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Preparation. Administration. Evidence.

IV Dilution &
Medication Reference

Search 255 medications, read preserved historical references, and inspect separately reviewed preparation statements. Full monograph updates remain pending.

Version 6.4Release date 2026-11-04For healthcare professionals
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Phenobarbital

Historical source. Current clinical review is incomplete. This monograph will be updated in the future.

Phenobarbital (opens in a new tab)Original source URL: https://globalrph.com/dilution/phenobarbital/ | Retrieved 2026-11-04

Source dates, location and integrity

This historical article is separate from the reviewed claim cards. Product formulations and source dates may differ.

Original source URL
https://globalrph.com/dilution/phenobarbital/ (opens in a new tab)
Source date
Not established in the retrieved source
Retrieved
2026-11-04T19:47:07.985247+00:00
Source location
div.post-content
Packaged content SHA-256
68ee476cb910945d8d0123da931d511a410c75f5c6f5a50d9a1f9632f6a15a60
Original response SHA-256
9a00f4da90e3b2d75e11174ab7eed7af731af9305c9b73a787c17a3ff116ded9
Source body SHA-256
a8509b61e42d631b7669c1db710ffa45303b134e3f214278619c9cd15d703274

Phenobarbital
The authors make no claims of the accuracy of the information contained herein; and these suggested doses and/or guidelines are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this document shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material. PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.

Usual Diluents
NS

Standard Dilutions [Amount of drug] [Infusion volume] [Infusion rate]
[0 to 100 mg] [50 ml] [30 min]
[Over 100 mg] [100 ml] [30 min]

Maximum rate: 100 mg/min.
Avoid rapid I.V. administration >50 mg/minute; avoid intra-arterial
injection; parenteral solutions are highly alkaline; avoid extravasation

Stability / Miscellaneous
Dosing (adults):
Alcohol withdrawal: 260 mg IV initially, followed by 130mg q30min to
achieve light sedation.

Sedation: Oral, I.M.: 30-120 mg/day in 2-3 divided doses

Hypnotic: Oral, I.M., I.V., SubQ: 100-320 mg at bedtime

Preoperative sedation: I.M.: 100-200 mg 1-1.5 hours before procedure

Anticonvulsant:
Status epilepticus:
Loading dose: I.V.:
------------------------------------
Adults: 300-800 mg initially followed by 120-240 mg/dose at 20-minute
intervals until seizures are controlled or a total dose of 1-2 g

Anticonvulsant maintenance dose: Oral, I.V.:
-------------------------------------------------------------
Adults: 1-3 mg/kg/day in divided doses or 50-100 mg 2-3 times/day

Therapeutic range: 15 - 40 mcg/ml.

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