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Preparation. Administration. Evidence.

IV Dilution &
Medication Reference

Search 255 medications, read preserved historical references, and inspect separately reviewed preparation statements. Full monograph updates remain pending.

Version 6.4Release date 2026-11-04For healthcare professionals
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Medication reference

Diphenhydramine

Monograph awaiting updateThis monograph will be updated in the future.

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Historical source. Current clinical review is incomplete. This monograph will be updated in the future.

Benadryl ® - Diphenhydramine (opens in a new tab)Original source URL: https://globalrph.com/dilution/benadryl-diphenhydramine/ | Retrieved 2026-11-04

Source dates, location and integrity

This historical article is separate from the reviewed claim cards. Product formulations and source dates may differ.

Original source URL
https://globalrph.com/dilution/benadryl-diphenhydramine/ (opens in a new tab)
Source date
Not established in the retrieved source
Retrieved
2026-11-04T19:46:12.493253+00:00
Source location
div.post-content
Packaged content SHA-256
18dc4118fcf3f984570cc73490b8ec9e6d2fc3490c82ac874e369c95ab0850fa
Original response SHA-256
bfaacc556de488c0856713be35d02c0655797245be2c7016dab8edb7dfc5b557
Source body SHA-256
e17312e7d6a89b41639e4639cc85d5134ca1b97e945620f609f9a01b83b65074

DIPHENHYDRAMINE (BENADRYL ®)

The authors make no claims of the accuracy of the information contained herein; and these suggested doses and/or guidelines are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this document shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material. PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.

Usual Diluents

D5W, NS

Standard Dilutions [Amount of drug] [Infusion volume] [Infusion rate]

[0 to 100 mg] [50 ml] [20 - 30min]

Stability / Miscellaneous

Stability data:

Drug Stability
Refrigerated
Stability
Room Temp.
Reconstituted
Vial/Powder
Notes
Benadryl - Diphenhydramine Store at 20 to 25°C (68 to 77°F) Solution Protect from freezing and light. Retain in carton until time of use.


EXP
: 1 DAY (RT).
Maximum dose/ 24 hours= 400 mg.
Dosing: 10 to 50mg IM or IV q2 to 6h.

DOSAGE AND ADMINISTRATION
THIS PRODUCT IS FOR INTRAVENOUS OR INTRAMUSCULAR ADMINISTRATION ONLY.

Benadryl in the injectable form is indicated when the oral form is impractical.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

DOSAGE SHOULD BE INDIVIDUALIZED ACCORDING TO THE NEEDS AND THE RESPONSE OF THE PATIENT.

Pediatric Patients, other than premature infants and neonates
5 mg/kg/24 hr or 150 mg/m2/24 hr. Maximum daily dosage is 300 mg. Divide into four doses, administered intravenously at a rate generally not exceeding 25 mg/min, or deep intramuscularly.

Adults
10 to 50 mg intravenously at a rate generally not exceeding 25 mg/min, or deep intramuscularly, 100 mg if required; maximum daily dosage is 400 mg.

HOW SUPPLIED
Benadryl in parenteral form is supplied as:

Benadryl Steri-Vials®
-sterile, pyrogen-free solution containing 50 mg diphenhydramine hydrochloride in each milliliter of solution with 0.1 mg/mL benzethonium chloride as a germicidal agent. Available in 10-mL (N 0071-4402-10) Steri-Vials.

-sterile, pyrogen-free solution containing 50 mg diphenhydramine hydrochloride in each milliliter of solution. Available in packages of twenty-five 1-mL (N 0071-4259-13) Steri-Vials.

Benadryl Steri-Dose ®
-sterile, pyrogen-free solution containing 50 mg diphenhydramine hydrochloride in a 1-mL disposable syringe (Steri-Dose). Available in packages of ten syringes (N 0071-4259-45).

Benadryl Ampoule
-sterile, pyrogen-free solution containing 50 mg diphenhydramine hydrochloride in a 1-mL ampoule. Available in packages of ten (N 0071-4259-03).

Store at controlled room temperature 15°-30°C (59°-86°F). Protect from freezing and light.

Rx only
Manufactured by:
Parkedale Pharmaceuticals, Inc.
Rochester, MI 48307

Open this historical article on its own

Product identifiers and clinical review status

This monograph will be updated in the future. Historical material is available where present in the original sources; full current exact-product and claim-level review remains pending.

Exact formulation, concentration, container, manufacturer, regulatory identifiers, and a reproducible label snapshot have not all been reconciled.

What remains to be completed
  • Retrievable exact-product SPL XML with version, revision, retrieval date and reproducible hash
  • Clinically reviewed, individually identified statements with two exact source mappings
  • Exact formulation, strength, container, manufacturer/labeler, application and NDC reconciliation
  • Renal-function methods and dialysis/CRRT modality review where applicable
  • Mechanism provenance, clinical source disagreements and full medication-specific safety reconciliation

Supplemental historical fields

Restored-data provenance and review notes

Source release: 2026-08-31. Current clinical review is incomplete. Original uses of current, verified, or normalized describe the historical source. They do not inherit the status of separately reviewed statements. Product formulations and source dates can differ.

Current review annotations for historical renal, dialysis, mechanism, and product fieldsSeparate renal reference: Open Renal Dosing Master (opens in a new tab)
Renal
Status
not_locally_normalized
Original classification
current_label_review_required
Entries
    General note
    Preserve the source-specific renal-function basis. An indexed CrCl table is not interchangeable with unindexed CrCl or eGFR. Generic advice to check a method does not identify the equation for a dose row.
    Dialysis
    Status
    no_local_structured_regimen
    Entries
      General note
      Named modality alone does not establish applicability. CRRT subtype, effluent rate, residual renal function, timing and interruptions require review. Historical absence is not evidence that no guidance exists.
      Mechanisms
      • Source kind
        first_look
        Local pointer
        /mechanism
        Original level
        drug_specific
        Provenance classification
        historical_drug_specific_uncorroborated
        Label derived verified
        false
        Independently corroborated
        false
        Exact label section
        Not recorded
        Original source note
        Not recorded
        Review status
        historical_unverified
        Note
        Drug-specific wording in the old file is not proof of independent corroboration or an exact label locator. Consult separately published current mechanism claims where present.
      Future update
      Status
      pending_review
      Message
      This monograph will be updated in the future as current exact-product and claim-level review is completed.
      Source unavailable
      false
      Reason
      The historical content is restored; comprehensive contemporary verification remains incomplete.
      Historical first look: uses, mechanism, dosing context, and administration

      Recovered v5.1 source content; historical, awaiting current review.

      Id
      diphenhydramine
      Source IDH51-F985FDC82644C6C3F7FC90B6
      Generic name
      Diphenhydramine
      Source IDH51-0BAEED66D25FE46BCE9350D3
      Class
      Other intravenous medications
      Source IDH51-F58C3FF3A8AE69D4B5692520
      Subclass
      H1 antihistamine
      Source IDH51-C7E2C3A160F10820FB6CDEAF
      Primary uses
      1. Acute allergic reactions as adjunctive treatment
        Source IDH51-49A7E60DF2CBF4E70EFB1120
      2. Dystonic reaction
        Source IDH51-2A78511DD0F5D142EC2E575C
      Mechanism
      Acts as an H1 inverse agonist with antimuscarinic activity.
      Source IDH51-098AF14C5C2D775E0153B9B5
      Mechanism level
      drug_specific
      Source IDH51-1BA4380D6EB941901924CF5F
      Basic dosing orientation
      Adult / Pediatric | Common adult dose 10 to 50 mg; pediatric dose weight based | Common adult dose 10 to 50 mg; pediatric dose weight based | Patient- and indication-specific | See current package insert | IV push
      Source IDH51-FBE49E803B86A0A178CE8EC9
      Administration orientation
      No faster than 25 mg/min; 50 mg/mL; dilution may improve control; No faster than 25 mg/min
      Source IDH51-1256AFBB74FF7ADA2E0AADAA
      Renal and population orientation
      Separate renal reference: Open Renal Dosing Master (opens in a new tab)Renal dosing status has not been locally normalized; use the current package insert before ordering or administration.
      Source IDH51-861EF9B0DC6B1B44AE08A217
      Key safety orientation
      1. Sedation, hypotension, anticholinergic toxicity, and tissue irritation.
        Source IDH51-F269362D03D24737E8F4A6F7
      Coverage path
      structured_local_snapshot
      Source IDH51-0D4BD77DC41D118E38193FED
      Coverage path label
      Structured GlobalRPh route snapshot
      Source IDH51-4B3F98D9DDDED530D7AEA64C
      Legacy title
      Diphenhydramine (Benadryl)
      Source IDH51-BD7FC8F84295AFF1CFC080E6
      Review note
      First-look orientation only. Verify indication, patient population, weight basis, organ function, exact IV product, dose, concentration, compatibility, rate, and current labeling before use.
      Source IDH51-F01478DF66222CFE687FBA9C
      Search text
      Diphenhydramine Other intravenous medications H1 antihistamine Acute allergic reactions as adjunctive treatment Dystonic reaction Acts as an H1 inverse agonist with antimuscarinic activity. Adult / Pediatric | Common adult dose 10 to 50 mg; pediatric dose weight based | Common adult dose 10 to 50 mg; pediatric dose weight based | Patient- and indication-specific | See current package insert | IV push No faster than 25 mg/min; 50 mg/mL; dilution may improve control; No faster than 25 mg/min Renal dosing status has not been locally normalized; use the current package insert before ordering or administration. Sedation, hypotension, anticholinergic toxicity, and tissue irritation. Structured GlobalRPh route snapshot
      Source IDH51-9A343EC29D1A3D8D7F9759E9
      Official access mode
      search
      Source IDH51-C315A5D84540C571BF78DEBD
      Official search query
      Diphenhydramine
      Source IDH51-4FE8056FC65910974289734E
      Official access reason
      A source-backed DailyMed search is available; select and confirm the exact IV product.
      Source IDH51-7952B49809D2C71BCF6B8991

      No separate structured rows were bundled for preparation, continuous infusion, dialysis, CRRT. Historical article content and source links may cover these topics.

      Historical IV-push guidance

      Recovered v5.1 source content; historical, awaiting current review.

      PopulationDose scopeConcentrationRateStatusNotes
      Source IDH51-856D05132DB891F7BD425082
      Adult / Pediatric
      Source IDH51-075994E01BCD9B15B9D85175
      Common adult dose 10 to 50 mg; pediatric dose weight based
      Source IDH51-FD2427D81429994C4FD9A6F2
      50 mg/mL; dilution may improve control
      Source IDH51-6E27A5EC2CDA3D33D5BDC3FA
      No faster than 25 mg/min
      Source IDH51-9BBF06511322DBB43DF0D823
      Use only when ordered and supported by current labeling or institutional policy
      Source IDH51-433E37CB5D98E7E9F4BD7A2B
      Not a substitute for epinephrine in anaphylaxis. Prefer lower concentration for small or pediatric doses.
      Source IDH51-22B905E6D12BDFEA5EEB559A

      Historical indication and population dosing

      Recovered tables and source-separated snapshots; full clinical revalidation remains pending.

      Existing dose and route snapshots

      RoutePopulationIndicationDoseIntervalDurationAdministrationSource levelNotes
      Source IDH51-092CFB3A71C49F8A9EFCD7F5
      IV push
      Source IDH51-FD34C5DEA16860A2FB26B8A3
      Adult / Pediatric
      Source IDH51-DEDBDEC350752F4A13A861BF
      Common adult dose 10 to 50 mg; pediatric dose weight based
      Source IDH51-7E17F45F925FF0F28CE5177C
      Common adult dose 10 to 50 mg; pediatric dose weight based
      Source IDH51-3D9E0CC10B0AB2C89509A19E
      Patient- and indication-specific
      Source IDH51-0277134570E100047ACCA3A4
      See current package insert
      Source IDH51-FC8ED7F721BFB9DA29E23403
      No faster than 25 mg/min
      Source IDH51-FDAF8FDE27C5DF73110A12BB
      Existing GlobalRPh IV push snapshot
      Source IDH51-3C65FAADDB4C7DF936CCCA17
      Use only when ordered and supported by current labeling or institutional policy Not a substitute for epinephrine in anaphylaxis. Prefer lower concentration for small or pediatric doses.
      Source IDH51-EC55DF6F8247BDE09EFBD76E

      Historical renal-function guidance

      Recovered v5.1 source content; historical, awaiting current review.

      Separate renal reference: Open Renal Dosing Master (opens in a new tab)
      Classification
      current_label_review_required
      Source IDH51-5658EF58DC35CBC54CCB04B0
      Summary
      Renal dosing status has not been locally normalized; use the current package insert before ordering or administration.
      Source IDH51-FFF4908F36E060B55BBCA1C5
      Method note
      Use the renal function estimate and body-size convention specified by the selected label or institutional protocol. Do not interchange Cockcroft-Gault CrCl, indexed eGFR, and de-indexed eGFR without confirming the dosing source.
      Source IDH51-6FDC1185BDB49D2C58A0C885

      Historical Common IV uses

      Recovered v5.1 source content; historical, awaiting current review.

      1. Acute allergic reactions as adjunctive treatment
        Source IDH51-98F947328D9909555E5CD5BF
      2. Dystonic reaction
        Source IDH51-D8DDFC0F53881C5187C977FA

      Historical Warnings and safeguards

      Recovered v5.1 source content; historical, awaiting current review.

      1. Sedation, hypotension, anticholinergic toxicity, and tissue irritation.
        Source IDH51-60255579716E67C3EE667C4C

      Historical Monitoring

      Recovered v5.1 source content; historical, awaiting current review.

      1. Blood pressure, sedation, airway/allergic response
        Source IDH51-5F17B3267EFD972E2DFB0AD1
      Other recovered source fields and original editorial metadata

      Original status words such as current, verified, or normalized describe the historical source release. They do not change the clinical review status of this release.

      Catalog source fields

      Id
      diphenhydramine
      Source IDH51-F7A2CC8ECDAA4BAF1D9E541E
      Generic name
      Diphenhydramine
      Source IDH51-F67DEE16DBCD0B21AB7B8010
      Brand names
      1. Benadryl
        Source IDH51-197D6D5573975F40A71967EE
      Class
      Other intravenous medications
      Source IDH51-24C5CCFE2027D5397649DECB
      Subclass
      H1 antihistamine
      Source IDH51-BCF53F860B16E85EF5AFD3F2
      Summary
      Sedating antihistamine that should be given slowly to reduce hypotension and CNS toxicity.
      Source IDH51-22E7A8EB47DCB4277609CE06
      Populations
      1. Adult
        Source IDH51-6ACF2C122B0547C4B3199BBB
      2. Pediatric
        Source IDH51-91063E684F68AE61BBD36596
      Evidence tier
      IV push safety normalization - verify stocked product
      Source IDH51-5600CEDA9280D76D4E5EBB61
      High alert
      true
      Source IDH51-F476DC6C41C418A37DB28619
      Hazardous
      false
      Source IDH51-853470A35A4F8A0C28551689
      Status
      Active
      Source IDH51-4964F6D452F0EBDD2C5BC201
      Reviewed
      2026-08-29
      Source IDH51-1C173AB2C59F1522D2A4CA1D
      Version added
      1.2
      Source IDH51-0E34EA26DA055A029030D9A6
      Sources
      LabelUrlKind
      Source IDH51-40188D38FF0833F47DD16F9C
      DailyMed label search
      Source IDH51-A32CA3B2CF36392E536EEEA0
      https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=Diphenhydramine (opens in a new tab)
      Source IDH51-3DD70D82268C82BB062890D8
      Primary
      Source IDH51-37B352A57808176B5ACEDF8D
      Source IDH51-C7A163C9C9001B3C24442072
      GlobalRPh legacy IV dilution monograph
      Source IDH51-7D77D22F5DB9618B743729A6
      legacy:auto
      Source IDH51-09DEBE6CD4403E2079095BFA
      Legacy
      Source IDH51-1679FB2F0292A7C99F16C319
      Legacy title
      Diphenhydramine (Benadryl)
      Source IDH51-65C58C0EB195622F36BDE0F6
      Clinical release verification
      Audit version
      3.4
      Source IDH51-34C420E0041A03D94670086E
      Audited on
      2026-08-30
      Source IDH51-4839299B279FF220942387F1
      Level
      amber
      Source IDH51-3168BB83952FEB106E79B013
      Release gate
      trusted_professional_source_present_exact_label_unconfirmed
      Source IDH51-2C25C5F97531F380C50E4C73
      Exact current label candidate
      false
      Source IDH51-2AD826413114FA08710AFE92
      Numeric support ratio
      0
      Source IDH51-23495AC7B411EC306103E55A
      Reference url count
      1
      Source IDH51-12B6C0E9BECC357E2FC42DC4
      Broken reference count
      0
      Source IDH51-6117A3F31103830A1C810327
      Point of use confirmation required
      true
      Source IDH51-4BE803904E67B89934C9315B
      Note
      Do not treat this record as a fully current product-specific monograph until the exact IV formulation and current sources are confirmed.
      Source IDH51-491A9A94C0CA7375D2DBEAE8

      Dosing source fields

      Id
      diphenhydramine
      Source IDH51-63C997465C997E1CAD99E302
      Generic name
      Diphenhydramine
      Source IDH51-87CAD6DF79B5B8E08EBCB658
      Coverage status
      direct_official_label_access_plus_local_snapshot
      Source IDH51-6B3314697FE8060E2820A5C3
      Package insert
      Query name
      Diphenhydramine
      Source IDH51-2468BBD35AC3BA1EA4525220
      Product and route must match
      true
      Source IDH51-0652E06E727A8977F389366B
      Live current label enabled
      false
      Source IDH51-1C493C58F3623228D484BE09
      Source priority
      Reviewed local summary when available, then a verified DailyMed label or product search when available, followed by professional references and institutional policy.
      Source IDH51-95D3C032E7400A76A33B7B73
      Direct official label access enabled
      true
      Source IDH51-E0EE585F777754A0FA4B9D32
      Outbound server request required
      false
      Source IDH51-58492CD48F03040178D82B47
      Local summary status
      not_bundled
      Source IDH51-E1C91864391C1A3BA645E20A
      Clinical review
      Locally normalized
      false
      Source IDH51-4ED3D09F16D5FB996C230BF8
      Reviewed
      2026-08-29
      Source IDH51-DD6B5AF4BF6EB8576335E346
      Status
      Direct official package-insert access enabled; indication-specific local normalization pending.
      Source IDH51-2BAE94E8D009431D9A39C64F
      Clinical release verification
      Audit version
      3.4
      Source IDH51-1FC69AB7DD92D31A1741968A
      Audited on
      2026-08-30
      Source IDH51-BF96479890AE439BCBFA88EC
      Level
      amber
      Source IDH51-A4E894384B5FA716BFF73A47
      Release gate
      trusted_professional_source_present_exact_label_unconfirmed
      Source IDH51-A64DEFBB5B3B4F8B7D63FE61
      Exact current label candidate
      false
      Source IDH51-DFD0A14A4BF993D7C352FF0B
      Numeric support ratio
      0
      Source IDH51-AAD3BFDADA66679915AA961E
      Reference url count
      1
      Source IDH51-A687F329A549BC966540EC0D
      Broken reference count
      0
      Source IDH51-A98DD833B68F60AF895ED123
      Point of use confirmation required
      true
      Source IDH51-42E08CD515574D0B3134D35B
      Note
      Do not treat this record as a fully current product-specific monograph until the exact IV formulation and current sources are confirmed.
      Source IDH51-6D24E095E273A795A5E8CB94
      Historical preparation assessment

      Recovered v5.1 source content; historical, awaiting current review.

      Id
      diphenhydramine
      Source IDH51-1A7070B7DC9F4AC4CDC39775
      Name
      Diphenhydramine
      Source IDH51-EF0A3F938965B930D1BD326E
      Brands
      Benadryl
      Source IDH51-B38888CEAFF99FF8E47D857E
      Therapeutic class
      Other intravenous medications
      Source IDH51-F96908EF547179D10F7F2BEA
      Review version
      3.1
      Source IDH51-C068DAE4B9564373D5AA5243
      Review date
      2026-08-30
      Source IDH51-A16154CEBDEDDDA68926F6EF
      Release status
      no_released_dilution_current_label_review_required
      Source IDH51-6CC3749456149D56023B6FD5
      Market status
      Status
      no_current_us_iv_spl_confirmed
      Source IDH51-377FC6C30EC39097B1D4813E
      Basis
      No high-confidence current IV SPL was automatically selected; legacy information is segregated
      Source IDH51-25652A84E236DECE9EF9B6D7
      Ten point assessment
      Exact formulation
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-4D56A14C5DA2697248541462
      Reconstitution concentration
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-A97B0146CF817B520505E4D3
      Maximum or recommended final concentration
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-C51F0177FB9DF09249D85D5D
      Appropriate standardized containers
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-750C977AB31752F79D0DC3DB
      Adult dosing range
      Common adult dose 10 to 50 mg; pediatric dose weight based Common adult dose 10 to 50 mg; pediatric dose weight based
      Source IDH51-E6E6EC4263A4F25F94667979
      Pediatric dosing range
      Separate renal reference: Open Renal Dosing Master (opens in a new tab)Do not interchange Cockcroft-Gault CrCl, indexed eGFR, and de-indexed eGFR without confirming the dosing source. | existing_route_snapshots: route: IV push | population: Adult / Pediatric | indication: Common adult dose 10 to 50 mg; pediatric dose weight based | dose: Common adult dose 10 to 50 mg; pediatric dose weight based | interval: Patient- and indication-specific | duration: See current package insert | administration: No faster than 25 mg/min | source_level: Existing GlobalRPh IV push snapshot | notes: Use only when ordered and supported by current labeling or institutional policy Not a substitute for epinephrine in anaphylaxis. Prefer lower concentration for small or pediatric doses. | warnings: Sedation, hypotension, anticholinergic toxicity, and tissue irritation. | monitoring: Blood pressure, sedation, airway/allergic response | populations: Adult | Pediatric | evidence_tier: IV push safety normalization - verify stocked product | high_alert: true | hazardous: false | status: Active | reviewed: 2026-08-29 | version_added: 1.2 | sources: label: DailyMed label search | url: https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=Diphenhydramine | kind: Primary | label: GlobalRPh legacy IV dilution monograph | url: legacy:auto | kind: Legacy | legacy_title: Diphenhydramine (Benadryl)
      Source IDH51-0D9FF3F0A41AE285917006ED
      Neonatal dosing range
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-71D0155AF2686A64033D2342
      Infusion time
      No faster than 25 mg/min
      Source IDH51-1850E3B49ED11DC632FA35F2
      Fluid restriction alternatives
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-A21049C7A28F0A4EDD013651
      Current manufacturer labeling
      Match confidence
      unresolved
      Source IDH51-26CB8CA83DC21388B3C7E48A
      Field provenance
      Exact formulation
      Primary
      not_found
      Source IDH51-B2FBCCD3A944AD02C1DE2261
      Reconstitution concentration
      Primary
      not_found
      Source IDH51-436688646886A47F95EDFE39
      Maximum or recommended final concentration
      Primary
      not_found
      Source IDH51-729D9BD27C924543A2800256
      Appropriate standardized containers
      Primary
      not_found
      Source IDH51-95DA38C7D8DCEA74AD633D58
      Adult dosing range
      Primary
      existing_structured_record
      Source IDH51-998CB22FDD2955B061100DA0
      Pediatric dosing range
      Primary
      existing_record_text
      Source IDH51-DB1ABED89FD121ACD15A3965
      Neonatal dosing range
      Primary
      not_found
      Source IDH51-67254B2D21D76EF3A0D98B06
      Infusion time
      Primary
      existing_structured_record
      Source IDH51-2260EE566F0A6E5164F6511C
      Fluid restriction alternatives
      Primary
      not_found
      Source IDH51-E675BAD07E6E495CEC8BAD3F
      Current manufacturer labeling
      Primary
      DailyMed search gateway
      Source IDH51-8631487EAA5CD058EE6B0C32
      Population applicability
      Adult
      Applicability
      supported_or_source_present
      Source IDH51-BF6D1D40B9989340B85A4D39
      Guide generation allowed
      true
      Source IDH51-527CF45D609297DFBA7B38D9
      Pediatric
      Applicability
      supported_or_source_present
      Source IDH51-7963F9B878031EF1A71283A6
      Guide generation allowed
      false
      Source IDH51-55D5E4DD18EEA37404743668
      Neonatal
      Applicability
      not_established
      Source IDH51-8C1FD0383647FD2F5DACFE50
      Guide generation allowed
      false
      Source IDH51-4112EB5EF8D1A9F20AE3C960
      Route presence
      Structured dilution
      false
      Source IDH51-A274ED3AAC384AB9E09194C3
      Iv push
      true
      Source IDH51-12B5354B806F9B17EBF0C92A
      Continuous infusion
      false
      Source IDH51-24928260A44692A8C7DA81DE
      Pediatric source
      true
      Source IDH51-12189314B6FA7D61706745DC
      Neonatal source
      false
      Source IDH51-AC9FF16799638485A43A24C1
      Legacy reference
      Status
      not_available
      Source IDH51-039C3052E9100357ADCAE7BA
      Label resolution
      Status
      build_environment_network_unavailable
      Source IDH51-94F33B792C59A9A15F41E736
      Source files
      1. catalog.json
        Source IDH51-F1744FBF16AF91E307A73083
      2. dosing.json
        Source IDH51-FD3A3C4921D7C0BD9D05F2E7
      3. legacy-map.json
        Source IDH51-0189F4D758D3BB527243C9F3
      4. new-in-v1.2.json
        Source IDH51-1E39ECEF15F4A3AEE0E430E8
      Clinical release note
      Preparation instructions are released only at the evidence level shown. Legacy content remains visibly separate. Exact product, NDC, route, current labeling, and institutional policy must be confirmed.
      Source IDH51-455D7F37EF9C62A1A215C02A
      Historical statement IDs and source locations

      These IDs identify recovered source units. They are not evidence-qualified clinical claims.

      Historical IDOriginal source locationStatus
      H51-F7A2CC8ECDAA4BAF1D9E541Ecatalog.json
      /records/81/id
      Historical; current review incomplete
      H51-F67DEE16DBCD0B21AB7B8010catalog.json
      /records/81/generic_name
      Historical; current review incomplete
      H51-197D6D5573975F40A71967EEcatalog.json
      /records/81/brand_names/0
      Historical; current review incomplete
      H51-24C5CCFE2027D5397649DECBcatalog.json
      /records/81/class
      Historical; current review incomplete
      H51-BCF53F860B16E85EF5AFD3F2catalog.json
      /records/81/subclass
      Historical; current review incomplete
      H51-22E7A8EB47DCB4277609CE06catalog.json
      /records/81/summary
      Historical; current review incomplete
      H51-98F947328D9909555E5CD5BFcatalog.json
      /records/81/common_uses/0
      Historical; current review incomplete
      H51-D8DDFC0F53881C5187C977FAcatalog.json
      /records/81/common_uses/1
      Historical; current review incomplete
      H51-856D05132DB891F7BD425082catalog.json
      /records/81/iv_push/0
      Historical; current review incomplete
      H51-075994E01BCD9B15B9D85175catalog.json
      /records/81/iv_push/0/population
      Historical; current review incomplete
      H51-FD2427D81429994C4FD9A6F2catalog.json
      /records/81/iv_push/0/dose_scope
      Historical; current review incomplete
      H51-6E27A5EC2CDA3D33D5BDC3FAcatalog.json
      /records/81/iv_push/0/concentration
      Historical; current review incomplete
      H51-9BBF06511322DBB43DF0D823catalog.json
      /records/81/iv_push/0/rate
      Historical; current review incomplete
      H51-433E37CB5D98E7E9F4BD7A2Bcatalog.json
      /records/81/iv_push/0/status
      Historical; current review incomplete
      H51-22B905E6D12BDFEA5EEB559Acatalog.json
      /records/81/iv_push/0/notes
      Historical; current review incomplete
      H51-60255579716E67C3EE667C4Ccatalog.json
      /records/81/warnings/0
      Historical; current review incomplete
      H51-5F17B3267EFD972E2DFB0AD1catalog.json
      /records/81/monitoring/0
      Historical; current review incomplete
      H51-6ACF2C122B0547C4B3199BBBcatalog.json
      /records/81/populations/0
      Historical; current review incomplete
      H51-91063E684F68AE61BBD36596catalog.json
      /records/81/populations/1
      Historical; current review incomplete
      H51-5600CEDA9280D76D4E5EBB61catalog.json
      /records/81/evidence_tier
      Historical; current review incomplete
      H51-F476DC6C41C418A37DB28619catalog.json
      /records/81/high_alert
      Historical; current review incomplete
      H51-853470A35A4F8A0C28551689catalog.json
      /records/81/hazardous
      Historical; current review incomplete
      H51-4964F6D452F0EBDD2C5BC201catalog.json
      /records/81/status
      Historical; current review incomplete
      H51-1C173AB2C59F1522D2A4CA1Dcatalog.json
      /records/81/reviewed
      Historical; current review incomplete
      H51-0E34EA26DA055A029030D9A6catalog.json
      /records/81/version_added
      Historical; current review incomplete
      H51-40188D38FF0833F47DD16F9Ccatalog.json
      /records/81/sources/0
      Historical; current review incomplete
      H51-A32CA3B2CF36392E536EEEA0catalog.json
      /records/81/sources/0/label
      Historical; current review incomplete
      H51-3DD70D82268C82BB062890D8catalog.json
      /records/81/sources/0/url
      Historical; current review incomplete
      H51-37B352A57808176B5ACEDF8Dcatalog.json
      /records/81/sources/0/kind
      Historical; current review incomplete
      H51-C7A163C9C9001B3C24442072catalog.json
      /records/81/sources/1
      Historical; current review incomplete
      H51-7D77D22F5DB9618B743729A6catalog.json
      /records/81/sources/1/label
      Historical; current review incomplete
      H51-09DEBE6CD4403E2079095BFAcatalog.json
      /records/81/sources/1/url
      Historical; current review incomplete
      H51-1679FB2F0292A7C99F16C319catalog.json
      /records/81/sources/1/kind
      Historical; current review incomplete
      H51-65C58C0EB195622F36BDE0F6catalog.json
      /records/81/legacy_title
      Historical; current review incomplete
      H51-34C420E0041A03D94670086Ecatalog.json
      /records/81/clinical_release_verification/audit_version
      Historical; current review incomplete
      H51-4839299B279FF220942387F1catalog.json
      /records/81/clinical_release_verification/audited_on
      Historical; current review incomplete
      H51-3168BB83952FEB106E79B013catalog.json
      /records/81/clinical_release_verification/level
      Historical; current review incomplete
      H51-2C25C5F97531F380C50E4C73catalog.json
      /records/81/clinical_release_verification/release_gate
      Historical; current review incomplete
      H51-2AD826413114FA08710AFE92catalog.json
      /records/81/clinical_release_verification/exact_current_label_candidate
      Historical; current review incomplete
      H51-F963C9FFBA93E1858C84CE98catalog.json
      /records/81/clinical_release_verification/selected_setid
      Historical; current review incomplete
      H51-722471E04D410C13E16E32F9catalog.json
      /records/81/clinical_release_verification/selected_label_title
      Historical; current review incomplete
      H51-23495AC7B411EC306103E55Acatalog.json
      /records/81/clinical_release_verification/numeric_support_ratio
      Historical; current review incomplete
      H51-12B6C0E9BECC357E2FC42DC4catalog.json
      /records/81/clinical_release_verification/reference_url_count
      Historical; current review incomplete
      H51-6117A3F31103830A1C810327catalog.json
      /records/81/clinical_release_verification/broken_reference_count
      Historical; current review incomplete
      H51-4BE803904E67B89934C9315Bcatalog.json
      /records/81/clinical_release_verification/point_of_use_confirmation_required
      Historical; current review incomplete
      H51-491A9A94C0CA7375D2DBEAE8catalog.json
      /records/81/clinical_release_verification/note
      Historical; current review incomplete
      H51-18A1200DEF423CB70F886F4Ccatalog.json
      /records/81/clinical_release_verification/dailymed_search_url
      Historical; current review incomplete
      H51-63C997465C997E1CAD99E302dosing.json
      /records/81/id
      Historical; current review incomplete
      H51-87CAD6DF79B5B8E08EBCB658dosing.json
      /records/81/generic_name
      Historical; current review incomplete
      H51-6B3314697FE8060E2820A5C3dosing.json
      /records/81/coverage_status
      Historical; current review incomplete
      H51-2468BBD35AC3BA1EA4525220dosing.json
      /records/81/package_insert/query_name
      Historical; current review incomplete
      H51-0875E8D6BFF4BAD6D6329DE3dosing.json
      /records/81/package_insert/preferred_setid
      Historical; current review incomplete
      H51-0652E06E727A8977F389366Bdosing.json
      /records/81/package_insert/product_and_route_must_match
      Historical; current review incomplete
      H51-1C493C58F3623228D484BE09dosing.json
      /records/81/package_insert/live_current_label_enabled
      Historical; current review incomplete
      H51-95D3C032E7400A76A33B7B73dosing.json
      /records/81/package_insert/source_priority
      Historical; current review incomplete
      H51-E0EE585F777754A0FA4B9D32dosing.json
      /records/81/package_insert/direct_official_label_access_enabled
      Historical; current review incomplete
      H51-58492CD48F03040178D82B47dosing.json
      /records/81/package_insert/outbound_server_request_required
      Historical; current review incomplete
      H51-E1C91864391C1A3BA645E20Adosing.json
      /records/81/package_insert/local_summary_status
      Historical; current review incomplete
      H51-5658EF58DC35CBC54CCB04B0dosing.json
      /records/81/renal/classification
      Historical; current review incomplete
      H51-FFF4908F36E060B55BBCA1C5dosing.json
      /records/81/renal/summary
      Historical; current review incomplete
      H51-6FDC1185BDB49D2C58A0C885dosing.json
      /records/81/renal/method_note
      Historical; current review incomplete
      H51-092CFB3A71C49F8A9EFCD7F5dosing.json
      /records/81/existing_route_snapshots/0
      Historical; current review incomplete
      H51-FD34C5DEA16860A2FB26B8A3dosing.json
      /records/81/existing_route_snapshots/0/route
      Historical; current review incomplete
      H51-DEDBDEC350752F4A13A861BFdosing.json
      /records/81/existing_route_snapshots/0/population
      Historical; current review incomplete
      H51-7E17F45F925FF0F28CE5177Cdosing.json
      /records/81/existing_route_snapshots/0/indication
      Historical; current review incomplete
      H51-3D9E0CC10B0AB2C89509A19Edosing.json
      /records/81/existing_route_snapshots/0/dose
      Historical; current review incomplete
      H51-0277134570E100047ACCA3A4dosing.json
      /records/81/existing_route_snapshots/0/interval
      Historical; current review incomplete
      H51-FC8ED7F721BFB9DA29E23403dosing.json
      /records/81/existing_route_snapshots/0/duration
      Historical; current review incomplete
      H51-FDAF8FDE27C5DF73110A12BBdosing.json
      /records/81/existing_route_snapshots/0/administration
      Historical; current review incomplete
      H51-3C65FAADDB4C7DF936CCCA17dosing.json
      /records/81/existing_route_snapshots/0/source_level
      Historical; current review incomplete
      H51-EC55DF6F8247BDE09EFBD76Edosing.json
      /records/81/existing_route_snapshots/0/notes
      Historical; current review incomplete
      H51-4ED3D09F16D5FB996C230BF8dosing.json
      /records/81/clinical_review/locally_normalized
      Historical; current review incomplete
      H51-DD6B5AF4BF6EB8576335E346dosing.json
      /records/81/clinical_review/reviewed
      Historical; current review incomplete
      H51-2BAE94E8D009431D9A39C64Fdosing.json
      /records/81/clinical_review/status
      Historical; current review incomplete
      H51-1FC69AB7DD92D31A1741968Adosing.json
      /records/81/clinical_release_verification/audit_version
      Historical; current review incomplete
      H51-BF96479890AE439BCBFA88ECdosing.json
      /records/81/clinical_release_verification/audited_on
      Historical; current review incomplete
      H51-A4E894384B5FA716BFF73A47dosing.json
      /records/81/clinical_release_verification/level
      Historical; current review incomplete
      H51-A64DEFBB5B3B4F8B7D63FE61dosing.json
      /records/81/clinical_release_verification/release_gate
      Historical; current review incomplete
      H51-DFD0A14A4BF993D7C352FF0Bdosing.json
      /records/81/clinical_release_verification/exact_current_label_candidate
      Historical; current review incomplete
      H51-DE401FC80CAF34DEC98D1489dosing.json
      /records/81/clinical_release_verification/selected_setid
      Historical; current review incomplete
      H51-93E42AD4E33CBA1532527F47dosing.json
      /records/81/clinical_release_verification/selected_label_title
      Historical; current review incomplete
      H51-AAD3BFDADA66679915AA961Edosing.json
      /records/81/clinical_release_verification/numeric_support_ratio
      Historical; current review incomplete
      H51-A687F329A549BC966540EC0Ddosing.json
      /records/81/clinical_release_verification/reference_url_count
      Historical; current review incomplete
      H51-A98DD833B68F60AF895ED123dosing.json
      /records/81/clinical_release_verification/broken_reference_count
      Historical; current review incomplete
      H51-42E08CD515574D0B3134D35Bdosing.json
      /records/81/clinical_release_verification/point_of_use_confirmation_required
      Historical; current review incomplete
      H51-6D24E095E273A795A5E8CB94dosing.json
      /records/81/clinical_release_verification/note
      Historical; current review incomplete
      H51-55DFD12539D95DC63D059887dosing.json
      /records/81/clinical_release_verification/dailymed_search_url
      Historical; current review incomplete
      H51-F985FDC82644C6C3F7FC90B6first-look-v5.1.json
      /records/81/id
      Historical; current review incomplete
      H51-0BAEED66D25FE46BCE9350D3first-look-v5.1.json
      /records/81/generic_name
      Historical; current review incomplete
      H51-F58C3FF3A8AE69D4B5692520first-look-v5.1.json
      /records/81/class
      Historical; current review incomplete
      H51-C7E2C3A160F10820FB6CDEAFfirst-look-v5.1.json
      /records/81/subclass
      Historical; current review incomplete
      H51-49A7E60DF2CBF4E70EFB1120first-look-v5.1.json
      /records/81/primary_uses/0
      Historical; current review incomplete
      H51-2A78511DD0F5D142EC2E575Cfirst-look-v5.1.json
      /records/81/primary_uses/1
      Historical; current review incomplete
      H51-098AF14C5C2D775E0153B9B5first-look-v5.1.json
      /records/81/mechanism
      Historical; current review incomplete
      H51-1BA4380D6EB941901924CF5Ffirst-look-v5.1.json
      /records/81/mechanism_level
      Historical; current review incomplete
      H51-FBE49E803B86A0A178CE8EC9first-look-v5.1.json
      /records/81/basic_dosing_orientation
      Historical; current review incomplete
      H51-1256AFBB74FF7ADA2E0AADAAfirst-look-v5.1.json
      /records/81/administration_orientation
      Historical; current review incomplete
      H51-861EF9B0DC6B1B44AE08A217first-look-v5.1.json
      /records/81/renal_and_population_orientation
      Historical; current review incomplete
      H51-F269362D03D24737E8F4A6F7first-look-v5.1.json
      /records/81/key_safety_orientation/0
      Historical; current review incomplete
      H51-0D4BD77DC41D118E38193FEDfirst-look-v5.1.json
      /records/81/coverage_path
      Historical; current review incomplete
      H51-4B3F98D9DDDED530D7AEA64Cfirst-look-v5.1.json
      /records/81/coverage_path_label
      Historical; current review incomplete
      H51-CCDD53785E35C9C992978353first-look-v5.1.json
      /records/81/official_label_url
      Historical; current review incomplete
      H51-BD7FC8F84295AFF1CFC080E6first-look-v5.1.json
      /records/81/legacy_title
      Historical; current review incomplete
      H51-F01478DF66222CFE687FBA9Cfirst-look-v5.1.json
      /records/81/review_note
      Historical; current review incomplete
      H51-9A343EC29D1A3D8D7F9759E9first-look-v5.1.json
      /records/81/search_text
      Historical; current review incomplete
      H51-C9AD092391C8544655C8BF97first-look-v5.1.json
      /records/81/official_search_url
      Historical; current review incomplete
      H51-C315A5D84540C571BF78DEBDfirst-look-v5.1.json
      /records/81/official_access_mode
      Historical; current review incomplete
      H51-B239481A4673D0C87532A39Cfirst-look-v5.1.json
      /records/81/official_access_url
      Historical; current review incomplete
      H51-4FE8056FC65910974289734Efirst-look-v5.1.json
      /records/81/official_search_query
      Historical; current review incomplete
      H51-7952B49809D2C71BCF6B8991first-look-v5.1.json
      /records/81/official_access_reason
      Historical; current review incomplete
      H51-1A7070B7DC9F4AC4CDC39775preparation-assessments-v3.8.json
      /81/id
      Historical; current review incomplete
      H51-EF0A3F938965B930D1BD326Epreparation-assessments-v3.8.json
      /81/name
      Historical; current review incomplete
      H51-B38888CEAFF99FF8E47D857Epreparation-assessments-v3.8.json
      /81/brands
      Historical; current review incomplete
      H51-F96908EF547179D10F7F2BEApreparation-assessments-v3.8.json
      /81/therapeutic_class
      Historical; current review incomplete
      H51-C068DAE4B9564373D5AA5243preparation-assessments-v3.8.json
      /81/review_version
      Historical; current review incomplete
      H51-A16154CEBDEDDDA68926F6EFpreparation-assessments-v3.8.json
      /81/review_date
      Historical; current review incomplete
      H51-6CC3749456149D56023B6FD5preparation-assessments-v3.8.json
      /81/release_status
      Historical; current review incomplete
      H51-377FC6C30EC39097B1D4813Epreparation-assessments-v3.8.json
      /81/market_status/status
      Historical; current review incomplete
      H51-25652A84E236DECE9EF9B6D7preparation-assessments-v3.8.json
      /81/market_status/basis
      Historical; current review incomplete
      H51-4D56A14C5DA2697248541462preparation-assessments-v3.8.json
      /81/ten_point_assessment/exact_formulation
      Historical; current review incomplete
      H51-A97B0146CF817B520505E4D3preparation-assessments-v3.8.json
      /81/ten_point_assessment/reconstitution_concentration
      Historical; current review incomplete
      H51-C51F0177FB9DF09249D85D5Dpreparation-assessments-v3.8.json
      /81/ten_point_assessment/maximum_or_recommended_final_concentration
      Historical; current review incomplete
      H51-750C977AB31752F79D0DC3DBpreparation-assessments-v3.8.json
      /81/ten_point_assessment/appropriate_standardized_containers
      Historical; current review incomplete
      H51-E6E6EC4263A4F25F94667979preparation-assessments-v3.8.json
      /81/ten_point_assessment/adult_dosing_range
      Historical; current review incomplete
      H51-0D9FF3F0A41AE285917006EDpreparation-assessments-v3.8.json
      /81/ten_point_assessment/pediatric_dosing_range
      Historical; current review incomplete
      H51-71D0155AF2686A64033D2342preparation-assessments-v3.8.json
      /81/ten_point_assessment/neonatal_dosing_range
      Historical; current review incomplete
      H51-1850E3B49ED11DC632FA35F2preparation-assessments-v3.8.json
      /81/ten_point_assessment/infusion_time
      Historical; current review incomplete
      H51-A21049C7A28F0A4EDD013651preparation-assessments-v3.8.json
      /81/ten_point_assessment/fluid_restriction_alternatives
      Historical; current review incomplete
      H51-C012BD8F5874A4D58F25CC1Epreparation-assessments-v3.8.json
      /81/ten_point_assessment/current_manufacturer_labeling/setid
      Historical; current review incomplete
      H51-E538F3DCDEF8701ADA93D854preparation-assessments-v3.8.json
      /81/ten_point_assessment/current_manufacturer_labeling/title
      Historical; current review incomplete
      H51-3D257FF9A2584412EFBACE8Bpreparation-assessments-v3.8.json
      /81/ten_point_assessment/current_manufacturer_labeling/published_date
      Historical; current review incomplete
      H51-B00BCF47755E216D1B8E2400preparation-assessments-v3.8.json
      /81/ten_point_assessment/current_manufacturer_labeling/manufacturer
      Historical; current review incomplete
      H51-26CB8CA83DC21388B3C7E48Apreparation-assessments-v3.8.json
      /81/ten_point_assessment/current_manufacturer_labeling/match_confidence
      Historical; current review incomplete
      H51-FD640D4F9D0A66E694DFAA2Fpreparation-assessments-v3.8.json
      /81/ten_point_assessment/current_manufacturer_labeling/url
      Historical; current review incomplete
      H51-B2FBCCD3A944AD02C1DE2261preparation-assessments-v3.8.json
      /81/field_provenance/exact_formulation/primary
      Historical; current review incomplete
      H51-436688646886A47F95EDFE39preparation-assessments-v3.8.json
      /81/field_provenance/reconstitution_concentration/primary
      Historical; current review incomplete
      H51-729D9BD27C924543A2800256preparation-assessments-v3.8.json
      /81/field_provenance/maximum_or_recommended_final_concentration/primary
      Historical; current review incomplete
      H51-95DA38C7D8DCEA74AD633D58preparation-assessments-v3.8.json
      /81/field_provenance/appropriate_standardized_containers/primary
      Historical; current review incomplete
      H51-998CB22FDD2955B061100DA0preparation-assessments-v3.8.json
      /81/field_provenance/adult_dosing_range/primary
      Historical; current review incomplete
      H51-DB1ABED89FD121ACD15A3965preparation-assessments-v3.8.json
      /81/field_provenance/pediatric_dosing_range/primary
      Historical; current review incomplete
      H51-67254B2D21D76EF3A0D98B06preparation-assessments-v3.8.json
      /81/field_provenance/neonatal_dosing_range/primary
      Historical; current review incomplete
      H51-2260EE566F0A6E5164F6511Cpreparation-assessments-v3.8.json
      /81/field_provenance/infusion_time/primary
      Historical; current review incomplete
      H51-E675BAD07E6E495CEC8BAD3Fpreparation-assessments-v3.8.json
      /81/field_provenance/fluid_restriction_alternatives/primary
      Historical; current review incomplete
      H51-8631487EAA5CD058EE6B0C32preparation-assessments-v3.8.json
      /81/field_provenance/current_manufacturer_labeling/primary
      Historical; current review incomplete
      H51-BF6D1D40B9989340B85A4D39preparation-assessments-v3.8.json
      /81/population_applicability/adult/applicability
      Historical; current review incomplete
      H51-527CF45D609297DFBA7B38D9preparation-assessments-v3.8.json
      /81/population_applicability/adult/guide_generation_allowed
      Historical; current review incomplete
      H51-7963F9B878031EF1A71283A6preparation-assessments-v3.8.json
      /81/population_applicability/pediatric/applicability
      Historical; current review incomplete
      H51-55D5E4DD18EEA37404743668preparation-assessments-v3.8.json
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      H51-A274ED3AAC384AB9E09194C3preparation-assessments-v3.8.json
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      /81/clinical_release_note
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