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Preparation. Administration. Evidence.

IV Dilution &
Medication Reference

Search 255 medications, read preserved historical references, and inspect separately reviewed preparation statements. Full monograph updates remain pending.

Version 6.4Release date 2026-11-04For healthcare professionals
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Medication reference

Regular insulin

Monograph awaiting updateThis monograph will be updated in the future.

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Historical source. Current clinical review is incomplete. This monograph will be updated in the future.

Insulin (regular) (opens in a new tab)Original source URL: https://globalrph.com/dilution/insulin-regular/ | Retrieved 2026-11-04

Source dates, location and integrity

This historical article is separate from the reviewed claim cards. Product formulations and source dates may differ.

Original source URL
https://globalrph.com/dilution/insulin-regular/ (opens in a new tab)
Source date
Not established in the retrieved source
Retrieved
2026-11-04T19:49:26.880780+00:00
Source location
div.post-content
Packaged content SHA-256
a2b5b069680ea4ba8cef5a2ccc0bf3ce90f3ebfa062ec5ac9414a73f6afa3579
Original response SHA-256
d99491a293b06fa2b5db28aadcea3fad2a48bd655ee091fc4d64944f26ee32eb
Source body SHA-256
80437df13202ff632558c7e6a0b257696ccf90431e3edb643b096230a216506d

Insulin (regular)
The authors make no claims of the accuracy of the information contained herein; and these suggested doses and/or guidelines are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this document shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material. PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.

Usual Diluents
NS

Standard Dilutions [Amount of drug] [Infusion volume] [Infusion rate]
Usual final concentrations:
0.5 unit/ml or 1 unit/ml

(ICU's only - Detroit VAMC)
[120 units/ 240 ml] [Titrate]
[100 units] [100 ml] [Titrate]

Stability / Miscellaneous
EXP: 1 DAY (RT/REF)

Open this historical article on its own

Product identifiers and clinical review status

This monograph will be updated in the future. Historical material is available where present in the original sources; full current exact-product and claim-level review remains pending.

Exact formulation, concentration, container, manufacturer, regulatory identifiers, and a reproducible label snapshot have not all been reconciled.

What remains to be completed
  • Retrievable exact-product SPL XML with version, revision, retrieval date and reproducible hash
  • Clinically reviewed, individually identified statements with two exact source mappings
  • Exact formulation, strength, container, manufacturer/labeler, application and NDC reconciliation
  • Renal-function methods and dialysis/CRRT modality review where applicable
  • Mechanism provenance, clinical source disagreements and full medication-specific safety reconciliation

Supplemental historical fields

Restored-data provenance and review notes

Source release: 2026-08-31. Current clinical review is incomplete. Original uses of current, verified, or normalized describe the historical source. They do not inherit the status of separately reviewed statements. Product formulations and source dates can differ.

Current review annotations for historical renal, dialysis, mechanism, and product fieldsSeparate renal reference: Open Renal Dosing Master (opens in a new tab)
Renal
Status
not_locally_normalized
Original classification
monitor_or_titrate
Entries
    General note
    Preserve the source-specific renal-function basis. An indexed CrCl table is not interchangeable with unindexed CrCl or eGFR. Generic advice to check a method does not identify the equation for a dose row.
    Dialysis
    Status
    no_local_structured_regimen
    Entries
      General note
      Named modality alone does not establish applicability. CRRT subtype, effluent rate, residual renal function, timing and interruptions require review. Historical absence is not evidence that no guidance exists.
      Mechanisms
      • Source kind
        first_look
        Local pointer
        /mechanism
        Original level
        drug_specific
        Provenance classification
        historical_drug_specific_uncorroborated
        Label derived verified
        false
        Independently corroborated
        false
        Exact label section
        Not recorded
        Original source note
        Not recorded
        Review status
        historical_unverified
        Note
        Drug-specific wording in the old file is not proof of independent corroboration or an exact label locator. Consult separately published current mechanism claims where present.
      Future update
      Status
      pending_review
      Message
      This monograph will be updated in the future as current exact-product and claim-level review is completed.
      Source unavailable
      false
      Reason
      The historical content is restored; comprehensive contemporary verification remains incomplete.
      Historical first look: uses, mechanism, dosing context, and administration

      Recovered v5.1 source content; historical, awaiting current review.

      Id
      regular-insulin
      Source IDH51-90A97AEDD80AF98A0A6ED6CE
      Generic name
      Regular insulin
      Source IDH51-DF4F0CACF316F9700DE7CEAB
      Class
      Endocrine and metabolic
      Source IDH51-FDC87B51CA7EEDD613C36F92
      Subclass
      Short-acting insulin
      Source IDH51-A630F15112EAF7EF14B4A656
      Primary uses
      1. Diabetic ketoacidosis
        Source IDH51-07D10EB6108309113410599B
      2. Hyperglycemia in critical illness
        Source IDH51-4A913D16229C57EBDF1FE3BA
      3. Hyperkalemia as part of a treatment bundle
        Source IDH51-B2E943B4070D5AA083FFAA23
      Mechanism
      Activates insulin receptor tyrosine kinase, promotes glucose uptake, suppresses hepatic glucose output, and shifts potassium into cells.
      Source IDH51-A754E15EAA24FF56F6AA569F
      Mechanism level
      drug_specific
      Source IDH51-38EB1DFFD6A14A60E70FEB9F
      Basic dosing orientation
      Adult infusion | Existing preparation record; use current package insert for indication-specific selection | Common bag 100 units | Not normalized in the preparation record | See current package insert and professional guidance | IV infusion; Pediatric infusion | Existing preparation record; use current package insert for indication-specific selection | Weight-based protocol | Not normalized in the preparation record | See current package insert and professional guidance | IV infusion
      Source IDH51-A41BA7345B1DFBDCA3CECE4D
      Administration orientation
      Titrate by units/hour or units/kg/hour according to protocol; Titrate by units/kg/hour; 100 units/mL stock may require careful measurement; use standardized syringe; IV bolus per hyperkalemia protocol
      Source IDH51-49A33171559FDA755405B50F
      Renal and population orientation
      Separate renal reference: Open Renal Dosing Master (opens in a new tab)Renal function materially affects toxicity, monitoring, or titration even when a fixed table may not apply.
      Source IDH51-32172B699DD63A267988E8E8
      Key safety orientation
      1. Hypoglycemia and hypokalemia.
        Source IDH51-8FF16E0D7F4459BFFA948010
      2. Tenfold concentration errors can be fatal.
        Source IDH51-41C6376ED41AC383F5884361
      3. Only regular insulin is routinely used IV unless a specific product/protocol says otherwise.
        Source IDH51-A21934504DE408F785BE5E22
      Coverage path
      structured_local_snapshot
      Source IDH51-06C4DDBAF45DDAA500D537CD
      Coverage path label
      Structured GlobalRPh route snapshot
      Source IDH51-1DC669C50CABC7CFC4E61674
      Legacy title
      Regular insulin
      Source IDH51-19C995EC70FD0B010384281E
      Review note
      First-look orientation only. Verify indication, patient population, weight basis, organ function, exact IV product, dose, concentration, compatibility, rate, and current labeling before use.
      Source IDH51-BEB63915E2B2AF98140C1667
      Search text
      Regular insulin Endocrine and metabolic Short-acting insulin Diabetic ketoacidosis Hyperglycemia in critical illness Hyperkalemia as part of a treatment bundle Activates insulin receptor tyrosine kinase, promotes glucose uptake, suppresses hepatic glucose output, and shifts potassium into cells. Adult infusion | Existing preparation record; use current package insert for indication-specific selection | Common bag 100 units | Not normalized in the preparation record | See current package insert and professional guidance | IV infusion; Pediatric infusion | Existing preparation record; use current package insert for indication-specific selection | Weight-based protocol | Not normalized in the preparation record | See current package insert and professional guidance | IV infusion Titrate by units/hour or units/kg/hour according to protocol; Titrate by units/kg/hour; 100 units/mL stock may require careful measurement; use standardized syringe; IV bolus per hyperkalemia protocol Renal function materially affects toxicity, monitoring, or titration even when a fixed table may not apply. Hypoglycemia and hypokalemia. Tenfold concentration errors can be fatal. Only regular insulin is routinely used IV unless a specific product/protocol says otherwise. Structured GlobalRPh route snapshot
      Source IDH51-49D559980EBE24404E1377FF
      Official access mode
      search
      Source IDH51-0ABC8EF048E33A3CBE6D6249
      Official search query
      Regular insulin
      Source IDH51-F673A314EAD15F87C53850FD
      Official access reason
      A source-backed DailyMed search is available; select and confirm the exact IV product.
      Source IDH51-081289169F76DEF84A01A630

      No separate structured rows were bundled for dialysis, CRRT. Historical article content and source links may cover these topics.

      Historical dilution and intermittent infusion preparation

      Recovered v5.1 source content; historical, awaiting current review.

      PopulationAmountReconstitutionDiluentFinal volumeConcentrationRateStabilityNotes
      Source IDH51-F3E273BB0E48CB9293CC964E
      Adult infusion
      Source IDH51-0FACCA26B5682EF73B51EADB
      		Common bag 100 units
      Source IDH51-F5B9D40DE739C83F51EFF9A9
      		Add regular insulin to compatible bag using independent double check.
      Source IDH51-6F3034A456C019A90756B1F3
      		NS
      Source IDH51-73AFAD5788BB6FB0816BC64A
      		100 mL
      Source IDH51-C883F472086513D392200348
      		1 unit/mL
      Source IDH51-6989D752FF76B94BFC8C01F6
      		Titrate by units/hour or units/kg/hour according to protocol
      Source IDH51-ED6A4C5A5D1810FBD56C23FF
      		Use the shorter of current product labeling, validated stability data, and the applicable USP <797> sterility-based BUD ceiling.
      Source IDH51-4554F8C3A754A513C7E46E68
      		Prime tubing with insulin solution per local policy to reduce adsorption.
      Source IDH51-20F6FC44E8240376BBD806AF
      Source IDH51-BC5D4A057D15BB5EA4CBE48A
      Pediatric infusion
      Source IDH51-5663BD58F110BCF31448BDDD
      		Weight-based protocol
      Source IDH51-17CCF9817ABDA92DA81B30FB
      		Pharmacy-prepared standardized concentration.
      Source IDH51-85E7F2146DC27384E6B2879C
      		NS
      Source IDH51-4CA579D6890B64B8C91F07BD
      		Weight-appropriate volume
      Source IDH51-09C1E838D979939151499ECF
      		Commonly 0.1 or 1 unit/mL depending on age and device
      Source IDH51-207FC6CB56FD30FC85D93592
      		Titrate by units/kg/hour
      Source IDH51-61B796B4593244BCEE0DED4F
      		Use the shorter of current product labeling, validated stability data, and the applicable USP <797> sterility-based BUD ceiling.
      Source IDH51-B29D1C31531B8426C8DE7288

      Historical IV-push guidance

      Recovered v5.1 source content; historical, awaiting current review.

      PopulationDose scopeConcentrationRateStatusNotes
      Source IDH51-17D811A90BC1A4955934B22C
      Adult hyperkalemia bundle
      Source IDH51-F0ECAD09B30F4BC050DCC07D
      		Commonly 5 to 10 units regular insulin with dextrose per protocol
      Source IDH51-F6924C5E5086406522933F3F
      		100 units/mL stock may require careful measurement; use standardized syringe
      Source IDH51-D47F1D0B8829FFB65C0EE92F
      		IV bolus per hyperkalemia protocol
      Source IDH51-5958F7254FDE3ED7C88CE135
      		High-alert protocol only
      Source IDH51-CDE724012C78EA86704D3FA4
      		Hypoglycemia can occur several hours later; dextrose and monitoring plan are mandatory.
      Source IDH51-0C9AA4501F9ADBAAC2E1CBB7

      Historical continuous-infusion guidance

      Recovered v5.1 source content; historical, awaiting current review.

      PopulationStandard concentrationInitial rateTitrationMaximumNotes
      Source IDH51-2728AAA8F1212E0424D241BB
      Adult
      Source IDH51-4652432F6C874C4D5D399B75
      		100 units/100 mL NS (1 unit/mL)
      Source IDH51-C4A5E8E735CC53F8809CDD5D
      		Indication-specific; DKA often 0.1 unit/kg/hour or protocol alternative
      Source IDH51-24DA306C3FC1329449F23E7F
      		Titrate to glucose, ketone, and anion-gap goals
      Source IDH51-3411EC538DF25A44D1D4B904
      		Protocol-specific
      Source IDH51-EAB99F7A6AC9540D8319BED5
      		Use a dedicated line and standardized glucose/potassium monitoring.
      Source IDH51-8BBF9351223C3FEB04B3ADB3

      Historical indication and population dosing

      Recovered tables and source-separated snapshots; full clinical revalidation remains pending.

      Existing dose and route snapshots

      RoutePopulationIndicationDoseIntervalDurationAdministrationSource levelNotes
      Source IDH51-7362A06452A1F8245FFD52EA
      IV infusion
      Source IDH51-7289AAFE716ADC06B35A1812
      		Adult infusion
      Source IDH51-A98183C6A0CD5CDC5F29C97E
      		Existing preparation record; use current package insert for indication-specific selection
      Source IDH51-EAC690941F373CCCEA744AFC
      		Common bag 100 units
      Source IDH51-8369F0831362D17396CBF38A
      		Not normalized in the preparation record
      Source IDH51-421FCF7C5D706126CEF6FBB9
      		See current package insert and professional guidance
      Source IDH51-D50F2BBC4442FDBA914AB5AA
      		Titrate by units/hour or units/kg/hour according to protocol
      Source IDH51-D5AA4A7231CF86F174DCE77C
      		Existing GlobalRPh structured preparation snapshot
      Source IDH51-C84B3602ED0696918B1A19D7
      		Prime tubing with insulin solution per local policy to reduce adsorption.
      Source IDH51-1AFAA3101DB42E4BF1CC7F80
      Source IDH51-2CC4B8D6BB6CDCDA4BEECA2A
      IV infusion
      Source IDH51-805626FBAE368D50E445D236
      		Pediatric infusion
      Source IDH51-063F0301FF7AF28FC9B4B121
      		Existing preparation record; use current package insert for indication-specific selection
      Source IDH51-F781A823A182AA128B2FC225
      		Weight-based protocol
      Source IDH51-D2A9EA5A8A3D25AB42D24C04
      		Not normalized in the preparation record
      Source IDH51-7DA55DFD6626EE1F05935987
      		See current package insert and professional guidance
      Source IDH51-165535F13B067E8C7D853B46
      		Titrate by units/kg/hour
      Source IDH51-09A56030125531A303972FDC
      		Existing GlobalRPh structured preparation snapshot
      Source IDH51-2BB273A7ECBD15CD7DFCA2F8
      Source IDH51-3CA35283BAF521CFEC7309AE
      IV push
      Source IDH51-F0A02E31CF55D00EEB027462
      		Adult hyperkalemia bundle
      Source IDH51-29511568983B73AB2F20F86C
      		Commonly 5 to 10 units regular insulin with dextrose per protocol
      Source IDH51-DB4D56D567C6609FDA4DA3E2
      		Commonly 5 to 10 units regular insulin with dextrose per protocol
      Source IDH51-B86CDAEB8ABC333FD06097F5
      		Patient- and indication-specific
      Source IDH51-046FC436CF2BD3F23B923770
      		See current package insert
      Source IDH51-26C530EC2AF97CE8D36BFA64
      		IV bolus per hyperkalemia protocol
      Source IDH51-12C9AE46F42BDE483690719E
      		Existing GlobalRPh IV push snapshot
      Source IDH51-C6698E83BB3D9FDAC3D4225C
      		High-alert protocol only Hypoglycemia can occur several hours later; dextrose and monitoring plan are mandatory.
      Source IDH51-AA2A1715341365E3FBBBA0A7
      Source IDH51-21BEEF996F4A2D3B2ABA524B
      Continuous IV infusion
      Source IDH51-A2DCCF12EA7D9588B70D7DFB
      		Adult
      Source IDH51-F7459B95706A9961BA5B3CDB
      		Existing continuous-infusion record
      Source IDH51-A438CA8D814186BB016B2055
      		Indication-specific; DKA often 0.1 unit/kg/hour or protocol alternative
      Source IDH51-F7B3C670199067E3AACC98A1
      		Continuous infusion; titration-specific
      Source IDH51-F0EF2A49602AC8C84F84E671
      		Clinical-response dependent
      Source IDH51-53F2915B984C53935B73E101
      		Titrate to glucose, ketone, and anion-gap goals
      Source IDH51-EAA54F7CE35933321F444EEF
      		Existing GlobalRPh continuous-infusion snapshot
      Source IDH51-0B19CC4773BDF57670C758D5
      		Protocol-specific Use a dedicated line and standardized glucose/potassium monitoring.
      Source IDH51-0535F452AC5AA1AD69EFCDEB

      Historical renal-function guidance

      Recovered v5.1 source content; historical, awaiting current review.

      Separate renal reference: Open Renal Dosing Master (opens in a new tab)
      Classification
      monitor_or_titrate
      Source IDH51-C2A2BAD2768E689DED2930D6
      Summary
      Renal function materially affects toxicity, monitoring, or titration even when a fixed table may not apply.
      Source IDH51-192FA71402BFD7C52E519123
      Method note
      Use the renal function estimate and body-size convention specified by the selected label or institutional protocol. Do not interchange Cockcroft-Gault CrCl, indexed eGFR, and de-indexed eGFR without confirming the dosing source.
      Source IDH51-F4905D2531FE17C2FE6A0CC2

      Historical Common IV uses

      Recovered v5.1 source content; historical, awaiting current review.

      1. Diabetic ketoacidosis
        Source IDH51-BC5706CA82339664D0B95A5D
      2. Hyperglycemia in critical illness
        Source IDH51-6D2B5139CF656A70BABBDC3F
      3. Hyperkalemia as part of a treatment bundle
        Source IDH51-B324CA44233667AD0B00B75E

      Historical Warnings and safeguards

      Recovered v5.1 source content; historical, awaiting current review.

      1. Hypoglycemia and hypokalemia.
        Source IDH51-32BEA36774A4DD8F12B064DB
      2. Tenfold concentration errors can be fatal.
        Source IDH51-085ECC1E43D020B707BC71AF
      3. Only regular insulin is routinely used IV unless a specific product/protocol says otherwise.
        Source IDH51-4E1C0952A4C4A0BBD5C7A3E9

      Historical Monitoring

      Recovered v5.1 source content; historical, awaiting current review.

      1. Point-of-care glucose at protocol intervals
        Source IDH51-6E30EE6C44A09D204A4B4D4B
      2. Potassium and metabolic parameters
        Source IDH51-7DD15B9CFC7212DCFABFA068
      3. Nutrition changes and interruptions
        Source IDH51-A5CDFBCED832F89013BFA47E
      Other recovered source fields and original editorial metadata

      Original status words such as current, verified, or normalized describe the historical source release. They do not change the clinical review status of this release.

      Catalog source fields

      Id
      regular-insulin
      Source IDH51-B84C222C904E37257B73EC17
      Generic name
      Regular insulin
      Source IDH51-3D168B31BD934548559EBCDE
      Brand names
      1. Humulin R
        Source IDH51-C317631755D21E81F4582853
      2. Novolin R
        Source IDH51-810872B2358FDCC9C8C5E769
      Aliases
      1. insulin infusion
        Source IDH51-C893676B444A7D196ECA9CE2
      Class
      Endocrine and metabolic
      Source IDH51-B60AEEA0D6BD244982026A56
      Subclass
      Short-acting insulin
      Source IDH51-DDF096019E43C31B40462B9E
      Summary
      High-alert medication administered by standardized IV infusion for indication-specific protocols; adsorption to tubing may require priming.
      Source IDH51-DA347F91BCF71B39F6F7865A
      Populations
      1. Adult
        Source IDH51-99D1AEF8B81FAC6891F7BFEE
      2. Pediatric
        Source IDH51-28DD3A4BDFA794B64AC95151
      Evidence tier
      Core reference - verify current label
      Source IDH51-2B87FDF8852763FDC73DDD13
      High alert
      true
      Source IDH51-BBB3CD18F9B6036574910486
      Hazardous
      false
      Source IDH51-736014E34929E59B0E796826
      Status
      Active
      Source IDH51-7413E4961F07249DC467561C
      Reviewed
      2026-08-29
      Source IDH51-CB4AE7EAADEEDC12C9EFDE3C
      Version added
      1.0
      Source IDH51-105B038D52A5CFA56CBF8C47
      Sources
      LabelUrlKind
      Source IDH51-0545D72E431C64E971A6A0D7
      DailyMed label search
      Source IDH51-C55B4035C1C18F3B041C3FBF
      		https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=Regular+insulin (opens in a new tab)
      Source IDH51-578DA5359F046E666761868E
      		Primary
      Source IDH51-86C5FFACA516E9B81DEC5270
      Source IDH51-AB7D5F632D6B9D94C5637AD5
      GlobalRPh legacy IV dilution monograph
      Source IDH51-540F66251AE209C63C794F55
      		legacy:auto
      Source IDH51-17AA1FF4F17F6CBC61661BCD
      		Legacy
      Source IDH51-493B93323C87F26E75E24833
      Legacy title
      Regular insulin
      Source IDH51-BAF2653ACFFFE3E794B228B6
      Clinical release verification
      Audit version
      3.4
      Source IDH51-146A3FE506DE75F2598C07ED
      Audited on
      2026-08-30
      Source IDH51-EB44B35F2729376CAF361707
      Level
      amber
      Source IDH51-B04243917B1BCCA4EFBD2632
      Release gate
      trusted_professional_source_present_exact_label_unconfirmed
      Source IDH51-58863893523EEA29CE6CA73F
      Exact current label candidate
      false
      Source IDH51-99D0C5D86C52E72618C2809E
      Numeric support ratio
      0
      Source IDH51-C51CC1309C386DB003D97E6C
      Reference url count
      1
      Source IDH51-9567188330475559646F6CC7
      Broken reference count
      0
      Source IDH51-50860821E191511BA930A774
      Point of use confirmation required
      true
      Source IDH51-044D7BA302DCC341FA72B6AA
      Note
      Do not treat this record as a fully current product-specific monograph until the exact IV formulation and current sources are confirmed.
      Source IDH51-C4D60B55CB6472C8891DEA66

      Dosing source fields

      Id
      regular-insulin
      Source IDH51-5E436D27668BEFC561082586
      Generic name
      Regular insulin
      Source IDH51-4FA009E075E67D4CD080CFE0
      Coverage status
      direct_official_label_access_plus_local_snapshot
      Source IDH51-BFA7C696F428CE3A5E7085AE
      Package insert
      Query name
      Regular insulin
      Source IDH51-9020DF1AFB0AAE02A97F6670
      Product and route must match
      true
      Source IDH51-8F159E04B23B7FB986633F0A
      Live current label enabled
      false
      Source IDH51-7D8D5FF91F93A4134642CCA6
      Source priority
      Reviewed local summary when available, then a verified DailyMed label or product search when available, followed by professional references and institutional policy.
      Source IDH51-DFC428B1AD1A93B5C51EF2A9
      Direct official label access enabled
      true
      Source IDH51-5C46B08CF7E0558C4D79216B
      Outbound server request required
      false
      Source IDH51-8E8B7936C2A7EF4F9A6BC2C4
      Local summary status
      not_bundled
      Source IDH51-94584DE3133E222B4090B639
      Clinical review
      Locally normalized
      false
      Source IDH51-0B9D54AE4CB919F32DFF8246
      Reviewed
      2026-08-29
      Source IDH51-A6015D666D8E8A45CB376737
      Status
      Direct official package-insert access enabled; indication-specific local normalization pending.
      Source IDH51-0EFC6B70E24F3CC5843BE3AF
      Clinical release verification
      Audit version
      3.4
      Source IDH51-FDF41AB8DB3A9F62EF49CEA3
      Audited on
      2026-08-30
      Source IDH51-3F5C69854F8F46BF0317F73D
      Level
      amber
      Source IDH51-E77412D7015B15DA63CC9AAE
      Release gate
      trusted_professional_source_present_exact_label_unconfirmed
      Source IDH51-DC64E7FE2F22DBC013ECF8A0
      Exact current label candidate
      false
      Source IDH51-1CF3F1B2E38E558A0743EAFE
      Numeric support ratio
      0
      Source IDH51-4F859FE76B20B978DFAE88E0
      Reference url count
      1
      Source IDH51-FAED69FC756B6A03824B8E05
      Broken reference count
      0
      Source IDH51-36F74629E55008391192C161
      Point of use confirmation required
      true
      Source IDH51-4736F24861A817B5CE1C8247
      Note
      Do not treat this record as a fully current product-specific monograph until the exact IV formulation and current sources are confirmed.
      Source IDH51-08A4F881CDFBEEFFD2354664
      Historical preparation assessment

      Recovered v5.1 source content; historical, awaiting current review.

      Id
      regular-insulin
      Source IDH51-154F5897CF80083FA671CC5D
      Name
      Regular insulin
      Source IDH51-3C420496170E3916CF7A2CAD
      Brands
      Humulin R | Novolin R
      Source IDH51-C38236A1C6FA2E56E86CA694
      Therapeutic class
      Endocrine and metabolic
      Source IDH51-CDFEF88443A14DC267FECF56
      Review version
      3.1
      Source IDH51-1CA5C1D699EE3CC100BEB0DA
      Review date
      2026-08-30
      Source IDH51-9C9F0A393F2F6DE0DE6DBC6E
      Release status
      structured_record_current_label_not_confirmed
      Source IDH51-E3CDFD7A73F45BF72264AEF4
      Market status
      Status
      no_current_us_iv_spl_confirmed
      Source IDH51-8125CADB79B5C298362C7B2A
      Basis
      No high-confidence current IV SPL was automatically selected; legacy information is segregated
      Source IDH51-E4F3B70836CBE584D2461FCA
      Ten point assessment
      Exact formulation
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-F0141FFD9EEBF19C1B20355E
      Reconstitution concentration
      Add regular insulin to compatible bag using independent double check. Pharmacy-prepared standardized concentration.
      Source IDH51-B06AA976A104560DDE8B3580
      Maximum or recommended final concentration
      100 units/100 mL NS (1 unit/mL)
      Source IDH51-A9E85BF8C37DAD6DB58B291F
      Appropriate standardized containers
      100 mL Weight-appropriate volume
      Source IDH51-18FEF30FEA811FCE537E6AB9
      Adult dosing range
      Common bag 100 units Weight-based protocol Commonly 5 to 10 units regular insulin with dextrose per protocol Indication-specific; DKA often 0.1 unit/kg/hour or protocol alternative Commonly 5 to 10 units regular insulin with dextrose per protocol
      Source IDH51-B23405F8D6C91FE2C2D574C5
      Pediatric dosing range
      DKA often 0.1 unit/kg/hour or protocol alternative | titration: Titrate to glucose, ketone, and anion-gap goals | maximum: Protocol-specific | notes: Use a dedicated line and standardized glucose/potassium monitoring. | warnings: Hypoglycemia and hypokalemia. | Tenfold concentration errors can be fatal. | Only regular insulin is routinely used IV unless a specific product/protocol says otherwise. | monitoring: Point-of-care glucose at protocol intervals | Potassium and metabolic parameters | Nutrition changes and interruptions | populations: Adult | Pediatric | evidence_tier: Core reference - verify current label | high_alert: true | hazardous: false | status: Active | reviewed: 2026-08-29 | version_added: 1.0 | sources: label: DailyMed label search | url: https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=Regular+insulin | kind: Primary | label: GlobalRPh legacy IV dilution monograph | url: legacy:auto | kind: Legacy | legacy_title: Regular insulin
      Source IDH51-9D331F9B61BA2FC1E1D8093E
      Neonatal dosing range
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-E5401B90F3CB2C3416A4C055
      Infusion time
      Titrate by units/hour or units/kg/hour according to protocol Titrate by units/kg/hour IV bolus per hyperkalemia protocol Indication-specific; DKA often 0.1 unit/kg/hour or protocol alternative
      Source IDH51-3B9C30D39DBAF23394DEE871
      Fluid restriction alternatives
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-79B73F083BEE8704C26AFA9B
      Current manufacturer labeling
      Match confidence
      unresolved
      Source IDH51-E9B249486B5FEC93039F7D94
      Field provenance
      Exact formulation
      Primary
      not_found
      Source IDH51-8ECF4326B4050B04C5822634
      Reconstitution concentration
      Primary
      existing_structured_record
      Source IDH51-901E01644C5D2B43B7150052
      Maximum or recommended final concentration
      Primary
      existing_structured_record
      Source IDH51-808532B59A948EB101E38BF6
      Appropriate standardized containers
      Primary
      existing_structured_record
      Source IDH51-4729F05CCCAA84E5A6AC64CB
      Adult dosing range
      Primary
      existing_structured_record
      Source IDH51-608CD4C7706247EFBFB021B9
      Pediatric dosing range
      Primary
      existing_record_text
      Source IDH51-A5F49FDA12E767E72D07CF86
      Neonatal dosing range
      Primary
      not_found
      Source IDH51-D7C3CB156B5CFBA42A2A0D8D
      Infusion time
      Primary
      existing_structured_record
      Source IDH51-71912A9E8B4138951A8C8634
      Fluid restriction alternatives
      Primary
      not_found
      Source IDH51-B8AA6E8B940FB7CDCBE2E5E2
      Current manufacturer labeling
      Primary
      DailyMed search gateway
      Source IDH51-495FC7F4D0A8ACEE3B39DC23
      Population applicability
      Adult
      Applicability
      supported_or_source_present
      Source IDH51-8A58D2F0CFDF9982B1F0A015
      Guide generation allowed
      true
      Source IDH51-847F375EE2B51A4C093CE8EB
      Pediatric
      Applicability
      supported_or_source_present
      Source IDH51-FFAFA020C719FC1B779309B7
      Guide generation allowed
      false
      Source IDH51-50566F13447A3782487DD6B2
      Neonatal
      Applicability
      not_established
      Source IDH51-4C95DC7AB172C26FE128C740
      Guide generation allowed
      false
      Source IDH51-FC30784B28B10848E5FEDF89
      Route presence
      Structured dilution
      true
      Source IDH51-CDF0DB50D5A7C0C366334934
      Iv push
      true
      Source IDH51-214A4DD1AB823F2130931FBD
      Continuous infusion
      true
      Source IDH51-A160F2E93D81B620338A69E7
      Pediatric source
      true
      Source IDH51-C422E2ACD004811DAE00EB8C
      Neonatal source
      false
      Source IDH51-A30F81AF0A3494065D80EBE0
      Legacy reference
      Status
      not_available
      Source IDH51-37FA0CFF58FA158477E0A059
      Label resolution
      Status
      build_environment_network_unavailable
      Source IDH51-89892570B56D13811A0277B7
      Concentration values detected
      HighUnitText
      Source IDH51-49146995F67584B540C7BBB7
      1
      Source IDH51-600FEAFA88BB393ED0C1E1DA
      		unit
      Source IDH51-9F5DE4D763259BBC896B84B2
      		1 unit/mL
      Source IDH51-6473E342F4846893E2B92679
      Source files
      1. catalog.json
        Source IDH51-27DF773B4B8AB26BC0477C5B
      2. dosing.json
        Source IDH51-2760441B884326A78438BDAD
      3. legacy-map.json
        Source IDH51-3ADAFDADD1B26C1E52943CF7
      Clinical release note
      Preparation instructions are released only at the evidence level shown. Legacy content remains visibly separate. Exact product, NDC, route, current labeling, and institutional policy must be confirmed.
      Source IDH51-962EB6FB18D776011BA8CDAA
      Historical statement IDs and source locations

      These IDs identify recovered source units. They are not evidence-qualified clinical claims.

      Historical IDOriginal source locationStatus
      H51-B84C222C904E37257B73EC17catalog.json
      /records/216/id      		Historical; current review incomplete
      H51-3D168B31BD934548559EBCDEcatalog.json
      /records/216/generic_name      		Historical; current review incomplete
      H51-C317631755D21E81F4582853catalog.json
      /records/216/brand_names/0      		Historical; current review incomplete
      H51-810872B2358FDCC9C8C5E769catalog.json
      /records/216/brand_names/1      		Historical; current review incomplete
      H51-C893676B444A7D196ECA9CE2catalog.json
      /records/216/aliases/0      		Historical; current review incomplete
      H51-B60AEEA0D6BD244982026A56catalog.json
      /records/216/class      		Historical; current review incomplete
      H51-DDF096019E43C31B40462B9Ecatalog.json
      /records/216/subclass      		Historical; current review incomplete
      H51-DA347F91BCF71B39F6F7865Acatalog.json
      /records/216/summary      		Historical; current review incomplete
      H51-BC5706CA82339664D0B95A5Dcatalog.json
      /records/216/common_uses/0      		Historical; current review incomplete
      H51-6D2B5139CF656A70BABBDC3Fcatalog.json
      /records/216/common_uses/1      		Historical; current review incomplete
      H51-B324CA44233667AD0B00B75Ecatalog.json
      /records/216/common_uses/2      		Historical; current review incomplete
      H51-F3E273BB0E48CB9293CC964Ecatalog.json
      /records/216/preparations/0      		Historical; current review incomplete
      H51-0FACCA26B5682EF73B51EADBcatalog.json
      /records/216/preparations/0/population      		Historical; current review incomplete
      H51-F5B9D40DE739C83F51EFF9A9catalog.json
      /records/216/preparations/0/amount      		Historical; current review incomplete
      H51-6F3034A456C019A90756B1F3catalog.json
      /records/216/preparations/0/reconstitution      		Historical; current review incomplete
      H51-73AFAD5788BB6FB0816BC64Acatalog.json
      /records/216/preparations/0/diluent      		Historical; current review incomplete
      H51-C883F472086513D392200348catalog.json
      /records/216/preparations/0/final_volume      		Historical; current review incomplete
      H51-6989D752FF76B94BFC8C01F6catalog.json
      /records/216/preparations/0/concentration      		Historical; current review incomplete
      H51-ED6A4C5A5D1810FBD56C23FFcatalog.json
      /records/216/preparations/0/rate      		Historical; current review incomplete
      H51-4554F8C3A754A513C7E46E68catalog.json
      /records/216/preparations/0/stability      		Historical; current review incomplete
      H51-20F6FC44E8240376BBD806AFcatalog.json
      /records/216/preparations/0/notes      		Historical; current review incomplete
      H51-BC5D4A057D15BB5EA4CBE48Acatalog.json
      /records/216/preparations/1      		Historical; current review incomplete
      H51-5663BD58F110BCF31448BDDDcatalog.json
      /records/216/preparations/1/population      		Historical; current review incomplete
      H51-17CCF9817ABDA92DA81B30FBcatalog.json
      /records/216/preparations/1/amount      		Historical; current review incomplete
      H51-85E7F2146DC27384E6B2879Ccatalog.json
      /records/216/preparations/1/reconstitution      		Historical; current review incomplete
      H51-4CA579D6890B64B8C91F07BDcatalog.json
      /records/216/preparations/1/diluent      		Historical; current review incomplete
      H51-09C1E838D979939151499ECFcatalog.json
      /records/216/preparations/1/final_volume      		Historical; current review incomplete
      H51-207FC6CB56FD30FC85D93592catalog.json
      /records/216/preparations/1/concentration      		Historical; current review incomplete
      H51-61B796B4593244BCEE0DED4Fcatalog.json
      /records/216/preparations/1/rate      		Historical; current review incomplete
      H51-B29D1C31531B8426C8DE7288catalog.json
      /records/216/preparations/1/stability      		Historical; current review incomplete
      H51-EE31F647C30085FED94BE96Ccatalog.json
      /records/216/preparations/1/notes      		Historical; current review incomplete
      H51-17D811A90BC1A4955934B22Ccatalog.json
      /records/216/iv_push/0      		Historical; current review incomplete
      H51-F0ECAD09B30F4BC050DCC07Dcatalog.json
      /records/216/iv_push/0/population      		Historical; current review incomplete
      H51-F6924C5E5086406522933F3Fcatalog.json
      /records/216/iv_push/0/dose_scope      		Historical; current review incomplete
      H51-D47F1D0B8829FFB65C0EE92Fcatalog.json
      /records/216/iv_push/0/concentration      		Historical; current review incomplete
      H51-5958F7254FDE3ED7C88CE135catalog.json
      /records/216/iv_push/0/rate      		Historical; current review incomplete
      H51-CDE724012C78EA86704D3FA4catalog.json
      /records/216/iv_push/0/status      		Historical; current review incomplete
      H51-0C9AA4501F9ADBAAC2E1CBB7catalog.json
      /records/216/iv_push/0/notes      		Historical; current review incomplete
      H51-2728AAA8F1212E0424D241BBcatalog.json
      /records/216/continuous_infusions/0      		Historical; current review incomplete
      H51-4652432F6C874C4D5D399B75catalog.json
      /records/216/continuous_infusions/0/population      		Historical; current review incomplete
      H51-C4A5E8E735CC53F8809CDD5Dcatalog.json
      /records/216/continuous_infusions/0/standard_concentration      		Historical; current review incomplete
      H51-24DA306C3FC1329449F23E7Fcatalog.json
      /records/216/continuous_infusions/0/initial_rate      		Historical; current review incomplete
      H51-3411EC538DF25A44D1D4B904catalog.json
      /records/216/continuous_infusions/0/titration      		Historical; current review incomplete
      H51-EAB99F7A6AC9540D8319BED5catalog.json
      /records/216/continuous_infusions/0/maximum      		Historical; current review incomplete
      H51-8BBF9351223C3FEB04B3ADB3catalog.json
      /records/216/continuous_infusions/0/notes      		Historical; current review incomplete
      H51-32BEA36774A4DD8F12B064DBcatalog.json
      /records/216/warnings/0      		Historical; current review incomplete
      H51-085ECC1E43D020B707BC71AFcatalog.json
      /records/216/warnings/1      		Historical; current review incomplete
      H51-4E1C0952A4C4A0BBD5C7A3E9catalog.json
      /records/216/warnings/2      		Historical; current review incomplete
      H51-6E30EE6C44A09D204A4B4D4Bcatalog.json
      /records/216/monitoring/0      		Historical; current review incomplete
      H51-7DD15B9CFC7212DCFABFA068catalog.json
      /records/216/monitoring/1      		Historical; current review incomplete
      H51-A5CDFBCED832F89013BFA47Ecatalog.json
      /records/216/monitoring/2      		Historical; current review incomplete
      H51-99D1AEF8B81FAC6891F7BFEEcatalog.json
      /records/216/populations/0      		Historical; current review incomplete
      H51-28DD3A4BDFA794B64AC95151catalog.json
      /records/216/populations/1      		Historical; current review incomplete
      H51-2B87FDF8852763FDC73DDD13catalog.json
      /records/216/evidence_tier      		Historical; current review incomplete
      H51-BBB3CD18F9B6036574910486catalog.json
      /records/216/high_alert      		Historical; current review incomplete
      H51-736014E34929E59B0E796826catalog.json
      /records/216/hazardous      		Historical; current review incomplete
      H51-7413E4961F07249DC467561Ccatalog.json
      /records/216/status      		Historical; current review incomplete
      H51-CB4AE7EAADEEDC12C9EFDE3Ccatalog.json
      /records/216/reviewed      		Historical; current review incomplete
      H51-105B038D52A5CFA56CBF8C47catalog.json
      /records/216/version_added      		Historical; current review incomplete
      H51-0545D72E431C64E971A6A0D7catalog.json
      /records/216/sources/0      		Historical; current review incomplete
      H51-C55B4035C1C18F3B041C3FBFcatalog.json
      /records/216/sources/0/label      		Historical; current review incomplete
      H51-578DA5359F046E666761868Ecatalog.json
      /records/216/sources/0/url      		Historical; current review incomplete
      H51-86C5FFACA516E9B81DEC5270catalog.json
      /records/216/sources/0/kind      		Historical; current review incomplete
      H51-AB7D5F632D6B9D94C5637AD5catalog.json
      /records/216/sources/1      		Historical; current review incomplete
      H51-540F66251AE209C63C794F55catalog.json
      /records/216/sources/1/label      		Historical; current review incomplete
      H51-17AA1FF4F17F6CBC61661BCDcatalog.json
      /records/216/sources/1/url      		Historical; current review incomplete
      H51-493B93323C87F26E75E24833catalog.json
      /records/216/sources/1/kind      		Historical; current review incomplete
      H51-BAF2653ACFFFE3E794B228B6catalog.json
      /records/216/legacy_title      		Historical; current review incomplete
      H51-146A3FE506DE75F2598C07EDcatalog.json
      /records/216/clinical_release_verification/audit_version      		Historical; current review incomplete
      H51-EB44B35F2729376CAF361707catalog.json
      /records/216/clinical_release_verification/audited_on      		Historical; current review incomplete
      H51-B04243917B1BCCA4EFBD2632catalog.json
      /records/216/clinical_release_verification/level      		Historical; current review incomplete
      H51-58863893523EEA29CE6CA73Fcatalog.json
      /records/216/clinical_release_verification/release_gate      		Historical; current review incomplete
      H51-99D0C5D86C52E72618C2809Ecatalog.json
      /records/216/clinical_release_verification/exact_current_label_candidate      		Historical; current review incomplete
      H51-6FD790957EA8B3B14AE3D0D3catalog.json
      /records/216/clinical_release_verification/selected_setid      		Historical; current review incomplete
      H51-405CD5DC2A0B83F709ADCFECcatalog.json
      /records/216/clinical_release_verification/selected_label_title      		Historical; current review incomplete
      H51-C51CC1309C386DB003D97E6Ccatalog.json
      /records/216/clinical_release_verification/numeric_support_ratio      		Historical; current review incomplete
      H51-9567188330475559646F6CC7catalog.json
      /records/216/clinical_release_verification/reference_url_count      		Historical; current review incomplete
      H51-50860821E191511BA930A774catalog.json
      /records/216/clinical_release_verification/broken_reference_count      		Historical; current review incomplete
      H51-044D7BA302DCC341FA72B6AAcatalog.json
      /records/216/clinical_release_verification/point_of_use_confirmation_required      		Historical; current review incomplete
      H51-C4D60B55CB6472C8891DEA66catalog.json
      /records/216/clinical_release_verification/note      		Historical; current review incomplete
      H51-F17CBFC45339B4148762FB20catalog.json
      /records/216/clinical_release_verification/dailymed_search_url      		Historical; current review incomplete
      H51-5E436D27668BEFC561082586dosing.json
      /records/216/id      		Historical; current review incomplete
      H51-4FA009E075E67D4CD080CFE0dosing.json
      /records/216/generic_name      		Historical; current review incomplete
      H51-BFA7C696F428CE3A5E7085AEdosing.json
      /records/216/coverage_status      		Historical; current review incomplete
      H51-9020DF1AFB0AAE02A97F6670dosing.json
      /records/216/package_insert/query_name      		Historical; current review incomplete
      H51-9FDB8A7AC6666341B2D98A6Edosing.json
      /records/216/package_insert/preferred_setid      		Historical; current review incomplete
      H51-8F159E04B23B7FB986633F0Adosing.json
      /records/216/package_insert/product_and_route_must_match      		Historical; current review incomplete
      H51-7D8D5FF91F93A4134642CCA6dosing.json
      /records/216/package_insert/live_current_label_enabled      		Historical; current review incomplete
      H51-DFC428B1AD1A93B5C51EF2A9dosing.json
      /records/216/package_insert/source_priority      		Historical; current review incomplete
      H51-5C46B08CF7E0558C4D79216Bdosing.json
      /records/216/package_insert/direct_official_label_access_enabled      		Historical; current review incomplete
      H51-8E8B7936C2A7EF4F9A6BC2C4dosing.json
      /records/216/package_insert/outbound_server_request_required      		Historical; current review incomplete
      H51-94584DE3133E222B4090B639dosing.json
      /records/216/package_insert/local_summary_status      		Historical; current review incomplete
      H51-C2A2BAD2768E689DED2930D6dosing.json
      /records/216/renal/classification      		Historical; current review incomplete
      H51-192FA71402BFD7C52E519123dosing.json
      /records/216/renal/summary      		Historical; current review incomplete
      H51-F4905D2531FE17C2FE6A0CC2dosing.json
      /records/216/renal/method_note      		Historical; current review incomplete
      H51-7362A06452A1F8245FFD52EAdosing.json
      /records/216/existing_route_snapshots/0      		Historical; current review incomplete
      H51-7289AAFE716ADC06B35A1812dosing.json
      /records/216/existing_route_snapshots/0/route      		Historical; current review incomplete
      H51-A98183C6A0CD5CDC5F29C97Edosing.json
      /records/216/existing_route_snapshots/0/population      		Historical; current review incomplete
      H51-EAC690941F373CCCEA744AFCdosing.json
      /records/216/existing_route_snapshots/0/indication      		Historical; current review incomplete
      H51-8369F0831362D17396CBF38Adosing.json
      /records/216/existing_route_snapshots/0/dose      		Historical; current review incomplete
      H51-421FCF7C5D706126CEF6FBB9dosing.json
      /records/216/existing_route_snapshots/0/interval      		Historical; current review incomplete
      H51-D50F2BBC4442FDBA914AB5AAdosing.json
      /records/216/existing_route_snapshots/0/duration      		Historical; current review incomplete
      H51-D5AA4A7231CF86F174DCE77Cdosing.json
      /records/216/existing_route_snapshots/0/administration      		Historical; current review incomplete
      H51-C84B3602ED0696918B1A19D7dosing.json
      /records/216/existing_route_snapshots/0/source_level      		Historical; current review incomplete
      H51-1AFAA3101DB42E4BF1CC7F80dosing.json
      /records/216/existing_route_snapshots/0/notes      		Historical; current review incomplete
      H51-2CC4B8D6BB6CDCDA4BEECA2Adosing.json
      /records/216/existing_route_snapshots/1      		Historical; current review incomplete
      H51-805626FBAE368D50E445D236dosing.json
      /records/216/existing_route_snapshots/1/route      		Historical; current review incomplete
      H51-063F0301FF7AF28FC9B4B121dosing.json
      /records/216/existing_route_snapshots/1/population      		Historical; current review incomplete
      H51-F781A823A182AA128B2FC225dosing.json
      /records/216/existing_route_snapshots/1/indication      		Historical; current review incomplete
      H51-D2A9EA5A8A3D25AB42D24C04dosing.json
      /records/216/existing_route_snapshots/1/dose      		Historical; current review incomplete
      H51-7DA55DFD6626EE1F05935987dosing.json
      /records/216/existing_route_snapshots/1/interval      		Historical; current review incomplete
      H51-165535F13B067E8C7D853B46dosing.json
      /records/216/existing_route_snapshots/1/duration      		Historical; current review incomplete
      H51-09A56030125531A303972FDCdosing.json
      /records/216/existing_route_snapshots/1/administration      		Historical; current review incomplete
      H51-2BB273A7ECBD15CD7DFCA2F8dosing.json
      /records/216/existing_route_snapshots/1/source_level      		Historical; current review incomplete
      H51-599E3BAB257A9FCC9E994D06dosing.json
      /records/216/existing_route_snapshots/1/notes      		Historical; current review incomplete
      H51-3CA35283BAF521CFEC7309AEdosing.json
      /records/216/existing_route_snapshots/2      		Historical; current review incomplete
      H51-F0A02E31CF55D00EEB027462dosing.json
      /records/216/existing_route_snapshots/2/route      		Historical; current review incomplete
      H51-29511568983B73AB2F20F86Cdosing.json
      /records/216/existing_route_snapshots/2/population      		Historical; current review incomplete
      H51-DB4D56D567C6609FDA4DA3E2dosing.json
      /records/216/existing_route_snapshots/2/indication      		Historical; current review incomplete
      H51-B86CDAEB8ABC333FD06097F5dosing.json
      /records/216/existing_route_snapshots/2/dose      		Historical; current review incomplete
      H51-046FC436CF2BD3F23B923770dosing.json
      /records/216/existing_route_snapshots/2/interval      		Historical; current review incomplete
      H51-26C530EC2AF97CE8D36BFA64dosing.json
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      H51-C6698E83BB3D9FDAC3D4225Cdosing.json
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      H51-21BEEF996F4A2D3B2ABA524Bdosing.json
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      H51-F7459B95706A9961BA5B3CDBdosing.json
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      H51-F0EF2A49602AC8C84F84E671dosing.json
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