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Preparation. Administration. Evidence.

IV Dilution &
Medication Reference

Search 255 medications, read preserved historical references, and inspect separately reviewed preparation statements. Full monograph updates remain pending.

Version 6.4Release date 2026-11-04For healthcare professionals
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Medication reference

Hydroxocobalamin

Monograph awaiting updateThis monograph will be updated in the future.

Jump to a section
Selected DailyMed label (opens in a new tab)

No original site article was mapped to this record. The available historical structured fields and official-source links are retained.

Historical first look: uses, mechanism, dosing context, and administration

Recovered v5.1 source content; historical, awaiting current review.

Id
hydroxocobalamin
Source IDH51-BCE3FBF7538D92601E94EBD5
Generic name
Hydroxocobalamin
Source IDH51-BEC29AC567658065E31281E7
Class
Toxicology and reversal
Source IDH51-26F8EB4DF2ACBF81CD88B18B
Subclass
Cyanide antidote
Source IDH51-42D0A3FE56620BEB3008296D
Primary uses
  1. Known or suspected cyanide poisoning
    Source IDH51-519CE8312284EB2AF6228520
Mechanism
Binds cyanide to form cyanocobalamin and restores cellular oxidative metabolism.
Source IDH51-FB885F6DB20C38B4B1DDF4C8
Mechanism level
drug_specific
Source IDH51-7A00B92C7BF110B752C91130
Basic dosing orientation
Adult | Existing preparation record; use current package insert for indication-specific selection | 5 g initial dose; second 5 g may be considered | Not normalized in the preparation record | See current package insert and professional guidance | IV infusion; Pediatric | Existing preparation record; use current package insert for indication-specific selection | 70 mg/kg, maximum 5 g initial dose | Not normalized in the preparation record | See current package insert and professional guidance | IV infusion
Source IDH51-6FBB085B346839B17C679C24
Administration orientation
Initial dose over 15 minutes; second dose over 15 minutes to 2 hours depending on condition; Over 15 minutes
Source IDH51-F53974A2A570F20C6817F370
Renal and population orientation
Separate renal reference: Open Renal Dosing Master (opens in a new tab)The existing monograph contains a renal or nephrotoxicity signal; verify exact adjustment and monitoring in the current label.
Source IDH51-B7D29B8CC1FF51D94BFAFD8C
Key safety orientation
  1. Hypertension, red skin/urine discoloration, laboratory interference, and dialysis-machine interference.
    Source IDH51-38EDE06A043D24E0DACAB359
  2. Do not delay treatment for confirmatory testing when cyanide poisoning is strongly suspected.
    Source IDH51-20F426ACAEE700A35F51CAF8
Coverage path
structured_local_snapshot
Source IDH51-EDF679F7104E8F8933541B6A
Coverage path label
Structured GlobalRPh route snapshot
Source IDH51-A6CA946F3693A655802EEEA5
Review note
First-look orientation only. Verify indication, patient population, weight basis, organ function, exact IV product, dose, concentration, compatibility, rate, and current labeling before use.
Source IDH51-CEF037D1A3F5997E87F3FBA6
Search text
Hydroxocobalamin Toxicology and reversal Cyanide antidote Known or suspected cyanide poisoning Binds cyanide to form cyanocobalamin and restores cellular oxidative metabolism. Adult | Existing preparation record; use current package insert for indication-specific selection | 5 g initial dose; second 5 g may be considered | Not normalized in the preparation record | See current package insert and professional guidance | IV infusion; Pediatric | Existing preparation record; use current package insert for indication-specific selection | 70 mg/kg, maximum 5 g initial dose | Not normalized in the preparation record | See current package insert and professional guidance | IV infusion Initial dose over 15 minutes; second dose over 15 minutes to 2 hours depending on condition; Over 15 minutes The existing monograph contains a renal or nephrotoxicity signal; verify exact adjustment and monitoring in the current label. Hypertension, red skin/urine discoloration, laboratory interference, and dialysis-machine interference. Do not delay treatment for confirmatory testing when cyanide poisoning is strongly suspected. Structured GlobalRPh route snapshot CYANOKIT CYANOKIT (hydroxocobalamin) kit DailyMed label snapshot dosage administration dosage forms strengths mechanism
Source IDH51-A26DF17B96C917C9902B7B75
Official access mode
direct_label
Source IDH51-49D06A6D07D54D73738510BF
Official search query
Hydroxocobalamin
Source IDH51-478E8DBCC22CA13BDDEE915B
Official access reason
Very-high-confidence exact IV product label selected during the v5.1 build-time review. Open the current full DailyMed monograph and verify the stocked product before use.
Source IDH51-D847B862ED7987D300BF698E
Label snapshot available
true
Source IDH51-DA7DB825407054636F9925AB
Label snapshot setid
d56fcc8d-bd64-46ab-b0c0-2124bd745a6b
Source IDH51-06BF86AA43B60EAF5ED5386C
Product identifiers and clinical review status

This monograph will be updated in the future. Historical material is available where present in the original sources; full current exact-product and claim-level review remains pending.

Exact formulation, concentration, container, manufacturer, regulatory identifiers, and a reproducible label snapshot have not all been reconciled.

What remains to be completed
  • A retrieved source document is available; clinical reconciliation and a second-source claim map remain incomplete
  • Clinically reviewed, individually identified statements with two exact source mappings
  • Exact formulation, strength, container, manufacturer/labeler, application and NDC reconciliation
  • Renal-function methods and dialysis/CRRT modality review where applicable
  • Mechanism provenance, clinical source disagreements and full medication-specific safety reconciliation

Supplemental historical fields

Restored-data provenance and review notes

Source release: 2026-08-31. Current clinical review is incomplete. Original uses of current, verified, or normalized describe the historical source. They do not inherit the status of separately reviewed statements. Product formulations and source dates can differ.

Current review annotations for historical renal, dialysis, mechanism, and product fieldsSeparate renal reference: Open Renal Dosing Master (opens in a new tab)
Renal
Status
not_locally_normalized
Original classification
renal_review_flagged
Entries
    General note
    Preserve the source-specific renal-function basis. An indexed CrCl table is not interchangeable with unindexed CrCl or eGFR. Generic advice to check a method does not identify the equation for a dose row.
    Dialysis
    Status
    no_local_structured_regimen
    Entries
      General note
      Named modality alone does not establish applicability. CRRT subtype, effluent rate, residual renal function, timing and interruptions require review. Historical absence is not evidence that no guidance exists.
      Mechanisms
      • Source kind
        first_look
        Local pointer
        /mechanism
        Original level
        drug_specific
        Provenance classification
        historical_drug_specific_uncorroborated
        Label derived verified
        false
        Independently corroborated
        false
        Exact label section
        Not recorded
        Original source note
        Not recorded
        Review status
        historical_unverified
        Note
        Drug-specific wording in the old file is not proof of independent corroboration or an exact label locator. Consult separately published current mechanism claims where present.
      • Source kind
        label_snapshot
        Local pointer
        /mechanism_summary
        Original level
        drug_specific
        Provenance classification
        historical_drug_specific_uncorroborated
        Label derived verified
        false
        Independently corroborated
        false
        Exact label section
        Not recorded
        Original source note
        Concise GlobalRPh summary reviewed against the selected DailyMed label clinical-pharmacology or microbiology content.
        Review status
        historical_unverified
        Note
        Drug-specific wording in the old file is not proof of independent corroboration or an exact label locator. Consult separately published current mechanism claims where present.
      Future update
      Status
      pending_review
      Message
      This monograph will be updated in the future as current exact-product and claim-level review is completed.
      Source unavailable
      false
      Reason
      The historical content is restored; comprehensive contemporary verification remains incomplete.

      No separate structured rows were bundled for IV push, continuous infusion, dialysis, CRRT. Historical article content and source links may cover these topics.

      Historical dilution and intermittent infusion preparation

      Recovered v5.1 source content; historical, awaiting current review.

      PopulationAmountReconstitutionDiluentFinal volumeConcentrationRateStabilityNotes
      Source IDH51-6CA4E0531F8E81A2DD136643
      Adult
      Source IDH51-1C73EF265E7BB9233535E9FE
      		5 g initial dose; second 5 g may be considered
      Source IDH51-76B6876DC6D8AF3BB59562D2
      		Reconstitute 5 g vial with 200 mL NS; LR or D5W may be used if NS is unavailable per label. Rock or invert; do not shake.
      Source IDH51-DF6025C5B35D2EB370FF2E87
      		Reconstitution fluid
      Source IDH51-18EC85BEBD835BFA7BB2D2D8
      		Approximately 200 mL
      Source IDH51-735A681665A2F730C35160AB
      		25 mg/mL
      Source IDH51-6D74F4D830F5B418B4A9A944
      		Initial dose over 15 minutes; second dose over 15 minutes to 2 hours depending on condition
      Source IDH51-D4B3320226B3EBF8A51CBD4C
      		Use the shorter of current product labeling, validated stability data, and the applicable USP <797> sterility-based BUD ceiling.
      Source IDH51-B054C1B401A44D9936979ABD
      		Use supplied transfer spike where available.
      Source IDH51-A9CFE7CFCBD1580457715727
      Source IDH51-E43E0DC951C7D7AF8EB66D14
      Pediatric
      Source IDH51-569BE7D3F8EFEB0F5F1AB6A5
      		70 mg/kg, maximum 5 g initial dose
      Source IDH51-6E0DC95976C580C5EF2FEC20
      		Same reconstitution method.
      Source IDH51-3EBF053EA18341723E915FF7
      		Label-compatible fluid
      Source IDH51-44F7AF641F75A3DE8CB8375E
      		Weight-based volume from reconstituted solution
      Source IDH51-34A0795CEF7112A5D20E4180
      		25 mg/mL
      Source IDH51-0CDCE63FCCEF1F5D7F9B32D0
      		Over 15 minutes
      Source IDH51-B69285FD0FC3A8CD0A791DF0
      		Use the shorter of current product labeling, validated stability data, and the applicable USP <797> sterility-based BUD ceiling.
      Source IDH51-E43A51CF7A3F3B8E0979D426

      Historical DailyMed label snapshot

      Recovered v5.1 source content; historical, awaiting current review.

      Id
      hydroxocobalamin
      Source IDH51-E52882CD5D2F6FB6A514C35F
      Catalog name
      Hydroxocobalamin
      Source IDH51-2991922AEA1C15FE63949B1B
      Selection status
      accepted_high_confidence
      Source IDH51-397AFE3AD54BDE12EACADE43
      Confidence
      very_high
      Source IDH51-719B92B6873C624E82B38486
      Match path
      search_to_exact_label
      Source IDH51-B4A4C8C9D33F8809A5CD68B9
      Brand name
      CYANOKIT
      Source IDH51-6527FAC8F36F9B3084C835E2
      Label title
      CYANOKIT (hydroxocobalamin) kit
      Source IDH51-035FA83DE95841C9201886B4
      Setid
      d56fcc8d-bd64-46ab-b0c0-2124bd745a6b
      Source IDH51-1FFA4C88909F97D735D0121A
      Route
      Intravenous infusion
      Source IDH51-993243D067EAD90FFB45A5D4
      Dosage form
      Lyophilized hydroxocobalamin emergency-treatment kit
      Source IDH51-54A317E74E0248F96CD033D0
      Dosage administration summary
      1. The initial adult dose is 5 g infused over 15 minutes. Depending on poisoning severity and clinical response, a second 5 g dose may be given over 15 minutes to 2 hours.
        Source IDH51-DE5A895C92C31BB3EDABBA50
      2. Reconstitute with the labeled volume; 0.9% sodium chloride is the preferred diluent unless unavailable.
        Source IDH51-38A8ADB0C789110F80DD7FE2
      3. Use a separate intravenous line when possible and review incompatibilities, laboratory interference, and the emergency-use instructions.
        Source IDH51-A5BA860AA053FE5B8C270B1C
      Dosage forms strengths
      1. 5 g hydroxocobalamin lyophilized powder in a single-use vial
        Source IDH51-2A787E4C220E966B3CA61047
      2. Approximately 25 mg/mL after labeled reconstitution
        Source IDH51-689630389331FB811ACC3BDD
      Mechanism summary
      Hydroxocobalamin binds cyanide to form cyanocobalamin, which is excreted in urine.
      Source IDH51-03A29140CF4C95FA37A9F0A0
      Scope note
      Selected CYANOKIT cyanide-antidote label. Treatment should not delay airway, oxygenation, circulatory, and decontamination measures.
      Source IDH51-E0BBF2770455A76F9BA417BC
      Reviewed on
      2026-08-31
      Source IDH51-0B3F8C1A0DFC7F3D7FC3F688
      Mechanism source
      Concise GlobalRPh summary reviewed against the selected DailyMed label clinical-pharmacology or microbiology content.
      Source IDH51-FEAADAF5ADC5976BB2A3CD3F
      Source sections
      1. Dosage and Administration
        Source IDH51-DB9F79029F4AF85A4CF3D3FF
      2. Dosage Forms and Strengths
        Source IDH51-AEF0BE6E5E290EDAF470398C
      3. Clinical Pharmacology or Microbiology as applicable
        Source IDH51-54038362D9FA7AD16FA2ED64
      Retrieval method
      Manual build-time review of the current DailyMed full prescribing information for the selected Set ID; no live server retrieval is required during page use.
      Source IDH51-9D901E27AA9DB93A651A4BD0
      Label status
      current
      Source IDH51-C7F28F101B2EBE3D3719C742
      Disclaimer
      Verify the exact formulation, strength, manufacturer, NDC, route, current label revision, patient-specific order, institutional policy, and monitoring before use.
      Source IDH51-DC8EF03467613AC0CAF4B96A

      Historical indication and population dosing

      Recovered tables and source-separated snapshots; full clinical revalidation remains pending.

      Existing dose and route snapshots

      RoutePopulationIndicationDoseIntervalDurationAdministrationSource levelNotes
      Source IDH51-87170C648EC328393127EB21
      IV infusion
      Source IDH51-DFB11F15E98E473E670C1A3D
      		Adult
      Source IDH51-585B46CF7ADD0DB069FBEA1B
      		Existing preparation record; use current package insert for indication-specific selection
      Source IDH51-292733156EF9BA883CB9F382
      		5 g initial dose; second 5 g may be considered
      Source IDH51-582F4E91BDF7B74029EFEB5F
      		Not normalized in the preparation record
      Source IDH51-62BFA07F6EE9D87F31AF38ED
      		See current package insert and professional guidance
      Source IDH51-EF8F03340A3EEBE1C4C74CAF
      		Initial dose over 15 minutes; second dose over 15 minutes to 2 hours depending on condition
      Source IDH51-36FE09C2E20AA96731BCC863
      		Existing GlobalRPh structured preparation snapshot
      Source IDH51-528DD00873E1715BD12ACC78
      		Use supplied transfer spike where available.
      Source IDH51-0E2A296962D5132CBACA7F5D
      Source IDH51-25C221F1AD885B0FB06E18B2
      IV infusion
      Source IDH51-2DEAC4955BAF2E80C50DDE7E
      		Pediatric
      Source IDH51-5A2E686188C4B05D7604C8D5
      		Existing preparation record; use current package insert for indication-specific selection
      Source IDH51-2D085D3E6C42D3E7F0515447
      		70 mg/kg, maximum 5 g initial dose
      Source IDH51-B1652E8B2D35A780F28E032A
      		Not normalized in the preparation record
      Source IDH51-B9C34C71649D21CEC95A1D17
      		See current package insert and professional guidance
      Source IDH51-021D41D820D3F92534F9299C
      		Over 15 minutes
      Source IDH51-39EF433555B7D599500547F4
      		Existing GlobalRPh structured preparation snapshot
      Source IDH51-497C42979D24A62E473EE908

      Historical renal-function guidance

      Recovered v5.1 source content; historical, awaiting current review.

      Separate renal reference: Open Renal Dosing Master (opens in a new tab)
      Classification
      renal_review_flagged
      Source IDH51-0FF1E0C6637A911DC36A14D7
      Summary
      The existing monograph contains a renal or nephrotoxicity signal; verify exact adjustment and monitoring in the current label.
      Source IDH51-90688FFDF2C8F98630DD42B9
      Method note
      Use the renal function estimate and body-size convention specified by the selected label or institutional protocol. Do not interchange Cockcroft-Gault CrCl, indexed eGFR, and de-indexed eGFR without confirming the dosing source.
      Source IDH51-908BE65DD2FBD539A4BC5650

      Historical Common IV uses

      Recovered v5.1 source content; historical, awaiting current review.

      1. Known or suspected cyanide poisoning
        Source IDH51-76170CC518900D1A95605A9D

      Historical Warnings and safeguards

      Recovered v5.1 source content; historical, awaiting current review.

      Separate renal reference: Open Renal Dosing Master (opens in a new tab)
      1. Hypertension, red skin/urine discoloration, laboratory interference, and dialysis-machine interference.
        Source IDH51-11D8DAF4B58C39054ACEF2AF
      2. Do not delay treatment for confirmatory testing when cyanide poisoning is strongly suspected.
        Source IDH51-47357D65C2BF69AD1BC6E902

      Historical Monitoring

      Recovered v5.1 source content; historical, awaiting current review.

      Separate renal reference: Open Renal Dosing Master (opens in a new tab)
      1. Hemodynamics and neurologic response
        Source IDH51-73AF45F808C6B50778A41BCF
      2. Lactate trend
        Source IDH51-F276DBA268A877769D9ABB73
      3. Communicate assay and dialysis interference
        Source IDH51-F67B04AC0FDD05ED99E63606
      Other recovered source fields and original editorial metadata

      Original status words such as current, verified, or normalized describe the historical source release. They do not change the clinical review status of this release.

      Catalog source fields

      Id
      hydroxocobalamin
      Source IDH51-1039A2F662D230CCB16FF5BC
      Generic name
      Hydroxocobalamin
      Source IDH51-3FA44CC8935AF24A54E9C3C7
      Brand names
      1. Cyanokit
        Source IDH51-83FA46E3808659CACE4C42C6
      Class
      Toxicology and reversal
      Source IDH51-F5349006D6BC3587CE216F65
      Subclass
      Cyanide antidote
      Source IDH51-4DD26BD218140A42058D3EBF
      Summary
      Separate renal reference: Open Renal Dosing Master (opens in a new tab)Cyanide antidote requiring reconstitution and rapid infusion; intense red coloration interferes with laboratory assays and dialysis blood-leak detectors.
      Source IDH51-2782943A453DA8928FAD897E
      Populations
      1. Adult
        Source IDH51-47BC0FC932C95B9027EFD7B3
      2. Pediatric
        Source IDH51-8F3B18EC4C7B186F8B645847
      Evidence tier
      Core reference - verify current label
      Source IDH51-3BF713D03E234466CE2BCEC5
      High alert
      true
      Source IDH51-7ED8EABBE9550704491BF00A
      Hazardous
      false
      Source IDH51-56D3E8524853C8FD8216B7CB
      Status
      Active
      Source IDH51-B3E520C30BE25F6905484E62
      Reviewed
      2026-08-29
      Source IDH51-2F48450347E73BE5F9A0176E
      Version added
      1.2
      Source IDH51-BFFD2A1C81B1F78399240CCB
      Sources
      LabelUrlKind
      Source IDH51-37B7B0885F46B1C979F17CEE
      DailyMed label search
      Source IDH51-E68BC3FAF09E2BBCEFA3883C
      		https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=Hydroxocobalamin (opens in a new tab)
      Source IDH51-F8727DED4992FC58CEDA9173
      		Primary
      Source IDH51-C2663CF6B67899D6A48227A0
      Source IDH51-64A104DD954E08D24C198C44
      GlobalRPh legacy IV dilution monograph
      Source IDH51-1C1A3026BC42CD139D5C1DAD
      		legacy:auto
      Source IDH51-D010A8CA4516BF83AE46A21D
      		Legacy
      Source IDH51-17577F1553F08982FC220BE9
      Clinical release verification
      Audit version
      3.4
      Source IDH51-C824448939A2D4C4C4FB4F24
      Audited on
      2026-08-30
      Source IDH51-89189B139245F941F4175743
      Level
      amber
      Source IDH51-0B26735FA6BAE595D0C3E5C9
      Release gate
      trusted_professional_source_present_exact_label_unconfirmed
      Source IDH51-7BF8EFA3780655128683734C
      Exact current label candidate
      false
      Source IDH51-BB246DBE1DE17B45FCC8AEA8
      Numeric support ratio
      0
      Source IDH51-A030C0016FF87148DA07F1DA
      Reference url count
      1
      Source IDH51-E934581CCA3B533A9D8175F0
      Broken reference count
      0
      Source IDH51-3C55F5CB3A61F671E7810F0C
      Point of use confirmation required
      true
      Source IDH51-7543BAB1AF025E247BF9A0B4
      Note
      Do not treat this record as a fully current product-specific monograph until the exact IV formulation and current sources are confirmed.
      Source IDH51-33227280A54F8EE3427DB54A
      Version updated
      5.1
      Source IDH51-10547EEF8E92C10D7D9676AB

      Dosing source fields

      Id
      hydroxocobalamin
      Source IDH51-4E1AE969D24C4A14E771D948
      Generic name
      Hydroxocobalamin
      Source IDH51-05C46050ADD6B7FDA3554B45
      Coverage status
      direct_official_label_access_plus_local_snapshot
      Source IDH51-5A10B3C5B9C08405CE698011
      Package insert
      Query name
      Hydroxocobalamin
      Source IDH51-B40B3923D4BB0F221F70167F
      Product and route must match
      true
      Source IDH51-ABB0234FE16D624528F95D19
      Live current label enabled
      false
      Source IDH51-3BCD1B24C0A5461F8217AA40
      Source priority
      Reviewed local summary when available, then a verified DailyMed label or product search when available, followed by professional references and institutional policy.
      Source IDH51-E02E633C8ECEDC1BED4D3755
      Direct official label access enabled
      true
      Source IDH51-371E9303E0E7A5FD8C7F7008
      Outbound server request required
      false
      Source IDH51-FAF5525A23F272CC6BEE1A57
      Local summary status
      not_bundled
      Source IDH51-7B85F56EE1B8CD98FBDE4024
      Clinical review
      Locally normalized
      false
      Source IDH51-74C7F5ED3D909979512DD5DD
      Reviewed
      2026-08-29
      Source IDH51-ED77EA327A92300B58A5A93A
      Status
      Direct official package-insert access enabled; indication-specific local normalization pending.
      Source IDH51-DC7AF32ACB34AFE357E85433
      Clinical release verification
      Audit version
      3.4
      Source IDH51-4381B9D858B5D6080D3A0896
      Audited on
      2026-08-30
      Source IDH51-D8787B2C64FB21D637B14AD0
      Level
      amber
      Source IDH51-E1312B47ABF668382FAC121D
      Release gate
      trusted_professional_source_present_exact_label_unconfirmed
      Source IDH51-F0007AACB2F5CAC9E2383CC0
      Exact current label candidate
      false
      Source IDH51-A514A07D39917D47CD3B410B
      Numeric support ratio
      0
      Source IDH51-436C6D044FE26B8719D51EBD
      Reference url count
      1
      Source IDH51-A8C4BC988891AA0ED8F8079A
      Broken reference count
      0
      Source IDH51-8683C0DDA740225AF4AFA72E
      Point of use confirmation required
      true
      Source IDH51-C5885F116F012F492C52AB5D
      Note
      Do not treat this record as a fully current product-specific monograph until the exact IV formulation and current sources are confirmed.
      Source IDH51-56AF9EC70ECCAF8C598A3199
      Historical preparation assessment

      Recovered v5.1 source content; historical, awaiting current review.

      Id
      hydroxocobalamin
      Source IDH51-C8969A51E64EC361EBE5196A
      Name
      Hydroxocobalamin
      Source IDH51-EEFF09AD4A4EF512EF299729
      Brands
      Cyanokit
      Source IDH51-908ADB6B34F4E05C4E13046D
      Therapeutic class
      Toxicology and reversal
      Source IDH51-AAD455E82A7FBF131E45555F
      Review version
      3.1
      Source IDH51-2C792361217F17824431B982
      Review date
      2026-08-30
      Source IDH51-A452DFCEDF0FCA81FF31E7E1
      Release status
      structured_record_current_label_not_confirmed
      Source IDH51-8F5937E2601C0758F85DF853
      Market status
      Status
      no_current_us_iv_spl_confirmed
      Source IDH51-239482CD84461BBC432B9647
      Basis
      No high-confidence current IV SPL was automatically selected; legacy information is segregated
      Source IDH51-9544BBAC2594BC732B7B3084
      Ten point assessment
      Exact formulation
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-D99A0BD19D049A166A76CF4F
      Reconstitution concentration
      Reconstitute 5 g vial with 200 mL NS; LR or D5W may be used if NS is unavailable per label. Rock or invert; do not shake. Same reconstitution method.
      Source IDH51-600CEA2D51177EC4F4F6457E
      Maximum or recommended final concentration
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-29FBB9061A5906489C15D591
      Appropriate standardized containers
      Approximately 200 mL Weight-based volume from reconstituted solution
      Source IDH51-BC4A4D6C5192781C2FC17071
      Adult dosing range
      5 g initial dose; second 5 g may be considered 70 mg/kg, maximum 5 g initial dose
      Source IDH51-D541112166CBF7080B968DBD
      Pediatric dosing range
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-A9AB649DF35893354C261D85
      Neonatal dosing range
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-C6347570AA40D588266BA660
      Infusion time
      Initial dose over 15 minutes; second dose over 15 minutes to 2 hours depending on condition Over 15 minutes
      Source IDH51-B0890B8D1393B8BCD0CDF877
      Fluid restriction alternatives
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-C52F9E3C5C3014984ED1A6F9
      Current manufacturer labeling
      Match confidence
      unresolved
      Source IDH51-2B1209892FABF9BB933888DC
      Field provenance
      Exact formulation
      Primary
      not_found
      Source IDH51-0330F631BF0B55D6A040DC8A
      Reconstitution concentration
      Primary
      existing_structured_record
      Source IDH51-19C602E5E7FB69955853924D
      Maximum or recommended final concentration
      Primary
      not_found
      Source IDH51-D6ABFA5928DB2CBDB6620F9A
      Appropriate standardized containers
      Primary
      existing_structured_record
      Source IDH51-99EE24149BF5C14C65777CA8
      Adult dosing range
      Primary
      existing_structured_record
      Source IDH51-EA1905797B1EC314039F386E
      Pediatric dosing range
      Primary
      not_found
      Source IDH51-A57B01DA679E994683E51F0F
      Neonatal dosing range
      Primary
      not_found
      Source IDH51-0EFBE556FB68058883391A73
      Infusion time
      Primary
      existing_structured_record
      Source IDH51-B081694043FB7BE0F0DF5B52
      Fluid restriction alternatives
      Primary
      not_found
      Source IDH51-596553D6CD7BA80EF06EEE37
      Current manufacturer labeling
      Primary
      DailyMed search gateway
      Source IDH51-144444BCF0A54A8F9B0D4C85
      Population applicability
      Adult
      Applicability
      supported_or_source_present
      Source IDH51-57ED374313E25A33A749531C
      Guide generation allowed
      true
      Source IDH51-9E0FF01C4CA34B2E07F98F7D
      Pediatric
      Applicability
      supported_or_source_present
      Source IDH51-8E2652E4B399E9194807714A
      Guide generation allowed
      false
      Source IDH51-1647B9D77CCFB89F5AF38ED2
      Neonatal
      Applicability
      not_established
      Source IDH51-68D5E2F337C9C1CF12092F71
      Guide generation allowed
      false
      Source IDH51-41FAC8D4AD8E479B3941D9EE
      Route presence
      Structured dilution
      true
      Source IDH51-3D6688C1BF63A779B8821A67
      Iv push
      false
      Source IDH51-8522387F3103515883BD6AC6
      Continuous infusion
      false
      Source IDH51-E3FA987ABC7DD36AA7F0E4EC
      Pediatric source
      true
      Source IDH51-8AAB7F93FA2532ADC7D43980
      Neonatal source
      false
      Source IDH51-E9B479D5728CD663BCDB1B29
      Legacy reference
      Status
      not_available
      Source IDH51-EAF652D1C8D24B876FD18758
      Label resolution
      Status
      build_environment_network_unavailable
      Source IDH51-52CB212D81CB3FC4C0EC43E2
      Source files
      1. catalog.json
        Source IDH51-A034474D6BDDC0E9C1A9F5BC
      2. dosing.json
        Source IDH51-C39135D41E4EFC3A3797B0BE
      3. new-in-v1.2.json
        Source IDH51-32E93DE809EC39E0548D4B5D
      Clinical release note
      Preparation instructions are released only at the evidence level shown. Legacy content remains visibly separate. Exact product, NDC, route, current labeling, and institutional policy must be confirmed.
      Source IDH51-48411E963CDCC52BF4AECE04
      Historical statement IDs and source locations

      These IDs identify recovered source units. They are not evidence-qualified clinical claims.

      Historical IDOriginal source locationStatus
      H51-1039A2F662D230CCB16FF5BCcatalog.json
      /records/126/id      		Historical; current review incomplete
      H51-3FA44CC8935AF24A54E9C3C7catalog.json
      /records/126/generic_name      		Historical; current review incomplete
      H51-83FA46E3808659CACE4C42C6catalog.json
      /records/126/brand_names/0      		Historical; current review incomplete
      H51-F5349006D6BC3587CE216F65catalog.json
      /records/126/class      		Historical; current review incomplete
      H51-4DD26BD218140A42058D3EBFcatalog.json
      /records/126/subclass      		Historical; current review incomplete
      H51-2782943A453DA8928FAD897Ecatalog.json
      /records/126/summary      		Historical; current review incomplete
      H51-76170CC518900D1A95605A9Dcatalog.json
      /records/126/common_uses/0      		Historical; current review incomplete
      H51-6CA4E0531F8E81A2DD136643catalog.json
      /records/126/preparations/0      		Historical; current review incomplete
      H51-1C73EF265E7BB9233535E9FEcatalog.json
      /records/126/preparations/0/population      		Historical; current review incomplete
      H51-76B6876DC6D8AF3BB59562D2catalog.json
      /records/126/preparations/0/amount      		Historical; current review incomplete
      H51-DF6025C5B35D2EB370FF2E87catalog.json
      /records/126/preparations/0/reconstitution      		Historical; current review incomplete
      H51-18EC85BEBD835BFA7BB2D2D8catalog.json
      /records/126/preparations/0/diluent      		Historical; current review incomplete
      H51-735A681665A2F730C35160ABcatalog.json
      /records/126/preparations/0/final_volume      		Historical; current review incomplete
      H51-6D74F4D830F5B418B4A9A944catalog.json
      /records/126/preparations/0/concentration      		Historical; current review incomplete
      H51-D4B3320226B3EBF8A51CBD4Ccatalog.json
      /records/126/preparations/0/rate      		Historical; current review incomplete
      H51-B054C1B401A44D9936979ABDcatalog.json
      /records/126/preparations/0/stability      		Historical; current review incomplete
      H51-A9CFE7CFCBD1580457715727catalog.json
      /records/126/preparations/0/notes      		Historical; current review incomplete
      H51-E43E0DC951C7D7AF8EB66D14catalog.json
      /records/126/preparations/1      		Historical; current review incomplete
      H51-569BE7D3F8EFEB0F5F1AB6A5catalog.json
      /records/126/preparations/1/population      		Historical; current review incomplete
      H51-6E0DC95976C580C5EF2FEC20catalog.json
      /records/126/preparations/1/amount      		Historical; current review incomplete
      H51-3EBF053EA18341723E915FF7catalog.json
      /records/126/preparations/1/reconstitution      		Historical; current review incomplete
      H51-44F7AF641F75A3DE8CB8375Ecatalog.json
      /records/126/preparations/1/diluent      		Historical; current review incomplete
      H51-34A0795CEF7112A5D20E4180catalog.json
      /records/126/preparations/1/final_volume      		Historical; current review incomplete
      H51-0CDCE63FCCEF1F5D7F9B32D0catalog.json
      /records/126/preparations/1/concentration      		Historical; current review incomplete
      H51-B69285FD0FC3A8CD0A791DF0catalog.json
      /records/126/preparations/1/rate      		Historical; current review incomplete
      H51-E43A51CF7A3F3B8E0979D426catalog.json
      /records/126/preparations/1/stability      		Historical; current review incomplete
      H51-FEF199E071DA012F8ABADFC0catalog.json
      /records/126/preparations/1/notes      		Historical; current review incomplete
      H51-11D8DAF4B58C39054ACEF2AFcatalog.json
      /records/126/warnings/0      		Historical; current review incomplete
      H51-47357D65C2BF69AD1BC6E902catalog.json
      /records/126/warnings/1      		Historical; current review incomplete
      H51-73AF45F808C6B50778A41BCFcatalog.json
      /records/126/monitoring/0      		Historical; current review incomplete
      H51-F276DBA268A877769D9ABB73catalog.json
      /records/126/monitoring/1      		Historical; current review incomplete
      H51-F67B04AC0FDD05ED99E63606catalog.json
      /records/126/monitoring/2      		Historical; current review incomplete
      H51-47BC0FC932C95B9027EFD7B3catalog.json
      /records/126/populations/0      		Historical; current review incomplete
      H51-8F3B18EC4C7B186F8B645847catalog.json
      /records/126/populations/1      		Historical; current review incomplete
      H51-3BF713D03E234466CE2BCEC5catalog.json
      /records/126/evidence_tier      		Historical; current review incomplete
      H51-7ED8EABBE9550704491BF00Acatalog.json
      /records/126/high_alert      		Historical; current review incomplete
      H51-56D3E8524853C8FD8216B7CBcatalog.json
      /records/126/hazardous      		Historical; current review incomplete
      H51-B3E520C30BE25F6905484E62catalog.json
      /records/126/status      		Historical; current review incomplete
      H51-2F48450347E73BE5F9A0176Ecatalog.json
      /records/126/reviewed      		Historical; current review incomplete
      H51-BFFD2A1C81B1F78399240CCBcatalog.json
      /records/126/version_added      		Historical; current review incomplete
      H51-37B7B0885F46B1C979F17CEEcatalog.json
      /records/126/sources/0      		Historical; current review incomplete
      H51-E68BC3FAF09E2BBCEFA3883Ccatalog.json
      /records/126/sources/0/label      		Historical; current review incomplete
      H51-F8727DED4992FC58CEDA9173catalog.json
      /records/126/sources/0/url      		Historical; current review incomplete
      H51-C2663CF6B67899D6A48227A0catalog.json
      /records/126/sources/0/kind      		Historical; current review incomplete
      H51-64A104DD954E08D24C198C44catalog.json
      /records/126/sources/1      		Historical; current review incomplete
      H51-1C1A3026BC42CD139D5C1DADcatalog.json
      /records/126/sources/1/label      		Historical; current review incomplete
      H51-D010A8CA4516BF83AE46A21Dcatalog.json
      /records/126/sources/1/url      		Historical; current review incomplete
      H51-17577F1553F08982FC220BE9catalog.json
      /records/126/sources/1/kind      		Historical; current review incomplete
      H51-CB66E94284D423F90FF85006catalog.json
      /records/126/legacy_title      		Historical; current review incomplete
      H51-C824448939A2D4C4C4FB4F24catalog.json
      /records/126/clinical_release_verification/audit_version      		Historical; current review incomplete
      H51-89189B139245F941F4175743catalog.json
      /records/126/clinical_release_verification/audited_on      		Historical; current review incomplete
      H51-0B26735FA6BAE595D0C3E5C9catalog.json
      /records/126/clinical_release_verification/level      		Historical; current review incomplete
      H51-7BF8EFA3780655128683734Ccatalog.json
      /records/126/clinical_release_verification/release_gate      		Historical; current review incomplete
      H51-BB246DBE1DE17B45FCC8AEA8catalog.json
      /records/126/clinical_release_verification/exact_current_label_candidate      		Historical; current review incomplete
      H51-C6F2EA54B2554CC691D6609Fcatalog.json
      /records/126/clinical_release_verification/selected_setid      		Historical; current review incomplete
      H51-FA1DC084DE8B84673E75D66Bcatalog.json
      /records/126/clinical_release_verification/selected_label_title      		Historical; current review incomplete
      H51-A030C0016FF87148DA07F1DAcatalog.json
      /records/126/clinical_release_verification/numeric_support_ratio      		Historical; current review incomplete
      H51-E934581CCA3B533A9D8175F0catalog.json
      /records/126/clinical_release_verification/reference_url_count      		Historical; current review incomplete
      H51-3C55F5CB3A61F671E7810F0Ccatalog.json
      /records/126/clinical_release_verification/broken_reference_count      		Historical; current review incomplete
      H51-7543BAB1AF025E247BF9A0B4catalog.json
      /records/126/clinical_release_verification/point_of_use_confirmation_required      		Historical; current review incomplete
      H51-33227280A54F8EE3427DB54Acatalog.json
      /records/126/clinical_release_verification/note      		Historical; current review incomplete
      H51-9D903F0908331664703521ABcatalog.json
      /records/126/clinical_release_verification/dailymed_search_url      		Historical; current review incomplete
      H51-10547EEF8E92C10D7D9676ABcatalog.json
      /records/126/version_updated      		Historical; current review incomplete
      H51-E52882CD5D2F6FB6A514C35Fdailymed-label-snapshots-v5.1.json
      /records/31/id      		Historical; current review incomplete
      H51-2991922AEA1C15FE63949B1Bdailymed-label-snapshots-v5.1.json
      /records/31/catalog_name      		Historical; current review incomplete
      H51-397AFE3AD54BDE12EACADE43dailymed-label-snapshots-v5.1.json
      /records/31/selection_status      		Historical; current review incomplete
      H51-719B92B6873C624E82B38486dailymed-label-snapshots-v5.1.json
      /records/31/confidence      		Historical; current review incomplete
      H51-B4A4C8C9D33F8809A5CD68B9dailymed-label-snapshots-v5.1.json
      /records/31/match_path      		Historical; current review incomplete
      H51-6527FAC8F36F9B3084C835E2dailymed-label-snapshots-v5.1.json
      /records/31/brand_name      		Historical; current review incomplete
      H51-035FA83DE95841C9201886B4dailymed-label-snapshots-v5.1.json
      /records/31/label_title      		Historical; current review incomplete
      H51-1FFA4C88909F97D735D0121Adailymed-label-snapshots-v5.1.json
      /records/31/setid      		Historical; current review incomplete
      H51-993243D067EAD90FFB45A5D4dailymed-label-snapshots-v5.1.json
      /records/31/route      		Historical; current review incomplete
      H51-54A317E74E0248F96CD033D0dailymed-label-snapshots-v5.1.json
      /records/31/dosage_form      		Historical; current review incomplete
      H51-DE5A895C92C31BB3EDABBA50dailymed-label-snapshots-v5.1.json
      /records/31/dosage_administration_summary/0      		Historical; current review incomplete
      H51-38A8ADB0C789110F80DD7FE2dailymed-label-snapshots-v5.1.json
      /records/31/dosage_administration_summary/1      		Historical; current review incomplete
      H51-A5BA860AA053FE5B8C270B1Cdailymed-label-snapshots-v5.1.json
      /records/31/dosage_administration_summary/2      		Historical; current review incomplete
      H51-2A787E4C220E966B3CA61047dailymed-label-snapshots-v5.1.json
      /records/31/dosage_forms_strengths/0      		Historical; current review incomplete
      H51-689630389331FB811ACC3BDDdailymed-label-snapshots-v5.1.json
      /records/31/dosage_forms_strengths/1      		Historical; current review incomplete
      H51-03A29140CF4C95FA37A9F0A0dailymed-label-snapshots-v5.1.json
      /records/31/mechanism_summary      		Historical; current review incomplete
      H51-E0BBF2770455A76F9BA417BCdailymed-label-snapshots-v5.1.json
      /records/31/scope_note      		Historical; current review incomplete
      H51-529AD267DDD8FD020445D8EDdailymed-label-snapshots-v5.1.json
      /records/31/labeler      		Historical; current review incomplete
      H51-AB994910FE152D6565C320FCdailymed-label-snapshots-v5.1.json
      /records/31/official_label_url      		Historical; current review incomplete
      H51-0B3F8C1A0DFC7F3D7FC3F688dailymed-label-snapshots-v5.1.json
      /records/31/reviewed_on      		Historical; current review incomplete
      H51-FEAADAF5ADC5976BB2A3CD3Fdailymed-label-snapshots-v5.1.json
      /records/31/mechanism_source      		Historical; current review incomplete
      H51-DB9F79029F4AF85A4CF3D3FFdailymed-label-snapshots-v5.1.json
      /records/31/source_sections/0      		Historical; current review incomplete
      H51-AEF0BE6E5E290EDAF470398Cdailymed-label-snapshots-v5.1.json
      /records/31/source_sections/1      		Historical; current review incomplete
      H51-54038362D9FA7AD16FA2ED64dailymed-label-snapshots-v5.1.json
      /records/31/source_sections/2      		Historical; current review incomplete
      H51-9D901E27AA9DB93A651A4BD0dailymed-label-snapshots-v5.1.json
      /records/31/retrieval_method      		Historical; current review incomplete
      H51-C7F28F101B2EBE3D3719C742dailymed-label-snapshots-v5.1.json
      /records/31/label_status      		Historical; current review incomplete
      H51-DC8EF03467613AC0CAF4B96Adailymed-label-snapshots-v5.1.json
      /records/31/disclaimer      		Historical; current review incomplete
      H51-4E1AE969D24C4A14E771D948dosing.json
      /records/126/id      		Historical; current review incomplete
      H51-05C46050ADD6B7FDA3554B45dosing.json
      /records/126/generic_name      		Historical; current review incomplete
      H51-5A10B3C5B9C08405CE698011dosing.json
      /records/126/coverage_status      		Historical; current review incomplete
      H51-B40B3923D4BB0F221F70167Fdosing.json
      /records/126/package_insert/query_name      		Historical; current review incomplete
      H51-4CD1A10FFCB6143C9B7C2CA3dosing.json
      /records/126/package_insert/preferred_setid      		Historical; current review incomplete
      H51-ABB0234FE16D624528F95D19dosing.json
      /records/126/package_insert/product_and_route_must_match      		Historical; current review incomplete
      H51-3BCD1B24C0A5461F8217AA40dosing.json
      /records/126/package_insert/live_current_label_enabled      		Historical; current review incomplete
      H51-E02E633C8ECEDC1BED4D3755dosing.json
      /records/126/package_insert/source_priority      		Historical; current review incomplete
      H51-371E9303E0E7A5FD8C7F7008dosing.json
      /records/126/package_insert/direct_official_label_access_enabled      		Historical; current review incomplete
      H51-FAF5525A23F272CC6BEE1A57dosing.json
      /records/126/package_insert/outbound_server_request_required      		Historical; current review incomplete
      H51-7B85F56EE1B8CD98FBDE4024dosing.json
      /records/126/package_insert/local_summary_status      		Historical; current review incomplete
      H51-0FF1E0C6637A911DC36A14D7dosing.json
      /records/126/renal/classification      		Historical; current review incomplete
      H51-90688FFDF2C8F98630DD42B9dosing.json
      /records/126/renal/summary      		Historical; current review incomplete
      H51-908BE65DD2FBD539A4BC5650dosing.json
      /records/126/renal/method_note      		Historical; current review incomplete
      H51-87170C648EC328393127EB21dosing.json
      /records/126/existing_route_snapshots/0      		Historical; current review incomplete
      H51-DFB11F15E98E473E670C1A3Ddosing.json
      /records/126/existing_route_snapshots/0/route      		Historical; current review incomplete
      H51-585B46CF7ADD0DB069FBEA1Bdosing.json
      /records/126/existing_route_snapshots/0/population      		Historical; current review incomplete
      H51-292733156EF9BA883CB9F382dosing.json
      /records/126/existing_route_snapshots/0/indication      		Historical; current review incomplete
      H51-582F4E91BDF7B74029EFEB5Fdosing.json
      /records/126/existing_route_snapshots/0/dose      		Historical; current review incomplete
      H51-62BFA07F6EE9D87F31AF38EDdosing.json
      /records/126/existing_route_snapshots/0/interval      		Historical; current review incomplete
      H51-EF8F03340A3EEBE1C4C74CAFdosing.json
      /records/126/existing_route_snapshots/0/duration      		Historical; current review incomplete
      H51-36FE09C2E20AA96731BCC863dosing.json
      /records/126/existing_route_snapshots/0/administration      		Historical; current review incomplete
      H51-528DD00873E1715BD12ACC78dosing.json
      /records/126/existing_route_snapshots/0/source_level      		Historical; current review incomplete
      H51-0E2A296962D5132CBACA7F5Ddosing.json
      /records/126/existing_route_snapshots/0/notes      		Historical; current review incomplete
      H51-25C221F1AD885B0FB06E18B2dosing.json
      /records/126/existing_route_snapshots/1      		Historical; current review incomplete
      H51-2DEAC4955BAF2E80C50DDE7Edosing.json
      /records/126/existing_route_snapshots/1/route      		Historical; current review incomplete
      H51-5A2E686188C4B05D7604C8D5dosing.json
      /records/126/existing_route_snapshots/1/population      		Historical; current review incomplete
      H51-2D085D3E6C42D3E7F0515447dosing.json
      /records/126/existing_route_snapshots/1/indication      		Historical; current review incomplete
      H51-B1652E8B2D35A780F28E032Adosing.json
      /records/126/existing_route_snapshots/1/dose      		Historical; current review incomplete
      H51-B9C34C71649D21CEC95A1D17dosing.json
      /records/126/existing_route_snapshots/1/interval      		Historical; current review incomplete
      H51-021D41D820D3F92534F9299Cdosing.json
      /records/126/existing_route_snapshots/1/duration      		Historical; current review incomplete
      H51-39EF433555B7D599500547F4dosing.json
      /records/126/existing_route_snapshots/1/administration      		Historical; current review incomplete
      H51-497C42979D24A62E473EE908dosing.json
      /records/126/existing_route_snapshots/1/source_level      		Historical; current review incomplete
      H51-C320BCAF059AE4B0C468142Fdosing.json
      /records/126/existing_route_snapshots/1/notes      		Historical; current review incomplete
      H51-74C7F5ED3D909979512DD5DDdosing.json
      /records/126/clinical_review/locally_normalized      		Historical; current review incomplete
      H51-ED77EA327A92300B58A5A93Adosing.json
      /records/126/clinical_review/reviewed      		Historical; current review incomplete
      H51-DC7AF32ACB34AFE357E85433dosing.json
      /records/126/clinical_review/status      		Historical; current review incomplete
      H51-4381B9D858B5D6080D3A0896dosing.json
      /records/126/clinical_release_verification/audit_version      		Historical; current review incomplete
      H51-D8787B2C64FB21D637B14AD0dosing.json
      /records/126/clinical_release_verification/audited_on      		Historical; current review incomplete
      H51-E1312B47ABF668382FAC121Ddosing.json
      /records/126/clinical_release_verification/level      		Historical; current review incomplete
      H51-F0007AACB2F5CAC9E2383CC0dosing.json
      /records/126/clinical_release_verification/release_gate      		Historical; current review incomplete
      H51-A514A07D39917D47CD3B410Bdosing.json
      /records/126/clinical_release_verification/exact_current_label_candidate      		Historical; current review incomplete
      H51-E421B087CE892443E6A7E1B8dosing.json
      /records/126/clinical_release_verification/selected_setid      		Historical; current review incomplete
      H51-99641F29B4FD6C3029A0A7DBdosing.json
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      H51-436C6D044FE26B8719D51EBDdosing.json
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      H51-A8C4BC988891AA0ED8F8079Adosing.json
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      H51-8683C0DDA740225AF4AFA72Edosing.json
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      H51-C5885F116F012F492C52AB5Ddosing.json
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      H51-56AF9EC70ECCAF8C598A3199dosing.json
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      H51-342C7F8ACD49D36266A17454dosing.json
      /records/126/clinical_release_verification/dailymed_search_url      		Historical; current review incomplete
      H51-BCE3FBF7538D92601E94EBD5first-look-v5.1.json
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      H51-519CE8312284EB2AF6228520first-look-v5.1.json
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      H51-C8969A51E64EC361EBE5196Apreparation-assessments-v3.8.json
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      H51-3D6688C1BF63A779B8821A67preparation-assessments-v3.8.json
      /126/route_presence/structured_dilution      		Historical; current review incomplete
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      /126/route_presence/iv_push      		Historical; current review incomplete
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      /126/route_presence/continuous_infusion      		Historical; current review incomplete
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      /126/route_presence/pediatric_source      		Historical; current review incomplete
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      /126/clinical_release_note      		Historical; current review incomplete
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