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Preparation. Administration. Evidence.

IV Dilution &
Medication Reference

Search 255 medications, read preserved historical references, and inspect separately reviewed preparation statements. Full monograph updates remain pending.

Version 6.4Release date 2026-11-04For healthcare professionals
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Medication reference

Ampicillin-sulbactam

Monograph awaiting updateThis monograph will be updated in the future.

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Historical source. Current clinical review is incomplete. This monograph will be updated in the future.

Unasyn®- Ampicillin Sulbactam (opens in a new tab)Original source URL: https://globalrph.com/dilution/unasyn-ampicillin-sulbactam/ | Retrieved 2026-11-04

Source dates, location and integrity

This historical article is separate from the reviewed claim cards. Product formulations and source dates may differ.

Original source URL
https://globalrph.com/dilution/unasyn-ampicillin-sulbactam/ (opens in a new tab)
Source date
Not established in the retrieved source
Retrieved
2026-11-04T19:50:13.741332+00:00
Source location
div.post-content
Packaged content SHA-256
8d655c438af986e0cc53bdf2e12c257e0cde1cf237e24f98011cf066d5a55b13
Original response SHA-256
87899cf25b3b147192e3497a2e9ab9aefa8f07b54ee5da0ba12719e4d236c56f
Source body SHA-256
278d92c43a3c4cfefb526f94bd7673dc11e96923d1b57cef087f7f60482898b1

AMPICILLIN/SULBACTAM (UNASYN ®)
The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material. PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.

Usual Diluents
NS

Standard Dilutions [Amount of drug] [Infusion volume] [Infusion rate]
[0 - 1.5 grams/ 50 ml] [30 min]
[Over 1.5 grams/ 100 ml] [30 min]

Stability / Miscellaneous
Label: Refrigerate.

DOSAGE AND ADMINISTRATION
Ampicillin and Sulbactam for Injection may be administered by either the IV or the IM routes. For IV administration, the dose can be given by slow intravenous injection over at least 10-15 minutes or can also be delivered, in greater dilutions with 50-100 mL of a compatible diluent as an intravenous infusion over 15-30 minutes.

Ampicillin and Sulbactam for Injection may be administered by deep intramuscular injection. (See Preparation for Intramuscular Injection.)

The recommended adult dosage of Ampicillin and Sulbactam for Injection is 1.5 g to 3 g every six hours. The total dose of sulbactam should not exceed 4 grams per day.

Impaired Renal Function

Separate renal reference: Open Renal Dosing Master (opens in a new tab)
Creatinine Clearance
(mL/min/1.73m2)		 Ampicillin/Sulbactam
Half-Life (Hours)		 Recommended Ampicillin and Sulbactam Dosage
≥ 30 1 1.5 - 3g q6h - q8h
15-29 5 1.5 - 3g q12h
5-14 9 1.5 - 3g q24h
Separate renal reference: Open Renal Dosing Master (opens in a new tab)

DIRECTIONS FOR USE
General Dissolution Procedures.
Ampicillin and Sulbactam for Injection sterile powder for intravenous and intramuscular use may be reconstituted with any of the compatible diluents described in this insert. Solutions should be allowed to stand after dissolution to allow any foaming to dissipate in order to permit visual inspection for complete solubilization.

Preparation for Intravenous Use
Reconstitution of Ampicillin and Sulbactam for Injection, at the specified concentrations, with these diluents provide stable solutions for the time periods indicated in the following table: (After the indicated time periods, any unused portions of solutions should be discarded.)

Stability
Diluent Maximum Concentration (mg/mL)
ampicillin and sulbactam		 Use Periods
Sterile Water for Injection 45 (30/15) 8 hrs @ 25°C
45 (30/15) 48 hrs @ 4°C
30 (20/10) 72 hrs @ 4°C
0.9% Sodium Chloride Injection 45 (30/15) 8 hrs @ 25°C
45 (30/15) 48 hrs @ 4°C
30 (20/10) 72 hrs @ 4°C
5% Dextrose Injection 30 (20/10) 2 hrs @ 25°C
30 (20/10) 4 hrs @ 4°C
3 (2/1) 4 hrs @ 25°C
Lactated Ringer's Injection 45 (30/15) 8 hrs @ 25°C
45 (30/15) 24 hrs @ 4°C
5% Dextrose in 0.45% Saline 3 (2/1) 4 hrs @ 25°C
15 (10/5) 4 hrs @ 4°C

Initially, the vials may be reconstituted with Sterile Water for Injection to yield solutions containing 375 mg Ampicillin and Sulbactam per mL (250 mg ampicillin/125 mg sulbactam per mL ). An appropriate volume should then be immediately diluted with a suitable parenteral diluent to yield solutions containing 3 to 45 mg Ampicillin and Sulbactam per mL (2 to 30 mg ampicillin/1 to 15 mg sulbactam/per mL).

Preparation for Intramuscular Injection
1.5 g and 3 g Standard vials

Vials for intramuscular use may be reconstituted with Sterile Water for Injection USP, 0.5% Lidocaine Hydrochloride Injection USP or 2% Lidocaine Hydrochloride Injection USP. Consult the following table for recommended volumes to be added to obtain solutions containing 375 mg ampicillin and sulbactam per mL (250 mg ampicillin/ 125 mg sulbactam per mL).

Note: Use only freshly prepared solutions and administer within one hour after preparation.

Ampicillin and Sulbactam Vial Size Volume of Diluent to be Added Withdrawal Volume
There is sufficient excess present to allow withdrawal and administration of the stated volumes.
1.5 g 3.2 mL 4 mL
3 g 6.4 mL 8 mL

Revised: June 2006
Manufactured in Austria by Sandoz GmbH,
Distributed by Lek Pharmaceuticals Inc.
an affiliate of Sandoz Inc., Princeton, NJ 08540

Open this historical article on its own

Product identifiers and clinical review status

This monograph will be updated in the future. Historical material is available where present in the original sources; full current exact-product and claim-level review remains pending.

Exact formulation, concentration, container, manufacturer, regulatory identifiers, and a reproducible label snapshot have not all been reconciled.

What remains to be completed
  • Retrievable exact-product SPL XML with version, revision, retrieval date and reproducible hash
  • Clinically reviewed, individually identified statements with two exact source mappings
  • Exact formulation, strength, container, manufacturer/labeler, application and NDC reconciliation
  • Renal-function methods and dialysis/CRRT modality review where applicable
  • Mechanism provenance, clinical source disagreements and full medication-specific safety reconciliation

Supplemental historical fields

Restored-data provenance and review notes

Source release: 2026-08-31. Current clinical review is incomplete. Original uses of current, verified, or normalized describe the historical source. They do not inherit the status of separately reviewed statements. Product formulations and source dates can differ.

Current review annotations for historical renal, dialysis, mechanism, and product fieldsSeparate renal reference: Open Renal Dosing Master (opens in a new tab)
Renal
Status
not_locally_normalized
Original classification
adjustment_required
Entries
    General note
    Preserve the source-specific renal-function basis. An indexed CrCl table is not interchangeable with unindexed CrCl or eGFR. Generic advice to check a method does not identify the equation for a dose row.
    Dialysis
    Status
    no_local_structured_regimen
    Entries
      General note
      Named modality alone does not establish applicability. CRRT subtype, effluent rate, residual renal function, timing and interruptions require review. Historical absence is not evidence that no guidance exists.
      Mechanisms
      • Source kind
        first_look
        Local pointer
        /mechanism
        Original level
        class_level
        Provenance classification
        historical_class_level
        Label derived verified
        false
        Independently corroborated
        false
        Exact label section
        Not recorded
        Original source note
        Not recorded
        Review status
        historical_unverified
        Note
        Drug-specific wording in the old file is not proof of independent corroboration or an exact label locator. Consult separately published current mechanism claims where present.
      Future update
      Status
      pending_review
      Message
      This monograph will be updated in the future as current exact-product and claim-level review is completed.
      Source unavailable
      false
      Reason
      The historical content is restored; comprehensive contemporary verification remains incomplete.
      Historical first look: uses, mechanism, dosing context, and administration

      Recovered v5.1 source content; historical, awaiting current review.

      Id
      ampicillin-sulbactam
      Source IDH51-8ABB0123271E1856197182A7
      Generic name
      Ampicillin-sulbactam
      Source IDH51-9B870231D64388FC6E2686B3
      Class
      Antibacterial
      Source IDH51-EF4319803759A67575548C67
      Subclass
      Aminopenicillin plus beta-lactamase inhibitor
      Source IDH51-21B9B7AF921538614A0B7395
      Primary uses
      1. Polymicrobial infections
        Source IDH51-3D3AEA8B6ABD89CF379B5FAF
      2. Aspiration-related infection
        Source IDH51-030730BC1FAD8757C74D27ED
      3. Skin and intra-abdominal infections
        Source IDH51-0DB6938CE2FA0B8BEB4E262D
      Mechanism
      The beta-lactam component inhibits penicillin-binding proteins and cell-wall synthesis; its partner protects or enhances activity against selected resistance mechanisms.
      Source IDH51-68BC2F3FBDC694700E732343
      Mechanism level
      class_level
      Source IDH51-FE351B91E32BA21772689048
      Basic dosing orientation
      Adult | Existing preparation record; use current package insert for indication-specific selection | Common dose 1.5 to 3 g | Not normalized in the preparation record | See current package insert and professional guidance | IV infusion; Pediatric | Existing preparation record; use current package insert for indication-specific selection | Dose expressed as total product or ampicillin component; verify convention | Not normalized in the preparation record | See current package insert and professional guidance | IV infusion
      Source IDH51-21C0DB5EB39B8A129393B034
      Administration orientation
      Infuse over 15 to 30 minutes
      Source IDH51-3ED293B9357395761E0F28ED
      Renal and population orientation
      Separate renal reference: Open Renal Dosing Master (opens in a new tab)Renal dose adjustment or interval modification is commonly required; verify the selected product label and patient-specific renal method.
      Source IDH51-AF9252BBF1B33182FD020199
      Key safety orientation
      1. Dose-expression errors can occur because references may use total product or ampicillin component.
        Source IDH51-15081CC55EB85B53E00A5CDE
      Coverage path
      structured_local_snapshot
      Source IDH51-4FCA8D011F5BB5EE30128F39
      Coverage path label
      Structured GlobalRPh route snapshot
      Source IDH51-49C69231BB63CFACC56F373A
      Legacy title
      Ampicillin-sulbactam
      Source IDH51-0580DC921CCCC829F8931EC0
      Review note
      First-look orientation only. Verify indication, patient population, weight basis, organ function, exact IV product, dose, concentration, compatibility, rate, and current labeling before use.
      Source IDH51-AF916BFD0FC9FF8BA8AD616E
      Search text
      Ampicillin-sulbactam Antibacterial Aminopenicillin plus beta-lactamase inhibitor Polymicrobial infections Aspiration-related infection Skin and intra-abdominal infections The beta-lactam component inhibits penicillin-binding proteins and cell-wall synthesis; its partner protects or enhances activity against selected resistance mechanisms. Adult | Existing preparation record; use current package insert for indication-specific selection | Common dose 1.5 to 3 g | Not normalized in the preparation record | See current package insert and professional guidance | IV infusion; Pediatric | Existing preparation record; use current package insert for indication-specific selection | Dose expressed as total product or ampicillin component; verify convention | Not normalized in the preparation record | See current package insert and professional guidance | IV infusion Infuse over 15 to 30 minutes Renal dose adjustment or interval modification is commonly required; verify the selected product label and patient-specific renal method. Dose-expression errors can occur because references may use total product or ampicillin component. Structured GlobalRPh route snapshot
      Source IDH51-DAA5AB616DF74EE9356D5716
      Official access mode
      search
      Source IDH51-C0F0D55E4CBC02046327CA8C
      Official search query
      Ampicillin-sulbactam
      Source IDH51-F7EC707B2967AE656301285F
      Official access reason
      A source-backed DailyMed search is available; select and confirm the exact IV product.
      Source IDH51-237734F40053B1853EF1BF6A

      No separate structured rows were bundled for IV push, continuous infusion, dialysis, CRRT. Historical article content and source links may cover these topics.

      Historical dilution and intermittent infusion preparation

      Recovered v5.1 source content; historical, awaiting current review.

      Separate renal reference: Open Renal Dosing Master (opens in a new tab)
      PopulationAmountReconstitutionDiluentFinal volumeConcentrationRateStabilityNotes
      Source IDH51-19582B6E95117FE01A663A68
      Adult
      Source IDH51-09AB6F7C0369F933077F88EC
      		Common dose 1.5 to 3 g
      Source IDH51-3179B5B8995ECC68EDE488DE
      		Reconstitute vial per product strength with Sterile Water for Injection or compatible diluent.
      Source IDH51-4D85E3B769FDEB6544E92BFC
      		NS or compatible solution
      Source IDH51-F5EDF462EAC9D20193704ACE
      		50 to 100 mL
      Source IDH51-D60AA2AFAFDDD2E0C54972FE
      		Commonly 15 to 30 mg/mL total drug
      Source IDH51-252F0FF553BA910744FB8044
      		Infuse over 15 to 30 minutes
      Source IDH51-32D25A551CB278A44BFD38F4
      		Use the shorter of current product labeling, validated stability data, and the applicable USP <797> sterility-based BUD ceiling.
      Source IDH51-EEB758D498CF9E9E9033A164
      		Renal adjustment is required; 3 g contains 2 g ampicillin and 1 g sulbactam.
      Source IDH51-90BED46D00004E0752F29DF5
      Source IDH51-02EF67576DB3020E1793A58C
      Pediatric
      Source IDH51-9F7480A6A54B3B32DFC3DDCD
      		Dose expressed as total product or ampicillin component; verify convention
      Source IDH51-4C6B79563E08347D7175D0E3
      		Reconstitute per vial labeling.
      Source IDH51-C620FE441C56D6E3934A4819
      		Compatible fluid
      Source IDH51-154D1367115596F415DB9971
      		Weight-appropriate volume
      Source IDH51-F365094B21DC54089EA107E9
      		Institution-specific
      Source IDH51-8EAC9E7BF25AEDF5BA558C14
      		Infuse over 15 to 30 minutes
      Source IDH51-541609FC9A92DB6F1EAB5CF7
      		Use the shorter of current product labeling, validated stability data, and the applicable USP <797> sterility-based BUD ceiling.
      Source IDH51-A888ED438FF29697306F521A
      		Always state whether mg/kg refers to total product or ampicillin component.
      Source IDH51-BF5BC217CB6F357D37131E46

      Historical indication and population dosing

      Recovered tables and source-separated snapshots; full clinical revalidation remains pending.

      Existing dose and route snapshots

      Separate renal reference: Open Renal Dosing Master (opens in a new tab)
      RoutePopulationIndicationDoseIntervalDurationAdministrationSource levelNotes
      Source IDH51-0B54C44665470FA54F915B10
      IV infusion
      Source IDH51-0334E9C770896C401D074493
      		Adult
      Source IDH51-5C7BC4EEAD2DCECA0B6572ED
      		Existing preparation record; use current package insert for indication-specific selection
      Source IDH51-B53EE030AD4128331D151955
      		Common dose 1.5 to 3 g
      Source IDH51-00D8605CD069F1E07D7080B7
      		Not normalized in the preparation record
      Source IDH51-DBFC296AAEFAD582868C908D
      		See current package insert and professional guidance
      Source IDH51-95FD296FA30783476A3AB836
      		Infuse over 15 to 30 minutes
      Source IDH51-A4C2BC034DF194152146B913
      		Existing GlobalRPh structured preparation snapshot
      Source IDH51-3AECE067E6922563CA8ABA9C
      		Renal adjustment is required; 3 g contains 2 g ampicillin and 1 g sulbactam.
      Source IDH51-33EE119F3C72ABAC5FDE4900
      Source IDH51-72572804A244CFF9BFC92795
      IV infusion
      Source IDH51-448433FCC374C5B6BF1D1D52
      		Pediatric
      Source IDH51-8C0CE3741AE03AEA81D9FCF6
      		Existing preparation record; use current package insert for indication-specific selection
      Source IDH51-D8C5EB980DC486014BD45DD6
      		Dose expressed as total product or ampicillin component; verify convention
      Source IDH51-5EC741CCA66AD5F05517E51F
      		Not normalized in the preparation record
      Source IDH51-947123034386D7C141E40CB2
      		See current package insert and professional guidance
      Source IDH51-B81CF9E83DEE62F29B423BEF
      		Infuse over 15 to 30 minutes
      Source IDH51-DF51BB65BFFE81FFD39C4C70
      		Existing GlobalRPh structured preparation snapshot
      Source IDH51-92E57CEC50B0EB680F413660
      		Always state whether mg/kg refers to total product or ampicillin component.
      Source IDH51-20C226B9C4AA32BB12677B23

      Historical renal-function guidance

      Recovered v5.1 source content; historical, awaiting current review.

      Separate renal reference: Open Renal Dosing Master (opens in a new tab)
      Classification
      adjustment_required
      Source IDH51-5400A8A84A8C56AF80DB8B48
      Summary
      Renal dose adjustment or interval modification is commonly required; verify the selected product label and patient-specific renal method.
      Source IDH51-5CA01AA622F40EB7BD10C045
      Method note
      Use the renal function estimate and body-size convention specified by the selected label or institutional protocol. Do not interchange Cockcroft-Gault CrCl, indexed eGFR, and de-indexed eGFR without confirming the dosing source.
      Source IDH51-DEC748773B4798DD9E73F161

      Historical Common IV uses

      Recovered v5.1 source content; historical, awaiting current review.

      1. Polymicrobial infections
        Source IDH51-571385EF0DFA0F5305C3B068
      2. Aspiration-related infection
        Source IDH51-331273664195528FD2257768
      3. Skin and intra-abdominal infections
        Source IDH51-01809DE71189A2D93A630EE5

      Historical Warnings and safeguards

      Recovered v5.1 source content; historical, awaiting current review.

      1. Dose-expression errors can occur because references may use total product or ampicillin component.
        Source IDH51-664E7ED14EEF7495A35833B0

      Historical Monitoring

      Recovered v5.1 source content; historical, awaiting current review.

      Separate renal reference: Open Renal Dosing Master (opens in a new tab)
      1. Renal function
        Source IDH51-71EE3AFDF1F328CBE66DEC42
      2. Hepatic tests and CBC with prolonged therapy
        Source IDH51-92F7FE8C82B5809879D1AF49
      3. Hypersensitivity
        Source IDH51-E52D75F182593FD7E2A078B6

      Historical supplemental professional sources

      Recovered v5.1 source content; historical, awaiting current review.

      LabelUrlKind
      Source IDH51-37CD2419133096E354883351
      UCSF adult antimicrobial dosing, non-dialysis
      Source IDH51-312FAC28D2178B5166077175
      		https://idmp.ucsf.edu/adult-antimicrobial-dosing-non-dialysis (opens in a new tab)
      Source IDH51-61A310089B25A2E69E4832B1
      		Professional institutional guidance
      Source IDH51-FE682C271EB30A67B6595481
      Source IDH51-211ADC6A161D2D7FF78E91B5
      UCSF antimicrobial dosing in intermittent and continuous hemodialysis
      Source IDH51-512F982BCB3D2514C5BF087A
      		https://idmp.ucsf.edu/antimicrobial-dosing-intermittent-continuous-hemodialysis (opens in a new tab)
      Source IDH51-3590349593A771A2EC03AA77
      		Professional institutional guidance
      Source IDH51-BF29B67D02AE98E30FFFB86C
      Source IDH51-18828CA9149829FD8629F4D0
      UCSF pediatric antimicrobial dosing
      Source IDH51-7F2BF56DDE1E48DA86147488
      		https://idmp.ucsf.edu/pediatric-antimicrobial-dosing-benioff-childrens-hospitals (opens in a new tab)
      Source IDH51-47AC37B7AA5D47B647C8E695
      		Professional institutional guidance
      Source IDH51-39997971F4341C9EF370372A
      Source IDH51-C2C516D478D9266F5EC61EC3
      UCSF neonatal antimicrobial dosing
      Source IDH51-2CBB59AAD7210067F7118531
      		https://idmp.ucsf.edu/neonatal-antimicrobial-dosing-benioff-childrens-hospitals (opens in a new tab)
      Source IDH51-D99E43212617A3FD43B93C62
      		Professional institutional guidance
      Source IDH51-7AF9BBCDF0AEC0791D8C56A2
      Other recovered source fields and original editorial metadata

      Original status words such as current, verified, or normalized describe the historical source release. They do not change the clinical review status of this release.

      Catalog source fields

      Id
      ampicillin-sulbactam
      Source IDH51-BD376B5AD6EF3D8E6E242A71
      Generic name
      Ampicillin-sulbactam
      Source IDH51-6930D4F0EC1009361432C3B1
      Brand names
      1. Unasyn
        Source IDH51-AC4BE6F6EEB44E4BE28E90A1
      Aliases
      1. ampicillin sulbactam
        Source IDH51-6427469D92ED77EF4BE99396
      Class
      Antibacterial
      Source IDH51-FCED2D08F04A707F6BBFE3A5
      Subclass
      Aminopenicillin plus beta-lactamase inhibitor
      Source IDH51-43D1B6B717C50521119DF4A5
      Summary
      Fixed 2:1 ampicillin-to-sulbactam product requiring reconstitution and dilution before intermittent infusion.
      Source IDH51-8B8012E446ED38A9E5DBF29D
      Populations
      1. Adult
        Source IDH51-984829D3A030FA25EF3139CC
      2. Pediatric
        Source IDH51-45CF263A47B2ECF35CAF7CEB
      Evidence tier
      Core reference - verify current label
      Source IDH51-2D1D9C160753007715CAFA0B
      High alert
      true
      Source IDH51-695D48A946B28C3D168CDB3B
      Hazardous
      false
      Source IDH51-4AC21102A85C527866974AC6
      Status
      Active
      Source IDH51-C34AE4CF7399142C92D81FE9
      Reviewed
      2026-08-29
      Source IDH51-20994035A8ADC8CCA4738391
      Version added
      1.0
      Source IDH51-B16ED3060748569B63B14F4E
      Sources
      LabelUrlKind
      Source IDH51-F6E46F4691C9EB73E544B862
      DailyMed label search
      Source IDH51-13C0B40AC24EEA3105F81FD5
      		https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=Ampicillin-sulbactam (opens in a new tab)
      Source IDH51-D7B526E4502420482704F11C
      		Primary
      Source IDH51-9F334F8E40CF206F9D59330F
      Source IDH51-E2D93F719B6C2E3FDC1D107A
      GlobalRPh legacy IV dilution monograph
      Source IDH51-5F45A3989F984363176A6287
      		legacy:auto
      Source IDH51-5B8B276BC2B5C97D7850583C
      		Legacy
      Source IDH51-D1DE53DFED00921E22ADB416
      Legacy title
      Ampicillin-sulbactam
      Source IDH51-341C1907B065E50A14BE075D
      Clinical release verification
      Audit version
      3.4
      Source IDH51-2CD49B49AA0949398795D888
      Audited on
      2026-08-30
      Source IDH51-55C03B5DFA76FAAF889D062A
      Level
      amber
      Source IDH51-B6565B5E3700AFE941A14661
      Release gate
      trusted_professional_source_present_exact_label_unconfirmed
      Source IDH51-7B8B1C15E01172DF1B43A401
      Exact current label candidate
      false
      Source IDH51-ED3857B27A2C6409CA33E151
      Numeric support ratio
      0
      Source IDH51-4CF2AC4256EAC29574EE5A9E
      Reference url count
      5
      Source IDH51-28AD03667DEA47F8F157B485
      Broken reference count
      0
      Source IDH51-452ABFC4A145074CDF3EEB81
      Point of use confirmation required
      true
      Source IDH51-20466B104F9C76A5E2994E71
      Note
      Do not treat this record as a fully current product-specific monograph until the exact IV formulation and current sources are confirmed.
      Source IDH51-EF305FBF581DF18E1A6E7F76

      Dosing source fields

      Id
      ampicillin-sulbactam
      Source IDH51-C40267DF5CD8D41860B923FA
      Generic name
      Ampicillin-sulbactam
      Source IDH51-0E16EFC63377760B90E54663
      Coverage status
      direct_official_label_access_plus_local_snapshot
      Source IDH51-504AB54A26F2458EE5ADC37F
      Package insert
      Query name
      Ampicillin-sulbactam
      Source IDH51-CAC1DED3E55971AA3C9D9425
      Product and route must match
      true
      Source IDH51-E4805F9AFD775EC19FAC3D4A
      Live current label enabled
      false
      Source IDH51-AE532CFA5D56BD59F6F13B23
      Source priority
      Reviewed local summary when available, then a verified DailyMed label or product search when available, followed by professional references and institutional policy.
      Source IDH51-240ADD03270B062E3D09FCB8
      Direct official label access enabled
      true
      Source IDH51-9C382DC23D0F749CA4905100
      Outbound server request required
      false
      Source IDH51-B20B06E558F748504A7BCCCF
      Local summary status
      not_bundled
      Source IDH51-30B239F2E879B11CB600C5E0
      Clinical review
      Locally normalized
      false
      Source IDH51-7DED8BA92CD771FFE356D061
      Reviewed
      2026-08-29
      Source IDH51-2537ACE28A7982379A949C99
      Status
      Direct official package-insert access enabled; indication-specific local normalization pending.
      Source IDH51-56123EE84E5A9495485C19F0
      Clinical release verification
      Audit version
      3.4
      Source IDH51-8747B3101BA3E6323D43A9E2
      Audited on
      2026-08-30
      Source IDH51-912E6626DC790963B493C31D
      Level
      amber
      Source IDH51-FC6C40DF24B70C15171FE1B1
      Release gate
      trusted_professional_source_present_exact_label_unconfirmed
      Source IDH51-478071E583E152376DBA51E2
      Exact current label candidate
      false
      Source IDH51-0264F41F630C20C39FD19287
      Numeric support ratio
      0
      Source IDH51-D8EAEB7EF15A63F76B9DE950
      Reference url count
      5
      Source IDH51-49D594D221E5AF8038EF1DF2
      Broken reference count
      0
      Source IDH51-204EC062FC267AE37879291F
      Point of use confirmation required
      true
      Source IDH51-8C34C2AC802C3285B9F788D3
      Note
      Do not treat this record as a fully current product-specific monograph until the exact IV formulation and current sources are confirmed.
      Source IDH51-35C36998EFED398282A843A7
      Historical preparation assessment

      Recovered v5.1 source content; historical, awaiting current review.

      Id
      ampicillin-sulbactam
      Source IDH51-C1E16C3A795934B709758AA9
      Name
      Ampicillin-sulbactam
      Source IDH51-749D13AD294FDD9488C1ACDE
      Brands
      Unasyn
      Source IDH51-09E616C9FC55D95195834409
      Therapeutic class
      Antibacterial
      Source IDH51-F77A1D0CF946AEF9F6F630C5
      Review version
      3.1
      Source IDH51-D369630A240F61422D1377F6
      Review date
      2026-08-30
      Source IDH51-DD538388E907C3275F386507
      Release status
      structured_record_current_label_not_confirmed
      Source IDH51-6F4811FA3CDE107975FFD3BB
      Market status
      Status
      no_current_us_iv_spl_confirmed
      Source IDH51-132D359E2E2C8B7C6F118487
      Basis
      No high-confidence current IV SPL was automatically selected; legacy information is segregated
      Source IDH51-A6AAF7381A35E82D62D38770
      Ten point assessment
      Exact formulation
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-A9BC5E53C7BE94138146B35E
      Reconstitution concentration
      Reconstitute vial per product strength with Sterile Water for Injection or compatible diluent. Reconstitute per vial labeling.
      Source IDH51-356428EC7FA34A47B306B7D5
      Maximum or recommended final concentration
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-EEEFE81010FC394188F7B4EC
      Appropriate standardized containers
      50 to 100 mL Weight-appropriate volume
      Source IDH51-4FEB47173DCCE6184CA07C02
      Adult dosing range
      Common dose 1.5 to 3 g Dose expressed as total product or ampicillin component; verify convention
      Source IDH51-02E7EF9021653441DD808F81
      Pediatric dosing range
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-FF7261C2CA99A6C3212C2F87
      Neonatal dosing range
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-2B8305F9B3C6DE7A3AA67F71
      Infusion time
      Infuse over 15 to 30 minutes
      Source IDH51-7C35915926302C35569ADD98
      Fluid restriction alternatives
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-20E2B3518EE8733D3A765D4B
      Current manufacturer labeling
      Match confidence
      unresolved
      Source IDH51-FDFC6369FB8046C2D5595DD5
      Field provenance
      Exact formulation
      Primary
      not_found
      Source IDH51-9034F3330EF46F0CAB493E37
      Reconstitution concentration
      Primary
      existing_structured_record
      Source IDH51-3A2370EABA8B6C5015B0D288
      Maximum or recommended final concentration
      Primary
      not_found
      Source IDH51-85379258E3E171C057263217
      Appropriate standardized containers
      Primary
      existing_structured_record
      Source IDH51-6C7296EA0740A20143E49377
      Adult dosing range
      Primary
      existing_structured_record
      Source IDH51-9B9C739F489229B217A5A4D0
      Pediatric dosing range
      Primary
      not_found
      Source IDH51-61FBEEB83F160EF09E29ACF5
      Neonatal dosing range
      Primary
      not_found
      Source IDH51-26601C918C09CB45420D0960
      Infusion time
      Primary
      existing_structured_record
      Source IDH51-5CF7F4E8FCD4BC9484DC453F
      Fluid restriction alternatives
      Primary
      not_found
      Source IDH51-01773984DAE57A4459403ABF
      Current manufacturer labeling
      Primary
      DailyMed search gateway
      Source IDH51-EA647FF67310310A4B9EF2DE
      Population applicability
      Adult
      Applicability
      supported_or_source_present
      Source IDH51-DC4769D91078094C6F41CA58
      Guide generation allowed
      true
      Source IDH51-B79C8232F1B74E64422536C2
      Pediatric
      Applicability
      supported_or_source_present
      Source IDH51-0EF81820556314AFD233F9E2
      Guide generation allowed
      false
      Source IDH51-88AE7E03C39B88256FC0DE05
      Neonatal
      Applicability
      supported_or_source_present
      Source IDH51-58305BE77F38B4847E350E5C
      Guide generation allowed
      false
      Source IDH51-56F21A65ADAAFE94C1B4593F
      Route presence
      Structured dilution
      true
      Source IDH51-98271B2E2CA44F5EC04CE0A1
      Iv push
      false
      Source IDH51-102D1C1E62509253B5EC9FB6
      Continuous infusion
      false
      Source IDH51-C5C509416FE3603FC1A4DE79
      Pediatric source
      true
      Source IDH51-D557F58D4A719B4E05768083
      Neonatal source
      true
      Source IDH51-CA5B9181A0E8006905CAF361
      Legacy reference
      Status
      not_available
      Source IDH51-A4771EEE8DCB90A69301A81D
      Label resolution
      Status
      build_environment_network_unavailable
      Source IDH51-DFC7359F0E553E6833BBFF1A
      Source files
      1. catalog.json
        Source IDH51-683305CCCAEA7269740195BC
      2. dosing.json
        Source IDH51-FCE0188716E2FF56B4BE6E95
      3. legacy-map.json
        Source IDH51-8FD27FAA4E313C464E9B3328
      Clinical release note
      Preparation instructions are released only at the evidence level shown. Legacy content remains visibly separate. Exact product, NDC, route, current labeling, and institutional policy must be confirmed.
      Source IDH51-7890007D7AAB59AA3DA7C554
      Historical statement IDs and source locations

      These IDs identify recovered source units. They are not evidence-qualified clinical claims.

      Historical IDOriginal source locationStatus
      H51-BD376B5AD6EF3D8E6E242A71catalog.json
      /records/20/id      		Historical; current review incomplete
      H51-6930D4F0EC1009361432C3B1catalog.json
      /records/20/generic_name      		Historical; current review incomplete
      H51-AC4BE6F6EEB44E4BE28E90A1catalog.json
      /records/20/brand_names/0      		Historical; current review incomplete
      H51-6427469D92ED77EF4BE99396catalog.json
      /records/20/aliases/0      		Historical; current review incomplete
      H51-FCED2D08F04A707F6BBFE3A5catalog.json
      /records/20/class      		Historical; current review incomplete
      H51-43D1B6B717C50521119DF4A5catalog.json
      /records/20/subclass      		Historical; current review incomplete
      H51-8B8012E446ED38A9E5DBF29Dcatalog.json
      /records/20/summary      		Historical; current review incomplete
      H51-571385EF0DFA0F5305C3B068catalog.json
      /records/20/common_uses/0      		Historical; current review incomplete
      H51-331273664195528FD2257768catalog.json
      /records/20/common_uses/1      		Historical; current review incomplete
      H51-01809DE71189A2D93A630EE5catalog.json
      /records/20/common_uses/2      		Historical; current review incomplete
      H51-19582B6E95117FE01A663A68catalog.json
      /records/20/preparations/0      		Historical; current review incomplete
      H51-09AB6F7C0369F933077F88ECcatalog.json
      /records/20/preparations/0/population      		Historical; current review incomplete
      H51-3179B5B8995ECC68EDE488DEcatalog.json
      /records/20/preparations/0/amount      		Historical; current review incomplete
      H51-4D85E3B769FDEB6544E92BFCcatalog.json
      /records/20/preparations/0/reconstitution      		Historical; current review incomplete
      H51-F5EDF462EAC9D20193704ACEcatalog.json
      /records/20/preparations/0/diluent      		Historical; current review incomplete
      H51-D60AA2AFAFDDD2E0C54972FEcatalog.json
      /records/20/preparations/0/final_volume      		Historical; current review incomplete
      H51-252F0FF553BA910744FB8044catalog.json
      /records/20/preparations/0/concentration      		Historical; current review incomplete
      H51-32D25A551CB278A44BFD38F4catalog.json
      /records/20/preparations/0/rate      		Historical; current review incomplete
      H51-EEB758D498CF9E9E9033A164catalog.json
      /records/20/preparations/0/stability      		Historical; current review incomplete
      H51-90BED46D00004E0752F29DF5catalog.json
      /records/20/preparations/0/notes      		Historical; current review incomplete
      H51-02EF67576DB3020E1793A58Ccatalog.json
      /records/20/preparations/1      		Historical; current review incomplete
      H51-9F7480A6A54B3B32DFC3DDCDcatalog.json
      /records/20/preparations/1/population      		Historical; current review incomplete
      H51-4C6B79563E08347D7175D0E3catalog.json
      /records/20/preparations/1/amount      		Historical; current review incomplete
      H51-C620FE441C56D6E3934A4819catalog.json
      /records/20/preparations/1/reconstitution      		Historical; current review incomplete
      H51-154D1367115596F415DB9971catalog.json
      /records/20/preparations/1/diluent      		Historical; current review incomplete
      H51-F365094B21DC54089EA107E9catalog.json
      /records/20/preparations/1/final_volume      		Historical; current review incomplete
      H51-8EAC9E7BF25AEDF5BA558C14catalog.json
      /records/20/preparations/1/concentration      		Historical; current review incomplete
      H51-541609FC9A92DB6F1EAB5CF7catalog.json
      /records/20/preparations/1/rate      		Historical; current review incomplete
      H51-A888ED438FF29697306F521Acatalog.json
      /records/20/preparations/1/stability      		Historical; current review incomplete
      H51-BF5BC217CB6F357D37131E46catalog.json
      /records/20/preparations/1/notes      		Historical; current review incomplete
      H51-664E7ED14EEF7495A35833B0catalog.json
      /records/20/warnings/0      		Historical; current review incomplete
      H51-71EE3AFDF1F328CBE66DEC42catalog.json
      /records/20/monitoring/0      		Historical; current review incomplete
      H51-92F7FE8C82B5809879D1AF49catalog.json
      /records/20/monitoring/1      		Historical; current review incomplete
      H51-E52D75F182593FD7E2A078B6catalog.json
      /records/20/monitoring/2      		Historical; current review incomplete
      H51-984829D3A030FA25EF3139CCcatalog.json
      /records/20/populations/0      		Historical; current review incomplete
      H51-45CF263A47B2ECF35CAF7CEBcatalog.json
      /records/20/populations/1      		Historical; current review incomplete
      H51-2D1D9C160753007715CAFA0Bcatalog.json
      /records/20/evidence_tier      		Historical; current review incomplete
      H51-695D48A946B28C3D168CDB3Bcatalog.json
      /records/20/high_alert      		Historical; current review incomplete
      H51-4AC21102A85C527866974AC6catalog.json
      /records/20/hazardous      		Historical; current review incomplete
      H51-C34AE4CF7399142C92D81FE9catalog.json
      /records/20/status      		Historical; current review incomplete
      H51-20994035A8ADC8CCA4738391catalog.json
      /records/20/reviewed      		Historical; current review incomplete
      H51-B16ED3060748569B63B14F4Ecatalog.json
      /records/20/version_added      		Historical; current review incomplete
      H51-F6E46F4691C9EB73E544B862catalog.json
      /records/20/sources/0      		Historical; current review incomplete
      H51-13C0B40AC24EEA3105F81FD5catalog.json
      /records/20/sources/0/label      		Historical; current review incomplete
      H51-D7B526E4502420482704F11Ccatalog.json
      /records/20/sources/0/url      		Historical; current review incomplete
      H51-9F334F8E40CF206F9D59330Fcatalog.json
      /records/20/sources/0/kind      		Historical; current review incomplete
      H51-E2D93F719B6C2E3FDC1D107Acatalog.json
      /records/20/sources/1      		Historical; current review incomplete
      H51-5F45A3989F984363176A6287catalog.json
      /records/20/sources/1/label      		Historical; current review incomplete
      H51-5B8B276BC2B5C97D7850583Ccatalog.json
      /records/20/sources/1/url      		Historical; current review incomplete
      H51-D1DE53DFED00921E22ADB416catalog.json
      /records/20/sources/1/kind      		Historical; current review incomplete
      H51-341C1907B065E50A14BE075Dcatalog.json
      /records/20/legacy_title      		Historical; current review incomplete
      H51-2CD49B49AA0949398795D888catalog.json
      /records/20/clinical_release_verification/audit_version      		Historical; current review incomplete
      H51-55C03B5DFA76FAAF889D062Acatalog.json
      /records/20/clinical_release_verification/audited_on      		Historical; current review incomplete
      H51-B6565B5E3700AFE941A14661catalog.json
      /records/20/clinical_release_verification/level      		Historical; current review incomplete
      H51-7B8B1C15E01172DF1B43A401catalog.json
      /records/20/clinical_release_verification/release_gate      		Historical; current review incomplete
      H51-ED3857B27A2C6409CA33E151catalog.json
      /records/20/clinical_release_verification/exact_current_label_candidate      		Historical; current review incomplete
      H51-AC420FFFE50D85F5DC449A39catalog.json
      /records/20/clinical_release_verification/selected_setid      		Historical; current review incomplete
      H51-F0DCCB18B313C423682BDD6Ecatalog.json
      /records/20/clinical_release_verification/selected_label_title      		Historical; current review incomplete
      H51-4CF2AC4256EAC29574EE5A9Ecatalog.json
      /records/20/clinical_release_verification/numeric_support_ratio      		Historical; current review incomplete
      H51-28AD03667DEA47F8F157B485catalog.json
      /records/20/clinical_release_verification/reference_url_count      		Historical; current review incomplete
      H51-452ABFC4A145074CDF3EEB81catalog.json
      /records/20/clinical_release_verification/broken_reference_count      		Historical; current review incomplete
      H51-20466B104F9C76A5E2994E71catalog.json
      /records/20/clinical_release_verification/point_of_use_confirmation_required      		Historical; current review incomplete
      H51-EF305FBF581DF18E1A6E7F76catalog.json
      /records/20/clinical_release_verification/note      		Historical; current review incomplete
      H51-A36283FEABCA90538A97431Fcatalog.json
      /records/20/clinical_release_verification/dailymed_search_url      		Historical; current review incomplete
      H51-C40267DF5CD8D41860B923FAdosing.json
      /records/20/id      		Historical; current review incomplete
      H51-0E16EFC63377760B90E54663dosing.json
      /records/20/generic_name      		Historical; current review incomplete
      H51-504AB54A26F2458EE5ADC37Fdosing.json
      /records/20/coverage_status      		Historical; current review incomplete
      H51-CAC1DED3E55971AA3C9D9425dosing.json
      /records/20/package_insert/query_name      		Historical; current review incomplete
      H51-79EFBC99DE48B3FB1E2E4CB9dosing.json
      /records/20/package_insert/preferred_setid      		Historical; current review incomplete
      H51-E4805F9AFD775EC19FAC3D4Adosing.json
      /records/20/package_insert/product_and_route_must_match      		Historical; current review incomplete
      H51-AE532CFA5D56BD59F6F13B23dosing.json
      /records/20/package_insert/live_current_label_enabled      		Historical; current review incomplete
      H51-240ADD03270B062E3D09FCB8dosing.json
      /records/20/package_insert/source_priority      		Historical; current review incomplete
      H51-9C382DC23D0F749CA4905100dosing.json
      /records/20/package_insert/direct_official_label_access_enabled      		Historical; current review incomplete
      H51-B20B06E558F748504A7BCCCFdosing.json
      /records/20/package_insert/outbound_server_request_required      		Historical; current review incomplete
      H51-30B239F2E879B11CB600C5E0dosing.json
      /records/20/package_insert/local_summary_status      		Historical; current review incomplete
      H51-5400A8A84A8C56AF80DB8B48dosing.json
      /records/20/renal/classification      		Historical; current review incomplete
      H51-5CA01AA622F40EB7BD10C045dosing.json
      /records/20/renal/summary      		Historical; current review incomplete
      H51-DEC748773B4798DD9E73F161dosing.json
      /records/20/renal/method_note      		Historical; current review incomplete
      H51-0B54C44665470FA54F915B10dosing.json
      /records/20/existing_route_snapshots/0      		Historical; current review incomplete
      H51-0334E9C770896C401D074493dosing.json
      /records/20/existing_route_snapshots/0/route      		Historical; current review incomplete
      H51-5C7BC4EEAD2DCECA0B6572EDdosing.json
      /records/20/existing_route_snapshots/0/population      		Historical; current review incomplete
      H51-B53EE030AD4128331D151955dosing.json
      /records/20/existing_route_snapshots/0/indication      		Historical; current review incomplete
      H51-00D8605CD069F1E07D7080B7dosing.json
      /records/20/existing_route_snapshots/0/dose      		Historical; current review incomplete
      H51-DBFC296AAEFAD582868C908Ddosing.json
      /records/20/existing_route_snapshots/0/interval      		Historical; current review incomplete
      H51-95FD296FA30783476A3AB836dosing.json
      /records/20/existing_route_snapshots/0/duration      		Historical; current review incomplete
      H51-A4C2BC034DF194152146B913dosing.json
      /records/20/existing_route_snapshots/0/administration      		Historical; current review incomplete
      H51-3AECE067E6922563CA8ABA9Cdosing.json
      /records/20/existing_route_snapshots/0/source_level      		Historical; current review incomplete
      H51-33EE119F3C72ABAC5FDE4900dosing.json
      /records/20/existing_route_snapshots/0/notes      		Historical; current review incomplete
      H51-72572804A244CFF9BFC92795dosing.json
      /records/20/existing_route_snapshots/1      		Historical; current review incomplete
      H51-448433FCC374C5B6BF1D1D52dosing.json
      /records/20/existing_route_snapshots/1/route      		Historical; current review incomplete
      H51-8C0CE3741AE03AEA81D9FCF6dosing.json
      /records/20/existing_route_snapshots/1/population      		Historical; current review incomplete
      H51-D8C5EB980DC486014BD45DD6dosing.json
      /records/20/existing_route_snapshots/1/indication      		Historical; current review incomplete
      H51-5EC741CCA66AD5F05517E51Fdosing.json
      /records/20/existing_route_snapshots/1/dose      		Historical; current review incomplete
      H51-947123034386D7C141E40CB2dosing.json
      /records/20/existing_route_snapshots/1/interval      		Historical; current review incomplete
      H51-B81CF9E83DEE62F29B423BEFdosing.json
      /records/20/existing_route_snapshots/1/duration      		Historical; current review incomplete
      H51-DF51BB65BFFE81FFD39C4C70dosing.json
      /records/20/existing_route_snapshots/1/administration      		Historical; current review incomplete
      H51-92E57CEC50B0EB680F413660dosing.json
      /records/20/existing_route_snapshots/1/source_level      		Historical; current review incomplete
      H51-20C226B9C4AA32BB12677B23dosing.json
      /records/20/existing_route_snapshots/1/notes      		Historical; current review incomplete
      H51-37CD2419133096E354883351dosing.json
      /records/20/professional_sources/0      		Historical; current review incomplete
      H51-312FAC28D2178B5166077175dosing.json
      /records/20/professional_sources/0/label      		Historical; current review incomplete
      H51-61A310089B25A2E69E4832B1dosing.json
      /records/20/professional_sources/0/url      		Historical; current review incomplete
      H51-FE682C271EB30A67B6595481dosing.json
      /records/20/professional_sources/0/kind      		Historical; current review incomplete
      H51-211ADC6A161D2D7FF78E91B5dosing.json
      /records/20/professional_sources/1      		Historical; current review incomplete
      H51-512F982BCB3D2514C5BF087Adosing.json
      /records/20/professional_sources/1/label      		Historical; current review incomplete
      H51-3590349593A771A2EC03AA77dosing.json
      /records/20/professional_sources/1/url      		Historical; current review incomplete
      H51-BF29B67D02AE98E30FFFB86Cdosing.json
      /records/20/professional_sources/1/kind      		Historical; current review incomplete
      H51-18828CA9149829FD8629F4D0dosing.json
      /records/20/professional_sources/2      		Historical; current review incomplete
      H51-7F2BF56DDE1E48DA86147488dosing.json
      /records/20/professional_sources/2/label      		Historical; current review incomplete
      H51-47AC37B7AA5D47B647C8E695dosing.json
      /records/20/professional_sources/2/url      		Historical; current review incomplete
      H51-39997971F4341C9EF370372Adosing.json
      /records/20/professional_sources/2/kind      		Historical; current review incomplete
      H51-C2C516D478D9266F5EC61EC3dosing.json
      /records/20/professional_sources/3      		Historical; current review incomplete
      H51-2CBB59AAD7210067F7118531dosing.json
      /records/20/professional_sources/3/label      		Historical; current review incomplete
      H51-D99E43212617A3FD43B93C62dosing.json
      /records/20/professional_sources/3/url      		Historical; current review incomplete
      H51-7AF9BBCDF0AEC0791D8C56A2dosing.json
      /records/20/professional_sources/3/kind      		Historical; current review incomplete
      H51-7DED8BA92CD771FFE356D061dosing.json
      /records/20/clinical_review/locally_normalized      		Historical; current review incomplete
      H51-2537ACE28A7982379A949C99dosing.json
      /records/20/clinical_review/reviewed      		Historical; current review incomplete
      H51-56123EE84E5A9495485C19F0dosing.json
      /records/20/clinical_review/status      		Historical; current review incomplete
      H51-8747B3101BA3E6323D43A9E2dosing.json
      /records/20/clinical_release_verification/audit_version      		Historical; current review incomplete
      H51-912E6626DC790963B493C31Ddosing.json
      /records/20/clinical_release_verification/audited_on      		Historical; current review incomplete
      H51-FC6C40DF24B70C15171FE1B1dosing.json
      /records/20/clinical_release_verification/level      		Historical; current review incomplete
      H51-478071E583E152376DBA51E2dosing.json
      /records/20/clinical_release_verification/release_gate      		Historical; current review incomplete
      H51-0264F41F630C20C39FD19287dosing.json
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      H51-2033B10FEAACA7983FC69785dosing.json
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      H51-D8EAEB7EF15A63F76B9DE950dosing.json
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      H51-35C36998EFED398282A843A7dosing.json
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      H51-260CF058F268B4672688AE9Fdosing.json
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      H51-8ABB0123271E1856197182A7first-look-v5.1.json
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      H51-0DB6938CE2FA0B8BEB4E262Dfirst-look-v5.1.json
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      H51-21C0DB5EB39B8A129393B034first-look-v5.1.json
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      H51-3ED293B9357395761E0F28EDfirst-look-v5.1.json
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      H51-C1E16C3A795934B709758AA9preparation-assessments-v3.8.json
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      /20/route_presence/structured_dilution      		Historical; current review incomplete
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      /20/clinical_release_note      		Historical; current review incomplete

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