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Preparation. Administration. Evidence.

IV Dilution &
Medication Reference

Search 255 medications, read preserved historical references, and inspect separately reviewed preparation statements. Full monograph updates remain pending.

Version 6.4Release date 2026-11-04For healthcare professionals
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Unasyn®- Ampicillin Sulbactam

Historical source. Current clinical review is incomplete. This monograph will be updated in the future.

Unasyn®- Ampicillin Sulbactam (opens in a new tab)Original source URL: https://globalrph.com/dilution/unasyn-ampicillin-sulbactam/ | Retrieved 2026-11-04

Source dates, location and integrity

This historical article is separate from the reviewed claim cards. Product formulations and source dates may differ.

Original source URL
https://globalrph.com/dilution/unasyn-ampicillin-sulbactam/ (opens in a new tab)
Source date
Not established in the retrieved source
Retrieved
2026-11-04T19:50:13.741332+00:00
Source location
div.post-content
Packaged content SHA-256
8d655c438af986e0cc53bdf2e12c257e0cde1cf237e24f98011cf066d5a55b13
Original response SHA-256
87899cf25b3b147192e3497a2e9ab9aefa8f07b54ee5da0ba12719e4d236c56f
Source body SHA-256
278d92c43a3c4cfefb526f94bd7673dc11e96923d1b57cef087f7f60482898b1

AMPICILLIN/SULBACTAM (UNASYN ®)
The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material. PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.

Usual Diluents
NS

Standard Dilutions [Amount of drug] [Infusion volume] [Infusion rate]
[0 - 1.5 grams/ 50 ml] [30 min]
[Over 1.5 grams/ 100 ml] [30 min]

Stability / Miscellaneous
Label: Refrigerate.

DOSAGE AND ADMINISTRATION
Ampicillin and Sulbactam for Injection may be administered by either the IV or the IM routes. For IV administration, the dose can be given by slow intravenous injection over at least 10-15 minutes or can also be delivered, in greater dilutions with 50-100 mL of a compatible diluent as an intravenous infusion over 15-30 minutes.

Ampicillin and Sulbactam for Injection may be administered by deep intramuscular injection. (See Preparation for Intramuscular Injection.)

The recommended adult dosage of Ampicillin and Sulbactam for Injection is 1.5 g to 3 g every six hours. The total dose of sulbactam should not exceed 4 grams per day.

Impaired Renal Function

Separate renal reference: Open Renal Dosing Master (opens in a new tab)
Creatinine Clearance
(mL/min/1.73m2)		 Ampicillin/Sulbactam
Half-Life (Hours)		 Recommended Ampicillin and Sulbactam Dosage
≥ 30 1 1.5 - 3g q6h - q8h
15-29 5 1.5 - 3g q12h
5-14 9 1.5 - 3g q24h
Separate renal reference: Open Renal Dosing Master (opens in a new tab)

DIRECTIONS FOR USE
General Dissolution Procedures.
Ampicillin and Sulbactam for Injection sterile powder for intravenous and intramuscular use may be reconstituted with any of the compatible diluents described in this insert. Solutions should be allowed to stand after dissolution to allow any foaming to dissipate in order to permit visual inspection for complete solubilization.

Preparation for Intravenous Use
Reconstitution of Ampicillin and Sulbactam for Injection, at the specified concentrations, with these diluents provide stable solutions for the time periods indicated in the following table: (After the indicated time periods, any unused portions of solutions should be discarded.)

Stability
Diluent Maximum Concentration (mg/mL)
ampicillin and sulbactam		 Use Periods
Sterile Water for Injection 45 (30/15) 8 hrs @ 25°C
45 (30/15) 48 hrs @ 4°C
30 (20/10) 72 hrs @ 4°C
0.9% Sodium Chloride Injection 45 (30/15) 8 hrs @ 25°C
45 (30/15) 48 hrs @ 4°C
30 (20/10) 72 hrs @ 4°C
5% Dextrose Injection 30 (20/10) 2 hrs @ 25°C
30 (20/10) 4 hrs @ 4°C
3 (2/1) 4 hrs @ 25°C
Lactated Ringer's Injection 45 (30/15) 8 hrs @ 25°C
45 (30/15) 24 hrs @ 4°C
5% Dextrose in 0.45% Saline 3 (2/1) 4 hrs @ 25°C
15 (10/5) 4 hrs @ 4°C

Initially, the vials may be reconstituted with Sterile Water for Injection to yield solutions containing 375 mg Ampicillin and Sulbactam per mL (250 mg ampicillin/125 mg sulbactam per mL ). An appropriate volume should then be immediately diluted with a suitable parenteral diluent to yield solutions containing 3 to 45 mg Ampicillin and Sulbactam per mL (2 to 30 mg ampicillin/1 to 15 mg sulbactam/per mL).

Preparation for Intramuscular Injection
1.5 g and 3 g Standard vials

Vials for intramuscular use may be reconstituted with Sterile Water for Injection USP, 0.5% Lidocaine Hydrochloride Injection USP or 2% Lidocaine Hydrochloride Injection USP. Consult the following table for recommended volumes to be added to obtain solutions containing 375 mg ampicillin and sulbactam per mL (250 mg ampicillin/ 125 mg sulbactam per mL).

Note: Use only freshly prepared solutions and administer within one hour after preparation.

Ampicillin and Sulbactam Vial Size Volume of Diluent to be Added Withdrawal Volume
There is sufficient excess present to allow withdrawal and administration of the stated volumes.
1.5 g 3.2 mL 4 mL
3 g 6.4 mL 8 mL

Revised: June 2006
Manufactured in Austria by Sandoz GmbH,
Distributed by Lek Pharmaceuticals Inc.
an affiliate of Sandoz Inc., Princeton, NJ 08540

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