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Preparation. Administration. Evidence.

IV Dilution &
Medication Reference

Search 255 medications, read preserved historical references, and inspect separately reviewed preparation statements. Full monograph updates remain pending.

Version 6.4Release date 2026-11-04For healthcare professionals
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Medication reference

Cefepime-zidebactam

Monograph awaiting updateThis monograph will be updated in the future.

Jump to a section

No original site article was mapped to this record. The available historical structured fields and official-source links are retained.

Historical first look: uses, mechanism, dosing context, and administration

Recovered v5.1 source content; historical, awaiting current review.

Id
cefepime-zidebactam
Source IDH51-8B80C184978E7D72ECDDA402
Generic name
Cefepime-zidebactam
Source IDH51-1A1D9E6E7EEE1AC4F9FFDCAE
Class
Antibacterial
Source IDH51-75568DBA30D03E24F4266EB4
Subclass
Cephalosporin plus beta-lactam enhancer
Source IDH51-1798195B7B3318D7C27F2F46
Primary uses
  1. Complicated urinary tract infection including pyelonephritis in adults
    Source IDH51-FF3BD8E99E25C0A6C19C15A5
Mechanism
The beta-lactam component inhibits penicillin-binding proteins and cell-wall synthesis; its partner protects or enhances activity against selected resistance mechanisms.
Source IDH51-D425D6BCD9C88A90086D511B
Mechanism level
class_level
Source IDH51-51A911043FA776EEB1349DE8
Basic dosing orientation
Adult, eGFR 60 mL/min or greater | Existing preparation record; use current package insert for indication-specific selection | 3 g total every 8 hours | Not normalized in the preparation record | See current package insert and professional guidance | IV infusion
Source IDH51-87C6471609F8DCAD829D88DF
Administration orientation
Infuse over 1 hour
Source IDH51-B8ACB2F19CB916236D1A926C
Renal and population orientation
Separate renal reference: Open Renal Dosing Master (opens in a new tab)Renal dose adjustment or interval modification is commonly required; verify the selected product label and patient-specific renal method.
Source IDH51-C7EC726C44DDFB7520FE17BD
Key safety orientation
  1. Cefepime-associated neurotoxicity, especially with renal dysfunction.
    Source IDH51-D471D64EA008797A6346A202
  2. Serious beta-lactam hypersensitivity.
    Source IDH51-CA71756CC07EA832AD31855C
  3. No pediatric indication in the initial label.
    Source IDH51-EAC8B82C32F61BF410A02151
Coverage path
structured_local_snapshot
Source IDH51-9A0C1EA59B0E05DF2D8F9518
Coverage path label
Structured GlobalRPh route snapshot
Source IDH51-D70CCF67B32B1EC12D44C23A
Review note
First-look orientation only. Verify indication, patient population, weight basis, organ function, exact IV product, dose, concentration, compatibility, rate, and current labeling before use.
Source IDH51-775AE426DAC8FCE5FB1A12A4
Search text
Cefepime-zidebactam Antibacterial Cephalosporin plus beta-lactam enhancer Complicated urinary tract infection including pyelonephritis in adults The beta-lactam component inhibits penicillin-binding proteins and cell-wall synthesis; its partner protects or enhances activity against selected resistance mechanisms. Adult, eGFR 60 mL/min or greater | Existing preparation record; use current package insert for indication-specific selection | 3 g total every 8 hours | Not normalized in the preparation record | See current package insert and professional guidance | IV infusion Infuse over 1 hour Renal dose adjustment or interval modification is commonly required; verify the selected product label and patient-specific renal method. Cefepime-associated neurotoxicity, especially with renal dysfunction. Serious beta-lactam hypersensitivity. No pediatric indication in the initial label. Structured GlobalRPh route snapshot
Source IDH51-6DC6149E9B9174D54A730FF2
Official access mode
direct_label
Source IDH51-FC997A599898122112356500
Official access reason
A source-specific DailyMed label route is available.
Source IDH51-0C34F46BE473B062BD389B2E
Label snapshot available
true
Source IDH51-E7F2DA699A14162149C7D3C6
Label snapshot setid
c84e652e-5e76-4568-8812-bd5fa34803b6
Source IDH51-E2E4FA5211D711060D79A216
Product identifiers and clinical review status

This monograph will be updated in the future. Historical material is available where present in the original sources; full current exact-product and claim-level review remains pending.

Exact formulation, concentration, container, manufacturer, regulatory identifiers, and a reproducible label snapshot have not all been reconciled.

What remains to be completed
  • A retrieved source document is available; clinical reconciliation and a second-source claim map remain incomplete
  • Clinically reviewed, individually identified statements with two exact source mappings
  • Exact formulation, strength, container, manufacturer/labeler, application and NDC reconciliation
  • Renal-function methods and dialysis/CRRT modality review where applicable
  • Mechanism provenance, clinical source disagreements and full medication-specific safety reconciliation

Supplemental historical fields

Restored-data provenance and review notes

Source release: 2026-08-31. Current clinical review is incomplete. Original uses of current, verified, or normalized describe the historical source. They do not inherit the status of separately reviewed statements. Product formulations and source dates can differ.

Current review annotations for historical renal, dialysis, mechanism, and product fieldsSeparate renal reference: Open Renal Dosing Master (opens in a new tab)
Renal
Status
not_locally_normalized
Original classification
adjustment_required
Entries
    General note
    Preserve the source-specific renal-function basis. An indexed CrCl table is not interchangeable with unindexed CrCl or eGFR. Generic advice to check a method does not identify the equation for a dose row.
    Dialysis
    Status
    no_local_structured_regimen
    Entries
      General note
      Named modality alone does not establish applicability. CRRT subtype, effluent rate, residual renal function, timing and interruptions require review. Historical absence is not evidence that no guidance exists.
      Mechanisms
      • Source kind
        first_look
        Local pointer
        /mechanism
        Original level
        class_level
        Provenance classification
        historical_class_level
        Label derived verified
        false
        Independently corroborated
        false
        Exact label section
        Not recorded
        Original source note
        Not recorded
        Review status
        historical_unverified
        Note
        Drug-specific wording in the old file is not proof of independent corroboration or an exact label locator. Consult separately published current mechanism claims where present.
      • Source kind
        label_snapshot
        Local pointer
        /mechanism_summary
        Original level
        class_level
        Provenance classification
        historical_class_level
        Label derived verified
        false
        Independently corroborated
        false
        Exact label section
        Not recorded
        Original source note
        Concise GlobalRPh summary reviewed against the selected DailyMed label clinical-pharmacology or microbiology content.
        Review status
        historical_unverified
        Note
        Drug-specific wording in the old file is not proof of independent corroboration or an exact label locator. Consult separately published current mechanism claims where present.
      Future update
      Status
      pending_review
      Message
      This monograph will be updated in the future as current exact-product and claim-level review is completed.
      Source unavailable
      false
      Reason
      The historical content is restored; comprehensive contemporary verification remains incomplete.

      No separate structured rows were bundled for IV push, continuous infusion, dialysis, CRRT. Historical article content and source links may cover these topics.

      Historical dilution and intermittent infusion preparation

      Recovered v5.1 source content; historical, awaiting current review.

      Separate renal reference: Open Renal Dosing Master (opens in a new tab)
      PopulationAmountReconstitutionDiluentFinal volumeConcentrationRateStabilityNotes
      Source IDH51-6CB560ABDD0009451ECC29D3
      Adult, eGFR 60 mL/min or greater
      Source IDH51-95D348C5F804C0A7AFC4326C
      3 g total every 8 hours
      Source IDH51-20368A8222B2BEF03DF63F19
      Reconstitute one vial with 10 mL NS, D5W, LR, or Sterile Water for Injection to an approximate final vial volume of 13 mL and concentration of 240 mg/mL total product.
      Source IDH51-59240AE483339D803EF49367
      Use the matching 100 mL NS, D5W, or LR bag for final dilution
      Source IDH51-CE1F826AD94D495731A12F43
      Approximately 100 mL
      Source IDH51-0E9BFB090CE21DF97555044C
      Full vial dose in 100 mL
      Source IDH51-C72E7D17E0B1B287A60E7DE8
      Infuse over 1 hour
      Source IDH51-33D2CB4EAD6F6BAA8A09368F
      Reconstituted vial: up to 6 hours at 20 to 25 C or 12 hours refrigerated, protected from light. Final bag: up to 12 hours at 20 to 25 C or 24 hours refrigerated.
      Source IDH51-8D8FD0F35CEB841D5CD953A2
      The reconstituted solution is not for direct injection. Renal dose adjustment begins below eGFR 60 mL/min.
      Source IDH51-8626EEAC66DB9FC6C7E8E5F5

      Historical DailyMed label snapshot

      Recovered v5.1 source content; historical, awaiting current review.

      Id
      cefepime-zidebactam
      Source IDH51-3B7F9B959DC0E51E1FECBB90
      Catalog name
      Cefepime-zidebactam
      Source IDH51-5F8D6676378EB518FA93C539
      Selection status
      accepted_high_confidence
      Source IDH51-6D68B718D7049D800CDC46EA
      Confidence
      very_high
      Source IDH51-2AD40F1E8E09F450F0451DBE
      Match path
      verified_direct_label
      Source IDH51-53908BEE88601C5BFD7CD0B6
      Brand name
      ZAYNICH
      Source IDH51-B39C64C14C43DB058EABB2FA
      Label title
      ZAYNICH (cefepime and zidebactam) injection, powder, for solution
      Source IDH51-75EBE7ECD700CB99930AF004
      Setid
      c84e652e-5e76-4568-8812-bd5fa34803b6
      Source IDH51-31DCB312666ACAF9B75B5004
      Route
      Intermittent intravenous infusion
      Source IDH51-64C95F5FF5CA82F17CE92D4C
      Dosage form
      Combination powder for reconstitution and dilution
      Source IDH51-6343D45FD64EA255FA740535
      Dosage administration summary
      Separate renal reference: Open Renal Dosing Master (opens in a new tab)
      1. The labeled adult regimen uses 3 g, containing 2 g cefepime and 1 g zidebactam, every 8 hours infused over 1 hour in patients with qualifying renal function.
        Source IDH51-1CD841AF85CB115D860E415B
      2. Reconstitute the vial with a label-supported diluent and further dilute the withdrawn dose in the specified infusion volume.
        Source IDH51-A516655CD6F559D127C7D5EF
      3. Use the current renal adjustment table; dose and interval change substantially with kidney function.
        Source IDH51-BF589F593AB1B942295F22A8
      Dosage forms strengths
      1. 3 g single-dose vial containing 2 g cefepime and 1 g zidebactam
        Source IDH51-14630681A4B9956CABB63009
      Mechanism summary
      Cefepime inhibits bacterial cell-wall synthesis; zidebactam has beta-lactam-enhancer activity through PBP2 binding and also inhibits selected beta-lactamases.
      Source IDH51-3656D5AC79169AD23B17862C
      Scope note
      Selected ZAYNICH combination label. Do not apply to cefepime alone.
      Source IDH51-1355439F5CF3DD6CFE8580BE
      Reviewed on
      2026-08-31
      Source IDH51-31EE59BB09223E5CDFC375CD
      Mechanism source
      Concise GlobalRPh summary reviewed against the selected DailyMed label clinical-pharmacology or microbiology content.
      Source IDH51-45D71A75864E6089377937EE
      Source sections
      1. Dosage and Administration
        Source IDH51-0787A2895DDDA7932E1C0289
      2. Dosage Forms and Strengths
        Source IDH51-0F247486E66E9A185ADD16A6
      3. Clinical Pharmacology or Microbiology as applicable
        Source IDH51-7D61EB4258E675A04038FC99
      Retrieval method
      Manual build-time review of the current DailyMed full prescribing information for the selected Set ID; no live server retrieval is required during page use.
      Source IDH51-D7074FF8758495970E429295
      Label status
      current
      Source IDH51-246999D5318464C6D596B175
      Disclaimer
      Verify the exact formulation, strength, manufacturer, NDC, route, current label revision, patient-specific order, institutional policy, and monitoring before use.
      Source IDH51-27F54B74D46EDB44F37427FE

      Historical indication and population dosing

      Recovered tables and source-separated snapshots; full clinical revalidation remains pending.

      Existing dose and route snapshots

      Separate renal reference: Open Renal Dosing Master (opens in a new tab)
      RoutePopulationIndicationDoseIntervalDurationAdministrationSource levelNotes
      Source IDH51-AF45299B748B36CF4CC6A685
      IV infusion
      Source IDH51-9AA280CADD4311CDA7C67CBF
      Adult, eGFR 60 mL/min or greater
      Source IDH51-1ED8DBC478A3508FC4F6FD19
      Existing preparation record; use current package insert for indication-specific selection
      Source IDH51-1F0BD44BF2A38DE328E04045
      3 g total every 8 hours
      Source IDH51-2468A9887A6CC2F9BB79B396
      Not normalized in the preparation record
      Source IDH51-66252B4B8E6250EE57E6CEE1
      See current package insert and professional guidance
      Source IDH51-A025C6E7C0AA49CF3364F413
      Infuse over 1 hour
      Source IDH51-8C93589F85BE63DEAB21AB76
      Existing GlobalRPh structured preparation snapshot
      Source IDH51-01355E7A41B68EA2D5E8C44A
      The reconstituted solution is not for direct injection. Renal dose adjustment begins below eGFR 60 mL/min.
      Source IDH51-5A6D2FD6FA7C4A3CECB24195

      Historical renal-function guidance

      Recovered v5.1 source content; historical, awaiting current review.

      Separate renal reference: Open Renal Dosing Master (opens in a new tab)
      Classification
      adjustment_required
      Source IDH51-BBBE1A4F4E56386E0B10E7D7
      Summary
      Renal dose adjustment or interval modification is commonly required; verify the selected product label and patient-specific renal method.
      Source IDH51-B8A70657B62DA10A51B19B58
      Method note
      Use the renal function estimate and body-size convention specified by the selected label or institutional protocol. Do not interchange Cockcroft-Gault CrCl, indexed eGFR, and de-indexed eGFR without confirming the dosing source.
      Source IDH51-3A250AB27BFC49D16D80D33A

      Historical Common IV uses

      Recovered v5.1 source content; historical, awaiting current review.

      1. Complicated urinary tract infection including pyelonephritis in adults
        Source IDH51-C6A3CBEE4665F3D3F6973AD9

      Historical Warnings and safeguards

      Recovered v5.1 source content; historical, awaiting current review.

      Separate renal reference: Open Renal Dosing Master (opens in a new tab)
      1. Cefepime-associated neurotoxicity, especially with renal dysfunction.
        Source IDH51-56A8FE118FCA0F5161D1851E
      2. Serious beta-lactam hypersensitivity.
        Source IDH51-7F7846D00008768A9076D4A0
      3. No pediatric indication in the initial label.
        Source IDH51-0562E22DC6D669BCD31BA465

      Historical Monitoring

      Recovered v5.1 source content; historical, awaiting current review.

      Separate renal reference: Open Renal Dosing Master (opens in a new tab)
      1. Renal function
        Source IDH51-006E9BDA9EA15E3C5FF6094E
      2. Mental status and seizure activity
        Source IDH51-BC85D8F0A97C5ABEF961BB19
      3. Clinical response
        Source IDH51-E07E737B2431F7F844A102CF

      Historical supplemental professional sources

      Recovered v5.1 source content; historical, awaiting current review.

      LabelUrlKind
      Source IDH51-736824BDF3E7AB857BABCA52
      UCSF adult antimicrobial dosing, non-dialysis
      Source IDH51-3873F459BE1F85ED223C54B1
      https://idmp.ucsf.edu/adult-antimicrobial-dosing-non-dialysis (opens in a new tab)
      Source IDH51-0147B8AFA276F7ED2548BEF1
      Professional institutional guidance
      Source IDH51-EAC2B42425C59DF66E20C2FC
      Source IDH51-071798322EC73E8F5F9C2B4B
      UCSF antimicrobial dosing in intermittent and continuous hemodialysis
      Source IDH51-DD02EE708103E74DDD67C80B
      https://idmp.ucsf.edu/antimicrobial-dosing-intermittent-continuous-hemodialysis (opens in a new tab)
      Source IDH51-D28744146D545194866F4D01
      Professional institutional guidance
      Source IDH51-75053DC45766143226E8F690
      Source IDH51-FDF13C712622E84652173280
      UCSF pediatric antimicrobial dosing
      Source IDH51-0245B5115B645915065C153E
      https://idmp.ucsf.edu/pediatric-antimicrobial-dosing-benioff-childrens-hospitals (opens in a new tab)
      Source IDH51-AAFD0D7864959AD843EFF6A7
      Professional institutional guidance
      Source IDH51-970702575AA35929FD2B863A
      Source IDH51-B14048B0509DD9653CE24A1C
      UCSF neonatal antimicrobial dosing
      Source IDH51-456024B2B2C3A14AC3F277FD
      https://idmp.ucsf.edu/neonatal-antimicrobial-dosing-benioff-childrens-hospitals (opens in a new tab)
      Source IDH51-2A592E519BAE160B6AA233FA
      Professional institutional guidance
      Source IDH51-58D398882DDBE029875E7B0E
      Other recovered source fields and original editorial metadata

      Original status words such as current, verified, or normalized describe the historical source release. They do not change the clinical review status of this release.

      Catalog source fields

      Id
      cefepime-zidebactam
      Source IDH51-D1B8867A52F4ED1D6815FD6C
      Generic name
      Cefepime-zidebactam
      Source IDH51-A09078B6CEBD9008AE632684
      Brand names
      1. Zaynich
        Source IDH51-3DFBB4DAEBEF07A4BA4D1B0C
      Aliases
      1. cefepime zidebactam
        Source IDH51-4197EC61977AE6F8B77F3AB7
      Class
      Antibacterial
      Source IDH51-05BDB0FBEF43CA002F0E9BE8
      Subclass
      Cephalosporin plus beta-lactam enhancer
      Source IDH51-4BEFB002376A9412692575DA
      Summary
      New fixed-dose product containing cefepime 2 g plus zidebactam 1 g per vial for one-hour infusion.
      Source IDH51-C0D9C76BE3E80F56535478CF
      Populations
      1. Adult
        Source IDH51-A8BE7C9FE805BFF78D28C2BE
      Evidence tier
      Current-label candidate - verify exact product
      Source IDH51-19F3CE9793FB390610B8259D
      High alert
      false
      Source IDH51-64560163F230CDC33D985593
      Hazardous
      false
      Source IDH51-5A04B872BE0AB427BEF0365A
      Status
      Active
      Source IDH51-559EE7B9836078AEAD11F5BB
      Reviewed
      2026-08-29
      Source IDH51-C639EEDAE52538DE85FE142E
      Version added
      1.2
      Source IDH51-3DF9CEAB25BB77E289473F63
      Sources
      LabelUrlKind
      Source IDH51-66044FE9DA3EE809CEBCA4E8
      DailyMed ZAYNICH prescribing information
      Source IDH51-AA66B843137D5B7C9D37BA27
      https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c84e652e-5e76-4568-8812-bd5fa34803b6 (opens in a new tab)
      Source IDH51-EC8C6AC8859E8253397B9B3E
      Primary
      Source IDH51-75F0D393FD3C645D3603ECAD
      Source IDH51-21C93FBFD6A16094908C93EA
      GlobalRPh legacy IV dilution monograph
      Source IDH51-72D862AD7C1B39F73B9CB687
      legacy:auto
      Source IDH51-3DC6A340ABD489221247FC95
      Legacy
      Source IDH51-8A63885598316D2C2697D888
      Clinical release verification
      Audit version
      3.4
      Source IDH51-90C38B8E29804949D15C9459
      Audited on
      2026-08-30
      Source IDH51-6D4EAFCCE695183CA1908A64
      Level
      amber
      Source IDH51-AF8C4B3C05AA0E2F4C27BBBE
      Release gate
      trusted_professional_source_present_exact_label_unconfirmed
      Source IDH51-14521A77EF6D2CD51A65DB88
      Exact current label candidate
      false
      Source IDH51-7D624703DF2060AB641B405B
      Selected setid
      c84e652e-5e76-4568-8812-bd5fa34803b6
      Source IDH51-DD061EFCC39A2929DF8F009D
      Numeric support ratio
      0
      Source IDH51-48742F57116E7D29C0243749
      Reference url count
      5
      Source IDH51-3CB19C8C163A23DA8B4A1AC0
      Broken reference count
      0
      Source IDH51-2863FCCD4D8830D1454D2E7C
      Point of use confirmation required
      true
      Source IDH51-728D3083AD21118377F10563
      Note
      Do not treat this record as a fully current product-specific monograph until the exact IV formulation and current sources are confirmed.
      Source IDH51-E9B11B847369FD60BEA74B6B

      Dosing source fields

      Id
      cefepime-zidebactam
      Source IDH51-0F931C20AB402913DE9C5ACB
      Generic name
      Cefepime-zidebactam
      Source IDH51-CCA33B8931CDA5483444522C
      Coverage status
      direct_official_label_access_plus_local_snapshot
      Source IDH51-F48307D1195DF2C2D335B073
      Package insert
      Query name
      Cefepime-zidebactam
      Source IDH51-890EEC086487E4158A55CFB4
      Preferred setid
      c84e652e-5e76-4568-8812-bd5fa34803b6
      Source IDH51-E777FE18237F75453C58BCF0
      Product and route must match
      true
      Source IDH51-49AEAB48E3FC150723AC3F29
      Live current label enabled
      false
      Source IDH51-83097ABD424C6F700C64B05C
      Source priority
      Reviewed local summary when available, then a verified DailyMed label or product search when available, followed by professional references and institutional policy.
      Source IDH51-092B35A46E142A68C1DED44C
      Direct official label access enabled
      true
      Source IDH51-84CEDE2A3AABEBF23CAFBA30
      Outbound server request required
      false
      Source IDH51-9C03C31F3AD030F1BCA4ADC5
      Local summary status
      not_bundled
      Source IDH51-D683A87C5C120B1DFD15110E
      Clinical review
      Locally normalized
      false
      Source IDH51-FFA68ADC2EBEC4CF06B5E8B0
      Reviewed
      2026-08-29
      Source IDH51-75EF0D54B69971017BB1C94F
      Status
      Direct official package-insert access enabled; indication-specific local normalization pending.
      Source IDH51-069E2E2FED129B54843CFAE1
      Clinical release verification
      Audit version
      3.4
      Source IDH51-12173C2A2CF224166332490A
      Audited on
      2026-08-30
      Source IDH51-CE7BB5AD6AE8C4F09A039115
      Level
      amber
      Source IDH51-50430E100CFDDE57C32517E2
      Release gate
      trusted_professional_source_present_exact_label_unconfirmed
      Source IDH51-996BF6D675006706C9D18A36
      Exact current label candidate
      false
      Source IDH51-793BD4C0DF412EA5CFFE4C54
      Selected setid
      c84e652e-5e76-4568-8812-bd5fa34803b6
      Source IDH51-ACF74A11A7C43ECBA37B1FCC
      Numeric support ratio
      0
      Source IDH51-022A0032F12859F05968C573
      Reference url count
      5
      Source IDH51-0A2ADD714DBB9267EF471257
      Broken reference count
      0
      Source IDH51-92CCDD3D1987566786DF4C22
      Point of use confirmation required
      true
      Source IDH51-77C4BE37DA08B8F4BC690F61
      Note
      Do not treat this record as a fully current product-specific monograph until the exact IV formulation and current sources are confirmed.
      Source IDH51-4E3E3D54CBB838E00CB0DA63
      Historical preparation assessment

      Recovered v5.1 source content; historical, awaiting current review.

      Id
      cefepime-zidebactam
      Source IDH51-E78ABB9B6516FEF30714C26B
      Name
      Cefepime-zidebactam
      Source IDH51-BB3CC2DBEE015799C683BF9B
      Brands
      Zaynich
      Source IDH51-1868B4531A196B97ED67E809
      Therapeutic class
      Antibacterial
      Source IDH51-14753EE2A76EB29D64175D00
      Review version
      3.1
      Source IDH51-D751C26E5ACD89B3A3D6F92A
      Review date
      2026-08-30
      Source IDH51-D7F0917CCF388B85646BE9C4
      Release status
      structured_record_current_label_not_confirmed
      Source IDH51-73A4A9A6D00EB839403A36D5
      Market status
      Status
      no_current_us_iv_spl_confirmed
      Source IDH51-A281E41C73EE1DF69670BC03
      Basis
      No high-confidence current IV SPL was automatically selected; legacy information is segregated
      Source IDH51-269DEE0A7CFBC045C7E2A03B
      Ten point assessment
      Exact formulation
      Separate renal reference: Open Renal Dosing Master (opens in a new tab)Do not interchange Cockcroft-Gault CrCl, indexed eGFR, and de-indexed eGFR without confirming the dosing source. | existing_route_snapshots: route: IV infusion | population: Adult, eGFR 60 mL/min or greater | indication: Existing preparation record; use current package insert for indication-specific selection | dose: 3 g total every 8 hours | interval: Not normalized in the preparation record | duration: See current package insert and professional guidance | administration: Infuse over 1 hour | source_level: Existing GlobalRPh structured preparation snapshot | notes: The reconstituted solution is not for direct injection. Final bag: up to 12 hours at 20 to 25 C or 24 hours refrigerated. | notes: The reconstituted solution is not for direct injection.
      Source IDH51-AAEB58A0F4E9920FA5EC9F53
      Reconstitution concentration
      Reconstitute one vial with 10 mL NS, D5W, LR, or Sterile Water for Injection to an approximate final vial volume of 13 mL and concentration of 240 mg/mL total product.
      Source IDH51-A5369C204281B3585BB8A43A
      Maximum or recommended final concentration
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-EED379F7AF778C210F2B1ED5
      Appropriate standardized containers
      Approximately 100 mL
      Source IDH51-E43050AD9E3F41F3822C2ED1
      Adult dosing range
      3 g total every 8 hours
      Source IDH51-2D9C5C6C4CE9C7287F6FF006
      Pediatric dosing range
      Separate renal reference: Open Renal Dosing Master (opens in a new tab)Renal dose adjustment begins below eGFR 60 mL/min. | warnings: Cefepime-associated neurotoxicity, especially with renal dysfunction. | Serious beta-lactam hypersensitivity. | No pediatric indication in the initial label. | monitoring: Renal function | Mental status and seizure activity | Clinical response | populations: Adult | evidence_tier: Current FDA label normalized | high_alert: false | hazardous: false | status: Active | reviewed: 2026-08-29 | version_added: 1.2 | sources: label: DailyMed ZAYNICH prescribing information | url: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c84e652e-5e76-4568-8812-bd5fa34803b6 | kind: Primary | label: GlobalRPh legacy IV dilution monograph | url: legacy:auto | kind: Legacy
      Source IDH51-FD8AD481CB0CA8D2FD40801D
      Neonatal dosing range
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-51164C7681774EBECCF4FD5F
      Infusion time
      Infuse over 1 hour
      Source IDH51-26438917A5222AC452007249
      Fluid restriction alternatives
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-A853FACFF4CCE8666F587884
      Current manufacturer labeling
      Setid
      c84e652e-5e76-4568-8812-bd5fa34803b6
      Source IDH51-21F7106EFE1196B5893E6CD7
      Match confidence
      unresolved
      Source IDH51-F25E312EA7F7696C495ECB54
      Field provenance
      Exact formulation
      Primary
      existing_record_text
      Source IDH51-0D05990754AEF16CBE7E30A2
      Reconstitution concentration
      Primary
      existing_structured_record
      Source IDH51-B6F960A6005961643B82C0D8
      Maximum or recommended final concentration
      Primary
      not_found
      Source IDH51-9E417681130144B2345747CD
      Appropriate standardized containers
      Primary
      existing_structured_record
      Source IDH51-6758A7DA2358860B383C25FD
      Adult dosing range
      Primary
      existing_structured_record
      Source IDH51-9CBB22BA644931CE7590854D
      Pediatric dosing range
      Primary
      existing_record_text
      Source IDH51-F9A0AB27A98AE4DEC68DAEFC
      Neonatal dosing range
      Primary
      not_found
      Source IDH51-CAA65A31AC54E9DCDF6756DA
      Infusion time
      Primary
      existing_structured_record
      Source IDH51-DD3AA1C51D9997441AD3E8F7
      Fluid restriction alternatives
      Primary
      not_found
      Source IDH51-8D4EBEAAF1247F90D45C393D
      Current manufacturer labeling
      Primary
      DailyMed current-label gateway
      Source IDH51-365AFDAE2EA4A176029C5A7C
      Population applicability
      Adult
      Applicability
      supported_or_source_present
      Source IDH51-AA8C07AE180660BDAA56B2C6
      Guide generation allowed
      true
      Source IDH51-3D141D9B9DE8FB611B5F32D6
      Pediatric
      Applicability
      supported_or_source_present
      Source IDH51-D2EEC2D19A4445262916D3E3
      Guide generation allowed
      false
      Source IDH51-3E61E040163CC3DF1CA06BF4
      Neonatal
      Applicability
      supported_or_source_present
      Source IDH51-358939AD167F698E727F336A
      Guide generation allowed
      false
      Source IDH51-379E43189E5CF2C9A409CB52
      Route presence
      Structured dilution
      true
      Source IDH51-3723291DB7905B3BA409086D
      Iv push
      false
      Source IDH51-CC07D46DEFB503EF34FAC75D
      Continuous infusion
      false
      Source IDH51-02C22CE1AD316E96A02C74B6
      Pediatric source
      true
      Source IDH51-2683E475F6F016C2A1CB6649
      Neonatal source
      true
      Source IDH51-00D76403421A84D229AD41E9
      Legacy reference
      Status
      not_available
      Source IDH51-3FC0509C41E6165657714ED6
      Label resolution
      Status
      build_environment_network_unavailable
      Source IDH51-D306D8E5DD860332985D3750
      Existing setids
      1. c84e652e-5e76-4568-8812-bd5fa34803b6
        Source IDH51-0A6C8D072293BD390A8F918F
      Source files
      1. catalog.json
        Source IDH51-AAF3AEDFE620234788A21CE9
      2. dosing.json
        Source IDH51-16B385FE7084C62A33CC11A7
      3. new-in-v1.2.json
        Source IDH51-EC474CA51CB8F41B353E2676
      Clinical release note
      Preparation instructions are released only at the evidence level shown. Legacy content remains visibly separate. Exact product, NDC, route, current labeling, and institutional policy must be confirmed.
      Source IDH51-0D040999247DB51CDD2A1F4C
      Historical statement IDs and source locations

      These IDs identify recovered source units. They are not evidence-qualified clinical claims.

      Historical IDOriginal source locationStatus
      H51-D1B8867A52F4ED1D6815FD6Ccatalog.json
      /records/45/id
      Historical; current review incomplete
      H51-A09078B6CEBD9008AE632684catalog.json
      /records/45/generic_name
      Historical; current review incomplete
      H51-3DFBB4DAEBEF07A4BA4D1B0Ccatalog.json
      /records/45/brand_names/0
      Historical; current review incomplete
      H51-4197EC61977AE6F8B77F3AB7catalog.json
      /records/45/aliases/0
      Historical; current review incomplete
      H51-05BDB0FBEF43CA002F0E9BE8catalog.json
      /records/45/class
      Historical; current review incomplete
      H51-4BEFB002376A9412692575DAcatalog.json
      /records/45/subclass
      Historical; current review incomplete
      H51-C0D9C76BE3E80F56535478CFcatalog.json
      /records/45/summary
      Historical; current review incomplete
      H51-C6A3CBEE4665F3D3F6973AD9catalog.json
      /records/45/common_uses/0
      Historical; current review incomplete
      H51-6CB560ABDD0009451ECC29D3catalog.json
      /records/45/preparations/0
      Historical; current review incomplete
      H51-95D348C5F804C0A7AFC4326Ccatalog.json
      /records/45/preparations/0/population
      Historical; current review incomplete
      H51-20368A8222B2BEF03DF63F19catalog.json
      /records/45/preparations/0/amount
      Historical; current review incomplete
      H51-59240AE483339D803EF49367catalog.json
      /records/45/preparations/0/reconstitution
      Historical; current review incomplete
      H51-CE1F826AD94D495731A12F43catalog.json
      /records/45/preparations/0/diluent
      Historical; current review incomplete
      H51-0E9BFB090CE21DF97555044Ccatalog.json
      /records/45/preparations/0/final_volume
      Historical; current review incomplete
      H51-C72E7D17E0B1B287A60E7DE8catalog.json
      /records/45/preparations/0/concentration
      Historical; current review incomplete
      H51-33D2CB4EAD6F6BAA8A09368Fcatalog.json
      /records/45/preparations/0/rate
      Historical; current review incomplete
      H51-8D8FD0F35CEB841D5CD953A2catalog.json
      /records/45/preparations/0/stability
      Historical; current review incomplete
      H51-8626EEAC66DB9FC6C7E8E5F5catalog.json
      /records/45/preparations/0/notes
      Historical; current review incomplete
      H51-56A8FE118FCA0F5161D1851Ecatalog.json
      /records/45/warnings/0
      Historical; current review incomplete
      H51-7F7846D00008768A9076D4A0catalog.json
      /records/45/warnings/1
      Historical; current review incomplete
      H51-0562E22DC6D669BCD31BA465catalog.json
      /records/45/warnings/2
      Historical; current review incomplete
      H51-006E9BDA9EA15E3C5FF6094Ecatalog.json
      /records/45/monitoring/0
      Historical; current review incomplete
      H51-BC85D8F0A97C5ABEF961BB19catalog.json
      /records/45/monitoring/1
      Historical; current review incomplete
      H51-E07E737B2431F7F844A102CFcatalog.json
      /records/45/monitoring/2
      Historical; current review incomplete
      H51-A8BE7C9FE805BFF78D28C2BEcatalog.json
      /records/45/populations/0
      Historical; current review incomplete
      H51-19F3CE9793FB390610B8259Dcatalog.json
      /records/45/evidence_tier
      Historical; current review incomplete
      H51-64560163F230CDC33D985593catalog.json
      /records/45/high_alert
      Historical; current review incomplete
      H51-5A04B872BE0AB427BEF0365Acatalog.json
      /records/45/hazardous
      Historical; current review incomplete
      H51-559EE7B9836078AEAD11F5BBcatalog.json
      /records/45/status
      Historical; current review incomplete
      H51-C639EEDAE52538DE85FE142Ecatalog.json
      /records/45/reviewed
      Historical; current review incomplete
      H51-3DF9CEAB25BB77E289473F63catalog.json
      /records/45/version_added
      Historical; current review incomplete
      H51-66044FE9DA3EE809CEBCA4E8catalog.json
      /records/45/sources/0
      Historical; current review incomplete
      H51-AA66B843137D5B7C9D37BA27catalog.json
      /records/45/sources/0/label
      Historical; current review incomplete
      H51-EC8C6AC8859E8253397B9B3Ecatalog.json
      /records/45/sources/0/url
      Historical; current review incomplete
      H51-75F0D393FD3C645D3603ECADcatalog.json
      /records/45/sources/0/kind
      Historical; current review incomplete
      H51-21C93FBFD6A16094908C93EAcatalog.json
      /records/45/sources/1
      Historical; current review incomplete
      H51-72D862AD7C1B39F73B9CB687catalog.json
      /records/45/sources/1/label
      Historical; current review incomplete
      H51-3DC6A340ABD489221247FC95catalog.json
      /records/45/sources/1/url
      Historical; current review incomplete
      H51-8A63885598316D2C2697D888catalog.json
      /records/45/sources/1/kind
      Historical; current review incomplete
      H51-FC89B67D532A76AE19489B13catalog.json
      /records/45/legacy_title
      Historical; current review incomplete
      H51-90C38B8E29804949D15C9459catalog.json
      /records/45/clinical_release_verification/audit_version
      Historical; current review incomplete
      H51-6D4EAFCCE695183CA1908A64catalog.json
      /records/45/clinical_release_verification/audited_on
      Historical; current review incomplete
      H51-AF8C4B3C05AA0E2F4C27BBBEcatalog.json
      /records/45/clinical_release_verification/level
      Historical; current review incomplete
      H51-14521A77EF6D2CD51A65DB88catalog.json
      /records/45/clinical_release_verification/release_gate
      Historical; current review incomplete
      H51-7D624703DF2060AB641B405Bcatalog.json
      /records/45/clinical_release_verification/exact_current_label_candidate
      Historical; current review incomplete
      H51-DD061EFCC39A2929DF8F009Dcatalog.json
      /records/45/clinical_release_verification/selected_setid
      Historical; current review incomplete
      H51-41ABD90C5033F1DB89148416catalog.json
      /records/45/clinical_release_verification/selected_label_title
      Historical; current review incomplete
      H51-48742F57116E7D29C0243749catalog.json
      /records/45/clinical_release_verification/numeric_support_ratio
      Historical; current review incomplete
      H51-3CB19C8C163A23DA8B4A1AC0catalog.json
      /records/45/clinical_release_verification/reference_url_count
      Historical; current review incomplete
      H51-2863FCCD4D8830D1454D2E7Ccatalog.json
      /records/45/clinical_release_verification/broken_reference_count
      Historical; current review incomplete
      H51-728D3083AD21118377F10563catalog.json
      /records/45/clinical_release_verification/point_of_use_confirmation_required
      Historical; current review incomplete
      H51-E9B11B847369FD60BEA74B6Bcatalog.json
      /records/45/clinical_release_verification/note
      Historical; current review incomplete
      H51-6412167C4FCCEB3A433A5F9Ccatalog.json
      /records/45/clinical_release_verification/dailymed_search_url
      Historical; current review incomplete
      H51-3B7F9B959DC0E51E1FECBB90dailymed-label-snapshots-v5.1.json
      /records/12/id
      Historical; current review incomplete
      H51-5F8D6676378EB518FA93C539dailymed-label-snapshots-v5.1.json
      /records/12/catalog_name
      Historical; current review incomplete
      H51-6D68B718D7049D800CDC46EAdailymed-label-snapshots-v5.1.json
      /records/12/selection_status
      Historical; current review incomplete
      H51-2AD40F1E8E09F450F0451DBEdailymed-label-snapshots-v5.1.json
      /records/12/confidence
      Historical; current review incomplete
      H51-53908BEE88601C5BFD7CD0B6dailymed-label-snapshots-v5.1.json
      /records/12/match_path
      Historical; current review incomplete
      H51-B39C64C14C43DB058EABB2FAdailymed-label-snapshots-v5.1.json
      /records/12/brand_name
      Historical; current review incomplete
      H51-75EBE7ECD700CB99930AF004dailymed-label-snapshots-v5.1.json
      /records/12/label_title
      Historical; current review incomplete
      H51-31DCB312666ACAF9B75B5004dailymed-label-snapshots-v5.1.json
      /records/12/setid
      Historical; current review incomplete
      H51-64C95F5FF5CA82F17CE92D4Cdailymed-label-snapshots-v5.1.json
      /records/12/route
      Historical; current review incomplete
      H51-6343D45FD64EA255FA740535dailymed-label-snapshots-v5.1.json
      /records/12/dosage_form
      Historical; current review incomplete
      H51-1CD841AF85CB115D860E415Bdailymed-label-snapshots-v5.1.json
      /records/12/dosage_administration_summary/0
      Historical; current review incomplete
      H51-A516655CD6F559D127C7D5EFdailymed-label-snapshots-v5.1.json
      /records/12/dosage_administration_summary/1
      Historical; current review incomplete
      H51-BF589F593AB1B942295F22A8dailymed-label-snapshots-v5.1.json
      /records/12/dosage_administration_summary/2
      Historical; current review incomplete
      H51-14630681A4B9956CABB63009dailymed-label-snapshots-v5.1.json
      /records/12/dosage_forms_strengths/0
      Historical; current review incomplete
      H51-3656D5AC79169AD23B17862Cdailymed-label-snapshots-v5.1.json
      /records/12/mechanism_summary
      Historical; current review incomplete
      H51-1355439F5CF3DD6CFE8580BEdailymed-label-snapshots-v5.1.json
      /records/12/scope_note
      Historical; current review incomplete
      H51-E6439892F25B720639EAAB57dailymed-label-snapshots-v5.1.json
      /records/12/labeler
      Historical; current review incomplete
      H51-685FC1FFFC8F2D663CD48CA4dailymed-label-snapshots-v5.1.json
      /records/12/official_label_url
      Historical; current review incomplete
      H51-31EE59BB09223E5CDFC375CDdailymed-label-snapshots-v5.1.json
      /records/12/reviewed_on
      Historical; current review incomplete
      H51-45D71A75864E6089377937EEdailymed-label-snapshots-v5.1.json
      /records/12/mechanism_source
      Historical; current review incomplete
      H51-0787A2895DDDA7932E1C0289dailymed-label-snapshots-v5.1.json
      /records/12/source_sections/0
      Historical; current review incomplete
      H51-0F247486E66E9A185ADD16A6dailymed-label-snapshots-v5.1.json
      /records/12/source_sections/1
      Historical; current review incomplete
      H51-7D61EB4258E675A04038FC99dailymed-label-snapshots-v5.1.json
      /records/12/source_sections/2
      Historical; current review incomplete
      H51-D7074FF8758495970E429295dailymed-label-snapshots-v5.1.json
      /records/12/retrieval_method
      Historical; current review incomplete
      H51-246999D5318464C6D596B175dailymed-label-snapshots-v5.1.json
      /records/12/label_status
      Historical; current review incomplete
      H51-27F54B74D46EDB44F37427FEdailymed-label-snapshots-v5.1.json
      /records/12/disclaimer
      Historical; current review incomplete
      H51-0F931C20AB402913DE9C5ACBdosing.json
      /records/45/id
      Historical; current review incomplete
      H51-CCA33B8931CDA5483444522Cdosing.json
      /records/45/generic_name
      Historical; current review incomplete
      H51-F48307D1195DF2C2D335B073dosing.json
      /records/45/coverage_status
      Historical; current review incomplete
      H51-890EEC086487E4158A55CFB4dosing.json
      /records/45/package_insert/query_name
      Historical; current review incomplete
      H51-E777FE18237F75453C58BCF0dosing.json
      /records/45/package_insert/preferred_setid
      Historical; current review incomplete
      H51-49AEAB48E3FC150723AC3F29dosing.json
      /records/45/package_insert/product_and_route_must_match
      Historical; current review incomplete
      H51-83097ABD424C6F700C64B05Cdosing.json
      /records/45/package_insert/live_current_label_enabled
      Historical; current review incomplete
      H51-092B35A46E142A68C1DED44Cdosing.json
      /records/45/package_insert/source_priority
      Historical; current review incomplete
      H51-84CEDE2A3AABEBF23CAFBA30dosing.json
      /records/45/package_insert/direct_official_label_access_enabled
      Historical; current review incomplete
      H51-9C03C31F3AD030F1BCA4ADC5dosing.json
      /records/45/package_insert/outbound_server_request_required
      Historical; current review incomplete
      H51-D683A87C5C120B1DFD15110Edosing.json
      /records/45/package_insert/local_summary_status
      Historical; current review incomplete
      H51-BBBE1A4F4E56386E0B10E7D7dosing.json
      /records/45/renal/classification
      Historical; current review incomplete
      H51-B8A70657B62DA10A51B19B58dosing.json
      /records/45/renal/summary
      Historical; current review incomplete
      H51-3A250AB27BFC49D16D80D33Adosing.json
      /records/45/renal/method_note
      Historical; current review incomplete
      H51-AF45299B748B36CF4CC6A685dosing.json
      /records/45/existing_route_snapshots/0
      Historical; current review incomplete
      H51-9AA280CADD4311CDA7C67CBFdosing.json
      /records/45/existing_route_snapshots/0/route
      Historical; current review incomplete
      H51-1ED8DBC478A3508FC4F6FD19dosing.json
      /records/45/existing_route_snapshots/0/population
      Historical; current review incomplete
      H51-1F0BD44BF2A38DE328E04045dosing.json
      /records/45/existing_route_snapshots/0/indication
      Historical; current review incomplete
      H51-2468A9887A6CC2F9BB79B396dosing.json
      /records/45/existing_route_snapshots/0/dose
      Historical; current review incomplete
      H51-66252B4B8E6250EE57E6CEE1dosing.json
      /records/45/existing_route_snapshots/0/interval
      Historical; current review incomplete
      H51-A025C6E7C0AA49CF3364F413dosing.json
      /records/45/existing_route_snapshots/0/duration
      Historical; current review incomplete
      H51-8C93589F85BE63DEAB21AB76dosing.json
      /records/45/existing_route_snapshots/0/administration
      Historical; current review incomplete
      H51-01355E7A41B68EA2D5E8C44Adosing.json
      /records/45/existing_route_snapshots/0/source_level
      Historical; current review incomplete
      H51-5A6D2FD6FA7C4A3CECB24195dosing.json
      /records/45/existing_route_snapshots/0/notes
      Historical; current review incomplete
      H51-736824BDF3E7AB857BABCA52dosing.json
      /records/45/professional_sources/0
      Historical; current review incomplete
      H51-3873F459BE1F85ED223C54B1dosing.json
      /records/45/professional_sources/0/label
      Historical; current review incomplete
      H51-0147B8AFA276F7ED2548BEF1dosing.json
      /records/45/professional_sources/0/url
      Historical; current review incomplete
      H51-EAC2B42425C59DF66E20C2FCdosing.json
      /records/45/professional_sources/0/kind
      Historical; current review incomplete
      H51-071798322EC73E8F5F9C2B4Bdosing.json
      /records/45/professional_sources/1
      Historical; current review incomplete
      H51-DD02EE708103E74DDD67C80Bdosing.json
      /records/45/professional_sources/1/label
      Historical; current review incomplete
      H51-D28744146D545194866F4D01dosing.json
      /records/45/professional_sources/1/url
      Historical; current review incomplete
      H51-75053DC45766143226E8F690dosing.json
      /records/45/professional_sources/1/kind
      Historical; current review incomplete
      H51-FDF13C712622E84652173280dosing.json
      /records/45/professional_sources/2
      Historical; current review incomplete
      H51-0245B5115B645915065C153Edosing.json
      /records/45/professional_sources/2/label
      Historical; current review incomplete
      H51-AAFD0D7864959AD843EFF6A7dosing.json
      /records/45/professional_sources/2/url
      Historical; current review incomplete
      H51-970702575AA35929FD2B863Adosing.json
      /records/45/professional_sources/2/kind
      Historical; current review incomplete
      H51-B14048B0509DD9653CE24A1Cdosing.json
      /records/45/professional_sources/3
      Historical; current review incomplete
      H51-456024B2B2C3A14AC3F277FDdosing.json
      /records/45/professional_sources/3/label
      Historical; current review incomplete
      H51-2A592E519BAE160B6AA233FAdosing.json
      /records/45/professional_sources/3/url
      Historical; current review incomplete
      H51-58D398882DDBE029875E7B0Edosing.json
      /records/45/professional_sources/3/kind
      Historical; current review incomplete
      H51-FFA68ADC2EBEC4CF06B5E8B0dosing.json
      /records/45/clinical_review/locally_normalized
      Historical; current review incomplete
      H51-75EF0D54B69971017BB1C94Fdosing.json
      /records/45/clinical_review/reviewed
      Historical; current review incomplete
      H51-069E2E2FED129B54843CFAE1dosing.json
      /records/45/clinical_review/status
      Historical; current review incomplete
      H51-12173C2A2CF224166332490Adosing.json
      /records/45/clinical_release_verification/audit_version
      Historical; current review incomplete
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