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Preparation. Administration. Evidence.

IV Dilution &
Medication Reference

Search 255 medications, read preserved historical references, and inspect separately reviewed preparation statements. Full monograph updates remain pending.

Version 6.4Release date 2026-11-04For healthcare professionals
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Benadryl ® - Diphenhydramine

Historical source. Current clinical review is incomplete. This monograph will be updated in the future.

Benadryl ® - Diphenhydramine (opens in a new tab)Original source URL: https://globalrph.com/dilution/benadryl-diphenhydramine/ | Retrieved 2026-11-04

Source dates, location and integrity

This historical article is separate from the reviewed claim cards. Product formulations and source dates may differ.

Original source URL
https://globalrph.com/dilution/benadryl-diphenhydramine/ (opens in a new tab)
Source date
Not established in the retrieved source
Retrieved
2026-11-04T19:46:12.493253+00:00
Source location
div.post-content
Packaged content SHA-256
18dc4118fcf3f984570cc73490b8ec9e6d2fc3490c82ac874e369c95ab0850fa
Original response SHA-256
bfaacc556de488c0856713be35d02c0655797245be2c7016dab8edb7dfc5b557
Source body SHA-256
e17312e7d6a89b41639e4639cc85d5134ca1b97e945620f609f9a01b83b65074

DIPHENHYDRAMINE (BENADRYL ®)

The authors make no claims of the accuracy of the information contained herein; and these suggested doses and/or guidelines are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this document shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material. PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.

Usual Diluents
D5W, NS

Standard Dilutions [Amount of drug] [Infusion volume] [Infusion rate]
[0 to 100 mg] [50 ml] [20 - 30min]

Stability / Miscellaneous

Stability data:
Drug Stability
Refrigerated		 Stability
Room Temp.		 Reconstituted
Vial/Powder 		Notes
Benadryl - Diphenhydramine Store at 20 to 25°C (68 to 77°F) Solution Protect from freezing and light. Retain in carton until time of use.


EXP: 1 DAY (RT).
Maximum dose/ 24 hours= 400 mg.
Dosing: 10 to 50mg IM or IV q2 to 6h.

DOSAGE AND ADMINISTRATION
THIS PRODUCT IS FOR INTRAVENOUS OR INTRAMUSCULAR ADMINISTRATION ONLY.

Benadryl in the injectable form is indicated when the oral form is impractical.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

DOSAGE SHOULD BE INDIVIDUALIZED ACCORDING TO THE NEEDS AND THE RESPONSE OF THE PATIENT.

Pediatric Patients, other than premature infants and neonates
5 mg/kg/24 hr or 150 mg/m2/24 hr. Maximum daily dosage is 300 mg. Divide into four doses, administered intravenously at a rate generally not exceeding 25 mg/min, or deep intramuscularly.

Adults
10 to 50 mg intravenously at a rate generally not exceeding 25 mg/min, or deep intramuscularly, 100 mg if required; maximum daily dosage is 400 mg.

HOW SUPPLIED
Benadryl in parenteral form is supplied as:

Benadryl Steri-Vials®
-sterile, pyrogen-free solution containing 50 mg diphenhydramine hydrochloride in each milliliter of solution with 0.1 mg/mL benzethonium chloride as a germicidal agent. Available in 10-mL (N 0071-4402-10) Steri-Vials.

-sterile, pyrogen-free solution containing 50 mg diphenhydramine hydrochloride in each milliliter of solution. Available in packages of twenty-five 1-mL (N 0071-4259-13) Steri-Vials.

Benadryl Steri-Dose ®
-sterile, pyrogen-free solution containing 50 mg diphenhydramine hydrochloride in a 1-mL disposable syringe (Steri-Dose). Available in packages of ten syringes (N 0071-4259-45).

Benadryl Ampoule
-sterile, pyrogen-free solution containing 50 mg diphenhydramine hydrochloride in a 1-mL ampoule. Available in packages of ten (N 0071-4259-03).

Store at controlled room temperature 15°-30°C (59°-86°F). Protect from freezing and light.

Rx only
Manufactured by:
Parkedale Pharmaceuticals, Inc.
Rochester, MI 48307

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