Longitudinal analysis

See how one laboratory result is changing over time

Analyze serial results with optional local ranges and reference-change-value inputs when validated CVa and CVi estimates are available.

GlobalRPh Internal Medicine illustration for longitudinal laboratory trend review
285lab records
80disease patterns
56conversion routes
112quick-add labs
Clinical safety: Reference intervals, critical values, and decision thresholds vary by laboratory, method, population, specimen, age, sex, and clinical setting. Always use the reporting laboratory's interval and critical-value policy. This tool supports interpretation; it does not diagnose or replace urgent clinical evaluation.
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Longitudinal laboratory analysis

Serial laboratory trend analyzer

Calculate net direction, absolute and percentage change, linear velocity, trend fit, interval crossings, doubling or halving time, and optional biological-variation significance.

GlobalRPh Internal Medicine illustration for therapeutic drug monitoring and serial laboratory assessment
Optional browser-saved local laboratory policy Use values from your reporting laboratory. These entries remain only in this browser and take precedence over embedded reference intervals.
No local policy saved for this test and unit.
Date and timeValueActions
Optional biological variation and RCV

Enter assay analytical variation (CVa) and within-person biological variation (CVi) from a validated source. The tool calculates RCV = sqrt(2) x Z x sqrt(CVa^2 + CVi^2).

The database does not embed a universal CVi or CVa table. Verify the estimates for the analyte, specimen, method, population, and intended use.

Interpretation safeguards

  • Confirm that all values use the same analyte, specimen, method, and unit.
  • Account for timing, fasting, posture, hydration, treatment, acute illness, and specimen quality.
  • Use an assay-specific absolute delta when required, particularly for cardiac troponin.
  • Do not equate a statistically significant RCV with clinical importance.
  • Urgent symptoms or critical results require direct clinical action, not trend-tool review.