Lille Model Scoring in Severe Alcoholic Hepatitis |
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Results: |
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Previous entries: (units converted in some cases) Age: 50 (Years) ---------------------------------------------- Albumin on day 0: 0.0 g/L [0.0 g/dL ] ---------------------------------------------- Serum Total Bilirubin: 7 umol/L [0.4 mg/dL] ---------------------------------------------- Serum Total Bilirubin (day 7): 8 umol/L [0.5 mg/dL] ---------------------------------------------- Serum creatinine (day 0): 1 mg/dL ---------------------------------------------- Prothrombin Time (PT) - Day 0: 10 Seconds ----------------------------------------------
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Background Info |
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The Lille Model
helps to identify patients 'early' with severe alcoholic hepatitis that are
likely to respond to steroid therapy or who will require alternative treatment
options. Louvet A, Naveau S, et al. studied 320 patients with
alcoholic hepatitis treated with corticosteroids for 7 days. Simple
baseline data was obtained (age, presense of renal insufficiency*, albumin,
prothrombin time, and bilirubin level). The bilirubin was monitored
again at day 7 to look for a change. The score was found to be
highly predictive of death at 6 months. Scores under 0.45:
estimated 6 month mortality rate is ~25%. Scores above 0.45:
estimated 6 month mortality is likely over 85%.1
The model is based on the following variables: -Age (years), -Albumin level at day 0 in g/L, -Initial bilirubin (umol/L) -Bilirubin on day 7 (umol/L) -Serum creatinine -Prothrombin time (seconds) |
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References |
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1. Louvet A, Naveau S, Abdelnour M, Ramond MJ, Diaz E, Fartoux L, Dharancy S, Texier F, Hollebecque A, Serfaty L, Boleslawski E, Deltenre P, Canva V, Pruvot FR, Mathurin P. The Lille model: a new tool for therapeutic strategy in patients with severe alcoholic hepatitis treated with steroids. Hepatology. 2007 Jun;45(6):1348-54. Pubmed.
2. Mathurin P, Abdelnour M, Ramond MJ, Carbonell N, Fartoux L, Serfaty L, Valla D, Poupon R, Chaput JC, Naveau S. Early change in bilirubin levels is an important prognostic factor in severe alcoholic hepatitis treated with prednisolone. Hepatology. 2003 Dec;38(6):1363-9. Pubmed. |