GlobalRPh Vancomycin Dosing and Bayesian AUC Calculator Advanced

Select Bayesian model-informed dosing or conventional first-order pharmacokinetic AUC estimation. Adult intermittent-infusion clinician decision support.

* Fields marked with an asterisk are required for the selected workflow.

1. Dosing method and clinical workflow
Bayesian is preferred when a suitable population prior and reliable dose history are available. The conventional method uses one-compartment first-order equations. With two suitable post-infusion levels, it also reports a linear/log trapezoidal AUC cross-check; a trapezoidal estimate cannot be derived from no levels or one level without additional assumptions.
Select the intended AUC before calculating. The guideline range remains 400–600 when MIC is assumed to be 1 mg/L.
For empiric AUC/MIC interpretation, use MIC 1 unless a reliable broth-microdilution value is available.
Selected workflow: Bayesian population-model estimation will be used. No current dose or measured concentration is required for this pre-dose estimate.
2. Patient parameters
3. Current regimen and measured concentrations
Used to reconstruct regular dose history for Bayesian estimation. The first-dose workflow forces one dose.
Sampling-time convention: Enter elapsed hours from the start of the most recent infusion. For guideline-style two-level equation dosing, the first sample should be postdistributional, generally 1–2 hours after the infusion ends, and the second should be near the end of the interval.
4. Conventional PK assumptions and legacy options
Default 0.65 L/kg. This assumption is used for empiric and single-level conventional calculations; two-level workflows calculate Vd from concentrations.
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