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Preparation. Administration. Evidence.

IV Dilution &
Medication Reference

Search 255 medications, read preserved historical references, and inspect separately reviewed preparation statements. Full monograph updates remain pending.

Version 6.4Release date 2026-11-04For healthcare professionals
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Medication reference

Protamine

Monograph awaiting updateThis monograph will be updated in the future.

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Historical source. Current clinical review is incomplete. This monograph will be updated in the future.

Protamine (opens in a new tab)Original source URL: https://globalrph.com/dilution/protamine/ | Retrieved 2026-11-04

Source dates, location and integrity

This historical article is separate from the reviewed claim cards. Product formulations and source dates may differ.

Original source URL
https://globalrph.com/dilution/protamine/ (opens in a new tab)
Source date
Not established in the retrieved source
Retrieved
2026-11-04T19:47:24.858756+00:00
Source location
div.post-content
Packaged content SHA-256
632a8f7f5a38809d655e2b9c2dc43f157b79bdbc95c7b79bc76cb0c522f4ab04
Original response SHA-256
99bce68ad57199e75750b0472039ad31eb9454306cf0db2ab764adbcbebb98bb
Source body SHA-256
f76121af3b48b70abf2ae461935ad0d11cc0e892c281dae14b58236f9b35e3ee

Protamine
The authors make no claims of the accuracy of the information contained herein; and these suggested doses and/or guidelines are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this document shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material. PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.

Usual Diluents
See comments

Standard Dilutions [Amount of drug] [Infusion volume] [Infusion rate]
Dilute 50 mg vial with 5 ml-sterile water (10mg/ml). Normally given undiluted.
May add to 25-50ml NS or D5W and infuse over 10-20 min.

[Too rapid administration can cause severe hypotensive and anaphylactoid reactions. Facilities to treat shock should be available.]

Stability / Miscellaneous
Treatment of heparin overdose: If immediate, give 1 mg (up to 1.5mg) IV for every 100u of heparin infused in preceding 2 hours. Give by slow IV injection (50mg over 10 minutes). Maximum of 50mg in any 10 minute period. May dilute with 25-50ml NS/D5W and infuse over 10-20 minutes.

Obtain PTT 5-15 minutes after protamine administration.

If 30 minutes to 1 hour have elapsed before starting protamine:
use 0.5 to 0.75 mg/100 u of heparin (in preceding 2 hours).

If > 2 hours have elapsed: use 0.25 to 0.375mg/ 100units. Symptoms of overdose of protamine include hypertension, and possible hemorrhage due to paradoxical anticoagulation with higher doses (eg > 100mg).

Source: [package insert]

Open this historical article on its own

Product identifiers and clinical review status

This monograph will be updated in the future. Historical material is available where present in the original sources; full current exact-product and claim-level review remains pending.

Exact formulation, concentration, container, manufacturer, regulatory identifiers, and a reproducible label snapshot have not all been reconciled.

What remains to be completed
  • Retrievable exact-product SPL XML with version, revision, retrieval date and reproducible hash
  • Clinically reviewed, individually identified statements with two exact source mappings
  • Exact formulation, strength, container, manufacturer/labeler, application and NDC reconciliation
  • Renal-function methods and dialysis/CRRT modality review where applicable
  • Mechanism provenance, clinical source disagreements and full medication-specific safety reconciliation

Supplemental historical fields

Restored-data provenance and review notes

Source release: 2026-08-31. Current clinical review is incomplete. Original uses of current, verified, or normalized describe the historical source. They do not inherit the status of separately reviewed statements. Product formulations and source dates can differ.

Current review annotations for historical renal, dialysis, mechanism, and product fieldsSeparate renal reference: Open Renal Dosing Master (opens in a new tab)
Renal
Status
not_locally_normalized
Original classification
current_label_review_required
Entries
    General note
    Preserve the source-specific renal-function basis. An indexed CrCl table is not interchangeable with unindexed CrCl or eGFR. Generic advice to check a method does not identify the equation for a dose row.
    Dialysis
    Status
    no_local_structured_regimen
    Entries
      General note
      Named modality alone does not establish applicability. CRRT subtype, effluent rate, residual renal function, timing and interruptions require review. Historical absence is not evidence that no guidance exists.
      Mechanisms
      • Source kind
        first_look
        Local pointer
        /mechanism
        Original level
        drug_specific
        Provenance classification
        historical_drug_specific_uncorroborated
        Label derived verified
        false
        Independently corroborated
        false
        Exact label section
        Not recorded
        Original source note
        Not recorded
        Review status
        historical_unverified
        Note
        Drug-specific wording in the old file is not proof of independent corroboration or an exact label locator. Consult separately published current mechanism claims where present.
      Future update
      Status
      pending_review
      Message
      This monograph will be updated in the future as current exact-product and claim-level review is completed.
      Source unavailable
      false
      Reason
      The historical content is restored; comprehensive contemporary verification remains incomplete.
      Historical first look: uses, mechanism, dosing context, and administration

      Recovered v5.1 source content; historical, awaiting current review.

      Id
      protamine
      Source IDH51-A5E1EE7D1330E523BC654F04
      Generic name
      Protamine
      Source IDH51-F0A93A5C2F6BBB3AA02AFB86
      Class
      Anticoagulation and hemostasis
      Source IDH51-3CD92D3768180D9BDF4763EB
      Subclass
      Heparin antagonist
      Source IDH51-0A14B63BD01ABF060AAC2846
      Primary uses
      1. Urgent heparin reversal
        Source IDH51-F3338000C2684C4D0191CE9A
      2. Partial enoxaparin reversal
        Source IDH51-013E5B96E925CDF76AD483AC
      Mechanism
      Forms an inactive ionic complex with heparin and reverses anticoagulant activity.
      Source IDH51-8AD71F6082A82FC0F77D6CCD
      Mechanism level
      drug_specific
      Source IDH51-32025B838608FAD03F818502
      Basic dosing orientation
      Adult | Existing preparation record; use current package insert for indication-specific selection | Dose based on heparin type, dose, and time since administration | Not normalized in the preparation record | See current package insert and professional guidance | IV infusion; Adult | Calculated reversal dose | Calculated reversal dose | Patient- and indication-specific | See current package insert | IV push
      Source IDH51-3A8479EF6AA06F7197325CB5
      Administration orientation
      Do not exceed 5 mg/min; common maximum 50 mg in any 10-minute period; No faster than 5 mg/min; 10 mg/mL or diluted; No faster than 5 mg/min
      Source IDH51-BEC5C1C3C60E9EAC1722A3A6
      Renal and population orientation
      Separate renal reference: Open Renal Dosing Master (opens in a new tab)Renal dosing status has not been locally normalized; use the current package insert before ordering or administration.
      Source IDH51-ABB16930990EDD54AC2D0DE4
      Key safety orientation
      1. Anaphylactoid reactions, severe hypotension, pulmonary hypertension, and bradycardia.
        Source IDH51-D61F31F92640C6E9FEC9F1B7
      2. Excess protamine has anticoagulant effects.
        Source IDH51-BB20130CD796580420691967
      Coverage path
      structured_local_snapshot
      Source IDH51-EA0500F4DEBA3845AAA0FFC5
      Coverage path label
      Structured GlobalRPh route snapshot
      Source IDH51-E985C8CB40661EEDE21AEE38
      Legacy title
      Protamine
      Source IDH51-011EC0C1C27A46268D43839A
      Review note
      First-look orientation only. Verify indication, patient population, weight basis, organ function, exact IV product, dose, concentration, compatibility, rate, and current labeling before use.
      Source IDH51-48EDB7C58C9306C1DC7F1920
      Search text
      Protamine Anticoagulation and hemostasis Heparin antagonist Urgent heparin reversal Partial enoxaparin reversal Forms an inactive ionic complex with heparin and reverses anticoagulant activity. Adult | Existing preparation record; use current package insert for indication-specific selection | Dose based on heparin type, dose, and time since administration | Not normalized in the preparation record | See current package insert and professional guidance | IV infusion; Adult | Calculated reversal dose | Calculated reversal dose | Patient- and indication-specific | See current package insert | IV push Do not exceed 5 mg/min; common maximum 50 mg in any 10-minute period; No faster than 5 mg/min; 10 mg/mL or diluted; No faster than 5 mg/min Renal dosing status has not been locally normalized; use the current package insert before ordering or administration. Anaphylactoid reactions, severe hypotension, pulmonary hypertension, and bradycardia. Excess protamine has anticoagulant effects. Structured GlobalRPh route snapshot
      Source IDH51-F8A31FFF8408848DDE0EC3C7
      Official access mode
      search
      Source IDH51-5D768A79A91161D35BF59E50
      Official search query
      Protamine
      Source IDH51-E66F01C86EFAFCD0F7AFF56C
      Official access reason
      A source-backed DailyMed search is available; select and confirm the exact IV product.
      Source IDH51-8A26AC18DF383325F049B084

      No separate structured rows were bundled for continuous infusion, dialysis, CRRT. Historical article content and source links may cover these topics.

      Historical dilution and intermittent infusion preparation

      Recovered v5.1 source content; historical, awaiting current review.

      PopulationAmountReconstitutionDiluentFinal volumeConcentrationRateStabilityNotes
      Source IDH51-E74E4AA61DFE977950C92B05
      Adult
      Source IDH51-710D8F4DA21F436A50871D98
      		Dose based on heparin type, dose, and time since administration
      Source IDH51-39A02403B54D1FAEBA3906DF
      		May administer from 10 mg/mL vial; dilute if local policy requires.
      Source IDH51-5AA09FA886513F75E0050D93
      		NS or D5W if diluted
      Source IDH51-E23C39CFFCBC986D0072EE93
      		Syringe or 50 mL
      Source IDH51-059F8D368C163F2FA91599DA
      		10 mg/mL or lower
      Source IDH51-DF05EBEA0E8EBA709A594281
      		Do not exceed 5 mg/min; common maximum 50 mg in any 10-minute period
      Source IDH51-70CD18D67960B4009AF0504E
      		Use the shorter of current product labeling, validated stability data, and the applicable USP <797> sterility-based BUD ceiling.
      Source IDH51-96AE8AE6769A86E464B9F47C
      		Recheck coagulation and clinical hemostasis before repeat dosing.
      Source IDH51-FE6F82AC3234A5C510C0A8E4

      Historical IV-push guidance

      Recovered v5.1 source content; historical, awaiting current review.

      PopulationDose scopeConcentrationRateStatus
      Source IDH51-AE75E654375000B07DF9B230
      Adult
      Source IDH51-BD9ABD553507E3183C926A28
      		Calculated reversal dose
      Source IDH51-8405D26135669AF258C8C4F2
      		10 mg/mL or diluted
      Source IDH51-CFC218B4245C13E5C006D428
      		No faster than 5 mg/min
      Source IDH51-308D30BCF8661BF8DCDF3CED
      		High-alert reversal use
      Source IDH51-1CC860A6743FF63F7E4CCB7B

      Historical indication and population dosing

      Recovered tables and source-separated snapshots; full clinical revalidation remains pending.

      Existing dose and route snapshots

      RoutePopulationIndicationDoseIntervalDurationAdministrationSource levelNotes
      Source IDH51-24FF8F38D9F37C9338F73569
      IV infusion
      Source IDH51-3025024E70D79275F3D3CE4B
      		Adult
      Source IDH51-AED100F5FAD25882246BBB2D
      		Existing preparation record; use current package insert for indication-specific selection
      Source IDH51-7E29D0FE4AD7A43AF20FAD1C
      		Dose based on heparin type, dose, and time since administration
      Source IDH51-550D4526CFDA5AF3D0A7D070
      		Not normalized in the preparation record
      Source IDH51-F80E31A49D24F3BAAEAD4CFC
      		See current package insert and professional guidance
      Source IDH51-A9A6DBE34D726D657F354833
      		Do not exceed 5 mg/min; common maximum 50 mg in any 10-minute period
      Source IDH51-07FFD0471E50D1EDCAD635E3
      		Existing GlobalRPh structured preparation snapshot
      Source IDH51-7F8B044A0C528CBD02CC4E17
      		Recheck coagulation and clinical hemostasis before repeat dosing.
      Source IDH51-411717E163BFBABF69002252
      Source IDH51-002F2E6CE80BB61125819796
      IV push
      Source IDH51-28EBB1D87DB2BB0041991D15
      		Adult
      Source IDH51-B2F62E16C440FA1EF217F514
      		Calculated reversal dose
      Source IDH51-9FCF2EEBF3BCE7D7C3BC4CC7
      		Calculated reversal dose
      Source IDH51-C018B3B603E285623F3291B7
      		Patient- and indication-specific
      Source IDH51-87750566F98CB31A63C8800F
      		See current package insert
      Source IDH51-3DBEC1D6D8985EEE3898434A
      		No faster than 5 mg/min
      Source IDH51-9DF4305482C08A147DE6A90A
      		Existing GlobalRPh IV push snapshot
      Source IDH51-35D874412FD150B85291D1A6
      		High-alert reversal use
      Source IDH51-C91A3403EFDCA01C7BDC4240

      Historical renal-function guidance

      Recovered v5.1 source content; historical, awaiting current review.

      Separate renal reference: Open Renal Dosing Master (opens in a new tab)
      Classification
      current_label_review_required
      Source IDH51-1C4E005D7A78083A58E08CBA
      Summary
      Renal dosing status has not been locally normalized; use the current package insert before ordering or administration.
      Source IDH51-06E28B8262ABCADA1AAF5ADB
      Method note
      Use the renal function estimate and body-size convention specified by the selected label or institutional protocol. Do not interchange Cockcroft-Gault CrCl, indexed eGFR, and de-indexed eGFR without confirming the dosing source.
      Source IDH51-96BD8B2020ACC814771752BA

      Historical Common IV uses

      Recovered v5.1 source content; historical, awaiting current review.

      1. Urgent heparin reversal
        Source IDH51-0A223949E9232A742431C109
      2. Partial enoxaparin reversal
        Source IDH51-E79EC07DDAECAEA52754EBC0

      Historical Warnings and safeguards

      Recovered v5.1 source content; historical, awaiting current review.

      1. Anaphylactoid reactions, severe hypotension, pulmonary hypertension, and bradycardia.
        Source IDH51-36EBFA76DD76D1F2C3191341
      2. Excess protamine has anticoagulant effects.
        Source IDH51-FFF17C33472F1178696CD2AA

      Historical Monitoring

      Recovered v5.1 source content; historical, awaiting current review.

      1. Blood pressure and cardiopulmonary status
        Source IDH51-5771783FB3645248BCB751DF
      2. aPTT/ACT or anti-Xa as appropriate
        Source IDH51-C8B44711BBD2C66306451310
      3. Bleeding
        Source IDH51-82655109731A377BAC2B1AC4
      Other recovered source fields and original editorial metadata

      Original status words such as current, verified, or normalized describe the historical source release. They do not change the clinical review status of this release.

      Catalog source fields

      Id
      protamine
      Source IDH51-619A16DE687D2022E1C53A4D
      Generic name
      Protamine
      Source IDH51-02514FFE6E956CE35C14203A
      Class
      Anticoagulation and hemostasis
      Source IDH51-DD6923FF7D8BD2BD3E336407
      Subclass
      Heparin antagonist
      Source IDH51-5E579C8FF7FE66C400D1F890
      Summary
      Cationic reversal agent for unfractionated heparin and partial LMWH reversal; excessive or rapid dosing can itself cause anticoagulation and severe reactions.
      Source IDH51-8013689DBB490F37081AE1D7
      Populations
      1. Adult
        Source IDH51-EA5D8E6CC901B90951406252
      2. Pediatric protocol-specific
        Source IDH51-1BF7FDD5B43B71BF4B6DDC7E
      Evidence tier
      Core reference - verify current label
      Source IDH51-6D98EDE6D3F9E59CA1991A3B
      High alert
      true
      Source IDH51-3F3CC47749D0967B4F8E5FEC
      Hazardous
      false
      Source IDH51-4C3CB725E51732FB4EC72D70
      Status
      Active
      Source IDH51-1C4462329A5A088B240695B9
      Reviewed
      2026-08-29
      Source IDH51-3FC435D0E2AC764893FC5A8D
      Version added
      1.2
      Source IDH51-46BBB4F83228CD828A303A8F
      Sources
      LabelUrlKind
      Source IDH51-3B627584F64E9012BF9E4A3B
      DailyMed label search
      Source IDH51-BB7484233DC10EA361112625
      		https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=Protamine (opens in a new tab)
      Source IDH51-288461CE70C05E376C436D8C
      		Primary
      Source IDH51-A24BEA5B31B70027DD2596F0
      Source IDH51-7751ADAD7CEB3DC925159408
      GlobalRPh legacy IV dilution monograph
      Source IDH51-3E770C1D5722A2A7BCAC6DE4
      		legacy:auto
      Source IDH51-148DA13367AD8DDAE5DCD151
      		Legacy
      Source IDH51-C0CFCA976C45AC4BBFF6F46A
      Legacy title
      Protamine
      Source IDH51-5F3615114DC256E3F664AEDC
      Clinical release verification
      Audit version
      3.4
      Source IDH51-7ED79B6A9BFCDDDA50EDC6EC
      Audited on
      2026-08-30
      Source IDH51-F0020D8D96999B47C7E745FD
      Level
      amber
      Source IDH51-3317A28CB2955F7160281497
      Release gate
      trusted_professional_source_present_exact_label_unconfirmed
      Source IDH51-AE1199FEAF77B0962D42C43D
      Exact current label candidate
      false
      Source IDH51-C8B72710C70814A306B5286E
      Numeric support ratio
      0
      Source IDH51-754E54BC5B14C0D386FE1177
      Reference url count
      1
      Source IDH51-60791D5AB23C2A2ED0F47DD2
      Broken reference count
      0
      Source IDH51-AC98AB49726519DF73BE704E
      Point of use confirmation required
      true
      Source IDH51-5F8E44A1349C929659F8E331
      Note
      Do not treat this record as a fully current product-specific monograph until the exact IV formulation and current sources are confirmed.
      Source IDH51-EDE14B51FEC52F34B56391C8

      Dosing source fields

      Id
      protamine
      Source IDH51-F024CBFD3334B44EDD71AC94
      Generic name
      Protamine
      Source IDH51-92CA216054235A2CA2AF3955
      Coverage status
      direct_official_label_access_plus_local_snapshot
      Source IDH51-CB886790CF9AAE35B827469E
      Package insert
      Query name
      Protamine
      Source IDH51-9DB305F7C0EF9D65A7FBE590
      Product and route must match
      true
      Source IDH51-67C94F7D1170DED8CF18E8AC
      Live current label enabled
      false
      Source IDH51-A4F46C337E1665567AAE55F4
      Source priority
      Reviewed local summary when available, then a verified DailyMed label or product search when available, followed by professional references and institutional policy.
      Source IDH51-0B4195F9FDBFF2504EC22982
      Direct official label access enabled
      true
      Source IDH51-C6241F5BD7EEC9478F5AD322
      Outbound server request required
      false
      Source IDH51-A036EC3DF847338AAD0165D2
      Local summary status
      not_bundled
      Source IDH51-45D7C3C4243895CF8764AFD6
      Clinical review
      Locally normalized
      false
      Source IDH51-82AAF8DF4C3CEDA52525C0B2
      Reviewed
      2026-08-29
      Source IDH51-E5B312AD7FCD6C2EB40E2A33
      Status
      Direct official package-insert access enabled; indication-specific local normalization pending.
      Source IDH51-3A96C3401DB1C60457C10175
      Clinical release verification
      Audit version
      3.4
      Source IDH51-CE3109485613A343DBB7066B
      Audited on
      2026-08-30
      Source IDH51-0AE517CB3490464630460B79
      Level
      amber
      Source IDH51-E1B618272E25CB8DDC8FCFE4
      Release gate
      trusted_professional_source_present_exact_label_unconfirmed
      Source IDH51-CA53E4D6A48C07C1D77684B9
      Exact current label candidate
      false
      Source IDH51-1C2D707AD572F57CBE01EA8C
      Numeric support ratio
      0
      Source IDH51-097E7B0EF98C012906E71CC0
      Reference url count
      1
      Source IDH51-164A743DF3ED859FB355CC57
      Broken reference count
      0
      Source IDH51-C487525236E4D5E5E3C55ECE
      Point of use confirmation required
      true
      Source IDH51-658919A7F9C447F2F970DD08
      Note
      Do not treat this record as a fully current product-specific monograph until the exact IV formulation and current sources are confirmed.
      Source IDH51-25F9A492F85555B822268715
      Historical preparation assessment

      Recovered v5.1 source content; historical, awaiting current review.

      Id
      protamine
      Source IDH51-32BEC1D0B536A38A5B3FF8D1
      Name
      Protamine
      Source IDH51-A851F6FBB85CE9837A1483C3
      Therapeutic class
      Anticoagulation and hemostasis
      Source IDH51-7C80595845B607146EBA3A6B
      Review version
      3.1
      Source IDH51-8DA61E6CB2E9BC5A73E21A98
      Review date
      2026-08-30
      Source IDH51-5719B9AE6624F258D4906FB9
      Release status
      structured_record_current_label_not_confirmed
      Source IDH51-149D63CDAB762399275F4663
      Market status
      Status
      no_current_us_iv_spl_confirmed
      Source IDH51-5C7926259B3FD47EFAFB1979
      Basis
      No high-confidence current IV SPL was automatically selected; legacy information is segregated
      Source IDH51-8D300CBC1E53F448BD1A0205
      Ten point assessment
      Exact formulation
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-F4EB58AABEE7219A42C0415B
      Reconstitution concentration
      May administer from 10 mg/mL vial; dilute if local policy requires.
      Source IDH51-E7EBCF494A0019EEADC7205F
      Maximum or recommended final concentration
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-0556351C5955708F14FDCFE2
      Appropriate standardized containers
      Syringe or 50 mL
      Source IDH51-67C4C2AA821E9F8C6DB78BE8
      Adult dosing range
      Dose based on heparin type, dose, and time since administration Calculated reversal dose Calculated reversal dose
      Source IDH51-892FC500D2F6E5D39CD7264F
      Pediatric dosing range
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-EB8293269F822C29F8FB6130
      Neonatal dosing range
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-30A035FACCA9AC8757CDE257
      Infusion time
      Do not exceed 5 mg/min; common maximum 50 mg in any 10-minute period No faster than 5 mg/min
      Source IDH51-07E9EB698EF009CCB59F097E
      Fluid restriction alternatives
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-40EC1CA3E63BE9AA9CD97C46
      Current manufacturer labeling
      Match confidence
      unresolved
      Source IDH51-070C13FFBAF78E8B28D1BA7D
      Field provenance
      Exact formulation
      Primary
      not_found
      Source IDH51-5484F70E7722FC371DB9F07D
      Reconstitution concentration
      Primary
      existing_structured_record
      Source IDH51-6CFF64BCA1084ADE818DD310
      Maximum or recommended final concentration
      Primary
      not_found
      Source IDH51-CD28FB69DF147EF0B49F7EB2
      Appropriate standardized containers
      Primary
      existing_structured_record
      Source IDH51-5F8BBE5B8457ECEB965D9883
      Adult dosing range
      Primary
      existing_structured_record
      Source IDH51-D2CFC8E89F94B0AD609196F5
      Pediatric dosing range
      Primary
      not_found
      Source IDH51-1AD417A8F642EC9890702238
      Neonatal dosing range
      Primary
      not_found
      Source IDH51-081BDEC2AB253FBF378AA96F
      Infusion time
      Primary
      existing_structured_record
      Source IDH51-AC08D6BB8685CEF709519DBA
      Fluid restriction alternatives
      Primary
      not_found
      Source IDH51-E1521DD5D49916C1DF49D853
      Current manufacturer labeling
      Primary
      DailyMed search gateway
      Source IDH51-B3D0A55921BA91E9370679ED
      Population applicability
      Adult
      Applicability
      supported_or_source_present
      Source IDH51-76D69EEDCE3ECEC358D53BEB
      Guide generation allowed
      true
      Source IDH51-392EF70393EACD8D2BC43BF0
      Pediatric
      Applicability
      supported_or_source_present
      Source IDH51-0046B6DEAD24268EFF141678
      Guide generation allowed
      false
      Source IDH51-CFF5951AB5E501749C6AD651
      Neonatal
      Applicability
      not_established
      Source IDH51-A6A4080313670BDB1AC576D1
      Guide generation allowed
      false
      Source IDH51-DC15B3C416BE4C071FC578A1
      Route presence
      Structured dilution
      true
      Source IDH51-5ABF7E8814C2796A8B7891E2
      Iv push
      true
      Source IDH51-8ED430577DE3EDE636FB6C13
      Continuous infusion
      false
      Source IDH51-47C590B8797941B4369578AA
      Pediatric source
      true
      Source IDH51-9EBC72B7711F01AEABC297A3
      Neonatal source
      false
      Source IDH51-37F04AAB0F9E76791BF2AD06
      Legacy reference
      Status
      not_available
      Source IDH51-8C43F7697F0B724F2674D412
      Label resolution
      Status
      build_environment_network_unavailable
      Source IDH51-0605FC5543574D6C0103C9EC
      Source files
      1. catalog.json
        Source IDH51-52943358C94403B8BBCAE91F
      2. dosing.json
        Source IDH51-A878B629E68D13EA8368E1EA
      3. legacy-map.json
        Source IDH51-F8FABBD674D42D708D24D590
      4. new-in-v1.2.json
        Source IDH51-7C58BC32422A39BE0F37DE84
      Clinical release note
      Preparation instructions are released only at the evidence level shown. Legacy content remains visibly separate. Exact product, NDC, route, current labeling, and institutional policy must be confirmed.
      Source IDH51-4B461D9E167AE3C403378072
      Historical statement IDs and source locations

      These IDs identify recovered source units. They are not evidence-qualified clinical claims.

      Historical IDOriginal source locationStatus
      H51-619A16DE687D2022E1C53A4Dcatalog.json
      /records/210/id      		Historical; current review incomplete
      H51-02514FFE6E956CE35C14203Acatalog.json
      /records/210/generic_name      		Historical; current review incomplete
      H51-DD6923FF7D8BD2BD3E336407catalog.json
      /records/210/class      		Historical; current review incomplete
      H51-5E579C8FF7FE66C400D1F890catalog.json
      /records/210/subclass      		Historical; current review incomplete
      H51-8013689DBB490F37081AE1D7catalog.json
      /records/210/summary      		Historical; current review incomplete
      H51-0A223949E9232A742431C109catalog.json
      /records/210/common_uses/0      		Historical; current review incomplete
      H51-E79EC07DDAECAEA52754EBC0catalog.json
      /records/210/common_uses/1      		Historical; current review incomplete
      H51-E74E4AA61DFE977950C92B05catalog.json
      /records/210/preparations/0      		Historical; current review incomplete
      H51-710D8F4DA21F436A50871D98catalog.json
      /records/210/preparations/0/population      		Historical; current review incomplete
      H51-39A02403B54D1FAEBA3906DFcatalog.json
      /records/210/preparations/0/amount      		Historical; current review incomplete
      H51-5AA09FA886513F75E0050D93catalog.json
      /records/210/preparations/0/reconstitution      		Historical; current review incomplete
      H51-E23C39CFFCBC986D0072EE93catalog.json
      /records/210/preparations/0/diluent      		Historical; current review incomplete
      H51-059F8D368C163F2FA91599DAcatalog.json
      /records/210/preparations/0/final_volume      		Historical; current review incomplete
      H51-DF05EBEA0E8EBA709A594281catalog.json
      /records/210/preparations/0/concentration      		Historical; current review incomplete
      H51-70CD18D67960B4009AF0504Ecatalog.json
      /records/210/preparations/0/rate      		Historical; current review incomplete
      H51-96AE8AE6769A86E464B9F47Ccatalog.json
      /records/210/preparations/0/stability      		Historical; current review incomplete
      H51-FE6F82AC3234A5C510C0A8E4catalog.json
      /records/210/preparations/0/notes      		Historical; current review incomplete
      H51-AE75E654375000B07DF9B230catalog.json
      /records/210/iv_push/0      		Historical; current review incomplete
      H51-BD9ABD553507E3183C926A28catalog.json
      /records/210/iv_push/0/population      		Historical; current review incomplete
      H51-8405D26135669AF258C8C4F2catalog.json
      /records/210/iv_push/0/dose_scope      		Historical; current review incomplete
      H51-CFC218B4245C13E5C006D428catalog.json
      /records/210/iv_push/0/concentration      		Historical; current review incomplete
      H51-308D30BCF8661BF8DCDF3CEDcatalog.json
      /records/210/iv_push/0/rate      		Historical; current review incomplete
      H51-1CC860A6743FF63F7E4CCB7Bcatalog.json
      /records/210/iv_push/0/status      		Historical; current review incomplete
      H51-9647C3CF55A71CA101156868catalog.json
      /records/210/iv_push/0/notes      		Historical; current review incomplete
      H51-36EBFA76DD76D1F2C3191341catalog.json
      /records/210/warnings/0      		Historical; current review incomplete
      H51-FFF17C33472F1178696CD2AAcatalog.json
      /records/210/warnings/1      		Historical; current review incomplete
      H51-5771783FB3645248BCB751DFcatalog.json
      /records/210/monitoring/0      		Historical; current review incomplete
      H51-C8B44711BBD2C66306451310catalog.json
      /records/210/monitoring/1      		Historical; current review incomplete
      H51-82655109731A377BAC2B1AC4catalog.json
      /records/210/monitoring/2      		Historical; current review incomplete
      H51-EA5D8E6CC901B90951406252catalog.json
      /records/210/populations/0      		Historical; current review incomplete
      H51-1BF7FDD5B43B71BF4B6DDC7Ecatalog.json
      /records/210/populations/1      		Historical; current review incomplete
      H51-6D98EDE6D3F9E59CA1991A3Bcatalog.json
      /records/210/evidence_tier      		Historical; current review incomplete
      H51-3F3CC47749D0967B4F8E5FECcatalog.json
      /records/210/high_alert      		Historical; current review incomplete
      H51-4C3CB725E51732FB4EC72D70catalog.json
      /records/210/hazardous      		Historical; current review incomplete
      H51-1C4462329A5A088B240695B9catalog.json
      /records/210/status      		Historical; current review incomplete
      H51-3FC435D0E2AC764893FC5A8Dcatalog.json
      /records/210/reviewed      		Historical; current review incomplete
      H51-46BBB4F83228CD828A303A8Fcatalog.json
      /records/210/version_added      		Historical; current review incomplete
      H51-3B627584F64E9012BF9E4A3Bcatalog.json
      /records/210/sources/0      		Historical; current review incomplete
      H51-BB7484233DC10EA361112625catalog.json
      /records/210/sources/0/label      		Historical; current review incomplete
      H51-288461CE70C05E376C436D8Ccatalog.json
      /records/210/sources/0/url      		Historical; current review incomplete
      H51-A24BEA5B31B70027DD2596F0catalog.json
      /records/210/sources/0/kind      		Historical; current review incomplete
      H51-7751ADAD7CEB3DC925159408catalog.json
      /records/210/sources/1      		Historical; current review incomplete
      H51-3E770C1D5722A2A7BCAC6DE4catalog.json
      /records/210/sources/1/label      		Historical; current review incomplete
      H51-148DA13367AD8DDAE5DCD151catalog.json
      /records/210/sources/1/url      		Historical; current review incomplete
      H51-C0CFCA976C45AC4BBFF6F46Acatalog.json
      /records/210/sources/1/kind      		Historical; current review incomplete
      H51-5F3615114DC256E3F664AEDCcatalog.json
      /records/210/legacy_title      		Historical; current review incomplete
      H51-7ED79B6A9BFCDDDA50EDC6ECcatalog.json
      /records/210/clinical_release_verification/audit_version      		Historical; current review incomplete
      H51-F0020D8D96999B47C7E745FDcatalog.json
      /records/210/clinical_release_verification/audited_on      		Historical; current review incomplete
      H51-3317A28CB2955F7160281497catalog.json
      /records/210/clinical_release_verification/level      		Historical; current review incomplete
      H51-AE1199FEAF77B0962D42C43Dcatalog.json
      /records/210/clinical_release_verification/release_gate      		Historical; current review incomplete
      H51-C8B72710C70814A306B5286Ecatalog.json
      /records/210/clinical_release_verification/exact_current_label_candidate      		Historical; current review incomplete
      H51-3FF098A9B3F989AE1AD6576Bcatalog.json
      /records/210/clinical_release_verification/selected_setid      		Historical; current review incomplete
      H51-CCDCD67F420CFC4D37679E0Ecatalog.json
      /records/210/clinical_release_verification/selected_label_title      		Historical; current review incomplete
      H51-754E54BC5B14C0D386FE1177catalog.json
      /records/210/clinical_release_verification/numeric_support_ratio      		Historical; current review incomplete
      H51-60791D5AB23C2A2ED0F47DD2catalog.json
      /records/210/clinical_release_verification/reference_url_count      		Historical; current review incomplete
      H51-AC98AB49726519DF73BE704Ecatalog.json
      /records/210/clinical_release_verification/broken_reference_count      		Historical; current review incomplete
      H51-5F8E44A1349C929659F8E331catalog.json
      /records/210/clinical_release_verification/point_of_use_confirmation_required      		Historical; current review incomplete
      H51-EDE14B51FEC52F34B56391C8catalog.json
      /records/210/clinical_release_verification/note      		Historical; current review incomplete
      H51-957BEE5B7CAE2E55D5C104DFcatalog.json
      /records/210/clinical_release_verification/dailymed_search_url      		Historical; current review incomplete
      H51-F024CBFD3334B44EDD71AC94dosing.json
      /records/210/id      		Historical; current review incomplete
      H51-92CA216054235A2CA2AF3955dosing.json
      /records/210/generic_name      		Historical; current review incomplete
      H51-CB886790CF9AAE35B827469Edosing.json
      /records/210/coverage_status      		Historical; current review incomplete
      H51-9DB305F7C0EF9D65A7FBE590dosing.json
      /records/210/package_insert/query_name      		Historical; current review incomplete
      H51-FABC8C4D28C58B05D0A9DC3Bdosing.json
      /records/210/package_insert/preferred_setid      		Historical; current review incomplete
      H51-67C94F7D1170DED8CF18E8ACdosing.json
      /records/210/package_insert/product_and_route_must_match      		Historical; current review incomplete
      H51-A4F46C337E1665567AAE55F4dosing.json
      /records/210/package_insert/live_current_label_enabled      		Historical; current review incomplete
      H51-0B4195F9FDBFF2504EC22982dosing.json
      /records/210/package_insert/source_priority      		Historical; current review incomplete
      H51-C6241F5BD7EEC9478F5AD322dosing.json
      /records/210/package_insert/direct_official_label_access_enabled      		Historical; current review incomplete
      H51-A036EC3DF847338AAD0165D2dosing.json
      /records/210/package_insert/outbound_server_request_required      		Historical; current review incomplete
      H51-45D7C3C4243895CF8764AFD6dosing.json
      /records/210/package_insert/local_summary_status      		Historical; current review incomplete
      H51-1C4E005D7A78083A58E08CBAdosing.json
      /records/210/renal/classification      		Historical; current review incomplete
      H51-06E28B8262ABCADA1AAF5ADBdosing.json
      /records/210/renal/summary      		Historical; current review incomplete
      H51-96BD8B2020ACC814771752BAdosing.json
      /records/210/renal/method_note      		Historical; current review incomplete
      H51-24FF8F38D9F37C9338F73569dosing.json
      /records/210/existing_route_snapshots/0      		Historical; current review incomplete
      H51-3025024E70D79275F3D3CE4Bdosing.json
      /records/210/existing_route_snapshots/0/route      		Historical; current review incomplete
      H51-AED100F5FAD25882246BBB2Ddosing.json
      /records/210/existing_route_snapshots/0/population      		Historical; current review incomplete
      H51-7E29D0FE4AD7A43AF20FAD1Cdosing.json
      /records/210/existing_route_snapshots/0/indication      		Historical; current review incomplete
      H51-550D4526CFDA5AF3D0A7D070dosing.json
      /records/210/existing_route_snapshots/0/dose      		Historical; current review incomplete
      H51-F80E31A49D24F3BAAEAD4CFCdosing.json
      /records/210/existing_route_snapshots/0/interval      		Historical; current review incomplete
      H51-A9A6DBE34D726D657F354833dosing.json
      /records/210/existing_route_snapshots/0/duration      		Historical; current review incomplete
      H51-07FFD0471E50D1EDCAD635E3dosing.json
      /records/210/existing_route_snapshots/0/administration      		Historical; current review incomplete
      H51-7F8B044A0C528CBD02CC4E17dosing.json
      /records/210/existing_route_snapshots/0/source_level      		Historical; current review incomplete
      H51-411717E163BFBABF69002252dosing.json
      /records/210/existing_route_snapshots/0/notes      		Historical; current review incomplete
      H51-002F2E6CE80BB61125819796dosing.json
      /records/210/existing_route_snapshots/1      		Historical; current review incomplete
      H51-28EBB1D87DB2BB0041991D15dosing.json
      /records/210/existing_route_snapshots/1/route      		Historical; current review incomplete
      H51-B2F62E16C440FA1EF217F514dosing.json
      /records/210/existing_route_snapshots/1/population      		Historical; current review incomplete
      H51-9FCF2EEBF3BCE7D7C3BC4CC7dosing.json
      /records/210/existing_route_snapshots/1/indication      		Historical; current review incomplete
      H51-C018B3B603E285623F3291B7dosing.json
      /records/210/existing_route_snapshots/1/dose      		Historical; current review incomplete
      H51-87750566F98CB31A63C8800Fdosing.json
      /records/210/existing_route_snapshots/1/interval      		Historical; current review incomplete
      H51-3DBEC1D6D8985EEE3898434Adosing.json
      /records/210/existing_route_snapshots/1/duration      		Historical; current review incomplete
      H51-9DF4305482C08A147DE6A90Adosing.json
      /records/210/existing_route_snapshots/1/administration      		Historical; current review incomplete
      H51-35D874412FD150B85291D1A6dosing.json
      /records/210/existing_route_snapshots/1/source_level      		Historical; current review incomplete
      H51-C91A3403EFDCA01C7BDC4240dosing.json
      /records/210/existing_route_snapshots/1/notes      		Historical; current review incomplete
      H51-82AAF8DF4C3CEDA52525C0B2dosing.json
      /records/210/clinical_review/locally_normalized      		Historical; current review incomplete
      H51-E5B312AD7FCD6C2EB40E2A33dosing.json
      /records/210/clinical_review/reviewed      		Historical; current review incomplete
      H51-3A96C3401DB1C60457C10175dosing.json
      /records/210/clinical_review/status      		Historical; current review incomplete
      H51-CE3109485613A343DBB7066Bdosing.json
      /records/210/clinical_release_verification/audit_version      		Historical; current review incomplete
      H51-0AE517CB3490464630460B79dosing.json
      /records/210/clinical_release_verification/audited_on      		Historical; current review incomplete
      H51-E1B618272E25CB8DDC8FCFE4dosing.json
      /records/210/clinical_release_verification/level      		Historical; current review incomplete
      H51-CA53E4D6A48C07C1D77684B9dosing.json
      /records/210/clinical_release_verification/release_gate      		Historical; current review incomplete
      H51-1C2D707AD572F57CBE01EA8Cdosing.json
      /records/210/clinical_release_verification/exact_current_label_candidate      		Historical; current review incomplete
      H51-B8E5DECBC88096727911B9D9dosing.json
      /records/210/clinical_release_verification/selected_setid      		Historical; current review incomplete
      H51-777558FD8999CBF1C368A71Ddosing.json
      /records/210/clinical_release_verification/selected_label_title      		Historical; current review incomplete
      H51-097E7B0EF98C012906E71CC0dosing.json
      /records/210/clinical_release_verification/numeric_support_ratio      		Historical; current review incomplete
      H51-164A743DF3ED859FB355CC57dosing.json
      /records/210/clinical_release_verification/reference_url_count      		Historical; current review incomplete
      H51-C487525236E4D5E5E3C55ECEdosing.json
      /records/210/clinical_release_verification/broken_reference_count      		Historical; current review incomplete
      H51-658919A7F9C447F2F970DD08dosing.json
      /records/210/clinical_release_verification/point_of_use_confirmation_required      		Historical; current review incomplete
      H51-25F9A492F85555B822268715dosing.json
      /records/210/clinical_release_verification/note      		Historical; current review incomplete
      H51-6EA711E75FFA6DBBD6A435D4dosing.json
      /records/210/clinical_release_verification/dailymed_search_url      		Historical; current review incomplete
      H51-A5E1EE7D1330E523BC654F04first-look-v5.1.json
      /records/210/id      		Historical; current review incomplete
      H51-F0A93A5C2F6BBB3AA02AFB86first-look-v5.1.json
      /records/210/generic_name      		Historical; current review incomplete
      H51-3CD92D3768180D9BDF4763EBfirst-look-v5.1.json
      /records/210/class      		Historical; current review incomplete
      H51-0A14B63BD01ABF060AAC2846first-look-v5.1.json
      /records/210/subclass      		Historical; current review incomplete
      H51-F3338000C2684C4D0191CE9Afirst-look-v5.1.json
      /records/210/primary_uses/0      		Historical; current review incomplete
      H51-013E5B96E925CDF76AD483ACfirst-look-v5.1.json
      /records/210/primary_uses/1      		Historical; current review incomplete
      H51-8AD71F6082A82FC0F77D6CCDfirst-look-v5.1.json
      /records/210/mechanism      		Historical; current review incomplete
      H51-32025B838608FAD03F818502first-look-v5.1.json
      /records/210/mechanism_level      		Historical; current review incomplete
      H51-3A8479EF6AA06F7197325CB5first-look-v5.1.json
      /records/210/basic_dosing_orientation      		Historical; current review incomplete
      H51-BEC5C1C3C60E9EAC1722A3A6first-look-v5.1.json
      /records/210/administration_orientation      		Historical; current review incomplete
      H51-ABB16930990EDD54AC2D0DE4first-look-v5.1.json
      /records/210/renal_and_population_orientation      		Historical; current review incomplete
      H51-D61F31F92640C6E9FEC9F1B7first-look-v5.1.json
      /records/210/key_safety_orientation/0      		Historical; current review incomplete
      H51-BB20130CD796580420691967first-look-v5.1.json
      /records/210/key_safety_orientation/1      		Historical; current review incomplete
      H51-EA0500F4DEBA3845AAA0FFC5first-look-v5.1.json
      /records/210/coverage_path      		Historical; current review incomplete
      H51-E985C8CB40661EEDE21AEE38first-look-v5.1.json
      /records/210/coverage_path_label      		Historical; current review incomplete
      H51-D414007D8E3202ABB56C3976first-look-v5.1.json
      /records/210/official_label_url      		Historical; current review incomplete
      H51-011EC0C1C27A46268D43839Afirst-look-v5.1.json
      /records/210/legacy_title      		Historical; current review incomplete
      H51-48EDB7C58C9306C1DC7F1920first-look-v5.1.json
      /records/210/review_note      		Historical; current review incomplete
      H51-F8A31FFF8408848DDE0EC3C7first-look-v5.1.json
      /records/210/search_text      		Historical; current review incomplete
      H51-150716A66D14C67BA1F19A6Dfirst-look-v5.1.json
      /records/210/official_search_url      		Historical; current review incomplete
      H51-5D768A79A91161D35BF59E50first-look-v5.1.json
      /records/210/official_access_mode      		Historical; current review incomplete
      H51-FAF576881F8223F1861128B9first-look-v5.1.json
      /records/210/official_access_url      		Historical; current review incomplete
      H51-E66F01C86EFAFCD0F7AFF56Cfirst-look-v5.1.json
      /records/210/official_search_query      		Historical; current review incomplete
      H51-8A26AC18DF383325F049B084first-look-v5.1.json
      /records/210/official_access_reason      		Historical; current review incomplete
      H51-32BEC1D0B536A38A5B3FF8D1preparation-assessments-v3.8.json
      /210/id      		Historical; current review incomplete
      H51-A851F6FBB85CE9837A1483C3preparation-assessments-v3.8.json
      /210/name      		Historical; current review incomplete
      H51-26C8FFCF9A025BEB4BF7C543preparation-assessments-v3.8.json
      /210/brands      		Historical; current review incomplete
      H51-7C80595845B607146EBA3A6Bpreparation-assessments-v3.8.json
      /210/therapeutic_class      		Historical; current review incomplete
      H51-8DA61E6CB2E9BC5A73E21A98preparation-assessments-v3.8.json
      /210/review_version      		Historical; current review incomplete
      H51-5719B9AE6624F258D4906FB9preparation-assessments-v3.8.json
      /210/review_date      		Historical; current review incomplete
      H51-149D63CDAB762399275F4663preparation-assessments-v3.8.json
      /210/release_status      		Historical; current review incomplete
      H51-5C7926259B3FD47EFAFB1979preparation-assessments-v3.8.json
      /210/market_status/status      		Historical; current review incomplete
      H51-8D300CBC1E53F448BD1A0205preparation-assessments-v3.8.json
      /210/market_status/basis      		Historical; current review incomplete
      H51-F4EB58AABEE7219A42C0415Bpreparation-assessments-v3.8.json
      /210/ten_point_assessment/exact_formulation      		Historical; current review incomplete
      H51-E7EBCF494A0019EEADC7205Fpreparation-assessments-v3.8.json
      /210/ten_point_assessment/reconstitution_concentration      		Historical; current review incomplete
      H51-0556351C5955708F14FDCFE2preparation-assessments-v3.8.json
      /210/ten_point_assessment/maximum_or_recommended_final_concentration      		Historical; current review incomplete
      H51-67C4C2AA821E9F8C6DB78BE8preparation-assessments-v3.8.json
      /210/ten_point_assessment/appropriate_standardized_containers      		Historical; current review incomplete
      H51-892FC500D2F6E5D39CD7264Fpreparation-assessments-v3.8.json
      /210/ten_point_assessment/adult_dosing_range      		Historical; current review incomplete
      H51-EB8293269F822C29F8FB6130preparation-assessments-v3.8.json
      /210/ten_point_assessment/pediatric_dosing_range      		Historical; current review incomplete
      H51-30A035FACCA9AC8757CDE257preparation-assessments-v3.8.json
      /210/ten_point_assessment/neonatal_dosing_range      		Historical; current review incomplete
      H51-07E9EB698EF009CCB59F097Epreparation-assessments-v3.8.json
      /210/ten_point_assessment/infusion_time      		Historical; current review incomplete
      H51-40EC1CA3E63BE9AA9CD97C46preparation-assessments-v3.8.json
      /210/ten_point_assessment/fluid_restriction_alternatives      		Historical; current review incomplete
      H51-FFC0C46D1DBAD1AC36942728preparation-assessments-v3.8.json
      /210/ten_point_assessment/current_manufacturer_labeling/setid      		Historical; current review incomplete
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      /210/clinical_release_note      		Historical; current review incomplete

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