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Preparation. Administration. Evidence.

IV Dilution &
Medication Reference

Search 255 medications, read preserved historical references, and inspect separately reviewed preparation statements. Full monograph updates remain pending.

Version 6.4Release date 2026-11-04For healthcare professionals
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Medication reference

Levetiracetam

Monograph awaiting updateThis monograph will be updated in the future.

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Historical source. Current clinical review is incomplete. This monograph will be updated in the future.

Keppra ® -levetiracetam (opens in a new tab)Original source URL: https://globalrph.com/dilution/keppra-levetiracetam/ | Retrieved 2026-11-04

Source dates, location and integrity

This historical article is separate from the reviewed claim cards. Product formulations and source dates may differ.

Original source URL
https://globalrph.com/dilution/keppra-levetiracetam/ (opens in a new tab)
Source date
Not established in the retrieved source
Retrieved
2026-11-04T19:47:56.089983+00:00
Source location
div.post-content
Packaged content SHA-256
050788abefe1db19eb1bb366ba3e0a1cef2c003066d0fc7b578de8f78ec1c200
Original response SHA-256
0643dc3ef66b4445ebb772d3a8b4087a44ab307f66d9178d39aa3d8672dbd05e
Source body SHA-256
1062b0e28a5b2b6f1fd9e6393afa3ad8a464a7f60bc333db1fc06887703c7da7

Levetiracetam (Keppra ®)
The authors make no claims of the accuracy of the information contained herein; and these suggested doses and/or guidelines are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this document shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material. PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.

Usual Diluents
NS, D5W, or LR

Standard Dilutions [Amount of drug] [Infusion volume] [Infusion rate]
[Prescribed dose] [100ml] [ 15 minutes]

Examples:
[500 mg] [100ml] [15 minutes]
[1000 mg ] [100ml] [15 minutes]
[1500 mg ] [100ml] [15 minutes]

(Product with particulate matter or discoloration should not be used.)

Stability / Miscellaneous

Stability
Preparation and Administration Instructions
KEPPRA injection is for intravenous use only and should be diluted in 100 mL of a compatible diluent prior to administration. If a smaller volume is required (e.g. pediatric patients), the amount of diluent should be calculated to not exceed a maximum levetiracetam concentration of 15 mg per mL of diluted solution. Consideration should also be given to the total daily fluid intake of the patient. KEPPRA injection should be administered as a 15-minute IV infusion. One vial of KEPPRA injection contains 500 mg levetiracetam (500 mg/5 mL).

KEPPRA injection may be mixed with the following diluents and antiepileptic drugs and may be stored in polyvinyl chloride (PVC) bags. The diluted solution should not be stored for more than 4 hours at controlled room temperature [15-30°C (59-86°F)].

Compatible Diluents:
• Sodium chloride (0.9%) injection, USP
• Lactated Ringer's injection
• Dextrose 5% injection, USP

Depending on the packager /NDC, a recent revision increased the stabililty back to 24 hours from 4 hours. Timeline: Prior to ~ 2019, 24 hours was listed in all cases. After ~2019, the stability was reduced to 4 hours which is still the case in ~ 80-90% of the current package inserts. Example.

Revised: 5/2024 (PDF)
Packager: Hospira, Inc.
Levetiracetam injection was found to be physically compatible and chemically stable when mixed with the following diluents and antiepileptic drugs for at least 24 hours and stored in polyvinyl chloride (PVC) bags at controlled room temperature 15 to 30°C (59 to 86°F).

Indications: KEPPRA injection is indicated as adjunctive therapy in the treatment of partial onset seizures in ADULTS with epilepsy. KEPPRA injection is an alternative for patients when oral administration is temporarily not feasible.
(Safety and effectiveness of KEPPRA injection in patients below the age of 16 years have not been established.)

Dosage: KEPPRA injection is for intravenous use only and must be diluted prior to administration. Treatment should be initiated with a daily dose of 1000 mg/day, given as twice-daily dosing (500 mg BID). Additional dosing increments may be given (1000 mg/day additional every 2 weeks) to a maximum recommended daily dose of 3000 mg. Doses greater than 3000 mg/day have been used in open label studies with KEPPRA tablets for periods of 6 months and longer. There is no evidence that doses greater than 3000 mg/day confer additional benefit.

Note: dosage adjustments are necessary in patients with impaired renal function.

Separate renal reference: Open Renal Dosing Master (opens in a new tab)
Impaired Renal Function:
First estimate the patient's creatinine clearance (ml/min):
Cockcroft and Gault equation:Separate renal reference: Open Renal Dosing Master (opens in a new tab)
Creatinine clearance for males =Separate renal reference: Open Renal Dosing Master (opens in a new tab) [140-age (years)]× [body wt (kg)]
72 × [serum creatinine (mg/dL)]
Creatinine clearance for females =Separate renal reference: Open Renal Dosing Master (opens in a new tab) [140-age (years)]× [body wt (kg)]× 0.85
72 × [serum creatinine (mg/dL)]

CRCL (ml/min)Separate renal reference: Open Renal Dosing Master (opens in a new tab) Dosage Frequency
> 80 ml/min 500-1500 mg q12h
50 - 80 500-1000 mg q12h
30 - 50 250-750 mg q12h
<30 250-550 mg q12h
ESRD patients on dialysisSeparate renal reference: Open Renal Dosing Master (opens in a new tab) 500-1000 mg q24h*
*Following dialysis, a 250 to 500mg supplemental dose is recommended

Replacement Therapy: When switching from oral KEPPRA, the initial total daily intravenous dosage of KEPPRA should be equivalent to the total daily dosage and frequency of oral KEPPRA . Any unused portion of the KEPPRA injection vial contents should be discarded.

Miscellaneous
Dilution:
Dilute prescribed dose in 100 ml of a compatible diluent and infuse over 15 minutes.

Compatible Diluents:
• Sodium chloride (0.9%) injection, USP
• Lactated Ringer's injection
• Dextrose 5% injection, USP

How Supplied
KEPPRA (levetiracetam) 500 mg/5 mL injection is a clear, colorless, sterile solution. It is supplied in single-use 5 mL vials, available in cartons of 10 vials (NDC 50474-002-63).

Storage
Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F) [see USP Controlled Room Temperature].

Source: [package insert]

Open this historical article on its own

Product identifiers and clinical review status

This monograph will be updated in the future. Historical material is available where present in the original sources; full current exact-product and claim-level review remains pending.

Exact formulation, concentration, container, manufacturer, regulatory identifiers, and a reproducible label snapshot have not all been reconciled.

What remains to be completed
  • Retrievable exact-product SPL XML with version, revision, retrieval date and reproducible hash
  • Clinically reviewed, individually identified statements with two exact source mappings
  • Exact formulation, strength, container, manufacturer/labeler, application and NDC reconciliation
  • Renal-function methods and dialysis/CRRT modality review where applicable
  • Mechanism provenance, clinical source disagreements and full medication-specific safety reconciliation

Supplemental historical fields

Restored-data provenance and review notes

Source release: 2026-08-31. Current clinical review is incomplete. Original uses of current, verified, or normalized describe the historical source. They do not inherit the status of separately reviewed statements. Product formulations and source dates can differ.

Current review annotations for historical renal, dialysis, mechanism, and product fieldsSeparate renal reference: Open Renal Dosing Master (opens in a new tab)
Renal
Status
not_locally_normalized
Original classification
adjustment_required
Entries
    General note
    Preserve the source-specific renal-function basis. An indexed CrCl table is not interchangeable with unindexed CrCl or eGFR. Generic advice to check a method does not identify the equation for a dose row.
    Dialysis
    Status
    no_local_structured_regimen
    Entries
      General note
      Named modality alone does not establish applicability. CRRT subtype, effluent rate, residual renal function, timing and interruptions require review. Historical absence is not evidence that no guidance exists.
      Mechanisms
      • Source kind
        first_look
        Local pointer
        /mechanism
        Original level
        drug_specific
        Provenance classification
        historical_drug_specific_uncorroborated
        Label derived verified
        false
        Independently corroborated
        false
        Exact label section
        Not recorded
        Original source note
        Not recorded
        Review status
        historical_unverified
        Note
        Drug-specific wording in the old file is not proof of independent corroboration or an exact label locator. Consult separately published current mechanism claims where present.
      Future update
      Status
      pending_review
      Message
      This monograph will be updated in the future as current exact-product and claim-level review is completed.
      Source unavailable
      false
      Reason
      The historical content is restored; comprehensive contemporary verification remains incomplete.
      Historical first look: uses, mechanism, dosing context, and administration

      Recovered v5.1 source content; historical, awaiting current review.

      Id
      levetiracetam
      Source IDH51-02BEC8FF4235EBAA7A352A4F
      Generic name
      Levetiracetam
      Source IDH51-7E165587EF30B1CF0F6623BB
      Class
      Neurology and anticonvulsants
      Source IDH51-B3622D02C623DC564F6A8E08
      Subclass
      Pyrrolidone anticonvulsant
      Source IDH51-BD91A5350717A22F29ABE3EA
      Primary uses
      1. Seizure treatment
        Source IDH51-D6223918F68B218F0D67B632
      2. Status epilepticus adjunct
        Source IDH51-ACEEFB0C3FD385C0863D46FC
      3. Temporary replacement for oral therapy
        Source IDH51-403229170EDED579916179D3
      Mechanism
      Binds synaptic vesicle protein 2A and modulates neurotransmitter release.
      Source IDH51-6F7A2A3F02B509EA657318D8
      Mechanism level
      drug_specific
      Source IDH51-6A74752A7CB8811EAAE08FEB
      Basic dosing orientation
      Adult | Existing preparation record; use current package insert for indication-specific selection | Common dose 500 to 1,500 mg; status loading may be higher per protocol | Not normalized in the preparation record | See current package insert and professional guidance | IV infusion; Pediatric | Existing preparation record; use current package insert for indication-specific selection | Weight-based dose | Not normalized in the preparation record | See current package insert and professional guidance | IV infusion
      Source IDH51-B17384DF606BAA31EDCC27B0
      Administration orientation
      Label-standard infusion over 15 minutes; Infuse over 15 minutes; 100 mg/mL or diluted; Commonly over 2 to 5 minutes
      Source IDH51-D5E202B982BC03E40612EA8F
      Renal and population orientation
      Separate renal reference: Open Renal Dosing Master (opens in a new tab)Renal dose adjustment or interval modification is commonly required; verify the selected product label and patient-specific renal method.
      Source IDH51-0C5431E466E7E33EBE71110D
      Key safety orientation
      1. Somnolence and behavioral effects.
        Source IDH51-FAC9E5B931DA537FDD5F8C9F
      2. Maintenance dosing requires renal adjustment.
        Source IDH51-724CB6DA65CF310DB4E0A68B
      Coverage path
      structured_local_snapshot
      Source IDH51-4D08E97AEF16429B62B5F55E
      Coverage path label
      Structured GlobalRPh route snapshot
      Source IDH51-566C03331B3D3D7B7C663801
      Legacy title
      Levetiracetam (Keppra)
      Source IDH51-D63C2DC3273F8A3F1E5D5F53
      Review note
      First-look orientation only. Verify indication, patient population, weight basis, organ function, exact IV product, dose, concentration, compatibility, rate, and current labeling before use.
      Source IDH51-4E9E61154D0DEBF3531DE71E
      Search text
      Levetiracetam Neurology and anticonvulsants Pyrrolidone anticonvulsant Seizure treatment Status epilepticus adjunct Temporary replacement for oral therapy Binds synaptic vesicle protein 2A and modulates neurotransmitter release. Adult | Existing preparation record; use current package insert for indication-specific selection | Common dose 500 to 1,500 mg; status loading may be higher per protocol | Not normalized in the preparation record | See current package insert and professional guidance | IV infusion; Pediatric | Existing preparation record; use current package insert for indication-specific selection | Weight-based dose | Not normalized in the preparation record | See current package insert and professional guidance | IV infusion Label-standard infusion over 15 minutes; Infuse over 15 minutes; 100 mg/mL or diluted; Commonly over 2 to 5 minutes Renal dose adjustment or interval modification is commonly required; verify the selected product label and patient-specific renal method. Somnolence and behavioral effects. Maintenance dosing requires renal adjustment. Structured GlobalRPh route snapshot
      Source IDH51-7C645363D71A438F8F17D59B
      Official access mode
      search
      Source IDH51-0B44AED99A0F4071D101504C
      Official search query
      Levetiracetam
      Source IDH51-828197A983F9ECC467C6A038
      Official access reason
      A source-backed DailyMed search is available; select and confirm the exact IV product.
      Source IDH51-6D42F2F8DF5FA11B20820BE7

      No separate structured rows were bundled for continuous infusion, dialysis, CRRT. Historical article content and source links may cover these topics.

      Historical dilution and intermittent infusion preparation

      Recovered v5.1 source content; historical, awaiting current review.

      Separate renal reference: Open Renal Dosing Master (opens in a new tab)
      PopulationAmountReconstitutionDiluentFinal volumeConcentrationRateStabilityNotes
      Source IDH51-D89F35D8F6ED9DF9B53FCFC3
      Adult
      Source IDH51-A4CC18FCFD83D50648D0BC49
      		Common dose 500 to 1,500 mg; status loading may be higher per protocol
      Source IDH51-6F248558EFFD4596C13A0757
      		Withdraw dose from 100 mg/mL vial.
      Source IDH51-1858580750735F2B35389CCE
      		NS, D5W, or LR
      Source IDH51-04EFF253DA9237F24645F32B
      		100 mL commonly
      Source IDH51-0CA7C38AF02DA16995D9AD22
      		Commonly 5 to 15 mg/mL
      Source IDH51-17C3E28EA29C9AF24B829BD3
      		Label-standard infusion over 15 minutes
      Source IDH51-2293339C961A8D119F6A8811
      		Use the shorter of current product labeling, validated stability data, and the applicable USP <797> sterility-based BUD ceiling.
      Source IDH51-5513EA382B7F4C0DF4A86029
      		Renal adjustment is required for maintenance therapy.
      Source IDH51-1C8DBEAA55074092651CC9F8
      Source IDH51-05A8AE841946ED6552126AE3
      Pediatric
      Source IDH51-08EA0A075D1BB77AAAF4D078
      		Weight-based dose
      Source IDH51-8B3AA1883914DD6BE49BF4A1
      		Withdraw from 100 mg/mL vial.
      Source IDH51-DAAA4C9D51C2836E7183AAD3
      		Compatible fluid
      Source IDH51-B0E85C5FD413B130B0AC1AD4
      		Weight-appropriate volume
      Source IDH51-09C62C5B070702FE7F98878F
      		Institution-specific
      Source IDH51-868EB4EC5DAC5AACFAB12BF3
      		Infuse over 15 minutes
      Source IDH51-2C2A02BF6DFB77E5C2504CBA
      		Use the shorter of current product labeling, validated stability data, and the applicable USP <797> sterility-based BUD ceiling.
      Source IDH51-C5BC8EC0A7E853798D2C7C57

      Historical IV-push guidance

      Recovered v5.1 source content; historical, awaiting current review.

      PopulationDose scopeConcentrationRateStatusNotes
      Source IDH51-25C0F569154D71F379BEC872
      Adult
      Source IDH51-BDCC1C68A1553B6658675702
      		Selected doses under institutional protocol
      Source IDH51-5CAB6B31EE2C09F85E772BB3
      		100 mg/mL or diluted
      Source IDH51-332143CBEF581891A446A32F
      		Commonly over 2 to 5 minutes
      Source IDH51-34A3F7CEB95454CB1972093D
      		Off-label/policy-dependent
      Source IDH51-710DC09D3F9D61B82B695BBC
      		Do not substitute rapid administration for label-standard infusion without approval.
      Source IDH51-3847F5F6FAC09C9E031CC601

      Historical indication and population dosing

      Recovered tables and source-separated snapshots; full clinical revalidation remains pending.

      Existing dose and route snapshots

      Separate renal reference: Open Renal Dosing Master (opens in a new tab)
      RoutePopulationIndicationDoseIntervalDurationAdministrationSource levelNotes
      Source IDH51-A8759F6467C38212364A2871
      IV infusion
      Source IDH51-8EA7D73617B6BDAD5922B022
      		Adult
      Source IDH51-B8EF359CC43E2A9232F2BC62
      		Existing preparation record; use current package insert for indication-specific selection
      Source IDH51-6C00586B2D5ED8ABCD2EC400
      		Common dose 500 to 1,500 mg; status loading may be higher per protocol
      Source IDH51-337C910A064EFACA180FF418
      		Not normalized in the preparation record
      Source IDH51-E02634DD17E5D2FA5EECBEE1
      		See current package insert and professional guidance
      Source IDH51-9B39F9F2F0B713C1F60114F1
      		Label-standard infusion over 15 minutes
      Source IDH51-F710BDFD53EFA7D2312F8F0E
      		Existing GlobalRPh structured preparation snapshot
      Source IDH51-9DA74D0EE29C539BB9B6340C
      		Renal adjustment is required for maintenance therapy.
      Source IDH51-BE109D361EF64F752C629D7C
      Source IDH51-7F1884CF6AF60C7E762E7315
      IV infusion
      Source IDH51-AE47047661A0C9AD2D00D2E8
      		Pediatric
      Source IDH51-3568CBD67AE3EAAB5386A9D1
      		Existing preparation record; use current package insert for indication-specific selection
      Source IDH51-8332DB2BCFA69E3AA734201F
      		Weight-based dose
      Source IDH51-8339771BC8B11B5C2595EAB6
      		Not normalized in the preparation record
      Source IDH51-AD271BD1325106FE4220A8DB
      		See current package insert and professional guidance
      Source IDH51-ECB78EE849702C261CB13DCC
      		Infuse over 15 minutes
      Source IDH51-D1EC7F36CA27A4B43AC37CF2
      		Existing GlobalRPh structured preparation snapshot
      Source IDH51-85AEB39682127DEC01C95107
      Source IDH51-5D4F7E28A128F10A769FD1C4
      IV push
      Source IDH51-08E26ECF0B443C3758CAF2BA
      		Adult
      Source IDH51-46C3CD324EACDB2200AADF0A
      		Selected doses under institutional protocol
      Source IDH51-7CCC766E23DC586116223578
      		Selected doses under institutional protocol
      Source IDH51-B8B38F07CBAEA40728BA2F29
      		Patient- and indication-specific
      Source IDH51-0563CCBA97B3B6DE3BC3618E
      		See current package insert
      Source IDH51-008F2710EF9E04AC2127D670
      		Commonly over 2 to 5 minutes
      Source IDH51-19EEE9521F8C79FAA541AD9F
      		Existing GlobalRPh IV push snapshot
      Source IDH51-28E7F12B4B533DB2B2D7FF55
      		Off-label/policy-dependent Do not substitute rapid administration for label-standard infusion without approval.
      Source IDH51-3EA1591DCA76AC01B849501B

      Historical renal-function guidance

      Recovered v5.1 source content; historical, awaiting current review.

      Separate renal reference: Open Renal Dosing Master (opens in a new tab)
      Classification
      adjustment_required
      Source IDH51-EBB2E3C706044DED64FCDC0B
      Summary
      Renal dose adjustment or interval modification is commonly required; verify the selected product label and patient-specific renal method.
      Source IDH51-71EF2883CAF3C513FCD27EC3
      Method note
      Use the renal function estimate and body-size convention specified by the selected label or institutional protocol. Do not interchange Cockcroft-Gault CrCl, indexed eGFR, and de-indexed eGFR without confirming the dosing source.
      Source IDH51-BFB00B2F98E46B3D44EAF02E

      Historical Common IV uses

      Recovered v5.1 source content; historical, awaiting current review.

      1. Seizure treatment
        Source IDH51-FA4FC564D242C97646A297D6
      2. Status epilepticus adjunct
        Source IDH51-84F29D039858A6029B9C2C85
      3. Temporary replacement for oral therapy
        Source IDH51-A03F99AA3BE74046C2F41565

      Historical Warnings and safeguards

      Recovered v5.1 source content; historical, awaiting current review.

      Separate renal reference: Open Renal Dosing Master (opens in a new tab)
      1. Somnolence and behavioral effects.
        Source IDH51-6A4D8F9C08AC86F3556A6E52
      2. Maintenance dosing requires renal adjustment.
        Source IDH51-3A34686917160836396740A9

      Historical Monitoring

      Recovered v5.1 source content; historical, awaiting current review.

      Separate renal reference: Open Renal Dosing Master (opens in a new tab)
      1. Neurologic response
        Source IDH51-5720098254E697AD1ECA6E76
      2. Renal function
        Source IDH51-F125B2309CFDF6C82887F6AE
      3. Behavioral adverse effects
        Source IDH51-3FF4DB300A50E97AAF1A8CC0
      Other recovered source fields and original editorial metadata

      Original status words such as current, verified, or normalized describe the historical source release. They do not change the clinical review status of this release.

      Catalog source fields

      Id
      levetiracetam
      Source IDH51-3CFB37E04EA547F6BF111DB0
      Generic name
      Levetiracetam
      Source IDH51-32192CEB824575888BC513C4
      Brand names
      1. Keppra
        Source IDH51-565A1192A4A475D5F8D50708
      Class
      Neurology and anticonvulsants
      Source IDH51-05B63E49F5C379CD04D27600
      Subclass
      Pyrrolidone anticonvulsant
      Source IDH51-7CCF4E2A46A8018455B1D684
      Summary
      IV formulation generally diluted and infused over 15 minutes; some centers use rapid or IV push administration under a separately validated protocol.
      Source IDH51-417AFFF0DD1122068A276A74
      Populations
      1. Adult
        Source IDH51-4032C9670E9D19EC1D4D169F
      2. Pediatric
        Source IDH51-664DCD4847D8750B257EBFC0
      Evidence tier
      Core reference - verify current label
      Source IDH51-A3D08C95F5537DACA25DAD3C
      High alert
      false
      Source IDH51-DFAD086FCA5ED3C29EBFF67F
      Hazardous
      false
      Source IDH51-E175B64B0CBB901754EB31DB
      Status
      Active
      Source IDH51-F39221384EA445FC166A908E
      Reviewed
      2026-08-29
      Source IDH51-0449A7A8BF8C2A8AB764392E
      Version added
      1.0
      Source IDH51-3DE23C6E9234EDB869B40FF3
      Sources
      LabelUrlKind
      Source IDH51-098875C99472301F0E2C0828
      DailyMed label search
      Source IDH51-15E6BE3578ABBAC99FCC7894
      		https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=Levetiracetam (opens in a new tab)
      Source IDH51-460C78676DAC0BAC8E79805D
      		Primary
      Source IDH51-E61D1D80F25414011019AB1B
      Source IDH51-BF5FC56A4D56C1652A317482
      GlobalRPh legacy IV dilution monograph
      Source IDH51-D0F07A1752BB58FDF95879CB
      		legacy:auto
      Source IDH51-4470ADDBEA208BF2BCE3E353
      		Legacy
      Source IDH51-195240BCDC813E806BD12BE5
      Legacy title
      Levetiracetam (Keppra)
      Source IDH51-F909892195201AF15EBA7DF5
      Clinical release verification
      Audit version
      3.4
      Source IDH51-67DF29968041F86054C173BA
      Audited on
      2026-08-30
      Source IDH51-1B203C87E193107DEB288030
      Level
      amber
      Source IDH51-F24AB704BB56D0FEFA939235
      Release gate
      trusted_professional_source_present_exact_label_unconfirmed
      Source IDH51-5FBE6AA34A311E1C14228908
      Exact current label candidate
      false
      Source IDH51-4B07AF5AF7E1BD9CF99D51C3
      Numeric support ratio
      0
      Source IDH51-62985E31E44F156562CE2C32
      Reference url count
      1
      Source IDH51-C14460BC221E931763366CE9
      Broken reference count
      0
      Source IDH51-5B0B365CBF5CB71D00123C85
      Point of use confirmation required
      true
      Source IDH51-FA1E2210C10FD9F0A27DA3DD
      Note
      Do not treat this record as a fully current product-specific monograph until the exact IV formulation and current sources are confirmed.
      Source IDH51-2F9C6D82FE505F80B4785C2F

      Dosing source fields

      Id
      levetiracetam
      Source IDH51-F9D420E115221D1DACF2B877
      Generic name
      Levetiracetam
      Source IDH51-C66743FC61B0EC4CB0B9FF9B
      Coverage status
      direct_official_label_access_plus_local_snapshot
      Source IDH51-6F4A5F2B9ABB8D2E47247307
      Package insert
      Query name
      Levetiracetam
      Source IDH51-8F5C36EF391A1221CEB83C2D
      Product and route must match
      true
      Source IDH51-1500294CEDC9413F3B501D22
      Live current label enabled
      false
      Source IDH51-8043870DD498EDF126CBEA11
      Source priority
      Reviewed local summary when available, then a verified DailyMed label or product search when available, followed by professional references and institutional policy.
      Source IDH51-2235DA9DDD057F2018196046
      Direct official label access enabled
      true
      Source IDH51-F538C59549DDA3F63635CD0D
      Outbound server request required
      false
      Source IDH51-4E5FACDCECE5E47B54AC80D0
      Local summary status
      not_bundled
      Source IDH51-E43917A80A83C14267F74781
      Clinical review
      Locally normalized
      false
      Source IDH51-391AA0D3ABB45321C2917F51
      Reviewed
      2026-08-29
      Source IDH51-81CEB911F4F195397F99BFEE
      Status
      Direct official package-insert access enabled; indication-specific local normalization pending.
      Source IDH51-1B07908510387464EDB2AC5A
      Clinical release verification
      Audit version
      3.4
      Source IDH51-11FDC7044718D5EF44E91024
      Audited on
      2026-08-30
      Source IDH51-B89946EB89FDB617E7A4731E
      Level
      amber
      Source IDH51-371C8B2C90CF8D4D39B60BF6
      Release gate
      trusted_professional_source_present_exact_label_unconfirmed
      Source IDH51-5DD9E0F815CCD3CB17F5FF2B
      Exact current label candidate
      false
      Source IDH51-054A10F9880E3485B87E58C8
      Numeric support ratio
      0
      Source IDH51-DF78CA10886091DDADBDC1C1
      Reference url count
      1
      Source IDH51-380D35CA377759D0CB507A0D
      Broken reference count
      0
      Source IDH51-F233D89C558C5690018FDB87
      Point of use confirmation required
      true
      Source IDH51-91E295F8AB35C7193511D355
      Note
      Do not treat this record as a fully current product-specific monograph until the exact IV formulation and current sources are confirmed.
      Source IDH51-06F993E0B6B6FBB24C39A34C
      Historical preparation assessment

      Recovered v5.1 source content; historical, awaiting current review.

      Id
      levetiracetam
      Source IDH51-5100E8C0BA7A7862F0F4AFF8
      Name
      Levetiracetam
      Source IDH51-D0AF49BEC52DC291F72C2608
      Brands
      Keppra
      Source IDH51-ED183FCC69F50E25FC8D3123
      Therapeutic class
      Neurology and anticonvulsants
      Source IDH51-AC2255A32A0FC44BDA4E8172
      Review version
      3.1
      Source IDH51-4CA3B4A426278266DFE3EA58
      Review date
      2026-08-30
      Source IDH51-6664EF9A60338DBE5672EEE0
      Release status
      structured_record_current_label_not_confirmed
      Source IDH51-31942E1FF6784F24BB15B623
      Market status
      Status
      no_current_us_iv_spl_confirmed
      Source IDH51-07F09F86B6C0893310D16A31
      Basis
      No high-confidence current IV SPL was automatically selected; legacy information is segregated
      Source IDH51-C3B418F7802DC0685190C90C
      Ten point assessment
      Exact formulation
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-64F8E3D6FAB39826FB2EA154
      Reconstitution concentration
      Withdraw dose from 100 mg/mL vial. Withdraw from 100 mg/mL vial.
      Source IDH51-F03776D811C33D728643B2B3
      Maximum or recommended final concentration
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-83CCCE1A338F1307F6B072A6
      Appropriate standardized containers
      100 mL commonly Weight-appropriate volume
      Source IDH51-C91E9C346922EA5F225718F1
      Adult dosing range
      Common dose 500 to 1,500 mg; status loading may be higher per protocol Weight-based dose Selected doses under institutional protocol Selected doses under institutional protocol
      Source IDH51-7920A7400945D7ADEBA7689B
      Pediatric dosing range
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-30500085CF2DBD539745748D
      Neonatal dosing range
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-475A1E3DFA0991EF07405782
      Infusion time
      Label-standard infusion over 15 minutes Infuse over 15 minutes Commonly over 2 to 5 minutes
      Source IDH51-B8A845083673E801C71FF0A0
      Fluid restriction alternatives
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-5BE57F4B2F4AFD3BAFCEE35D
      Current manufacturer labeling
      Match confidence
      unresolved
      Source IDH51-E370622700653F36DDF69898
      Field provenance
      Exact formulation
      Primary
      not_found
      Source IDH51-35FE3304246A80CB2CF5822C
      Reconstitution concentration
      Primary
      existing_structured_record
      Source IDH51-87181D91C5180344B781823C
      Maximum or recommended final concentration
      Primary
      not_found
      Source IDH51-1280EFA5906898527802F434
      Appropriate standardized containers
      Primary
      existing_structured_record
      Source IDH51-ECE2CCC82207C3715FE5D788
      Adult dosing range
      Primary
      existing_structured_record
      Source IDH51-817A9CDC7679F837CE1CF5C9
      Pediatric dosing range
      Primary
      not_found
      Source IDH51-919E00F49D96A2C8DA31F027
      Neonatal dosing range
      Primary
      not_found
      Source IDH51-8D7A01F2008BAEF1F9DED38D
      Infusion time
      Primary
      existing_structured_record
      Source IDH51-8B8C2A766B9B825C92D2287F
      Fluid restriction alternatives
      Primary
      not_found
      Source IDH51-A08274A3CB64A1A876A91375
      Current manufacturer labeling
      Primary
      DailyMed search gateway
      Source IDH51-6F162460E16E1C344C81B778
      Population applicability
      Adult
      Applicability
      supported_or_source_present
      Source IDH51-AD036554DE791E9040E7968D
      Guide generation allowed
      true
      Source IDH51-63A4E229009E6FB45A96FA7E
      Pediatric
      Applicability
      supported_or_source_present
      Source IDH51-EB465A0E96020F4E5D697260
      Guide generation allowed
      false
      Source IDH51-C10F3336522F0C9EF5505C5F
      Neonatal
      Applicability
      not_established
      Source IDH51-3DDAC3E5E48466E0EA91712B
      Guide generation allowed
      false
      Source IDH51-3BF232099D79321A172F9F86
      Route presence
      Structured dilution
      true
      Source IDH51-67D4DBE5601734B768F75F4C
      Iv push
      true
      Source IDH51-6B987DAE343DDD8A2BE3527B
      Continuous infusion
      false
      Source IDH51-3443E875BBDE9E199E1A00AF
      Pediatric source
      true
      Source IDH51-A6A46F907FDD15F438DFFA0E
      Neonatal source
      false
      Source IDH51-5A7574F1A008B1C284B5C2A9
      Legacy reference
      Status
      not_available
      Source IDH51-09D99E3BBE760D41CF296BCE
      Label resolution
      Status
      build_environment_network_unavailable
      Source IDH51-19117ED9DBF047CB50C40476
      Source files
      1. catalog.json
        Source IDH51-C2474D5E04263D76DCDEA561
      2. dosing.json
        Source IDH51-845149047BE9A20FECB6EE5A
      3. legacy-map.json
        Source IDH51-3E1B51CA405774C35EB4C196
      Clinical release note
      Preparation instructions are released only at the evidence level shown. Legacy content remains visibly separate. Exact product, NDC, route, current labeling, and institutional policy must be confirmed.
      Source IDH51-16DFFEDA1BA2852F2F5F65A1
      Historical statement IDs and source locations

      These IDs identify recovered source units. They are not evidence-qualified clinical claims.

      Historical IDOriginal source locationStatus
      H51-3CFB37E04EA547F6BF111DB0catalog.json
      /records/149/id      		Historical; current review incomplete
      H51-32192CEB824575888BC513C4catalog.json
      /records/149/generic_name      		Historical; current review incomplete
      H51-565A1192A4A475D5F8D50708catalog.json
      /records/149/brand_names/0      		Historical; current review incomplete
      H51-05B63E49F5C379CD04D27600catalog.json
      /records/149/class      		Historical; current review incomplete
      H51-7CCF4E2A46A8018455B1D684catalog.json
      /records/149/subclass      		Historical; current review incomplete
      H51-417AFFF0DD1122068A276A74catalog.json
      /records/149/summary      		Historical; current review incomplete
      H51-FA4FC564D242C97646A297D6catalog.json
      /records/149/common_uses/0      		Historical; current review incomplete
      H51-84F29D039858A6029B9C2C85catalog.json
      /records/149/common_uses/1      		Historical; current review incomplete
      H51-A03F99AA3BE74046C2F41565catalog.json
      /records/149/common_uses/2      		Historical; current review incomplete
      H51-D89F35D8F6ED9DF9B53FCFC3catalog.json
      /records/149/preparations/0      		Historical; current review incomplete
      H51-A4CC18FCFD83D50648D0BC49catalog.json
      /records/149/preparations/0/population      		Historical; current review incomplete
      H51-6F248558EFFD4596C13A0757catalog.json
      /records/149/preparations/0/amount      		Historical; current review incomplete
      H51-1858580750735F2B35389CCEcatalog.json
      /records/149/preparations/0/reconstitution      		Historical; current review incomplete
      H51-04EFF253DA9237F24645F32Bcatalog.json
      /records/149/preparations/0/diluent      		Historical; current review incomplete
      H51-0CA7C38AF02DA16995D9AD22catalog.json
      /records/149/preparations/0/final_volume      		Historical; current review incomplete
      H51-17C3E28EA29C9AF24B829BD3catalog.json
      /records/149/preparations/0/concentration      		Historical; current review incomplete
      H51-2293339C961A8D119F6A8811catalog.json
      /records/149/preparations/0/rate      		Historical; current review incomplete
      H51-5513EA382B7F4C0DF4A86029catalog.json
      /records/149/preparations/0/stability      		Historical; current review incomplete
      H51-1C8DBEAA55074092651CC9F8catalog.json
      /records/149/preparations/0/notes      		Historical; current review incomplete
      H51-05A8AE841946ED6552126AE3catalog.json
      /records/149/preparations/1      		Historical; current review incomplete
      H51-08EA0A075D1BB77AAAF4D078catalog.json
      /records/149/preparations/1/population      		Historical; current review incomplete
      H51-8B3AA1883914DD6BE49BF4A1catalog.json
      /records/149/preparations/1/amount      		Historical; current review incomplete
      H51-DAAA4C9D51C2836E7183AAD3catalog.json
      /records/149/preparations/1/reconstitution      		Historical; current review incomplete
      H51-B0E85C5FD413B130B0AC1AD4catalog.json
      /records/149/preparations/1/diluent      		Historical; current review incomplete
      H51-09C62C5B070702FE7F98878Fcatalog.json
      /records/149/preparations/1/final_volume      		Historical; current review incomplete
      H51-868EB4EC5DAC5AACFAB12BF3catalog.json
      /records/149/preparations/1/concentration      		Historical; current review incomplete
      H51-2C2A02BF6DFB77E5C2504CBAcatalog.json
      /records/149/preparations/1/rate      		Historical; current review incomplete
      H51-C5BC8EC0A7E853798D2C7C57catalog.json
      /records/149/preparations/1/stability      		Historical; current review incomplete
      H51-F171A331EF767A34B07FA589catalog.json
      /records/149/preparations/1/notes      		Historical; current review incomplete
      H51-25C0F569154D71F379BEC872catalog.json
      /records/149/iv_push/0      		Historical; current review incomplete
      H51-BDCC1C68A1553B6658675702catalog.json
      /records/149/iv_push/0/population      		Historical; current review incomplete
      H51-5CAB6B31EE2C09F85E772BB3catalog.json
      /records/149/iv_push/0/dose_scope      		Historical; current review incomplete
      H51-332143CBEF581891A446A32Fcatalog.json
      /records/149/iv_push/0/concentration      		Historical; current review incomplete
      H51-34A3F7CEB95454CB1972093Dcatalog.json
      /records/149/iv_push/0/rate      		Historical; current review incomplete
      H51-710DC09D3F9D61B82B695BBCcatalog.json
      /records/149/iv_push/0/status      		Historical; current review incomplete
      H51-3847F5F6FAC09C9E031CC601catalog.json
      /records/149/iv_push/0/notes      		Historical; current review incomplete
      H51-6A4D8F9C08AC86F3556A6E52catalog.json
      /records/149/warnings/0      		Historical; current review incomplete
      H51-3A34686917160836396740A9catalog.json
      /records/149/warnings/1      		Historical; current review incomplete
      H51-5720098254E697AD1ECA6E76catalog.json
      /records/149/monitoring/0      		Historical; current review incomplete
      H51-F125B2309CFDF6C82887F6AEcatalog.json
      /records/149/monitoring/1      		Historical; current review incomplete
      H51-3FF4DB300A50E97AAF1A8CC0catalog.json
      /records/149/monitoring/2      		Historical; current review incomplete
      H51-4032C9670E9D19EC1D4D169Fcatalog.json
      /records/149/populations/0      		Historical; current review incomplete
      H51-664DCD4847D8750B257EBFC0catalog.json
      /records/149/populations/1      		Historical; current review incomplete
      H51-A3D08C95F5537DACA25DAD3Ccatalog.json
      /records/149/evidence_tier      		Historical; current review incomplete
      H51-DFAD086FCA5ED3C29EBFF67Fcatalog.json
      /records/149/high_alert      		Historical; current review incomplete
      H51-E175B64B0CBB901754EB31DBcatalog.json
      /records/149/hazardous      		Historical; current review incomplete
      H51-F39221384EA445FC166A908Ecatalog.json
      /records/149/status      		Historical; current review incomplete
      H51-0449A7A8BF8C2A8AB764392Ecatalog.json
      /records/149/reviewed      		Historical; current review incomplete
      H51-3DE23C6E9234EDB869B40FF3catalog.json
      /records/149/version_added      		Historical; current review incomplete
      H51-098875C99472301F0E2C0828catalog.json
      /records/149/sources/0      		Historical; current review incomplete
      H51-15E6BE3578ABBAC99FCC7894catalog.json
      /records/149/sources/0/label      		Historical; current review incomplete
      H51-460C78676DAC0BAC8E79805Dcatalog.json
      /records/149/sources/0/url      		Historical; current review incomplete
      H51-E61D1D80F25414011019AB1Bcatalog.json
      /records/149/sources/0/kind      		Historical; current review incomplete
      H51-BF5FC56A4D56C1652A317482catalog.json
      /records/149/sources/1      		Historical; current review incomplete
      H51-D0F07A1752BB58FDF95879CBcatalog.json
      /records/149/sources/1/label      		Historical; current review incomplete
      H51-4470ADDBEA208BF2BCE3E353catalog.json
      /records/149/sources/1/url      		Historical; current review incomplete
      H51-195240BCDC813E806BD12BE5catalog.json
      /records/149/sources/1/kind      		Historical; current review incomplete
      H51-F909892195201AF15EBA7DF5catalog.json
      /records/149/legacy_title      		Historical; current review incomplete
      H51-67DF29968041F86054C173BAcatalog.json
      /records/149/clinical_release_verification/audit_version      		Historical; current review incomplete
      H51-1B203C87E193107DEB288030catalog.json
      /records/149/clinical_release_verification/audited_on      		Historical; current review incomplete
      H51-F24AB704BB56D0FEFA939235catalog.json
      /records/149/clinical_release_verification/level      		Historical; current review incomplete
      H51-5FBE6AA34A311E1C14228908catalog.json
      /records/149/clinical_release_verification/release_gate      		Historical; current review incomplete
      H51-4B07AF5AF7E1BD9CF99D51C3catalog.json
      /records/149/clinical_release_verification/exact_current_label_candidate      		Historical; current review incomplete
      H51-2B8AAA96A63CB79B11C9BDDCcatalog.json
      /records/149/clinical_release_verification/selected_setid      		Historical; current review incomplete
      H51-535BDF019D2164E78EB69D44catalog.json
      /records/149/clinical_release_verification/selected_label_title      		Historical; current review incomplete
      H51-62985E31E44F156562CE2C32catalog.json
      /records/149/clinical_release_verification/numeric_support_ratio      		Historical; current review incomplete
      H51-C14460BC221E931763366CE9catalog.json
      /records/149/clinical_release_verification/reference_url_count      		Historical; current review incomplete
      H51-5B0B365CBF5CB71D00123C85catalog.json
      /records/149/clinical_release_verification/broken_reference_count      		Historical; current review incomplete
      H51-FA1E2210C10FD9F0A27DA3DDcatalog.json
      /records/149/clinical_release_verification/point_of_use_confirmation_required      		Historical; current review incomplete
      H51-2F9C6D82FE505F80B4785C2Fcatalog.json
      /records/149/clinical_release_verification/note      		Historical; current review incomplete
      H51-9B60671A9E9DE1C5557F1C68catalog.json
      /records/149/clinical_release_verification/dailymed_search_url      		Historical; current review incomplete
      H51-F9D420E115221D1DACF2B877dosing.json
      /records/149/id      		Historical; current review incomplete
      H51-C66743FC61B0EC4CB0B9FF9Bdosing.json
      /records/149/generic_name      		Historical; current review incomplete
      H51-6F4A5F2B9ABB8D2E47247307dosing.json
      /records/149/coverage_status      		Historical; current review incomplete
      H51-8F5C36EF391A1221CEB83C2Ddosing.json
      /records/149/package_insert/query_name      		Historical; current review incomplete
      H51-39DA21E80F90A65A5312A775dosing.json
      /records/149/package_insert/preferred_setid      		Historical; current review incomplete
      H51-1500294CEDC9413F3B501D22dosing.json
      /records/149/package_insert/product_and_route_must_match      		Historical; current review incomplete
      H51-8043870DD498EDF126CBEA11dosing.json
      /records/149/package_insert/live_current_label_enabled      		Historical; current review incomplete
      H51-2235DA9DDD057F2018196046dosing.json
      /records/149/package_insert/source_priority      		Historical; current review incomplete
      H51-F538C59549DDA3F63635CD0Ddosing.json
      /records/149/package_insert/direct_official_label_access_enabled      		Historical; current review incomplete
      H51-4E5FACDCECE5E47B54AC80D0dosing.json
      /records/149/package_insert/outbound_server_request_required      		Historical; current review incomplete
      H51-E43917A80A83C14267F74781dosing.json
      /records/149/package_insert/local_summary_status      		Historical; current review incomplete
      H51-EBB2E3C706044DED64FCDC0Bdosing.json
      /records/149/renal/classification      		Historical; current review incomplete
      H51-71EF2883CAF3C513FCD27EC3dosing.json
      /records/149/renal/summary      		Historical; current review incomplete
      H51-BFB00B2F98E46B3D44EAF02Edosing.json
      /records/149/renal/method_note      		Historical; current review incomplete
      H51-A8759F6467C38212364A2871dosing.json
      /records/149/existing_route_snapshots/0      		Historical; current review incomplete
      H51-8EA7D73617B6BDAD5922B022dosing.json
      /records/149/existing_route_snapshots/0/route      		Historical; current review incomplete
      H51-B8EF359CC43E2A9232F2BC62dosing.json
      /records/149/existing_route_snapshots/0/population      		Historical; current review incomplete
      H51-6C00586B2D5ED8ABCD2EC400dosing.json
      /records/149/existing_route_snapshots/0/indication      		Historical; current review incomplete
      H51-337C910A064EFACA180FF418dosing.json
      /records/149/existing_route_snapshots/0/dose      		Historical; current review incomplete
      H51-E02634DD17E5D2FA5EECBEE1dosing.json
      /records/149/existing_route_snapshots/0/interval      		Historical; current review incomplete
      H51-9B39F9F2F0B713C1F60114F1dosing.json
      /records/149/existing_route_snapshots/0/duration      		Historical; current review incomplete
      H51-F710BDFD53EFA7D2312F8F0Edosing.json
      /records/149/existing_route_snapshots/0/administration      		Historical; current review incomplete
      H51-9DA74D0EE29C539BB9B6340Cdosing.json
      /records/149/existing_route_snapshots/0/source_level      		Historical; current review incomplete
      H51-BE109D361EF64F752C629D7Cdosing.json
      /records/149/existing_route_snapshots/0/notes      		Historical; current review incomplete
      H51-7F1884CF6AF60C7E762E7315dosing.json
      /records/149/existing_route_snapshots/1      		Historical; current review incomplete
      H51-AE47047661A0C9AD2D00D2E8dosing.json
      /records/149/existing_route_snapshots/1/route      		Historical; current review incomplete
      H51-3568CBD67AE3EAAB5386A9D1dosing.json
      /records/149/existing_route_snapshots/1/population      		Historical; current review incomplete
      H51-8332DB2BCFA69E3AA734201Fdosing.json
      /records/149/existing_route_snapshots/1/indication      		Historical; current review incomplete
      H51-8339771BC8B11B5C2595EAB6dosing.json
      /records/149/existing_route_snapshots/1/dose      		Historical; current review incomplete
      H51-AD271BD1325106FE4220A8DBdosing.json
      /records/149/existing_route_snapshots/1/interval      		Historical; current review incomplete
      H51-ECB78EE849702C261CB13DCCdosing.json
      /records/149/existing_route_snapshots/1/duration      		Historical; current review incomplete
      H51-D1EC7F36CA27A4B43AC37CF2dosing.json
      /records/149/existing_route_snapshots/1/administration      		Historical; current review incomplete
      H51-85AEB39682127DEC01C95107dosing.json
      /records/149/existing_route_snapshots/1/source_level      		Historical; current review incomplete
      H51-16FF1ABB0D3A453427A85B68dosing.json
      /records/149/existing_route_snapshots/1/notes      		Historical; current review incomplete
      H51-5D4F7E28A128F10A769FD1C4dosing.json
      /records/149/existing_route_snapshots/2      		Historical; current review incomplete
      H51-08E26ECF0B443C3758CAF2BAdosing.json
      /records/149/existing_route_snapshots/2/route      		Historical; current review incomplete
      H51-46C3CD324EACDB2200AADF0Adosing.json
      /records/149/existing_route_snapshots/2/population      		Historical; current review incomplete
      H51-7CCC766E23DC586116223578dosing.json
      /records/149/existing_route_snapshots/2/indication      		Historical; current review incomplete
      H51-B8B38F07CBAEA40728BA2F29dosing.json
      /records/149/existing_route_snapshots/2/dose      		Historical; current review incomplete
      H51-0563CCBA97B3B6DE3BC3618Edosing.json
      /records/149/existing_route_snapshots/2/interval      		Historical; current review incomplete
      H51-008F2710EF9E04AC2127D670dosing.json
      /records/149/existing_route_snapshots/2/duration      		Historical; current review incomplete
      H51-19EEE9521F8C79FAA541AD9Fdosing.json
      /records/149/existing_route_snapshots/2/administration      		Historical; current review incomplete
      H51-28E7F12B4B533DB2B2D7FF55dosing.json
      /records/149/existing_route_snapshots/2/source_level      		Historical; current review incomplete
      H51-3EA1591DCA76AC01B849501Bdosing.json
      /records/149/existing_route_snapshots/2/notes      		Historical; current review incomplete
      H51-391AA0D3ABB45321C2917F51dosing.json
      /records/149/clinical_review/locally_normalized      		Historical; current review incomplete
      H51-81CEB911F4F195397F99BFEEdosing.json
      /records/149/clinical_review/reviewed      		Historical; current review incomplete
      H51-1B07908510387464EDB2AC5Adosing.json
      /records/149/clinical_review/status      		Historical; current review incomplete
      H51-11FDC7044718D5EF44E91024dosing.json
      /records/149/clinical_release_verification/audit_version      		Historical; current review incomplete
      H51-B89946EB89FDB617E7A4731Edosing.json
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      H51-02BEC8FF4235EBAA7A352A4Ffirst-look-v5.1.json
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      /149/clinical_release_note      		Historical; current review incomplete

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