GlobalRPh Vancomycin Initial Dosing & Bayesian AUC Calculator

1. Calculation pathway

Calculate an initial regimen
No prior doses or levels required. Uses the selected population PK prior. Evaluate a current regimen
Enter dose history. Levels remain optional; one or two levels enable Bayesian MAP updating.

2. Patient information and model screening

Age (years)

Sex for renal equations

Height

Weight

Serum creatinine

BMD MIC (mg/L, informational)

Does not change the AUC 400–600 target.

Population PK prior

Auto-selection priority: CRRT; BMI ≥30; non-obese critical illness; then general hospitalized adult. Belabbas remains manual.

Native renal function clinically stable enough?

Required unless the patient is receiving CRRT.

No intermittent HD, SLED, PD, or ECMO?

Selecting No blocks calculation because these therapies are unsupported.

Receiving continuous renal replacement therapy (CRRT). Critically ill / ICU patient. Hematologic malignancy. Pregnant.

3. Current maintenance regimen and dose history

Dose (mg)

Interval (hours)

Infusion duration (hours)

Doses administered

First maintenance-dose start

Optional recorded loading dose

Include a separate loading dose in the exact history.

4. Vancomycin concentrations (optional, up to 2)

Level 1 (mg/L)

Level 1 sample time

Level 2 (mg/L)

Level 2 sample time

Exact administration and sampling times are required for Bayesian updating.

GlobalRPh Vancomycin Initial Dosing & Bayesian AUC Calculator

CRRT prescription details

Hematologic-malignancy modifiers