Methyldopate ( Aldomet ®)
Historical source. Current clinical review is incomplete. This monograph will be updated in the future.
Methyldopate ( Aldomet ®) (opens in a new tab)Original source URL: https://globalrph.com/dilution/methyldopate-aldomet/ | Retrieved 2026-11-04
Source dates, location and integrity
This historical article is separate from the reviewed claim cards. Product formulations and source dates may differ.
- Original source URL
- https://globalrph.com/dilution/methyldopate-aldomet/ (opens in a new tab)
- Source date
- Not established in the retrieved source
- Retrieved
- 2026-11-04T19:48:26.494092+00:00
- Source location
- div.post-content
- Packaged content SHA-256
- 813e12aa64fb94351a487fb25ce44377d59f434d80da4acc0089dab72826b1a9
- Original response SHA-256
- 91362faf37712d824d13e315c928844764ffd43535263e08f6a0db39f7b32d28
- Source body SHA-256
- 2bbbcdd3db08d6b1c20316fb4dbe095e73f58af3af718fb87fd0939026730df7
Methyldopate ( Aldomet ®) |
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Usual Diluents |
| D5W |
Standard Dilutions [Amount of drug] [Infusion volume] [Infusion rate] |
| [0 to 500 mg] [100 ml] [60 min] [over 500 mg] [250 ml] [60 min] |
Stability / Miscellaneous |
| EXP: 1 DAY (RT)
DOSAGE AND ADMINISTRATION Add the desired dose of Methyldopate HCl Injection to 100 mL of Dextrose Injection 5%, USP. Alternatively the desired dose may be given in 5% dextrose in water in a concentration of 100 mg/10 mL. Give this intravenous infusion slowly over a period of 30 to 60 minutes. Adults: The usual adult dosage intravenously is 250 mg to 500 mg at six hour intervals as required. The maximum recommended intravenous dose is 1 gram every six hours. When control has been obtained, oral therapy with tablets may be substituted for intravenous therapy, starting with the same dosage schedule used for the parenteral route. The effectiveness and anticipated responses are described in the circular for tablets. Since methyldopate has a relatively short duration of action, withdrawal is followed by return of hypertension usually within 48 hours. This is not complicated by an overshoot of blood pressure. Occasionally tolerance may occur, usually between the second and third month of therapy. Adding a diuretic or increasing the dosage of methyldopa frequently will restore effective control of blood pressure. A thiazide may be added at any time during methyldopa therapy and is recommended if therapy has not been started with a thiazide or if effective control of blood pressure cannot be maintained on 2 grams of methyldopa daily. Methyldopa is largely excreted by the kidney and patients with impaired renal function may respond to smaller doses. Syncope in older patients may be related to an increased sensitivity and advanced arteriosclerotic vascular disease. This may be avoided by lower doses. HOW SUPPLIED Store at controlled room temperature 15°-30°C (59°-86°F) (See USP). Rx Only American Source: [package insert] |