Epinephrine
Historical source. Current clinical review is incomplete. This monograph will be updated in the future.
Epinephrine (opens in a new tab)Original source URL: https://globalrph.com/dilution/epinephrine/ | Retrieved 2026-11-04
Source dates, location and integrity
This historical article is separate from the reviewed claim cards. Product formulations and source dates may differ.
- Original source URL
- https://globalrph.com/dilution/epinephrine/ (opens in a new tab)
- Source date
- Not established in the retrieved source
- Retrieved
- 2026-11-04T19:46:38.313662+00:00
- Source location
- div.post-content
- Packaged content SHA-256
- cbc6b045d985158fbe304a2a57b728461287ccedf1b7e09622710df4c6168178
- Original response SHA-256
- 6484c985c0a82de45b50d01c2cec75b438db30340bcc93b886221b85c037cdfa
- Source body SHA-256
- dd83b4834d7b3dc327660ba669088460bcab33b375cade354f2a7ed3a7bf2986
EPINEPHRINE |
| The authors make no claims of the accuracy of the information contained herein; and these suggested doses and/or guidelines are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this document shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material. PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER. |
Usual Diluents |
| NS, D5W |
Standard Dilutions [Amount of drug] [Infusion volume] [Infusion rate] |
| [1 to 5 mg] [250 ml] [Titrate]
Central line required for administration. |
Stability / Miscellaneous |
| EXP: 1 DAY (RT).
Dosing: Cardiac arrest: 0.5 to 1 mg bolus (1:10,000) q5min prn. May give 0.3 mg SC or start continuous infusion (range: 1 to 10 mcg/min). Calculation of drip rate (ml/hr) -------------------------------------------------------------------------------- Dosing (Adults): Intratracheal: Administer 2-2.5 times the recommended I.V. dose; dilute in 10 mL NS or distilled water. Note: Absorption is greater with distilled water, but causes more adverse effects on PaO2. Bronchodilator: I.M., SubQ ( 1:1000 ): 0.1-0.5 mg every 10-15 minutes to 4 hours Hypersensitivity reaction: I.M., SubQ: 0.3-0.5 mg every 15-20 minutes if condition requires; if hypotension is present: 0.1 mg I.V. slowly over 5-10 minutes followed by continuous infusion 1-10 mcg/minute Symptomatic bradycardia or heart block (not responsive to atropine or pacing): I.V. infusion: 1-10 mcg/minute; titrate to desired effect Refractory hypotension (refractory to dopamine/dobutamine): Continuous I.V. infusion 1 mcg/minute (range: 1-10 mcg/minute); titrate dosage to desired effect; severe cardiac dysfunction may require doses >10 mcg/minute (up to 0.1 mcg/kg/minute) Nebulization: Instill 8-15 drops into nebulizer reservoirs; administer 1-3 inhalations 4-6 times/day Administration Epinephrine can be administered SubQ, I.M., I.V., or intracardiac injection I.M. administration into the buttocks should be avoided Preparation of adult I.V. infusion: Dilute 1 mg in 250 mL of D5W or NS (4 mcg/mL); administer at an initial rate of 1 mcg/minute and increase to desired effects; at 20 mcg/minute pure alpha effects occur Extravasation management: Use phentolamine as antidote. Mix 5 mg with 9 mL of NS. Inject a small amount of this dilution into extravasated area. Blanching should reverse immediately. Monitor site. If blanching should recur, additional injections of phentolamine may be needed. Stability Oxidation turns drug pink, then a brown color; solutions should not be used if they are discolored or contain a precipitate. Stability of injection of parenteral admixture at room temperature (25°C) or refrigeration (4°C): 24 hours. Standard diluent: 1 mg/250 mL NS. Source: [package insert] |