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Preparation. Administration. Evidence.

IV Dilution &
Medication Reference

Search 255 medications, read preserved historical references, and inspect separately reviewed preparation statements. Full monograph updates remain pending.

Version 6.4Release date 2026-11-04For healthcare professionals
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Immune Globulin

Historical source. Current clinical review is incomplete. This monograph will be updated in the future.

Immune Globulin (opens in a new tab)Original source URL: https://globalrph.com/dilution/immune-globulin/ | Retrieved 2026-11-04

Source dates, location and integrity

This historical article is separate from the reviewed claim cards. Product formulations and source dates may differ.

Original source URL
https://globalrph.com/dilution/immune-globulin/ (opens in a new tab)
Source date
Not established in the retrieved source
Retrieved
2026-11-04T19:49:12.300738+00:00
Source location
div.post-content
Packaged content SHA-256
f48c96790e72bf9cff938a75b23d8c9a4b45cf62943f38563e577ceb2712301b
Original response SHA-256
79c081b6a5a36ed59ca609bab4ff48a8625191e56677c3b9f1f608b7fed973c9
Source body SHA-256
bd2f2e0a2aeaab7dcd93d63dc066cb09afdd9f7da7a69886b31ad922c241bd89

Immune Globulin
The authors make no claims of the accuracy of the information contained herein; and these suggested doses and/or guidelines are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this document shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material. PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.

Usual Diluents
Dilute with diluent provided

Standard Dilutions [Amount of drug] [Infusion volume] [Infusion rate]
Dilute with diluent provided

Stability / Miscellaneous
Initial rate: Variable (depends on product)

EXP: Variable. See package insert.
Label: Do not shake/Refrigerate.

Immune globulins with high concentrations of IgA:
(1) Venoglobulin-S (2) Gamimune-N (3) Gammar-P IV (4) Sandoglobulin (5) Panglobulin

Immune globulins with low concentrations of IgA: (1) Polygam S/D (2) Gammagard S/D

Before dispensing, determine if the patient has an IgA deficiency: In patients with IgA deficiency, IgA can be antigenic and anti-IgA antibodies can develop rapidly leading to anaphylaxis when a product containing significant concentrations of IgA is administered. Therefore, use Polygam S/D or Gammagard S/D for IgA deficient patients.

Overview:
IgG is comprised of 4 subclasses with a distribution similar to normal serum (IgG1 thru IgG4). IgG1 is the major component in IGIV preparations. IgG1 is involved in tissue protection, complement activation and virus inactivation. Bacterial cells are opsonized by IgG1, making them more prone to phagocytosis. Treatment of immune deficient states probably depends on straightforward replacement of missing antibodies. Immunomodulatory doses of IVIG for autoimmune conditions are considerably larger & are thought to promote blockade of Fc receptors in macrophages (preventing phagocytosis of circulating opsonized platelets or cells tagged c autoantibodies). IVIG may also neutralize pathogenic auto-antibodies, and possibly down regulate IgG production. According to the National Institutes of Health, the commercially available products are equally effective and they may be used interchangeably. (Exception: IgA deficient patients).

Source: [package insert]

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