IV Dilution &
Medication Reference

MVI (Multiple Vitamins for Infusion) - INFUVITE ® ADULT

Usual Diluents

Standard Dilutions [Amount of drug] [Infusion volume] [Infusion rate]

Label: Refrigerate.

Infusion rate: Maximum infusion rate not listed. Based on the possiblitity of an infusion related adverse reaction [e.g. urticaria, shortness of breath, wheezing and angioedema.] the maximum rate should probably not exceed 500 ml/hr (or 250 ml/hr max if a 500ml bag is used). [slower infusions reduce overall exposure and allow for prompt corrective action if an adverse effect is observed]

Allergic reactions have been known to occur following intravenous administration of thiamine, and vitamin K. The formulation is contraindicated prior to blood sampling for detection of megaloblastic anemia, as the folic acid and the cyanocobalamin in the vitamin solution can mask serum deficits.

Stability / Miscellaneous

INFUVITE ADULT - Multiple Vitamins for Infusion

DOSAGE AND ADMINISTRATION:
INFUVITE ADULT is ready for immediate use in adults and children aged 11 years and older when added to intravenous infusion fluids. INFUVITE ADULT should not be given as a direct, undiluted intravenous injection as it may give rise to dizziness, faintness and possible tissue irritation.
Preparation of INFUVITE ADULT for intravenous feeding should be done by transferring the contents of Vial 1 into the contents of Vial 2 (10 mL total). One daily 10 mL dose should be added directly to not less than 500 mL, and preferably 1 000 mL, of intravenous dextrose, saline or similar infusion solutions. Discard any unused portion.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.
After INFUVITE ADULT is diluted in an intravenous infusion, the resulting solution should be refrigerated unless it is to be used immediately. The solution should be used within 24 hours after dilution. Some of the vitamins in this product, particularly A, D and riboflavin, are light sensitive; therefore, exposure to light should be minimized. Once closure system has been compromised, withdrawal of container contents should be completed within 4 hours.

Store under refrigeration, 2-8 °C (36-46 °F).

Reference:
Multiple Vitamins for Infusion - INFUVITE® [package insert]. Boucherville, QC, Canada: Sab-Pharma Inc., May 21, 2003

Source: [package insert]