contains a renal or nephrotoxicity signal; verify exact adjustment and monitoring in the current label.
      Source IDH51-030A3C4957280ADBCFC7D865
      Method note
      Use the renal function estimate and body-size convention specified by the selected label or institutional protocol. Do not interchange Cockcroft-Gault CrCl, indexed eGFR, and de-indexed eGFR without confirming the dosing source.
      Source IDH51-87F12022E772C7AA9BAC7358

      Historical Common IV uses

      Recovered v5.1 source content; historical, awaiting current review.

      1. Severe pain
        Source IDH51-5818B880B9D5CA95D7E88676
      2. Palliative symptom control
        Source IDH51-8F2D0F6A76812B26A342A2C8

      Historical Warnings and safeguards

      Recovered v5.1 source content; historical, awaiting current review.

      1. Respiratory depression and hypotension.
        Source IDH51-BFE08A7C3F5765D048DCDCCD
      2. Look-alike/sound-alike and potency confusion with morphine.
        Source IDH51-EACA0FC8967E948B81BA9839

      Historical Monitoring

      Recovered v5.1 source content; historical, awaiting current review.

      Separate renal reference: Open Renal Dosing Master (opens in a new tab)
      1. Respiratory status and sedation
        Source IDH51-6E046D3EB039CDD12CF5611A
      2. Pain response
        Source IDH51-D77878398EF7B73720BCFAD1
      3. Renal function and neuroexcitation with prolonged use
        Source IDH51-D88516FAFDE32BAF543261C1
      Other recovered source fields and original editorial metadata

      Original status words such as current, verified, or normalized describe the historical source release. They do not change the clinical review status of this release.

      Catalog source fields

      Id
      hydromorphone
      Source IDH51-015AF45422D9351A5475B307
      Generic name
      Hydromorphone
      Source IDH51-5212BD91338DE4A19503C992
      Brand names
      1. Dilaudid
        Source IDH51-8F832F573E56C6715CF729E6
      Class
      Sedation, analgesia, and anesthesia
      Source IDH51-7F38A245391348B4EA72F52A
      Subclass
      Opioid analgesic
      Source IDH51-DDAC0CB3EA1F1518DC510237
      Summary
      Potent opioid with frequent mg-to-mg confusion risk versus morphine; slow IV administration reduces hypotension and respiratory compromise.
      Source IDH51-6F8C5BFB43B953A859608D44
      Populations
      1. Adult
        Source IDH51-DB4E9470314AB6B34BDF5315
      2. Pediatric
        Source IDH51-B08DA2CFCA9D0CD4AB7445E5
      Evidence tier
      Core reference - verify current label
      Source IDH51-5BBAD8DF96E90D5F0EBBBD91
      High alert
      true
      Source IDH51-6A7D11C0D78A8DACC494CFE7
      Hazardous
      false
      Source IDH51-CF43C726C5069D10F7E312CC
      Status
      Active
      Source IDH51-072FDD132ED3B904D38867D5
      Reviewed
      2026-08-29
      Source IDH51-48D897F2816E89DD9589B56B
      Version added
      1.0
      Source IDH51-6ACC332A4FBE4C43C90D0EE8
      Sources
      LabelUrlKind
      Source IDH51-1720B6152866E8D31BD3C0F1
      DailyMed label search
      Source IDH51-459CE48DF35BABDAA1FF9920
      		https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=Hydromorphone (opens in a new tab)
      Source IDH51-F8E10D5109D146E1CBC8F171
      		Primary
      Source IDH51-A47A8D9A7C2F10F491DA151E
      Source IDH51-F871F91BCBE93BD31A3A926F
      GlobalRPh legacy IV dilution monograph
      Source IDH51-A48320B7B7086CEEF6C85478
      		legacy:auto
      Source IDH51-410DF857A4C2967714F9DB80
      		Legacy
      Source IDH51-D74B1F2A25EEECE9C2E07887
      Legacy title
      Hydromorphone
      Source IDH51-3D6C968850D611A3631F6C35
      Clinical release verification
      Audit version
      3.4
      Source IDH51-268245C254102FD7EEC1C265
      Audited on
      2026-08-30
      Source IDH51-46D10FA1D075921E6787DB88
      Level
      amber
      Source IDH51-92C550023DF5C2553E6B34D0
      Release gate
      trusted_professional_source_present_exact_label_unconfirmed
      Source IDH51-A2656AAEDA1D43F340BD1948
      Exact current label candidate
      false
      Source IDH51-BB03C95E5F62EF52EF6270A5
      Numeric support ratio
      0
      Source IDH51-422C391BAECBB0ACFAF3DC86
      Reference url count
      1
      Source IDH51-D725E4026AAEDD2C7328ECEE
      Broken reference count
      0
      Source IDH51-C2B6805B0158E1C202BAC499
      Point of use confirmation required
      true
      Source IDH51-90C519ABFCED9B960A2FD23E
      Note
      Do not treat this record as a fully current product-specific monograph until the exact IV formulation and current sources are confirmed.
      Source IDH51-3E4F4AD7E165AE7418C6EB96

      Dosing source fields

      Id
      hydromorphone
      Source IDH51-037BE6E743580C04FB6007A2
      Generic name
      Hydromorphone
      Source IDH51-F2C04461CF4DCBC346CE9E63
      Coverage status
      direct_official_label_access_plus_local_snapshot
      Source IDH51-2FB164576530ACF2BF1211E5
      Package insert
      Query name
      Hydromorphone
      Source IDH51-41F83A5ABDE6094F585D4579
      Product and route must match
      true
      Source IDH51-B4DFBD50BEB6DCE828824EF3
      Live current label enabled
      false
      Source IDH51-3FF499EFEE95EAFC420028D1
      Source priority
      Reviewed local summary when available, then a verified DailyMed label or product search when available, followed by professional references and institutional policy.
      Source IDH51-F66A2EC8B683953DAFDADD11
      Direct official label access enabled
      true
      Source IDH51-6B9A6F5C2F58258E9E663C3E
      Outbound server request required
      false
      Source IDH51-262600E74840BD544EE1E57E
      Local summary status
      not_bundled
      Source IDH51-2A21FB363CC952E662E10A3E
      Clinical review
      Locally normalized
      false
      Source IDH51-6D9EF600B7F5A3590984D4CF
      Reviewed
      2026-08-29
      Source IDH51-A1FD0A17B035E660AB1741F3
      Status
      Direct official package-insert access enabled; indication-specific local normalization pending.
      Source IDH51-DBB43E8AC2A1A418CD348903
      Clinical release verification
      Audit version
      3.4
      Source IDH51-3E6F2B54948A7FCAB53329DC
      Audited on
      2026-08-30
      Source IDH51-F4BD8592705A6C0AA67C7A59
      Level
      amber
      Source IDH51-561C81E4A2C9030A5CF53EE3
      Release gate
      trusted_professional_source_present_exact_label_unconfirmed
      Source IDH51-E18FE8C297C08999588F1276
      Exact current label candidate
      false
      Source IDH51-6D6F500BF34BE74106AE562A
      Numeric support ratio
      0
      Source IDH51-19A6FF4ECF10E2596EE954B6
      Reference url count
      1
      Source IDH51-E6EEAF38DF2CDDB0FEAF617D
      Broken reference count
      0
      Source IDH51-FF79594B552E222D55AB3DF5
      Point of use confirmation required
      true
      Source IDH51-870A75FF6FE5A221CABE6220
      Note
      Do not treat this record as a fully current product-specific monograph until the exact IV formulation and current sources are confirmed.
      Source IDH51-737ED86D44A634BD71174AE9
      Historical preparation assessment

      Recovered v5.1 source content; historical, awaiting current review.

      Id
      hydromorphone
      Source IDH51-51E955B4275587F6CE17F3DC
      Name
      Hydromorphone
      Source IDH51-26000BED24DE1BD7A9AC5495
      Brands
      Dilaudid
      Source IDH51-75445C4AF61912AC5F1ACD43
      Therapeutic class
      Sedation, analgesia, and anesthesia
      Source IDH51-4625923B19ED8EBC2F22ED55
      Review version
      3.1
      Source IDH51-9C354F89EE11EBA843A62D7F
      Review date
      2026-08-30
      Source IDH51-BFBBC1476602EB17DBAB8A79
      Release status
      structured_record_current_label_not_confirmed
      Source IDH51-17933E27FBD4F94942FA2259
      Market status
      Status
      no_current_us_iv_spl_confirmed
      Source IDH51-CEA0128863BB6BD0CD00C823
      Basis
      No high-confidence current IV SPL was automatically selected; legacy information is segregated
      Source IDH51-B174529399C862F5B2069415
      Ten point assessment
      Exact formulation
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-B1A43E2B8799C75F4A81C26C
      Reconstitution concentration
      Dilute concentrate or use premix.
      Source IDH51-2FDFA2FD0AA66EC798E247C0
      Maximum or recommended final concentration
      0.2 to 1 mg/mL standardized concentration
      Source IDH51-2B9901A3A76A8FB33555DC32
      Appropriate standardized containers
      50 to 100 mL
      Source IDH51-988F10C4DDA80FD8F924A129
      Adult dosing range
      Patient-specific dose Common incremental dose 0.2 to 1 mg Weight-based dose Patient-specific Common incremental dose 0.2 to 1 mg Weight-based dose
      Source IDH51-9388D8DE0F9BFDC07C0AD0EF
      Pediatric dosing range
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-163515507C43673022C0902B
      Neonatal dosing range
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-A49D58B66F9814A4D07835FF
      Infusion time
      Titrate by mg/hour Over at least 2 to 3 minutes Slow IV over 2 to 3 minutes Patient-specific
      Source IDH51-0639FDCB5BA82E4F9087EFDD
      Fluid restriction alternatives
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-65499989E66A508271495401
      Current manufacturer labeling
      Match confidence
      unresolved
      Source IDH51-FFD82F5A6D2CED3E7EE0BA12
      Field provenance
      Exact formulation
      Primary
      not_found
      Source IDH51-FAD34F7086DFAC55B4AE82FE
      Reconstitution concentration
      Primary
      existing_structured_record
      Source IDH51-AAFFF6EF5919D7E7959666FA
      Maximum or recommended final concentration
      Primary
      existing_structured_record
      Source IDH51-A3ED51F545168D46273490F6
      Appropriate standardized containers
      Primary
      existing_structured_record
      Source IDH51-149462FEFC7A295893F50842
      Adult dosing range
      Primary
      existing_structured_record
      Source IDH51-6476C1D8CBE0D781706AE2B8
      Pediatric dosing range
      Primary
      not_found
      Source IDH51-1A4EDA675E62BC5803E8AF5D
      Neonatal dosing range
      Primary
      not_found
      Source IDH51-11DA81A43CCAA46BCD2D5DBD
      Infusion time
      Primary
      existing_structured_record
      Source IDH51-81AA38D5D14950986F2DB147
      Fluid restriction alternatives
      Primary
      not_found
      Source IDH51-3A1A817F858EE2837C126AB5
      Current manufacturer labeling
      Primary
      DailyMed search gateway
      Source IDH51-63FED45D0E06E620358ED0DF
      Population applicability
      Adult
      Applicability
      supported_or_source_present
      Source IDH51-74CF3242D0F44BDB6A031D99
      Guide generation allowed
      true
      Source IDH51-86BC3D00542F2870513CCCB8
      Pediatric
      Applicability
      supported_or_source_present
      Source IDH51-818D56B204C54B93074DDA52
      Guide generation allowed
      false
      Source IDH51-7A6C03B8310AE53382F05E3E
      Neonatal
      Applicability
      not_established
      Source IDH51-B96B8D62560FCC5097EA24A6
      Guide generation allowed
      false
      Source IDH51-0B7D31B8815878E76A3A2578
      Route presence
      Structured dilution
      true
      Source IDH51-64BBEB218743E431D9E56057
      Iv push
      true
      Source IDH51-635A43A85C7A2FEEF4C9DE6F
      Continuous infusion
      true
      Source IDH51-8396FA11EC5952A5F7C297A6
      Pediatric source
      true
      Source IDH51-658561E5819CF97A34EACDBA
      Neonatal source
      false
      Source IDH51-EEA21664FBBF8D7DA7586891
      Legacy reference
      Status
      not_available
      Source IDH51-9B971B7B26AB7D2B58873152
      Label resolution
      Status
      build_environment_network_unavailable
      Source IDH51-E621DAB3E81A71916C377E1F
      Concentration values detected
      LowHighUnitText
      Source IDH51-9247F95ADFE53B0AC0FBC29D
      0.2
      Source IDH51-EEBBC2B9C4951A772592DA09
      		1
      Source IDH51-E974CF47221799CD5A6DD4CF
      		mg
      Source IDH51-D948531D979B0CBEB2766E76
      		0.2 to 1 mg/mL
      Source IDH51-FC2068A9103EE8917A939D69
      Source files
      1. catalog.json
        Source IDH51-2D436BC7AB32E83D81C2F4A9
      2. dosing.json
        Source IDH51-0CCE03E88C54B454A868BCB2
      3. legacy-map.json
        Source IDH51-7B189704A6A5BB1377E0B22B
      Clinical release note
      Preparation instructions are released only at the evidence level shown. Legacy content remains visibly separate. Exact product, NDC, route, current labeling, and institutional policy must be confirmed.
      Source IDH51-4A52DBE0D0F5B7D21F22A1EF
      Historical statement IDs and source locations

      These IDs identify recovered source units. They are not evidence-qualified clinical claims.

      Historical IDOriginal source locationStatus
      H51-015AF45422D9351A5475B307catalog.json
      /records/125/id      		Historical; current review incomplete
      H51-5212BD91338DE4A19503C992catalog.json
      /records/125/generic_name      		Historical; current review incomplete
      H51-8F832F573E56C6715CF729E6catalog.json
      /records/125/brand_names/0      		Historical; current review incomplete
      H51-7F38A245391348B4EA72F52Acatalog.json
      /records/125/class      		Historical; current review incomplete
      H51-DDAC0CB3EA1F1518DC510237catalog.json
      /records/125/subclass      		Historical; current review incomplete
      H51-6F8C5BFB43B953A859608D44catalog.json
      /records/125/summary      		Historical; current review incomplete
      H51-5818B880B9D5CA95D7E88676catalog.json
      /records/125/common_uses/0      		Historical; current review incomplete
      H51-8F2D0F6A76812B26A342A2C8catalog.json
      /records/125/common_uses/1      		Historical; current review incomplete
      H51-C7F5E8C3E5A7D0FB0D8B5518catalog.json
      /records/125/preparations/0      		Historical; current review incomplete
      H51-F9B179D8BFB27B1D7A5076FAcatalog.json
      /records/125/preparations/0/population      		Historical; current review incomplete
      H51-90D4A4D0E6B4018EA0C3117Ecatalog.json
      /records/125/preparations/0/amount      		Historical; current review incomplete
      H51-7FB2FACD20AB8EB229B046B8catalog.json
      /records/125/preparations/0/reconstitution      		Historical; current review incomplete
      H51-5E495E0B024180BB9C8A2026catalog.json
      /records/125/preparations/0/diluent      		Historical; current review incomplete
      H51-0D6CF15680A6E0533419C93Acatalog.json
      /records/125/preparations/0/final_volume      		Historical; current review incomplete
      H51-B0B65E144EA4F635CE8F6CF5catalog.json
      /records/125/preparations/0/concentration      		Historical; current review incomplete
      H51-BBB3C173348E55C4975648C8catalog.json
      /records/125/preparations/0/rate      		Historical; current review incomplete
      H51-E39E56577B616E859D93BE19catalog.json
      /records/125/preparations/0/stability      		Historical; current review incomplete
      H51-6E7993B4B7B1CC01037097FAcatalog.json
      /records/125/preparations/0/notes      		Historical; current review incomplete
      H51-3F3AE4E4945BACFDD0CF68A0catalog.json
      /records/125/iv_push/0      		Historical; current review incomplete
      H51-BE595EC292A5A4CD30EDDD56catalog.json
      /records/125/iv_push/0/population      		Historical; current review incomplete
      H51-6BFAD725949168A1576CEAE1catalog.json
      /records/125/iv_push/0/dose_scope      		Historical; current review incomplete
      H51-6AE81047D4BE13FE7DE812BCcatalog.json
      /records/125/iv_push/0/concentration      		Historical; current review incomplete
      H51-3FE7F630FDE3CD3949BABB7Acatalog.json
      /records/125/iv_push/0/rate      		Historical; current review incomplete
      H51-0BBD9C657E3847FFEA3FA031catalog.json
      /records/125/iv_push/0/status      		Historical; current review incomplete
      H51-53220D4E5ED0FA7638520F43catalog.json
      /records/125/iv_push/0/notes      		Historical; current review incomplete
      H51-0FAFF4B33FC8795F951F3408catalog.json
      /records/125/iv_push/1      		Historical; current review incomplete
      H51-D09460470B6F40259D5D0145catalog.json
      /records/125/iv_push/1/population      		Historical; current review incomplete
      H51-FFC57F5666EB65CDACA6E7E1catalog.json
      /records/125/iv_push/1/dose_scope      		Historical; current review incomplete
      H51-24BD39309DD69502B51CAC85catalog.json
      /records/125/iv_push/1/concentration      		Historical; current review incomplete
      H51-72BD7C75EC653B8AF87812D4catalog.json
      /records/125/iv_push/1/rate      		Historical; current review incomplete
      H51-50B19E9D9E8C65CCB0472F08catalog.json
      /records/125/iv_push/1/status      		Historical; current review incomplete
      H51-4003044B8DF2E6180E60747Ccatalog.json
      /records/125/iv_push/1/notes      		Historical; current review incomplete
      H51-E04379CE33D45F626E675051catalog.json
      /records/125/continuous_infusions/0      		Historical; current review incomplete
      H51-D445EB4637862945C9C0A21Acatalog.json
      /records/125/continuous_infusions/0/population      		Historical; current review incomplete
      H51-D3428871F1182C80D9A8F637catalog.json
      /records/125/continuous_infusions/0/standard_concentration      		Historical; current review incomplete
      H51-D6ED2EAECDBC692A7F420528catalog.json
      /records/125/continuous_infusions/0/initial_rate      		Historical; current review incomplete
      H51-5ABDD09EBD0D0C8BAC037B4Fcatalog.json
      /records/125/continuous_infusions/0/titration      		Historical; current review incomplete
      H51-33F31A859EDA0E85F2A51FD7catalog.json
      /records/125/continuous_infusions/0/maximum      		Historical; current review incomplete
      H51-6D604924605CAD55523B4740catalog.json
      /records/125/continuous_infusions/0/notes      		Historical; current review incomplete
      H51-BFE08A7C3F5765D048DCDCCDcatalog.json
      /records/125/warnings/0      		Historical; current review incomplete
      H51-EACA0FC8967E948B81BA9839catalog.json
      /records/125/warnings/1      		Historical; current review incomplete
      H51-6E046D3EB039CDD12CF5611Acatalog.json
      /records/125/monitoring/0      		Historical; current review incomplete
      H51-D77878398EF7B73720BCFAD1catalog.json
      /records/125/monitoring/1      		Historical; current review incomplete
      H51-D88516FAFDE32BAF543261C1catalog.json
      /records/125/monitoring/2      		Historical; current review incomplete
      H51-DB4E9470314AB6B34BDF5315catalog.json
      /records/125/populations/0      		Historical; current review incomplete
      H51-B08DA2CFCA9D0CD4AB7445E5catalog.json
      /records/125/populations/1      		Historical; current review incomplete
      H51-5BBAD8DF96E90D5F0EBBBD91catalog.json
      /records/125/evidence_tier      		Historical; current review incomplete
      H51-6A7D11C0D78A8DACC494CFE7catalog.json
      /records/125/high_alert      		Historical; current review incomplete
      H51-CF43C726C5069D10F7E312CCcatalog.json
      /records/125/hazardous      		Historical; current review incomplete
      H51-072FDD132ED3B904D38867D5catalog.json
      /records/125/status      		Historical; current review incomplete
      H51-48D897F2816E89DD9589B56Bcatalog.json
      /records/125/reviewed      		Historical; current review incomplete
      H51-6ACC332A4FBE4C43C90D0EE8catalog.json
      /records/125/version_added      		Historical; current review incomplete
      H51-1720B6152866E8D31BD3C0F1catalog.json
      /records/125/sources/0      		Historical; current review incomplete
      H51-459CE48DF35BABDAA1FF9920catalog.json
      /records/125/sources/0/label      		Historical; current review incomplete
      H51-F8E10D5109D146E1CBC8F171catalog.json
      /records/125/sources/0/url      		Historical; current review incomplete
      H51-A47A8D9A7C2F10F491DA151Ecatalog.json
      /records/125/sources/0/kind      		Historical; current review incomplete
      H51-F871F91BCBE93BD31A3A926Fcatalog.json
      /records/125/sources/1      		Historical; current review incomplete
      H51-A48320B7B7086CEEF6C85478catalog.json
      /records/125/sources/1/label      		Historical; current review incomplete
      H51-410DF857A4C2967714F9DB80catalog.json
      /records/125/sources/1/url      		Historical; current review incomplete
      H51-D74B1F2A25EEECE9C2E07887catalog.json
      /records/125/sources/1/kind      		Historical; current review incomplete
      H51-3D6C968850D611A3631F6C35catalog.json
      /records/125/legacy_title      		Historical; current review incomplete
      H51-268245C254102FD7EEC1C265catalog.json
      /records/125/clinical_release_verification/audit_version      		Historical; current review incomplete
      H51-46D10FA1D075921E6787DB88catalog.json
      /records/125/clinical_release_verification/audited_on      		Historical; current review incomplete
      H51-92C550023DF5C2553E6B34D0catalog.json
      /records/125/clinical_release_verification/level      		Historical; current review incomplete
      H51-A2656AAEDA1D43F340BD1948catalog.json
      /records/125/clinical_release_verification/release_gate      		Historical; current review incomplete
      H51-BB03C95E5F62EF52EF6270A5catalog.json
      /records/125/clinical_release_verification/exact_current_label_candidate      		Historical; current review incomplete
      H51-80F86FC42B7CE8B2E656ADD7catalog.json
      /records/125/clinical_release_verification/selected_setid      		Historical; current review incomplete
      H51-C44D8C1638D5CE04C1DAC82Ccatalog.json
      /records/125/clinical_release_verification/selected_label_title      		Historical; current review incomplete
      H51-422C391BAECBB0ACFAF3DC86catalog.json
      /records/125/clinical_release_verification/numeric_support_ratio      		Historical; current review incomplete
      H51-D725E4026AAEDD2C7328ECEEcatalog.json
      /records/125/clinical_release_verification/reference_url_count      		Historical; current review incomplete
      H51-C2B6805B0158E1C202BAC499catalog.json
      /records/125/clinical_release_verification/broken_reference_count      		Historical; current review incomplete
      H51-90C519ABFCED9B960A2FD23Ecatalog.json
      /records/125/clinical_release_verification/point_of_use_confirmation_required      		Historical; current review incomplete
      H51-3E4F4AD7E165AE7418C6EB96catalog.json
      /records/125/clinical_release_verification/note      		Historical; current review incomplete
      H51-CDBD0585C31C0C6E35727302catalog.json
      /records/125/clinical_release_verification/dailymed_search_url      		Historical; current review incomplete
      H51-037BE6E743580C04FB6007A2dosing.json
      /records/125/id      		Historical; current review incomplete
      H51-F2C04461CF4DCBC346CE9E63dosing.json
      /records/125/generic_name      		Historical; current review incomplete
      H51-2FB164576530ACF2BF1211E5dosing.json
      /records/125/coverage_status      		Historical; current review incomplete
      H51-41F83A5ABDE6094F585D4579dosing.json
      /records/125/package_insert/query_name      		Historical; current review incomplete
      H51-ED242987EEB0B2E99AD64A0Ddosing.json
      /records/125/package_insert/preferred_setid      		Historical; current review incomplete
      H51-B4DFBD50BEB6DCE828824EF3dosing.json
      /records/125/package_insert/product_and_route_must_match      		Historical; current review incomplete
      H51-3FF499EFEE95EAFC420028D1dosing.json
      /records/125/package_insert/live_current_label_enabled      		Historical; current review incomplete
      H51-F66A2EC8B683953DAFDADD11dosing.json
      /records/125/package_insert/source_priority      		Historical; current review incomplete
      H51-6B9A6F5C2F58258E9E663C3Edosing.json
      /records/125/package_insert/direct_official_label_access_enabled      		Historical; current review incomplete
      H51-262600E74840BD544EE1E57Edosing.json
      /records/125/package_insert/outbound_server_request_required      		Historical; current review incomplete
      H51-2A21FB363CC952E662E10A3Edosing.json
      /records/125/package_insert/local_summary_status      		Historical; current review incomplete
      H51-5E9DE10D7AE7212AE5F897A5dosing.json
      /records/125/renal/classification      		Historical; current review incomplete
      H51-030A3C4957280ADBCFC7D865dosing.json
      /records/125/renal/summary      		Historical; current review incomplete
      H51-87F12022E772C7AA9BAC7358dosing.json
      /records/125/renal/method_note      		Historical; current review incomplete
      H51-9B7AADB76CF6110E1F2D56B9dosing.json
      /records/125/existing_route_snapshots/0      		Historical; current review incomplete
      H51-41D94F81E6FD656622C7DFB1dosing.json
      /records/125/existing_route_snapshots/0/route      		Historical; current review incomplete
      H51-B20ABADB2D3469B05BF211A4dosing.json
      /records/125/existing_route_snapshots/0/population      		Historical; current review incomplete
      H51-A12C5672741731E2A512BF12dosing.json
      /records/125/existing_route_snapshots/0/indication      		Historical; current review incomplete
      H51-B916D287637819420E3F5F07dosing.json
      /records/125/existing_route_snapshots/0/dose      		Historical; current review incomplete
      H51-B9CE134C90C0040A51883EB1dosing.json
      /records/125/existing_route_snapshots/0/interval      		Historical; current review incomplete
      H51-D4E0A23928F8F38512DDBEC4dosing.json
      /records/125/existing_route_snapshots/0/duration      		Historical; current review incomplete
      H51-35C009B8AEA6AC2CC54FAC23dosing.json
      /records/125/existing_route_snapshots/0/administration      		Historical; current review incomplete
      H51-EBD046D84F237F590C4436AEdosing.json
      /records/125/existing_route_snapshots/0/source_level      		Historical; current review incomplete
      H51-9268996245AB2F11C3F59A9Adosing.json
      /records/125/existing_route_snapshots/0/notes      		Historical; current review incomplete
      H51-5863CFCC44C44BEE503A70C5dosing.json
      /records/125/existing_route_snapshots/1      		Historical; current review incomplete
      H51-AEF5B69A3E622CAB89DE6D7Fdosing.json
      /records/125/existing_route_snapshots/1/route      		Historical; current review incomplete
      H51-A100C373A5F9A4D98E5FF1F1dosing.json
      /records/125/existing_route_snapshots/1/population      		Historical; current review incomplete
      H51-467C520F71CA46069818462Edosing.json
      /records/125/existing_route_snapshots/1/indication      		Historical; current review incomplete
      H51-2E949DF8498F67E6DA8E3F0Adosing.json
      /records/125/existing_route_snapshots/1/dose      		Historical; current review incomplete
      H51-0BC4D06F389DDF85522753DEdosing.json
      /records/125/existing_route_snapshots/1/interval      		Historical; current review incomplete
      H51-942A5C1A540D38E4213D3987dosing.json
      /records/125/existing_route_snapshots/1/duration      		Historical; current review incomplete
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