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Version 6.4Release date 2026-11-04For healthcare professionals
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Mesna (Mesnex ®)

Historical source. Current clinical review is incomplete. This monograph will be updated in the future.

Mesna (Mesnex ®) (opens in a new tab)Original source URL: https://globalrph.com/dilution/mesna-mesnex/ | Retrieved 2026-11-04

Source dates, location and integrity

This historical article is separate from the reviewed claim cards. Product formulations and source dates may differ.

Original source URL
https://globalrph.com/dilution/mesna-mesnex/ (opens in a new tab)
Source date
Not established in the retrieved source
Retrieved
2026-11-04T19:48:23.166187+00:00
Source location
div.post-content
Packaged content SHA-256
032c0be40e9ba83d830085725fa7d9eae7240fc033899a324aca6799046c8fb5
Original response SHA-256
6d44948788cb0a4554910836d87d45641314e2d317c6fb5c76f52a3c393619d7
Source body SHA-256
1f8f8e2582c0f47243901f2dff9cf09bc97a184ee3aeaa54d35a41f82edcc961

Mesna ( Mesnex ®)
The authors make no claims of the accuracy of the information contained herein; and these suggested doses and/or guidelines are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this document shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material. PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.

Usual Diluents
D5W, NS

Standard Dilutions [Amount of drug] [Infusion volume] [Infusion rate]
[Usual dose] [100 ml] [15-30min]
(Concentration range: 1-20 mg/ml)

Stability / Miscellaneous
Dosing: usual dose=20% of ifosfamide dose given just before and 4 and 8 hours after ifosfamide (total=60%).
May also be given as a continuous IV infusion concurrently with ifosfamide. Total daily dose= 60% to 160% of ifosfamide dose or 60% to 200% of cyclophosphamide dose. May give 20% W/W 15min prior, and then q3hrs x 3-6 doses.Administration: IVPB in 50 ml or more of D5W or normal saline over 5 minutes or longer. Also by continuous IV infusion.Storage/stability: Vials stored at RT. Diluted solutions (1-20 mg/ml)-24 hrs (REF). 20 mg/ml (D5W)-48hrs RT; 1-mg/ml (D5W)-24 hours RT.Preparation: May be further diluted in D5W, NS, D5/.45NS, or LR to a final concentration of 1-20 mg/ml.

DOSAGE AND ADMINISTRATION
For the prophylaxis of ifosfamide induced hemorrhagic cystitis, mesna may be given on a fractionated dosing schedule of three bolus intravenous injections as outlined below.

Intravenous Schedule
Mesna is given as intravenous bolus injections in a dosage equal to 20% of the ifosfamide dosage (w/w) at the time of ifosfamide administration and 4 and 8 hours after each dose of ifosfamide. The total daily dose of mesna is 60% of the ifosfamide dose.

The recommended dosing schedule is outlined below:

0 Hours 4 Hours 8 Hours
Ifosfamide 1.2 g/m2 - -
Mesna 240 mg/m2 240 mg/m2 240 mg/m2

Preparation of Intravenous Solutions/Stability
The mesna multidose vials may be stored and used for up to 8 days.
For IV administration the drug can be diluted by adding the Mesna Injection solution to any of the following fluids obtaining final concentrations of 20 mg mesna/mL.

*5% Dextrose Injection, USP
*5% Dextrose and 0.2% Sodium Chloride Injection, USP
*5% Dextrose and 0.33% Sodium Chloride Injection, USP
*5% Dextrose and 0.45% Sodium Chloride Injection, USP
*0.92% Sodium Chloride Injection, USP
*Lactated Ringer's Injection, USP

For example:
One mL of Mesna Injection multidose vial 100 mg/mL may be added to 4 mL of any of the solutions listed above to create a final concentration of 20 mg mesna/mL.

Diluted solutions are chemically and physically stable for 24 hours at 25°C (77°F).

Mesna is not compatible with cisplatin or carboplatin.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

HOW SUPPLIED
Mesna Injection is available as follows:
NDC 55390-266-01 1 gram; 10 mL Multidose Vial, individually boxed.
Store at 20° to 25°C (68° to 77°F). See USP for controlled room temperature.

Manufactured by: Manufactured for:
Ben Venue Laboratories, Inc. Amerinet Choice®
Bedford, OH 44146 St. Louis, MO 63146
July 2005 ANMSN-P00

Source: [package insert]

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