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Preparation. Administration. Evidence.

IV Dilution &
Medication Reference

Search 255 medications, read preserved historical references, and inspect separately reviewed preparation statements. Full monograph updates remain pending.

Version 6.4Release date 2026-11-04For healthcare professionals
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Medication reference

Ticarcillin-clavulanate

Monograph awaiting updateThis monograph will be updated in the future.

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Historical source. Current clinical review is incomplete. This monograph will be updated in the future.

Ticarcillin /Clavulonic acid -Timentin® (opens in a new tab)Original source URL: https://globalrph.com/dilution/ticarcillin-clavulonic-acid-timentin/ | Retrieved 2026-11-04

Source dates, location and integrity

This historical article is separate from the reviewed claim cards. Product formulations and source dates may differ.

Original source URL
https://globalrph.com/dilution/ticarcillin-clavulonic-acid-timentin/ (opens in a new tab)
Source date
Not established in the retrieved source
Retrieved
2026-11-04T19:50:05.126528+00:00
Source location
div.post-content
Packaged content SHA-256
eb7dbfe7052bff1ad3b659834155c40399838540996dfb17c0ff7b8da325515c
Original response SHA-256
8462f98c5d7ce54903a41eca1550c6db80550410a83ed507d84a70d23fe4a76c
Source body SHA-256
514e88d6fc0a6fe3e53a1468717f11e1271f1b7d8fea21ba11a21136e18d3f09

Ticarcillin / Clavulonic acid ( Timentin ®)

The authors make no claims of the accuracy of the information contained herein; and these suggested doses and/or guidelines are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this document shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material. PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.

Usual Diluents

NS, D5W

Standard Dilutions [Amount of drug] [Infusion volume] [Infusion rate]

[0 to 2.5 grams] [50 ml] [30 min]

[Over 2.5 grams] [100ml] [30 min]

Stability / Miscellaneous

EXP: 1 DAY room temperature or 3 DAYS if refrigerated.
Label
: Refrigerate.
Cannot be given IM.Usual dose: 3.1g IVPB q4-6h.

Open this historical article on its own

Product identifiers and clinical review status

This monograph will be updated in the future. Historical material is available where present in the original sources; full current exact-product and claim-level review remains pending.

Exact formulation, concentration, container, manufacturer, regulatory identifiers, and a reproducible label snapshot have not all been reconciled.

What remains to be completed
  • Retrievable exact-product SPL XML with version, revision, retrieval date and reproducible hash
  • Clinically reviewed, individually identified statements with two exact source mappings
  • Exact formulation, strength, container, manufacturer/labeler, application and NDC reconciliation
  • Renal-function methods and dialysis/CRRT modality review where applicable
  • Mechanism provenance, clinical source disagreements and full medication-specific safety reconciliation

Supplemental historical fields

Restored-data provenance and review notes

Source release: 2026-08-31. Current clinical review is incomplete. Original uses of current, verified, or normalized describe the historical source. They do not inherit the status of separately reviewed statements. Product formulations and source dates can differ.

Current review annotations for historical renal, dialysis, mechanism, and product fieldsSeparate renal reference: Open Renal Dosing Master (opens in a new tab)
Renal
Status
not_locally_normalized
Original classification
adjustment_required
Entries
    General note
    Preserve the source-specific renal-function basis. An indexed CrCl table is not interchangeable with unindexed CrCl or eGFR. Generic advice to check a method does not identify the equation for a dose row.
    Dialysis
    Status
    no_local_structured_regimen
    Entries
      General note
      Named modality alone does not establish applicability. CRRT subtype, effluent rate, residual renal function, timing and interruptions require review. Historical absence is not evidence that no guidance exists.
      Mechanisms
      • Source kind
        first_look
        Local pointer
        /mechanism
        Original level
        class_level
        Provenance classification
        historical_class_level
        Label derived verified
        false
        Independently corroborated
        false
        Exact label section
        Not recorded
        Original source note
        Not recorded
        Review status
        historical_unverified
        Note
        Drug-specific wording in the old file is not proof of independent corroboration or an exact label locator. Consult separately published current mechanism claims where present.
      Future update
      Status
      pending_review
      Message
      This monograph will be updated in the future as current exact-product and claim-level review is completed.
      Source unavailable
      false
      Reason
      The historical content is restored; comprehensive contemporary verification remains incomplete.
      Historical first look: uses, mechanism, dosing context, and administration

      Recovered v5.1 source content; historical, awaiting current review.

      Id
      ticarcillin-clavulanate
      Source IDH51-0CE7358F81CC1AD404D429E5
      Generic name
      Ticarcillin-clavulanate
      Source IDH51-70F424BDE4D24A224A41EF8C
      Class
      Antibacterial
      Source IDH51-310C979C74C90E97111FD904
      Subclass
      Legacy GlobalRPh directory entry
      Source IDH51-94EA6D565282C4A6712A2011
      Primary uses
      1. Selected susceptible bacterial infections; indication, site, organism, local susceptibility, and current labeling determine use.
        Source IDH51-A19D70DE8BBE9AA1F68C3D43
      Mechanism
      Beta-lactam binding to bacterial penicillin-binding proteins inhibits peptidoglycan cross-linking and cell-wall synthesis.
      Source IDH51-347913BBEEE703A2E8B0280E
      Mechanism level
      class_level
      Source IDH51-3CBE34884E18CD013BDEE3D5
      Basic dosing orientation
      The existing GlobalRPh dose and preparation quick reference loads automatically below. Treat it as historical continuity, then confirm the exact current DailyMed label, population, indication, renal function, and institutional policy.
      Source IDH51-9986AE81F90766BD36A6BC1C
      Administration orientation
      Route, dilution, concentration, and administration details load automatically from the existing GlobalRPh quick reference below; current exact-product verification remains required.
      Source IDH51-7A95C3F93FDFE2F8E04F421B
      Renal and population orientation
      Separate renal reference: Open Renal Dosing Master (opens in a new tab)Renal dose adjustment or interval modification is commonly required; verify the selected product label and patient-specific renal method.
      Source IDH51-8C69423B16F71FFF652AC53D
      Key safety orientation
      1. Legacy content must be reconciled against current labeling and institutional policy before clinical use.
        Source IDH51-9CD909427E1FD602903BF8F7
      Coverage path
      automatic_legacy_quick_reference
      Source IDH51-57F50DAA2468EAF3D8721315
      Coverage path label
      Automatic legacy GlobalRPh quick reference
      Source IDH51-6E346F62834A7496588E4218
      Legacy title
      Ticarcillin-clavulanate
      Source IDH51-9E452E244876EE1C90730BB6
      Review note
      First-look orientation only. Verify indication, patient population, weight basis, organ function, exact IV product, dose, concentration, compatibility, rate, and current labeling before use.
      Source IDH51-6187F552EF439E167164FAB4
      Search text
      Ticarcillin-clavulanate Antibacterial Legacy GlobalRPh directory entry Selected susceptible bacterial infections; indication, site, organism, local susceptibility, and current labeling determine use. Beta-lactam binding to bacterial penicillin-binding proteins inhibits peptidoglycan cross-linking and cell-wall synthesis. The existing GlobalRPh dose and preparation quick reference loads automatically below. Treat it as historical continuity, then confirm the exact current DailyMed label, population, indication, renal function, and institutional policy. Route, dilution, concentration, and administration details load automatically from the existing GlobalRPh quick reference below; current exact-product verification remains required. Renal dose adjustment or interval modification is commonly required; verify the selected product label and patient-specific renal method. Legacy content must be reconciled against current labeling and institutional policy before clinical use. Automatic legacy GlobalRPh quick reference
      Source IDH51-8A0605C912D96817F411F2F3
      Official access mode
      search
      Source IDH51-97E1E831D720E22D5815A076
      Official search query
      Ticarcillin-clavulanate
      Source IDH51-1216751BD861035EB1064842
      Official access reason
      A source-backed DailyMed search is available; select and confirm the exact IV product.
      Source IDH51-A8A69FCFA2C6078BFED090E0

      No separate structured rows were bundled for preparation, IV push, continuous infusion, population dosing, dialysis, CRRT. Historical article content and source links may cover these topics.

      Historical renal-function guidance

      Recovered v5.1 source content; historical, awaiting current review.

      Separate renal reference: Open Renal Dosing Master (opens in a new tab)
      Classification
      adjustment_required
      Source IDH51-48B6066FFD914D7897DB5AC1
      Summary
      Renal dose adjustment or interval modification is commonly required; verify the selected product label and patient-specific renal method.
      Source IDH51-E0B4966A7E11C55D69066118
      Method note
      Use the renal function estimate and body-size convention specified by the selected label or institutional protocol. Do not interchange Cockcroft-Gault CrCl, indexed eGFR, and de-indexed eGFR without confirming the dosing source.
      Source IDH51-FC3011E7E75591A90F9C2ACF

      Historical Warnings and safeguards

      Recovered v5.1 source content; historical, awaiting current review.

      1. Legacy content must be reconciled against current labeling and institutional policy before clinical use.
        Source IDH51-9E20CB35EA41B605B92C5CAB

      Historical Stability notes

      Recovered v5.1 source content; historical, awaiting current review.

      1. Legacy product stability information is not automatically equivalent to a USP <797> BUD.
        Source IDH51-84717314840BE9B6B5024C4A

      Historical supplemental professional sources

      Recovered v5.1 source content; historical, awaiting current review.

      LabelUrlKind
      Source IDH51-80CFDEA872ADD221535AF4FC
      UCSF adult antimicrobial dosing, non-dialysis
      Source IDH51-C2552D02F306E036E2633958
      https://idmp.ucsf.edu/adult-antimicrobial-dosing-non-dialysis (opens in a new tab)
      Source IDH51-1F27A14A2486A675BA8924A8
      Professional institutional guidance
      Source IDH51-F727C5239DB0CEA5E510832C
      Source IDH51-D36B0ACCD0F97DFA46FA8022
      UCSF antimicrobial dosing in intermittent and continuous hemodialysis
      Source IDH51-4F0207CDAE38D4B267B124B2
      https://idmp.ucsf.edu/antimicrobial-dosing-intermittent-continuous-hemodialysis (opens in a new tab)
      Source IDH51-1BE192FBF911CECA0A6D692E
      Professional institutional guidance
      Source IDH51-0A23A5241444BA50315EE7C8
      Source IDH51-D4AE976D20074774246307C5
      UCSF pediatric antimicrobial dosing
      Source IDH51-B827B7F3DB96E4D0F17763E5
      https://idmp.ucsf.edu/pediatric-antimicrobial-dosing-benioff-childrens-hospitals (opens in a new tab)
      Source IDH51-73CBC5D68E13C9A7752E359E
      Professional institutional guidance
      Source IDH51-15C978364427040D478089D1
      Source IDH51-6E2704F6B746D4F80A9460F7
      UCSF neonatal antimicrobial dosing
      Source IDH51-687F184E88EA7D934BD9CEEF
      https://idmp.ucsf.edu/neonatal-antimicrobial-dosing-benioff-childrens-hospitals (opens in a new tab)
      Source IDH51-3E35402727CB5FC605A8670A
      Professional institutional guidance
      Source IDH51-C988F560642AE97189E4D410
      Other recovered source fields and original editorial metadata

      Original status words such as current, verified, or normalized describe the historical source release. They do not change the clinical review status of this release.

      Catalog source fields

      Id
      ticarcillin-clavulanate
      Source IDH51-1F28120FA296A2B548694BF5
      Legacy title
      Ticarcillin-clavulanate
      Source IDH51-6FC724E9939F32A75C70C3E6
      Generic name
      Ticarcillin-clavulanate
      Source IDH51-FB94B0F30236E0FA31EB0381
      Class
      Antibacterial
      Source IDH51-E5FA197996EA49A5D561FAC7
      Subclass
      Legacy GlobalRPh directory entry
      Source IDH51-1E5862CC19B922848BF03A5A
      Summary
      Existing GlobalRPh IV dilution monograph retained for migration into the unified reference.
      Source IDH51-8B27F3B9EEB6D27FDA9F4444
      Populations
      1. Population not yet normalized
        Source IDH51-576788D25EAFA981754E60C0
      Evidence tier
      Legacy catalog - migration review required
      Source IDH51-C25E611EE68796C8AEB6C4DA
      High alert
      false
      Source IDH51-DA9E609F9DD25AE3D34188C2
      Hazardous
      false
      Source IDH51-7DCC9A6AC7B249683F8CA034
      Status
      Legacy migration
      Source IDH51-CB2EC4FF24FCD8297CE426F0
      Version added
      Legacy
      Source IDH51-1D7C90605722A35E08BEE37C
      Sources
      LabelUrlKind
      Source IDH51-E2E8507C9D0ED42D158B32B0
      GlobalRPh legacy IV dilution monograph
      Source IDH51-DA530E162A9828941F289240
      legacy:auto
      Source IDH51-DE7663E352F44322EC3F1983
      Legacy
      Source IDH51-F2C63AFF97A5675BA1FCD5C6
      Clinical release verification
      Audit version
      3.4
      Source IDH51-6B74F11B0712A96C9EE84CFC
      Audited on
      2026-08-30
      Source IDH51-123211166B0B3B0D5D814816
      Level
      amber
      Source IDH51-53D9BFC34D1E8369D7AAC4CA
      Release gate
      trusted_professional_source_present_exact_label_unconfirmed
      Source IDH51-55DF32F4F5CCB14B8A2BAC2C
      Exact current label candidate
      false
      Source IDH51-2D9D466F0C9992596D5E0839
      Reference url count
      4
      Source IDH51-FF953787D59B8B23C17B3A03
      Broken reference count
      0
      Source IDH51-DA253502DAD7852E91E49C8D
      Point of use confirmation required
      true
      Source IDH51-08C35974A147A8C19F04AEED
      Note
      Do not treat this record as a fully current product-specific monograph until the exact IV formulation and current sources are confirmed.
      Source IDH51-1D4B6B33A262CAC7C366357B

      Dosing source fields

      Id
      ticarcillin-clavulanate
      Source IDH51-AB0B8FF38820239F414E463E
      Generic name
      Ticarcillin-clavulanate
      Source IDH51-F8ADF848D016AEA8B96137BF
      Coverage status
      direct_official_label_access_plus_legacy_reference
      Source IDH51-F0AC3EA5ADBB58E4CA7C9DC4
      Package insert
      Query name
      Ticarcillin-clavulanate
      Source IDH51-2A4E5D80AE9921F17EE6E3A6
      Product and route must match
      true
      Source IDH51-94A5031FF77E962B0E0D641E
      Live current label enabled
      false
      Source IDH51-D548112E06D147F5FA38EB57
      Source priority
      Reviewed local summary when available, then a verified DailyMed label or product search when available, followed by professional references and institutional policy.
      Source IDH51-8E5AA0D489DE3304A0C6FC78
      Direct official label access enabled
      true
      Source IDH51-B0F137936E6126C4D1083D1C
      Outbound server request required
      false
      Source IDH51-E8E26CE59330D3382244C7BE
      Local summary status
      not_bundled
      Source IDH51-E3AEA12A7DA1136F95A42F72
      Clinical review
      Locally normalized
      false
      Source IDH51-CDC5E2F249F4A75FEE48E479
      Reviewed
      2026-08-29
      Source IDH51-17442425B26BCF795BB276D7
      Status
      Direct official package-insert access enabled; indication-specific local normalization pending.
      Source IDH51-D567C09EE606EC3C1B89409B
      Clinical release verification
      Audit version
      3.4
      Source IDH51-75759A3774B62CDCDFD34CB6
      Audited on
      2026-08-30
      Source IDH51-3E8C5DE769888AAA7BFAF8EB
      Level
      amber
      Source IDH51-956CB2109748A30D681116DA
      Release gate
      trusted_professional_source_present_exact_label_unconfirmed
      Source IDH51-955699410A3FE79924339B97
      Exact current label candidate
      false
      Source IDH51-1EEF41176D5B1CE2587DE479
      Reference url count
      4
      Source IDH51-F65E906278FD5A8A76FE5266
      Broken reference count
      0
      Source IDH51-1AD405A2E60FACDC7884AA02
      Point of use confirmation required
      true
      Source IDH51-50EA0A2A9B69FCC1A7FF11A6
      Note
      Do not treat this record as a fully current product-specific monograph until the exact IV formulation and current sources are confirmed.
      Source IDH51-93C66717FA010F36C0EE107E
      Historical preparation assessment

      Recovered v5.1 source content; historical, awaiting current review.

      Id
      ticarcillin-clavulanate
      Source IDH51-CAB4848D652FDD31F093DA8A
      Name
      Ticarcillin-clavulanate
      Source IDH51-9AC42E683E0E883792D7EC96
      Therapeutic class
      Antibacterial
      Source IDH51-A46101A49719123BFEBCAC4E
      Review version
      3.1
      Source IDH51-3C50CC6B6956F213D0C311D1
      Review date
      2026-08-30
      Source IDH51-2CB0B73EEF0EBFD9D57066C4
      Release status
      no_released_dilution_current_label_review_required
      Source IDH51-E89B7630AE8757D5BC7467D7
      Market status
      Status
      no_current_us_iv_spl_confirmed
      Source IDH51-0EDC594099942CB397F99F7B
      Basis
      No high-confidence current IV SPL was automatically selected; legacy information is segregated
      Source IDH51-B1F430FA1C46FB5CF5DA974A
      Ten point assessment
      Exact formulation
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-957F337252BAB613B2E96F2B
      Reconstitution concentration
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-F301A2B3DA882FAA802BAF48
      Maximum or recommended final concentration
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-C039839C8CBE720118CB2081
      Appropriate standardized containers
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-ACE119A3C2300BD99E1F1A76
      Adult dosing range
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-E9E079E7BBBD8CFC23A58A37
      Pediatric dosing range
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-2D5E2E1150616295F4A29676
      Neonatal dosing range
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-B39FF5EC09E28E3DC704197F
      Infusion time
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-3C1BDCECBCAFF243A3AD2046
      Fluid restriction alternatives
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-8EAB7581A5717FCB88E11FFD
      Current manufacturer labeling
      Match confidence
      unresolved
      Source IDH51-BB3E3873F8D38683B6323357
      Field provenance
      Exact formulation
      Primary
      not_found
      Source IDH51-B3E5A13765FF30B405EDB203
      Reconstitution concentration
      Primary
      not_found
      Source IDH51-03F7B22452811F409850C3FA
      Maximum or recommended final concentration
      Primary
      not_found
      Source IDH51-2F100AAE8EEDF3C91CF52931
      Appropriate standardized containers
      Primary
      not_found
      Source IDH51-E6F581D2243154F42F6EA8A1
      Adult dosing range
      Primary
      not_found
      Source IDH51-F4F068CF498F213C7325DD77
      Pediatric dosing range
      Primary
      not_found
      Source IDH51-BD2E06B0C89BD075A5306784
      Neonatal dosing range
      Primary
      not_found
      Source IDH51-4B45FD488A4666F4E568E551
      Infusion time
      Primary
      not_found
      Source IDH51-75245B72E546850B06A7B5C8
      Fluid restriction alternatives
      Primary
      not_found
      Source IDH51-B68FA4134166DA225F9117D6
      Current manufacturer labeling
      Primary
      DailyMed search gateway
      Source IDH51-7DCA5D876109A8EED3D01FF3
      Population applicability
      Adult
      Applicability
      not_established
      Source IDH51-6D13E4FD2E26F8A8817B469B
      Guide generation allowed
      false
      Source IDH51-6D34BCD4FCCF08CEA61AEEF0
      Pediatric
      Applicability
      supported_or_source_present
      Source IDH51-E932CAF270B7E7255427BD13
      Guide generation allowed
      false
      Source IDH51-E9EF5EFE96856F14CE5639A5
      Neonatal
      Applicability
      supported_or_source_present
      Source IDH51-E286A879A34C0A8B4A6AFBC1
      Guide generation allowed
      false
      Source IDH51-4C8E31147097BA0B65FCAF4A
      Route presence
      Structured dilution
      false
      Source IDH51-3FABC158E3786D1658CA32D3
      Iv push
      false
      Source IDH51-F371713903FBB4B4A90F9749
      Continuous infusion
      false
      Source IDH51-56AB29F5C36D2FF16C9FDDCB
      Pediatric source
      true
      Source IDH51-BF755C62AC27FF12B6CF6CC5
      Neonatal source
      true
      Source IDH51-2AA29F0FC4BCD4BBF046D1B4
      Legacy reference
      Status
      not_available
      Source IDH51-37B075A3F724B70CA81D70B8
      Label resolution
      Status
      build_environment_network_unavailable
      Source IDH51-E3EF27A516DB903F79D6809A
      Source files
      1. catalog.json
        Source IDH51-88A00CD757E36727BB876267
      2. dosing.json
        Source IDH51-E9AF760F6139E12436D5C23B
      3. legacy-map.json
        Source IDH51-BB59E469ECDD569AE4CA1C4F
      4. review-queue.json
        Source IDH51-6659AD47CDBB7E23F27B2FC9
      Clinical release note
      Preparation instructions are released only at the evidence level shown. Legacy content remains visibly separate. Exact product, NDC, route, current labeling, and institutional policy must be confirmed.
      Source IDH51-D0A63380C8C041C955999C89
      Historical statement IDs and source locations

      These IDs identify recovered source units. They are not evidence-qualified clinical claims.

      Historical IDOriginal source locationStatus
      H51-1F28120FA296A2B548694BF5catalog.json
      /records/238/id
      Historical; current review incomplete
      H51-6FC724E9939F32A75C70C3E6catalog.json
      /records/238/legacy_title
      Historical; current review incomplete
      H51-FB94B0F30236E0FA31EB0381catalog.json
      /records/238/generic_name
      Historical; current review incomplete
      H51-E5FA197996EA49A5D561FAC7catalog.json
      /records/238/class
      Historical; current review incomplete
      H51-1E5862CC19B922848BF03A5Acatalog.json
      /records/238/subclass
      Historical; current review incomplete
      H51-8B27F3B9EEB6D27FDA9F4444catalog.json
      /records/238/summary
      Historical; current review incomplete
      H51-9E20CB35EA41B605B92C5CABcatalog.json
      /records/238/warnings/0
      Historical; current review incomplete
      H51-84717314840BE9B6B5024C4Acatalog.json
      /records/238/stability_notes/0
      Historical; current review incomplete
      H51-576788D25EAFA981754E60C0catalog.json
      /records/238/populations/0
      Historical; current review incomplete
      H51-C25E611EE68796C8AEB6C4DAcatalog.json
      /records/238/evidence_tier
      Historical; current review incomplete
      H51-DA9E609F9DD25AE3D34188C2catalog.json
      /records/238/high_alert
      Historical; current review incomplete
      H51-7DCC9A6AC7B249683F8CA034catalog.json
      /records/238/hazardous
      Historical; current review incomplete
      H51-CB2EC4FF24FCD8297CE426F0catalog.json
      /records/238/status
      Historical; current review incomplete
      H51-0F93F2C9B12505E1EF3F8F60catalog.json
      /records/238/reviewed
      Historical; current review incomplete
      H51-1D7C90605722A35E08BEE37Ccatalog.json
      /records/238/version_added
      Historical; current review incomplete
      H51-E2E8507C9D0ED42D158B32B0catalog.json
      /records/238/sources/0
      Historical; current review incomplete
      H51-DA530E162A9828941F289240catalog.json
      /records/238/sources/0/label
      Historical; current review incomplete
      H51-DE7663E352F44322EC3F1983catalog.json
      /records/238/sources/0/url
      Historical; current review incomplete
      H51-F2C63AFF97A5675BA1FCD5C6catalog.json
      /records/238/sources/0/kind
      Historical; current review incomplete
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