Skip to application
All calculators and tools

Preparation. Administration. Evidence.

IV Dilution &
Medication Reference

Search 255 medications, read preserved historical references, and inspect separately reviewed preparation statements. Full monograph updates remain pending.

Version 6.4Release date 2026-11-04For healthcare professionals
All historical articlesMedication search

Rifampin

Historical source. Current clinical review is incomplete. This monograph will be updated in the future.

Rifampin (opens in a new tab)Original source URL: https://globalrph.com/dilution/rifampin/ | Retrieved 2026-11-04

Source dates, location and integrity

This historical article is separate from the reviewed claim cards. Product formulations and source dates may differ.

Original source URL
https://globalrph.com/dilution/rifampin/ (opens in a new tab)
Source date
Not established in the retrieved source
Retrieved
2026-11-04T19:50:40.597907+00:00
Source location
div.post-content
Packaged content SHA-256
1d8487ae6674731c310050e2063cc2a4307b83abb51efc3ece8f7f9a674ff7b1
Original response SHA-256
17c5ba835d7eabec025c78f79debaac8db9dc2ac0752e4f54cb453081a4f9038
Source body SHA-256
086d78732ac0179e9fb12ca6b6f2e2b35ba4a81f6e9652304420ae5e9d6c4ce8

Rifampin
The authors make no claims of the accuracy of the information contained herein; and these suggested doses and/or guidelines are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this document shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material. PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.

Usual Diluents
D5W, NS

Standard Dilutions [Amount of drug] [Infusion volume] [Infusion rate]

Preparation of Solution for IV Infusion:
Reconstitute the lyophilized powder by transferring 10 mL of sterile water for injection to a vial containing 600 mg of rifampin for injection. Swirl vial gently to completely dissolve the antibiotic.
[Vial stability] The reconstituted solution contains 60 mg rifampin per mL and is stable at room temperature for up to 30 hours. Prior to administration, withdraw from the reconstituted solution a volume equivalent to the amount of rifampin calculated to be administered and add to 500 mL of infusion medium. Mix well and infuse at a rate allowing for complete infusion within 3 hours. Alternatively, the amount of rifampin calculated to be administered may be added to 100 mL of infusion medium and infused in 30 minutes.

[Admixture stability] Dilutions in dextrose 5% for injection (D5W) are stable at room temperature for up to 8 hours and should be prepared and used within this time. Precipitation of rifampin from the infusion solution may occur beyond this time. Dilutions in normal saline are stable at room temperature for up to 6 hours and should be prepared and used within this time. Other infusion solutions are not recommended. [July 2018]

Standard Dilutions [Amount of drug] [Infusion volume] [Infusion rate]
[600 mg] [500 ml] [3 hours]

Minimum dilution:
[300 - 600mg] [100 ml] [30 minutes]

Stability / Miscellaneous
DOSAGE AND ADMINISTRATION
=======================================
Rifampin can be administered by the oral route or by IV infusion. IV doses are the same as those for oral.

Tuberculosis
Adults: 10 mg/kg, in a single daily administration, not to exceed 600 mg/day, oral or IV.
Pediatric Patients: 10-20 mg/kg, not to exceed 600 mg/day, oral or IV.

Meningococcal Carriers
Adults: For adults, it is recommended that 600 mg rifampin be administered twice daily for two days.
Pediatric Patients: Pediatric patients 1 month of age or older: 10 mg/kg (not to exceed 600 mg per dose) every 12 hours for two days.
Pediatric patients under 1 month of age: 5 mg/kg every 12 hours for two days.

STABILITY:
=======================================
Dilutions in dextrose 5% for injection (D5W) are stable at room temperature for up to 8 hours and should be prepared and used within this time. Precipitation of rifampin from the infusion solution may occur beyond this time. Dilutions in normal saline are stable at room temperature for up to 6 hours and should be prepared and used within this time. Other infusion solutions are not recommended. [July 2018]

PREPARATION of Solution for IV Infusion :
=======================================
Reconstitute the lyophilized powder by transferring 10 mL of sterile water for injection to a vial containing 600 mg of rifampin for injection. Swirl vial gently to completely dissolve the antibiotic. The reconstituted solution contains 60 mg rifampin per mL and is stable at room temperature for up to 30 hours. Prior to administration, withdraw from the reconstituted solution a volume equivalent to the amount of rifampin calculated to be administered and add to 500 mL of infusion medium. Mix well and infuse at a rate allowing for complete infusion within 3 hours. Alternatively, the amount of rifampin calculated to be administered may be added to 100 mL of infusion medium and infused in 30 minutes.

Source: [package insert]

Matching medication records

Return to top