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Preparation. Administration. Evidence.

IV Dilution &
Medication Reference

Search 255 medications, read preserved historical references, and inspect separately reviewed preparation statements. Full monograph updates remain pending.

Version 6.4Release date 2026-11-04For healthcare professionals
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Medication reference

Cefepime-enmetazobactam

Monograph awaiting updateThis monograph will be updated in the future.

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No original site article was mapped to this record. The available historical structured fields and official-source links are retained.

Historical first look: uses, mechanism, dosing context, and administration

Recovered v5.1 source content; historical, awaiting current review.

Id
cefepime-enmetazobactam
Source IDH51-AE8233083D1A0473EB6C5871
Generic name
Cefepime-enmetazobactam
Source IDH51-261A20DA03D25F29F28F32DC
Class
Antibacterial
Source IDH51-E330C4DAB9F52D2D0C20C89A
Subclass
Cephalosporin plus beta-lactamase inhibitor
Source IDH51-4FF0EF4417FF09657DD962A4
Primary uses
  1. FDA-approved use: complicated urinary tract infection, including pyelonephritis, in adults 18 years and older when caused by designated susceptible organisms
    Source IDH51-32869A3A2E96012FCACBF657
  2. Historical/current-label preparation reference; confirm current product availability and formulary status before any operational use
    Source IDH51-986E4BC5CB90418F72422BBB
Mechanism
The beta-lactam component inhibits penicillin-binding proteins and cell-wall synthesis; its partner protects or enhances activity against selected resistance mechanisms.
Source IDH51-2D6C620B3925B91AA29651BE
Mechanism level
class_level
Source IDH51-4175907E3A2A548DE4A5EE7E
Basic dosing orientation
Adult, eGFR 130 mL/min or greater | Existing preparation record; use current package insert for indication-specific selection | 2.5 g total (cefepime 2 g/enmetazobactam 0.5 g) every 8 hours | Not normalized in the preparation record | See current package insert and professional guidance | IV infusion; Adult, eGFR 90 to 129 mL/min | Existing preparation record; use current package insert for indication-specific selection | 2.5 g total (cefepime 2 g/enmetazobactam 0.5 g) every 8 hours | Not normalized in the preparation record | See current package insert and professional guidance | IV infusion
Source IDH51-0159874E6F00308986C2F40A
Administration orientation
Infuse over 4 hours; Infuse over 2 hours
Source IDH51-16C43EB3A32392A3674CF5AE
Renal and population orientation
Separate renal reference: Open Renal Dosing Master (opens in a new tab)Renal dose adjustment or interval modification is commonly required; verify the selected product label and patient-specific renal method.
Source IDH51-90882F0C095F0EE2ECC06D3F
Key safety orientation
  1. U.S. marketing status is listed as discontinued in Drugs@FDA. Do not treat this record as evidence that EXBLIFEP is currently available or on formulary.
    Source IDH51-FF37A29668AB4476B980B36B
  2. Serious and occasionally fatal beta-lactam hypersensitivity reactions, including anaphylaxis and serious skin reactions, can occur.
    Source IDH51-7D3C7A877F98F15B783C11FA
  3. Cefepime-associated neurotoxicity can include encephalopathy, aphasia, myoclonus, seizures, and nonconvulsive status epilepticus; risk is increased when renal adjustment is inadequate.
    Source IDH51-BD926C7F0FD55029726AE05B
  4. Clostridioides difficile-associated diarrhea can occur during or after antibacterial therapy.
    Source IDH51-5E619D7BB99EFA892D1EE877
Coverage path
structured_local_snapshot
Source IDH51-535EE35E31159206FBF30694
Coverage path label
Structured GlobalRPh route snapshot
Source IDH51-A9887A859536ED51F3C91C02
Review note
First-look orientation only. Verify indication, patient population, weight basis, organ function, exact IV product, dose, concentration, compatibility, rate, and current labeling before use.
Source IDH51-88EB2BBBE1C247932B5C720F
Search text
Cefepime-enmetazobactam Antibacterial Cephalosporin plus beta-lactamase inhibitor FDA-approved use: complicated urinary tract infection, including pyelonephritis, in adults 18 years and older when caused by designated susceptible organisms Historical/current-label preparation reference; confirm current product availability and formulary status before any operational use The beta-lactam component inhibits penicillin-binding proteins and cell-wall synthesis; its partner protects or enhances activity against selected resistance mechanisms. Adult, eGFR 130 mL/min or greater | Existing preparation record; use current package insert for indication-specific selection | 2.5 g total (cefepime 2 g/enmetazobactam 0.5 g) every 8 hours | Not normalized in the preparation record | See current package insert and professional guidance | IV infusion; Adult, eGFR 90 to 129 mL/min | Existing preparation record; use current package insert for indication-specific selection | 2.5 g total (cefepime 2 g/enmetazobactam 0.5 g) every 8 hours | Not normalized in the preparation record | See current package insert and professional guidance | IV infusion Infuse over 4 hours; Infuse over 2 hours Renal dose adjustment or interval modification is commonly required; verify the selected product label and patient-specific renal method. U.S. marketing status is listed as discontinued in Drugs@FDA. Do not treat this record as evidence that EXBLIFEP is currently available or on formulary. Serious and occasionally fatal beta-lactam hypersensitivity reactions, including anaphylaxis and serious skin reactions, can occur. Cefepime-associated neurotoxicity can include encephalopathy, aphasia, myoclonus, seizures, and nonconvulsive status epilepticus; risk is increased when renal adjustment is inadequate. Clostridioides difficile-associated diarrhea can occur during or after antibacterial therapy. Structured GlobalRPh route snapshot
Source IDH51-E5D02D3BB5B701DBE44314E4
Official access mode
search
Source IDH51-2002F1D0357638931761E999
Official search query
Cefepime-enmetazobactam
Source IDH51-1D09051B1F9E2C83D00B8A32
Official access reason
A source-backed DailyMed search is available; select and confirm the exact IV product.
Source IDH51-30B7113F7EC4FBA8017A0CC0
Product identifiers and clinical review status

This monograph will be updated in the future. Historical material is available where present in the original sources; full current exact-product and claim-level review remains pending.

Exact formulation, concentration, container, manufacturer, regulatory identifiers, and a reproducible label snapshot have not all been reconciled.

What remains to be completed
  • Retrievable exact-product SPL XML with version, revision, retrieval date and reproducible hash
  • Clinically reviewed, individually identified statements with two exact source mappings
  • Exact formulation, strength, container, manufacturer/labeler, application and NDC reconciliation
  • Renal-function methods and dialysis/CRRT modality review where applicable
  • Mechanism provenance, clinical source disagreements and full medication-specific safety reconciliation

Supplemental historical fields

Restored-data provenance and review notes

Source release: 2026-08-31. Current clinical review is incomplete. Original uses of current, verified, or normalized describe the historical source. They do not inherit the status of separately reviewed statements. Product formulations and source dates can differ.

Current review annotations for historical renal, dialysis, mechanism, and product fieldsSeparate renal reference: Open Renal Dosing Master (opens in a new tab)
Renal
Status
not_locally_normalized
Original classification
adjustment_required
Entries
    General note
    Preserve the source-specific renal-function basis. An indexed CrCl table is not interchangeable with unindexed CrCl or eGFR. Generic advice to check a method does not identify the equation for a dose row.
    Dialysis
    Status
    no_local_structured_regimen
    Entries
      General note
      Named modality alone does not establish applicability. CRRT subtype, effluent rate, residual renal function, timing and interruptions require review. Historical absence is not evidence that no guidance exists.
      Mechanisms
      • Source kind
        first_look
        Local pointer
        /mechanism
        Original level
        class_level
        Provenance classification
        historical_class_level
        Label derived verified
        false
        Independently corroborated
        false
        Exact label section
        Not recorded
        Original source note
        Not recorded
        Review status
        historical_unverified
        Note
        Drug-specific wording in the old file is not proof of independent corroboration or an exact label locator. Consult separately published current mechanism claims where present.
      Future update
      Status
      pending_review
      Message
      This monograph will be updated in the future as current exact-product and claim-level review is completed.
      Source unavailable
      false
      Reason
      The historical content is restored; comprehensive contemporary verification remains incomplete.

      No separate structured rows were bundled for IV push, continuous infusion, dialysis, CRRT. Historical article content and source links may cover these topics.

      Historical dilution and intermittent infusion preparation

      Recovered v5.1 source content; historical, awaiting current review.

      Separate renal reference: Open Renal Dosing Master (opens in a new tab)
      PopulationAmountReconstitutionDiluentFinal volumeConcentrationRateStabilityNotes
      Source IDH51-D196E903D1F068F1925A97C4
      Adult, eGFR 130 mL/min or greater
      Source IDH51-4BA3CAE4DE1EAA2C78885CC0
      2.5 g total (cefepime 2 g/enmetazobactam 0.5 g) every 8 hours
      Source IDH51-6E5BE1BD0074139E07A8003D
      Withdraw 10 mL from a 250 mL bag of NS, D5W, or 2.5% dextrose/0.45% sodium chloride and use it to reconstitute one vial. Mix gently. The resulting vial concentration is 0.2 g/mL total product (cefepime 0.16 g/mL and enmetazobactam 0.04 g/mL), with an approximate vial volume of 13 mL. Not for direct injection.
      Source IDH51-97271438D1B299C9564DF754
      Use the same NS, D5W, or 2.5% dextrose/0.45% sodium chloride solution for reconstitution and final dilution
      Source IDH51-39AF97B6B18610F84539AAD8
      Return the entire reconstituted vial contents (approximately 13 mL) to the same labeled 250 mL infusion bag
      Source IDH51-76D7186981C9A82A18435DF7
      Nominal 10 mg/mL total product based on the labeled 250 mL bag volume; actual concentration depends on container overfill and displacement
      Source IDH51-53FDC3A1338547646E244FE9
      Infuse over 4 hours
      Source IDH51-4A672707B818C7D5F4E5D493
      The prepared diluted solution may be refrigerated at 2 to 8 C for up to 4 hours before administration, but the infusion must be completed within 6 hours of dilution.
      Source IDH51-325EC2C61F297EBE02F5BD9D
      Because the infusion lasts 4 hours and must be completed within 6 hours of dilution, no more than 2 hours can elapse between dilution and the start of infusion. The label uses MDRD-calculated eGFR.
      Source IDH51-2849B41DE527DEDC7D7253FF
      Source IDH51-8C0F90196D087B71AC03C226
      Adult, eGFR 90 to 129 mL/min
      Source IDH51-8DACC3A78539A68E282A35CD
      2.5 g total (cefepime 2 g/enmetazobactam 0.5 g) every 8 hours
      Source IDH51-48C8AB8206085031295FA6A7
      Reconstitute one vial with 10 mL drawn from the final 250 mL NS, D5W, or 2.5% dextrose/0.45% sodium chloride bag. Resulting concentration: 0.2 g/mL total product; approximate vial volume: 13 mL. Not for direct injection.
      Source IDH51-3AF13EA417EDAC398550D0C9
      Use the same solution for reconstitution and final dilution
      Source IDH51-C739E115EF4B32E75EBB827B
      Return the entire reconstituted vial contents (approximately 13 mL) to the same labeled 250 mL infusion bag
      Source IDH51-C53E1E98A3AEDD09DE33633E
      Nominal 10 mg/mL total product based on labeled bag volume; account for overfill and displacement
      Source IDH51-0F9DD05F9FA20A5155854B88
      Infuse over 2 hours
      Source IDH51-FBFFAA65C8C443C4893FB320
      Refrigerate the prepared diluted solution at 2 to 8 C for up to 4 hours before administration; complete infusion within 6 hours of dilution.
      Source IDH51-8C053E00C8878E24DBEC9385
      Use aseptic technique. Inspect for particles and discoloration. Discard unused vial contents.
      Source IDH51-AD661037F00E0E7A78F4F53C
      Source IDH51-323651D699D0EE812E4B9E39
      Adult, eGFR 60 to 89 mL/min
      Source IDH51-6EE1CD75030B17E26D7FB59C
      2.5 g total (cefepime 2 g/enmetazobactam 0.5 g) every 8 hours
      Source IDH51-97D119FEB63310F57915690F
      Reconstitute one vial with 10 mL drawn from the final 250 mL bag. Resulting concentration: 0.2 g/mL total product; approximate vial volume: 13 mL. Not for direct injection.
      Source IDH51-AD47895B840E53ED325963D3
      NS, D5W, or 2.5% dextrose/0.45% sodium chloride; use the same solution for both steps
      Source IDH51-EDEF60A813865A84C600A1F7
      Return the entire reconstituted vial contents (approximately 13 mL) to the same labeled 250 mL infusion bag
      Source IDH51-601EDE570900603541A900F6
      Nominal 10 mg/mL total product based on labeled bag volume; account for overfill and displacement
      Source IDH51-D5DA8133151CD58E842ABED3
      Infuse over 2 hours
      Source IDH51-ECE5FA3C1FBE4FC567069270
      Refrigerate the prepared diluted solution at 2 to 8 C for up to 4 hours before administration; complete infusion within 6 hours of dilution.
      Source IDH51-78B34AAADA105C07ADD578F5
      Monitor renal function and revise the regimen if eGFR changes during therapy.
      Source IDH51-AF91120DDCF7608FD8CE947C
      Source IDH51-5A781E30EF29A81D8C9CA51D
      Adult, eGFR 30 to 59 mL/min
      Source IDH51-118E4D90656CE0087B5EF9F8
      1.25 g total (cefepime 1 g/enmetazobactam 0.25 g) every 8 hours
      Source IDH51-AF9FA542E797464CD0F965A0
      Reconstitute one 2.5 g vial with 10 mL drawn from the final 250 mL bag. After dissolution, withdraw 6.5 mL of the reconstituted 0.2 g/mL total-product solution. Not for direct injection.
      Source IDH51-3BFDD781E1C80151429EF30E
      NS, D5W, or 2.5% dextrose/0.45% sodium chloride; use the same solution for both steps
      Source IDH51-A9F1F8ADB56C2FBDE6F9575F
      Add 6.5 mL to the same labeled 250 mL infusion bag
      Source IDH51-463D1195D494F8CFF55AD072
      Nominal 5 mg/mL total product based on labeled bag volume; account for overfill and displacement
      Source IDH51-003EFB8588AFAFED1C7AED18
      Infuse over 2 hours
      Source IDH51-658ADF37E7D1B1CD3D5C060F
      Refrigerate the prepared diluted solution at 2 to 8 C for up to 4 hours before administration; complete infusion within 6 hours of dilution.
      Source IDH51-8EB0C35BDAAA191E65A89A73
      Discard the unused reconstituted vial portion. Monitor changing renal function at least daily as directed in the label.
      Source IDH51-69685019FDF3B28A42E07440
      Source IDH51-71509B7B7AB96E24A8868E07
      Adult, eGFR 15 to 29 mL/min
      Source IDH51-71931975FF12B9937AE12B9C
      1.25 g total (cefepime 1 g/enmetazobactam 0.25 g) every 12 hours
      Source IDH51-8064DF2509C7433D74D6F9FD
      Reconstitute one 2.5 g vial with 10 mL drawn from the final 250 mL bag. After dissolution, withdraw 6.5 mL of the reconstituted 0.2 g/mL total-product solution. Not for direct injection.
      Source IDH51-960E8CAE61D05AD7AFC11DF5
      NS, D5W, or 2.5% dextrose/0.45% sodium chloride; use the same solution for both steps
      Source IDH51-F84C3311048C781F1B70F3F7
      Add 6.5 mL to the same labeled 250 mL infusion bag
      Source IDH51-A708E40BF88304F4FFD85C5A
      Nominal 5 mg/mL total product based on labeled bag volume; account for overfill and displacement
      Source IDH51-44E970161B71822BFBDB1424
      Infuse over 2 hours
      Source IDH51-B401F472B75A687EEDEF2B2E
      Refrigerate the prepared diluted solution at 2 to 8 C for up to 4 hours before administration; complete infusion within 6 hours of dilution.
      Source IDH51-F1AC441C3F7FF6BD442D66D2
      Discard the unused reconstituted vial portion. Reassess eGFR during therapy.
      Source IDH51-2A1310D3820699B3F3E708DC
      Source IDH51-D14B7CE8053984F69442E4B2
      Adult, eGFR below 15 mL/min or intermittent hemodialysis - day 1 loading dose
      Source IDH51-467E6F649E5ACFD85C63BCEB
      1.25 g total (cefepime 1 g/enmetazobactam 0.25 g) once on the first day
      Source IDH51-D0D4C18BA42D6A13F64AB0AC
      Reconstitute one 2.5 g vial with 10 mL drawn from the final 250 mL bag. Withdraw 6.5 mL of the reconstituted 0.2 g/mL total-product solution. Not for direct injection.
      Source IDH51-200963F2DFE98D5A04C0C69C
      NS, D5W, or 2.5% dextrose/0.45% sodium chloride; use the same solution for both steps
      Source IDH51-F2CC831D6E34FAA320732E1D
      Add 6.5 mL to the same labeled 250 mL infusion bag
      Source IDH51-6E5928D8F3DD8F063A82E168
      Nominal 5 mg/mL total product based on labeled bag volume; account for overfill and displacement
      Source IDH51-6401275A7C5ADEE07DC0E700
      Infuse over 2 hours
      Source IDH51-3246A90E56A1BB1BD4659755
      Refrigerate the prepared diluted solution at 2 to 8 C for up to 4 hours before administration; complete infusion within 6 hours of dilution.
      Source IDH51-3F7F4035F394FDCE871FD183
      For intermittent hemodialysis, complete the hemodialysis session before EXBLIFEP dosing.
      Source IDH51-0C6BF4F33A4B9DE45550B77B
      Source IDH51-B755D14F53D6F4F096D2A14B
      Adult, eGFR below 15 mL/min or intermittent hemodialysis - maintenance
      Source IDH51-038974CB4DC5BA78BF36B92A
      0.625 g total (cefepime 0.5 g/enmetazobactam 0.125 g) every 24 hours after the day 1 loading dose
      Source IDH51-2BF3A14659386DC6816C179E
      Reconstitute one 2.5 g vial with 10 mL drawn from the final 250 mL bag. Withdraw 3.3 mL of the reconstituted 0.2 g/mL total-product solution. Not for direct injection.
      Source IDH51-5E8CC2C0D0D8FDCC864B1D85
      NS, D5W, or 2.5% dextrose/0.45% sodium chloride; use the same solution for both steps
      Source IDH51-8250B696048EDF32FA2F18A1
      Add 3.3 mL to the same labeled 250 mL infusion bag
      Source IDH51-F37AB76B3842CD69FD7846EE
      Nominal 2.5 mg/mL total product based on labeled bag volume; account for overfill and displacement
      Source IDH51-CDF1AB822BAFADD7E8F71BFF
      Infuse over 2 hours
      Source IDH51-30B686C3E5C322087EF785A3
      Refrigerate the prepared diluted solution at 2 to 8 C for up to 4 hours before administration; complete infusion within 6 hours of dilution.
      Source IDH51-C81FA0392A89498C804A1395
      For intermittent hemodialysis, dose after completion of the hemodialysis session and, when possible, at the same time each day. Discard unused vial contents.
      Source IDH51-7DBE25D53BA7F12CDE398DB6

      Historical indication and population dosing

      Recovered tables and source-separated snapshots; full clinical revalidation remains pending.

      Existing dose and route snapshots

      Separate renal reference: Open Renal Dosing Master (opens in a new tab)
      RoutePopulationIndicationDoseIntervalDurationAdministrationSource levelNotes
      Source IDH51-9F72130096C0AAA9E90B42B2
      IV infusion
      Source IDH51-8ACBC4CDCE4E8C82BC8D7009
      Adult, eGFR 130 mL/min or greater
      Source IDH51-5316329AB1D3EDB832A9E400
      Existing preparation record; use current package insert for indication-specific selection
      Source IDH51-CE594B04A950C91026695A63
      2.5 g total (cefepime 2 g/enmetazobactam 0.5 g) every 8 hours
      Source IDH51-D54B38C2D5C23BB701E8D829
      Not normalized in the preparation record
      Source IDH51-21B93F309C7015674A798A72
      See current package insert and professional guidance
      Source IDH51-6CF2E535FA078ADDD0786B01
      Infuse over 4 hours
      Source IDH51-EE3EB8DA4B6F3207302E8DD4
      Existing GlobalRPh structured preparation snapshot
      Source IDH51-C434E22F58DD11AF838ADFCB
      Because the infusion lasts 4 hours and must be completed within 6 hours of dilution, no more than 2 hours can elapse between dilution and the start of infusion. The label uses MDRD-calculated eGFR.
      Source IDH51-FFD7A27ED6B99611C4E5DC7F
      Source IDH51-BC36A6C2B3D9F229759A8C15
      IV infusion
      Source IDH51-AD67F836A58A26625EB1F65F
      Adult, eGFR 90 to 129 mL/min
      Source IDH51-BA0B3BA4ADC229735EAEC7BD
      Existing preparation record; use current package insert for indication-specific selection
      Source IDH51-2E087C9F18EF3CC536518513
      2.5 g total (cefepime 2 g/enmetazobactam 0.5 g) every 8 hours
      Source IDH51-7544CF088E51D89329AC61CB
      Not normalized in the preparation record
      Source IDH51-A445F0537F0684A392A3AB90
      See current package insert and professional guidance
      Source IDH51-D8CAF0C7657BFD8F44D12AF0
      Infuse over 2 hours
      Source IDH51-0599FB426E25B91DA14D3BBB
      Existing GlobalRPh structured preparation snapshot
      Source IDH51-2A583F71D4EE5AE0ACC1BEB3
      Use aseptic technique. Inspect for particles and discoloration. Discard unused vial contents.
      Source IDH51-5C5C24A051B084EE6B1EE595
      Source IDH51-3B089FAD85DDDD53B10AA104
      IV infusion
      Source IDH51-1966B997BACC4B97F616A722
      Adult, eGFR 60 to 89 mL/min
      Source IDH51-8591039AB70253A22460F202
      Existing preparation record; use current package insert for indication-specific selection
      Source IDH51-69633B18C9C5BCB712F11A8C
      2.5 g total (cefepime 2 g/enmetazobactam 0.5 g) every 8 hours
      Source IDH51-5C71DB7F2B93A9841CAA7234
      Not normalized in the preparation record
      Source IDH51-FEE0BD9DC4CBB40CA5655F20
      See current package insert and professional guidance
      Source IDH51-77CB744F188E2ADB90951488
      Infuse over 2 hours
      Source IDH51-8249BAA1A6087E676356C809
      Existing GlobalRPh structured preparation snapshot
      Source IDH51-4550EFD5067A5BF9C9EE746E
      Monitor renal function and revise the regimen if eGFR changes during therapy.
      Source IDH51-7AECB625F695F716A8988606
      Source IDH51-3DB86E3B025F1DB8BF07D37F
      IV infusion
      Source IDH51-5FB80CA33B9BB52DC1B57A0C
      Adult, eGFR 30 to 59 mL/min
      Source IDH51-9EAD519DA507A1C8D4E1198A
      Existing preparation record; use current package insert for indication-specific selection
      Source IDH51-3D58D857D4B3A70B7F094961
      1.25 g total (cefepime 1 g/enmetazobactam 0.25 g) every 8 hours
      Source IDH51-0997B119ED48EE87695C3B35
      Not normalized in the preparation record
      Source IDH51-6FA1688AC9F9877583B0B41C
      See current package insert and professional guidance
      Source IDH51-C7405B915EAB7FAC692D1D5B
      Infuse over 2 hours
      Source IDH51-5E35EBBFD13CAC16FE87B953
      Existing GlobalRPh structured preparation snapshot
      Source IDH51-51CC3922F040B55A962BBF4E
      Discard the unused reconstituted vial portion. Monitor changing renal function at least daily as directed in the label.
      Source IDH51-7B1D9F3BCCFDAED71BD2915F
      Source IDH51-B1E9D55B87DCA3EBDD6EC96F
      IV infusion
      Source IDH51-BD1849EC746CBDC3E1CA53EA
      Adult, eGFR 15 to 29 mL/min
      Source IDH51-7726D8BDB9EF8C6D1B21ECE3
      Existing preparation record; use current package insert for indication-specific selection
      Source IDH51-6A27D91150FFC10BBBC44089
      1.25 g total (cefepime 1 g/enmetazobactam 0.25 g) every 12 hours
      Source IDH51-492D2E689AF1C7BE4418457D
      Not normalized in the preparation record
      Source IDH51-EAC3D7606767B1CC68DF9474
      See current package insert and professional guidance
      Source IDH51-E52036DB004BE873FA2A3B31
      Infuse over 2 hours
      Source IDH51-D13FCE8233717AD482D1690C
      Existing GlobalRPh structured preparation snapshot
      Source IDH51-3447A8DA589FD573204D5A13
      Discard the unused reconstituted vial portion. Reassess eGFR during therapy.
      Source IDH51-8D34B47623F9BBA6D0F44F17
      Source IDH51-B0DE2B72D5102091261069FD
      IV infusion
      Source IDH51-D095D62B67BCC90A7489EED6
      Adult, eGFR below 15 mL/min or intermittent hemodialysis - day 1 loading dose
      Source IDH51-9A031E5FB04AABDE7F03D4DC
      Existing preparation record; use current package insert for indication-specific selection
      Source IDH51-51A989B0501BE33C31710DAB
      1.25 g total (cefepime 1 g/enmetazobactam 0.25 g) once on the first day
      Source IDH51-B95E22FF43F60611A410718D
      Not normalized in the preparation record
      Source IDH51-1CBEED715CF8A380CE18CBC8
      See current package insert and professional guidance
      Source IDH51-39309D304BD13885FD424EA2
      Infuse over 2 hours
      Source IDH51-60268302780A0618EFC7A3C5
      Existing GlobalRPh structured preparation snapshot
      Source IDH51-63135ADB46A1C437AF37AAC4
      For intermittent hemodialysis, complete the hemodialysis session before EXBLIFEP dosing.
      Source IDH51-4B81FF0827571A5132A26E76
      Source IDH51-2A22FC4FD11C65FA34D33BA5
      IV infusion
      Source IDH51-5EB401B8D6B413B73EED8018
      Adult, eGFR below 15 mL/min or intermittent hemodialysis - maintenance
      Source IDH51-2A973A522840CE0AC0BEA052
      Existing preparation record; use current package insert for indication-specific selection
      Source IDH51-B918BAD928938E208190D9E1
      0.625 g total (cefepime 0.5 g/enmetazobactam 0.125 g) every 24 hours after the day 1 loading dose
      Source IDH51-32BBEF777B11823C71AC5714
      Not normalized in the preparation record
      Source IDH51-16A1EA876C0FFB45ACDAA320
      See current package insert and professional guidance
      Source IDH51-770AC4527EDC7B2B762F2A30
      Infuse over 2 hours
      Source IDH51-92DB9971916A99657355FC35
      Existing GlobalRPh structured preparation snapshot
      Source IDH51-0994A2448A5D17EEA4588D01
      For intermittent hemodialysis, dose after completion of the hemodialysis session and, when possible, at the same time each day. Discard unused vial contents.
      Source IDH51-36AC0B0DB25B96A56BEEA93F

      Historical renal-function guidance

      Recovered v5.1 source content; historical, awaiting current review.

      Separate renal reference: Open Renal Dosing Master (opens in a new tab)
      Classification
      adjustment_required
      Source IDH51-F2B4BC28937F41F72A65090C
      Summary
      Renal dose adjustment or interval modification is commonly required; verify the selected product label and patient-specific renal method.
      Source IDH51-32879C3BA0FC61EE8487CA59
      Method note
      Use the renal function estimate and body-size convention specified by the selected label or institutional protocol. Do not interchange Cockcroft-Gault CrCl, indexed eGFR, and de-indexed eGFR without confirming the dosing source.
      Source IDH51-D30DFAFD002C47EA1699E31D

      Historical Common IV uses

      Recovered v5.1 source content; historical, awaiting current review.

      1. FDA-approved use: complicated urinary tract infection, including pyelonephritis, in adults 18 years and older when caused by designated susceptible organisms
        Source IDH51-2996803C045A63D8EC326913
      2. Historical/current-label preparation reference; confirm current product availability and formulary status before any operational use
        Source IDH51-74F6193CA6F4393F211716FF

      Historical Warnings and safeguards

      Recovered v5.1 source content; historical, awaiting current review.

      Separate renal reference: Open Renal Dosing Master (opens in a new tab)
      1. U.S. marketing status is listed as discontinued in Drugs@FDA. Do not treat this record as evidence that EXBLIFEP is currently available or on formulary.
        Source IDH51-7DF9490C480A14F96F409D7E
      2. Serious and occasionally fatal beta-lactam hypersensitivity reactions, including anaphylaxis and serious skin reactions, can occur.
        Source IDH51-7F4DB032BF46117AF82B5E0D
      3. Cefepime-associated neurotoxicity can include encephalopathy, aphasia, myoclonus, seizures, and nonconvulsive status epilepticus; risk is increased when renal adjustment is inadequate.
        Source IDH51-57133BC4DDA6DCB04E3C3647
      4. Clostridioides difficile-associated diarrhea can occur during or after antibacterial therapy.
        Source IDH51-1432350FD9333BA1FC2C6FC3
      5. The reconstituted vial solution is not for direct injection and must be immediately further diluted.
        Source IDH51-F48DFDD8363DEE35C70FA32D

      Historical Monitoring

      Recovered v5.1 source content; historical, awaiting current review.

      Separate renal reference: Open Renal Dosing Master (opens in a new tab)
      1. Current product availability, U.S. marketing status, and local formulary status before use
        Source IDH51-32F65B0BC59FDE344C33E4D4
      2. Serum creatinine and eGFR at least daily when renal function is changing
        Source IDH51-814AFE9A1FC4CE9AE110A46A
      3. Mental status, myoclonus, seizure activity, and other neurotoxicity findings
        Source IDH51-4B3CDBDA465ED5BC6D04FC81
      4. Hypersensitivity during administration
        Source IDH51-8C5DAD38A5A477195455EA9C
      5. Clinical and microbiologic response
        Source IDH51-A3260A06EBBEA694C012581A
      6. Diarrhea and other findings concerning for C. difficile infection
        Source IDH51-45DC213DF6608B408724144B

      Historical Compatibility

      Recovered v5.1 source content; historical, awaiting current review.

      1. Compatible preparation fluids in the U.S. label: 0.9% Sodium Chloride Injection, 5% Dextrose Injection, and 2.5% Dextrose/0.45% Sodium Chloride Injection.
        Source IDH51-96965FA7B79269B0AB0B9D1B
      2. Use the same solution for vial reconstitution and final bag dilution.
        Source IDH51-86E859AB54A41F0FA9D2B2D9
      3. Compatibility with other drugs for administration has not been established; do not combine in the same solution without an approved compatibility source.
        Source IDH51-38FCE6F318CFE5B47D188029

      Historical Stability notes

      Recovered v5.1 source content; historical, awaiting current review.

      1. The reconstituted solution must be immediately further diluted in the same 250 mL bag used to obtain the 10 mL reconstitution volume.
        Source IDH51-DBF37CAEDE65827C83E6A26A
      2. The prepared diluted solution may be stored refrigerated at 2 to 8 C for up to 4 hours before administration.
        Source IDH51-36BDAFA8839874363E813FD2
      3. The intravenous infusion must be completed within 6 hours of dilution. This product-specific completion limit is shorter than many sterility-based BUD ceilings and remains controlling.
        Source IDH51-2AE8020D9D22E7F36CF15E3F
      4. Discard unused portions from the single-dose vial.
        Source IDH51-38C7E76A01BDFBE00180C95C

      Historical supplemental professional sources

      Recovered v5.1 source content; historical, awaiting current review.

      LabelUrlKind
      Source IDH51-58042A72B369425C41F51A55
      UCSF adult antimicrobial dosing, non-dialysis
      Source IDH51-89F6F0DC2E03C1C9FAFAE2D3
      https://idmp.ucsf.edu/adult-antimicrobial-dosing-non-dialysis (opens in a new tab)
      Source IDH51-F83D2910C7BEB7AE3F1D885B
      Professional institutional guidance
      Source IDH51-A7E24F6163A389D3CCF259D9
      Source IDH51-667DDB0FB655FE20462B878A
      UCSF antimicrobial dosing in intermittent and continuous hemodialysis
      Source IDH51-E5E1EE59F28DEAE3B7A2F1B1
      https://idmp.ucsf.edu/antimicrobial-dosing-intermittent-continuous-hemodialysis (opens in a new tab)
      Source IDH51-D765765B40766F5A13F4090C
      Professional institutional guidance
      Source IDH51-3F410F1043B7EF867B7A8BB0
      Source IDH51-37486DF66AE06227ED4A2C9C
      UCSF pediatric antimicrobial dosing
      Source IDH51-0DB22ED4407FBA70925DD143
      https://idmp.ucsf.edu/pediatric-antimicrobial-dosing-benioff-childrens-hospitals (opens in a new tab)
      Source IDH51-C1827080793AF81180C26405
      Professional institutional guidance
      Source IDH51-B6C7FF31800707759219B3C6
      Source IDH51-B74E4ACFB4F51CAF7FE57CB3
      UCSF neonatal antimicrobial dosing
      Source IDH51-8DF8E1AE9B97CB701412E075
      https://idmp.ucsf.edu/neonatal-antimicrobial-dosing-benioff-childrens-hospitals (opens in a new tab)
      Source IDH51-3A29A44C99361D2A91A9F7FB
      Professional institutional guidance
      Source IDH51-8CBD5B21C1054113A9D6901E
      Other recovered source fields and original editorial metadata

      Original status words such as current, verified, or normalized describe the historical source release. They do not change the clinical review status of this release.

      Catalog source fields

      Id
      cefepime-enmetazobactam
      Source IDH51-46EB92497506B74D51402FCD
      Generic name
      Cefepime-enmetazobactam
      Source IDH51-F49C0CBA6634C6E5D9C26355
      Brand names
      1. Exblifep
        Source IDH51-276940F4CC87ABD001F0A943
      Aliases
      1. cefepime enmetazobactam
        Source IDH51-708FA9719A4FAA9F0720FE58
      Class
      Antibacterial
      Source IDH51-E3AB3B1F00B618F44A837C03
      Subclass
      Cephalosporin plus beta-lactamase inhibitor
      Source IDH51-265F06C371E911BBE622CC52
      Summary
      Separate renal reference: Open Renal Dosing Master (opens in a new tab)Fixed cefepime 2 g plus enmetazobactam 0.5 g single-dose vial approved for adult complicated urinary tract infection. The U.S. prescribing information provides renal-function-specific regimens, reconstitution, final bag preparation, and a six-hour completion limit. Drugs@FDA currently lists the U.S. product marketing status as discontinued, so this record is retained as a clearly labeled regulatory and preparation reference rather than an active formulary recommendation.
      Source IDH51-91A22AB8AC71156B422A9F00
      Populations
      Separate renal reference: Open Renal Dosing Master (opens in a new tab)
      1. Adult
        Source IDH51-7F5CDB53D1108B230D3FB162
      2. Renal impairment
        Source IDH51-8FFC8A2E617FCB175126954E
      3. Intermittent hemodialysis
        Source IDH51-4AC8B9472D50CA3310616BB9
      Evidence tier
      Current-label candidate - verify exact product - U.S. marketing discontinued
      Source IDH51-2B547F1549342AC7A7D57B52
      High alert
      false
      Source IDH51-84408EBF689BF7A3ADA4C819
      Hazardous
      false
      Source IDH51-9A333A437A202065F03C12F3
      Status
      Discontinued in U.S. marketing status
      Source IDH51-503D78AE9E06C6D722988E23
      Reviewed
      2026-08-29
      Source IDH51-EF29C28F5783A3FC581A29B6
      Version added
      1.2
      Source IDH51-7D956356D3881E7936A40292
      Version updated
      1.3
      Source IDH51-BCB71E9AE7A2A34B849E4D3B
      Sources
      LabelUrlKind
      Source IDH51-A2D7B8C06B1869216F4C91B5
      FDA Drugs@FDA overview for NDA 216165 (current U.S. marketing status and label history)
      Source IDH51-B2CB5FCD16AFF8B972A92E4E
      https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=216165 (opens in a new tab)
      Source IDH51-2681BA71C13608180679EB27
      Regulatory
      Source IDH51-D1F2D7965FA78F0A5280720F
      Source IDH51-481400DAD7BF0F589D66013D
      FDA EXBLIFEP full prescribing information, original approval label
      Source IDH51-637E6C8DDFE7310661A2E558
      https://www.accessdata.fda.gov/drugsatfda_docs/label/2024/216165s000lbl.pdf (opens in a new tab)
      Source IDH51-E2EFE8603E158F813A3D63A8
      Primary
      Source IDH51-BDBEB77E3400B2C1A44385E0
      Clinical release verification
      Audit version
      3.4
      Source IDH51-6A812AAD7EE3BA9EB3CF0FC1
      Audited on
      2026-08-30
      Source IDH51-4BCE6FA778EDFCFB8696DD0B
      Level
      amber
      Source IDH51-D253CE70F551AFE9D13EBA4D
      Release gate
      trusted_professional_source_present_exact_label_unconfirmed
      Source IDH51-54A75AF25C67E4243E63403F
      Exact current label candidate
      false
      Source IDH51-13DC94D6086E9231D66FF494
      Numeric support ratio
      0
      Source IDH51-299A7DCDAE97A236E428A2B8
      Reference url count
      6
      Source IDH51-BC20F6981681DA0C84FAE168
      Broken reference count
      0
      Source IDH51-653788941C60CFB1A72F78CB
      Point of use confirmation required
      true
      Source IDH51-A22B0D9695A7D0A35373B7E0
      Note
      Do not treat this record as a fully current product-specific monograph until the exact IV formulation and current sources are confirmed.
      Source IDH51-BC22D4166245BAFC309A0EE0

      Dosing source fields

      Id
      cefepime-enmetazobactam
      Source IDH51-EECB65B75CE753EF7BA479B7
      Generic name
      Cefepime-enmetazobactam
      Source IDH51-59EBEE32D757C99BD17FC4F1
      Coverage status
      direct_official_label_access_plus_local_snapshot
      Source IDH51-15F962620A951F2B578250F0
      Package insert
      Query name
      Cefepime-enmetazobactam
      Source IDH51-98779493A7CA6A2403CE1042
      Product and route must match
      true
      Source IDH51-5A958FAFC7696605F738E368
      Live current label enabled
      false
      Source IDH51-C7B64CC3061AC0F95B8D81BE
      Source priority
      Reviewed local summary when available, then a verified DailyMed label or product search when available, followed by professional references and institutional policy.
      Source IDH51-38B18947FAE8F9DEA98A3445
      Direct official label access enabled
      true
      Source IDH51-AA7A39D2E57BB7958F233654
      Outbound server request required
      false
      Source IDH51-9EF3C5386C5616D7A71AD88F
      Local summary status
      not_bundled
      Source IDH51-8B1AECADCDDFCE187B14467A
      Clinical review
      Locally normalized
      false
      Source IDH51-1C48A7F002688EA43F746185
      Reviewed
      2026-08-29
      Source IDH51-C4B7E9C105E2105DFFD436A2
      Status
      Direct official package-insert access enabled; indication-specific local normalization pending.
      Source IDH51-28CAA1BEAF9FA4605351CD5E
      Clinical release verification
      Audit version
      3.4
      Source IDH51-4579819D41F9779464F03B16
      Audited on
      2026-08-30
      Source IDH51-0470C4CDB96C9EB85A17B54B
      Level
      amber
      Source IDH51-5C0643BDFB92E0777DB3B7DB
      Release gate
      trusted_professional_source_present_exact_label_unconfirmed
      Source IDH51-54CBA48A3B18B647C369B2DF
      Exact current label candidate
      false
      Source IDH51-A9A56937D5486CB65EA21F97
      Numeric support ratio
      0
      Source IDH51-2C794906157C1E393D174E3D
      Reference url count
      6
      Source IDH51-A626A40B88B8BC29814881BB
      Broken reference count
      0
      Source IDH51-528E1732D9908DD78ECBB427
      Point of use confirmation required
      true
      Source IDH51-19BEE3F6420BE6EBC958E714
      Note
      Do not treat this record as a fully current product-specific monograph until the exact IV formulation and current sources are confirmed.
      Source IDH51-54EF86654C58113AE7B626AA
      Historical preparation assessment

      Recovered v5.1 source content; historical, awaiting current review.

      Id
      cefepime-enmetazobactam
      Source IDH51-EEFB6393B6F063B308597572
      Name
      Cefepime-enmetazobactam
      Source IDH51-FFCCD6558AF38982DAA76A07
      Brands
      Exblifep
      Source IDH51-F413A2D9AC7D4A659D82C09F
      Therapeutic class
      Antibacterial
      Source IDH51-7B6D3E6AA3F188883FD83DF5
      Review version
      3.1
      Source IDH51-68147BABFD0B964BE1DB3DE0
      Review date
      2026-08-30
      Source IDH51-84CAB8C693D96AE8C35EE21F
      Release status
      structured_record_current_label_not_confirmed
      Source IDH51-A9EF30C666F38EEF3C5C174F
      Market status
      Status
      verified_or_explicitly_flagged_discontinued
      Source IDH51-B5EFED6805C16991002EE6E6
      Basis
      existing catalog or editorial record
      Source IDH51-C0460F7CA2924A104A0563CC
      Ten point assessment
      Exact formulation
      Separate renal reference: Open Renal Dosing Master (opens in a new tab)Monitor changing renal function at least daily as directed in the label. | route: IV infusion | population: Adult, eGFR 15 to 29 mL/min | indication: Existing preparation record; use current package insert for indication-specific selection | dose: 1.25 g total (cefepime 1 g/enmetazobactam 0.25 g) every 12 hours | interval: Not normalized in the preparation record | duration: See current package insert and professional guidance | administration: Infuse over 2 hours | source_level: Existing GlobalRPh structured preparation snapshot | notes: Discard the unused reconstituted vial portion. Drugs@FDA currently lists the U.S. product marketing status as discontinued, so this record is retained as a clearly labeled regulatory and preparation reference rather than an active formulary recommendation. | common_uses: FDA-approved use: complicated urinary tract infection, including pyelonephritis, in adults 18 years and older when caused by designated susceptible organisms | Historical/current-label preparation reference; confirm current product availability and formulary status before any operational use | preparations: population: Adult, eGFR 130 mL/min or greater | amount: 2.5 g total (cefepime 2 g/enmetazobactam 0.5 g) every 8 hours | reconstitution: Withdraw 10 mL from a 250 mL bag of NS, D5W, or 2.5% dextrose/0.45% sodium chloride and use it to reconstitute one vial. The resulting vial concentration is 0.2 g/mL total product (cefepime 0.16 g/mL and enmetazobactam 0.04 g/mL), with an approximate vial volume of 13 mL. Not for direct injection. | diluent: Use the same NS, D5W, or 2.5% dextrose/0.45% sodium chloride solution for reconstitution and final dilution | final_volume: Return the entire reconstituted vial contents (approximately 13 mL) to the same labeled 250 mL infusion bag | concentration: Nominal 10 mg/mL total product based on the labeled 250 mL bag volume; actual concentration depends on container overfill and displacement | rate: Infuse over 4 hours | stability: The prepared diluted solution may be refrigerated at 2 to 8 C for up to 4 hours before administration, but the infusion must be completed within 6 hours of dilution. | notes: Because the infusion lasts 4 hours and must be completed within 6 hours of dilution, no more than 2 hours can elapse between dilution and the start of infusion. The label uses MDRD-calculated eGFR. | population: Adult, eGFR 90 to 129 mL/min | amount: 2.5 g total (cefepime 2 g/enmetazobactam 0.5 g) every 8 hours | reconstitution: Reconstitute one vial with 10 mL drawn from the final 250 mL NS, D5W, or 2.5% dextrose/0.45% sodium chloride bag.
      Source IDH51-FC5288D4BA4C9AB79E5F75E8
      Reconstitution concentration
      Withdraw 10 mL from a 250 mL bag of NS, D5W, or 2.5% dextrose/0.45% sodium chloride and use it to reconstitute one vial. Mix gently. The resulting vial concentration is 0.2 g/mL total product (cefepime 0.16 g/mL and enmetazobactam 0.04 g/mL), with an approximate vial volume of 13 mL. Not for direct injection. Reconstitute one vial with 10 mL drawn from the final 250 mL NS, D5W, or 2.5% dextrose/0.45% sodium chloride bag. Resulting concentration: 0.2 g/mL total product; approximate vial volume: 13 mL. Not for direct injection. Reconstitute one vial with 10 mL drawn from the final 250 mL bag. Resulting concentration: 0.2 g/mL total product; approximate vial volume: 13 mL. Not for direct injection. Reconstitute one 2.5 g vial with 10 mL drawn from the final 250 mL bag. After dissolution, withdraw 6.5 mL of the reconstituted 0.2 g/mL total-product solution. Not for direct injection. Reconstitute one 2.5 g vial with 10 mL drawn from the final 250 mL bag. Withdraw 6.5 mL of the reconstituted 0.2 g/mL total-product solution. Not for direct injection. Reconstitute one 2.5 g vial with 10 mL drawn from the final 250 mL bag. Withdraw 3.3 mL of the reconstituted 0.2 g/mL total-product solution. Not for direct injection.
      Source IDH51-64478A7DC1C492FE03D0BD9C
      Maximum or recommended final concentration
      Separate renal reference: Open Renal Dosing Master (opens in a new tab)Not for direct injection. | diluent: Use the same NS, D5W, or 2.5% dextrose/0.45% sodium chloride solution for reconstitution and final dilution | final_volume: Return the entire reconstituted vial contents (approximately 13 mL) to the same labeled 250 mL infusion bag | concentration: Nominal 10 mg/mL total product based on the labeled 250 mL bag volume; actual concentration depends on container overfill and displacement | rate: Infuse over 4 hours | stability: The prepared diluted solution may be refrigerated at 2 to 8 C for up to 4 hours before administration, but the infusion must be completed within 6 hours of dilution. | notes: Because the infusion lasts 4 hours and must be completed within 6 hours of dilution, no more than 2 hours can elapse between dilution and the start of infusion. Not for direct injection. | diluent: Use the same solution for reconstitution and final dilution | final_volume: Return the entire reconstituted vial contents (approximately 13 mL) to the same labeled 250 mL infusion bag | concentration: Nominal 10 mg/mL total product based on labeled bag volume; account for overfill and displacement | rate: Infuse over 2 hours | stability: Refrigerate the prepared diluted solution at 2 to 8 C for up to 4 hours before administration; complete infusion within 6 hours of dilution. | notes: Use aseptic technique. Not for direct injection. | diluent: NS, D5W, or 2.5% dextrose/0.45% sodium chloride; use the same solution for both steps | final_volume: Return the entire reconstituted vial contents (approximately 13 mL) to the same labeled 250 mL infusion bag | concentration: Nominal 10 mg/mL total product based on labeled bag volume; account for overfill and displacement | rate: Infuse over 2 hours | stability: Refrigerate the prepared diluted solution at 2 to 8 C for up to 4 hours before administration; complete infusion within 6 hours of dilution. | notes: Monitor renal function and revise the regimen if eGFR changes during therapy. | population: Adult, eGFR 30 to 59 mL/min | amount: 1.25 g total (cefepime 1 g/enmetazobactam 0.25 g) every 8 hours | reconstitution: Reconstitute one 2.5 g vial with 10 mL drawn from the final 250 mL bag. Not for direct injection. | diluent: NS, D5W, or 2.5% dextrose/0.45% sodium chloride; use the same solution for both steps | final_volume: Add 6.5 mL to the same labeled 250 mL infusion bag | concentration: Nominal 5 mg/mL total product based on labeled bag volume; account for overfill and displacement | rate: Infuse over 2 hours | stability: Refrigerate the prepared diluted solution at 2 to 8 C for up to 4 hours before administration; complete infusion within 6 hours of dilution. | notes: Discard the unused reconstituted vial portion. Not for direct injection. | diluent: NS, D5W, or 2.5% dextrose/0.45% sodium chloride; use the same solution for both steps | final_volume: Add 6.5 mL to the same labeled 250 mL infusion bag | concentration: Nominal 5 mg/mL total product based on labeled bag volume; account for overfill and displacement | rate: Infuse over 2 hours | stability: Refrigerate the prepared diluted solution at 2 to 8 C for up to 4 hours before administration; complete infusion within 6 hours of dilution. | notes: Discard the unused reconstituted vial portion.
      Source IDH51-A83F9F5D851832D0E0A68A43
      Appropriate standardized containers
      Return the entire reconstituted vial contents (approximately 13 mL) to the same labeled 250 mL infusion bag Add 6.5 mL to the same labeled 250 mL infusion bag Add 3.3 mL to the same labeled 250 mL infusion bag
      Source IDH51-D35B6A76D32F2DE2ED6EC042
      Adult dosing range
      2.5 g total (cefepime 2 g/enmetazobactam 0.5 g) every 8 hours 1.25 g total (cefepime 1 g/enmetazobactam 0.25 g) every 8 hours 1.25 g total (cefepime 1 g/enmetazobactam 0.25 g) every 12 hours 1.25 g total (cefepime 1 g/enmetazobactam 0.25 g) once on the first day 0.625 g total (cefepime 0.5 g/enmetazobactam 0.125 g) every 24 hours after the day 1 loading dose
      Source IDH51-5299D5D3F9E733F9E93C38A1
      Pediatric dosing range
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-4E192A887A762883D39F603B
      Neonatal dosing range
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-5A4817576C2A0BFF789B25EC
      Infusion time
      Infuse over 4 hours Infuse over 2 hours
      Source IDH51-EB8C4E26BFC1F4A45842791C
      Fluid restriction alternatives
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-71D4D064D78D66D382D1B252
      Current manufacturer labeling
      Match confidence
      unresolved
      Source IDH51-D6D36E5C3BD5212BFF6A74E7
      Field provenance
      Exact formulation
      Primary
      existing_record_text
      Source IDH51-899DA0DE1DCE77D47714197D
      Reconstitution concentration
      Primary
      existing_structured_record
      Source IDH51-3E2756E39D1FB83FECC81DF0
      Maximum or recommended final concentration
      Primary
      existing_record_text
      Source IDH51-EC1E8B31A31079475AD61F7C
      Appropriate standardized containers
      Primary
      existing_structured_record
      Source IDH51-A42476AB25AF7C3203FFFEAE
      Adult dosing range
      Primary
      existing_structured_record
      Source IDH51-351E59FD40B003DDE8AF6AB6
      Pediatric dosing range
      Primary
      not_found
      Source IDH51-27349557128DC0D6425C2A40
      Neonatal dosing range
      Primary
      not_found
      Source IDH51-3B64BB3029C22797056B1F5E
      Infusion time
      Primary
      existing_structured_record
      Source IDH51-3DFE789C2F23F3130C346B9B
      Fluid restriction alternatives
      Primary
      not_found
      Source IDH51-7272DB92F1127F8F38A84C19
      Current manufacturer labeling
      Primary
      DailyMed search gateway
      Source IDH51-ACA7A76CDCDC035ADB21A5F2
      Population applicability
      Adult
      Applicability
      supported_or_source_present
      Source IDH51-DFF4364C4DAA5C39420CA1BC
      Guide generation allowed
      true
      Source IDH51-2B541ED2B708540FBDD27C62
      Pediatric
      Applicability
      supported_or_source_present
      Source IDH51-535376DEF835B48CFEA59C2E
      Guide generation allowed
      false
      Source IDH51-5ABC4825F17ADE5B913B3804
      Neonatal
      Applicability
      supported_or_source_present
      Source IDH51-5EF0CE2C1E12207E29315A97
      Guide generation allowed
      false
      Source IDH51-5B816986B3DB0E6513D4C504
      Route presence
      Structured dilution
      true
      Source IDH51-DFAF4CE8D3BC3B852C4A75E5
      Iv push
      false
      Source IDH51-3226EE5CF4EFE2C51DEA84A8
      Continuous infusion
      false
      Source IDH51-35842DAA1A21CFB9AACF4401
      Pediatric source
      true
      Source IDH51-A6BDE781A7918A46E1B4F8BF
      Neonatal source
      true
      Source IDH51-E61A086684524653F03DB886
      Legacy reference
      Status
      not_available
      Source IDH51-96275E048E0E4B458B9D0CE4
      Label resolution
      Status
      build_environment_network_unavailable
      Source IDH51-F2040E832223CFBC6687B07E
      Concentration values detected
      HighUnitText
      Source IDH51-0FA193FE1C0F68FD6FB20602
      10
      Source IDH51-A43E381EF5019B1FF1F819D6
      mg
      Source IDH51-EBFB76D5E11232FC17072E13
      10 mg/mL
      Source IDH51-AED65E6BD265ACB71DB8F7E9
      Source IDH51-767FF0E746CAAD9714E9F209
      10
      Source IDH51-5496516B585BC1D16F39BF37
      mg
      Source IDH51-259195B4096C59232D806EAA
      10 mg/mL
      Source IDH51-48D677EF1CDFE66FF3674810
      Source IDH51-1A7FE3A8E1EF6EEB603A493E
      10
      Source IDH51-BF2C331D85FE937A4352743F
      mg
      Source IDH51-9E2471C8324E08408D1454F8
      10 mg/mL
      Source IDH51-EE42E54DCF1151941F5B9FC2
      Source IDH51-66A2BEB83C7CA476E52E7F67
      5
      Source IDH51-8E35B8C97A93C2E37EB19219
      mg
      Source IDH51-EF60A5107DFCEF9468A4EF3C
      5 mg/mL
      Source IDH51-FD3F89FFC8F6BEAD1A0E4C04
      Source IDH51-A1C879824298F24A6A5ABE6F
      5
      Source IDH51-01E6EF6803321F074B724014
      mg
      Source IDH51-302FB2753E20759B098038F9
      5 mg/mL
      Source IDH51-735DE0A7AE75A86991AB7723
      Source files
      1. catalog.json
        Source IDH51-7ED657A1EBA5C20C8044BDF0
      2. dosing.json
        Source IDH51-7E0002B607542072F8B10D03
      3. new-in-v1.2.json
        Source IDH51-B5BAF62D15B1BB492E10C247
      4. new-in-v1.3.json
        Source IDH51-7C58E7ACC6C1E7D1DDF9D6E3
      Clinical release note
      Preparation instructions are released only at the evidence level shown. Legacy content remains visibly separate. Exact product, NDC, route, current labeling, and institutional policy must be confirmed.
      Source IDH51-A95AB7946F5C8FE8801CDE6A
      Historical statement IDs and source locations

      These IDs identify recovered source units. They are not evidence-qualified clinical claims.

      Historical IDOriginal source locationStatus
      H51-46EB92497506B74D51402FCDcatalog.json
      /records/44/id
      Historical; current review incomplete
      H51-F49C0CBA6634C6E5D9C26355catalog.json
      /records/44/generic_name
      Historical; current review incomplete
      H51-276940F4CC87ABD001F0A943catalog.json
      /records/44/brand_names/0
      Historical; current review incomplete
      H51-708FA9719A4FAA9F0720FE58catalog.json
      /records/44/aliases/0
      Historical; current review incomplete
      H51-E3AB3B1F00B618F44A837C03catalog.json
      /records/44/class
      Historical; current review incomplete
      H51-265F06C371E911BBE622CC52catalog.json
      /records/44/subclass
      Historical; current review incomplete
      H51-91A22AB8AC71156B422A9F00catalog.json
      /records/44/summary
      Historical; current review incomplete
      H51-2996803C045A63D8EC326913catalog.json
      /records/44/common_uses/0
      Historical; current review incomplete
      H51-74F6193CA6F4393F211716FFcatalog.json
      /records/44/common_uses/1
      Historical; current review incomplete
      H51-D196E903D1F068F1925A97C4catalog.json
      /records/44/preparations/0
      Historical; current review incomplete
      H51-4BA3CAE4DE1EAA2C78885CC0catalog.json
      /records/44/preparations/0/population
      Historical; current review incomplete
      H51-6E5BE1BD0074139E07A8003Dcatalog.json
      /records/44/preparations/0/amount
      Historical; current review incomplete
      H51-97271438D1B299C9564DF754catalog.json
      /records/44/preparations/0/reconstitution
      Historical; current review incomplete
      H51-39AF97B6B18610F84539AAD8catalog.json
      /records/44/preparations/0/diluent
      Historical; current review incomplete
      H51-76D7186981C9A82A18435DF7catalog.json
      /records/44/preparations/0/final_volume
      Historical; current review incomplete
      H51-53FDC3A1338547646E244FE9catalog.json
      /records/44/preparations/0/concentration
      Historical; current review incomplete
      H51-4A672707B818C7D5F4E5D493catalog.json
      /records/44/preparations/0/rate
      Historical; current review incomplete
      H51-325EC2C61F297EBE02F5BD9Dcatalog.json
      /records/44/preparations/0/stability
      Historical; current review incomplete
      H51-2849B41DE527DEDC7D7253FFcatalog.json
      /records/44/preparations/0/notes
      Historical; current review incomplete
      H51-8C0F90196D087B71AC03C226catalog.json
      /records/44/preparations/1
      Historical; current review incomplete
      H51-8DACC3A78539A68E282A35CDcatalog.json
      /records/44/preparations/1/population
      Historical; current review incomplete
      H51-48C8AB8206085031295FA6A7catalog.json
      /records/44/preparations/1/amount
      Historical; current review incomplete
      H51-3AF13EA417EDAC398550D0C9catalog.json
      /records/44/preparations/1/reconstitution
      Historical; current review incomplete
      H51-C739E115EF4B32E75EBB827Bcatalog.json
      /records/44/preparations/1/diluent
      Historical; current review incomplete
      H51-C53E1E98A3AEDD09DE33633Ecatalog.json
      /records/44/preparations/1/final_volume
      Historical; current review incomplete
      H51-0F9DD05F9FA20A5155854B88catalog.json
      /records/44/preparations/1/concentration
      Historical; current review incomplete
      H51-FBFFAA65C8C443C4893FB320catalog.json
      /records/44/preparations/1/rate
      Historical; current review incomplete
      H51-8C053E00C8878E24DBEC9385catalog.json
      /records/44/preparations/1/stability
      Historical; current review incomplete
      H51-AD661037F00E0E7A78F4F53Ccatalog.json
      /records/44/preparations/1/notes
      Historical; current review incomplete
      H51-323651D699D0EE812E4B9E39catalog.json
      /records/44/preparations/2
      Historical; current review incomplete
      H51-6EE1CD75030B17E26D7FB59Ccatalog.json
      /records/44/preparations/2/population
      Historical; current review incomplete
      H51-97D119FEB63310F57915690Fcatalog.json
      /records/44/preparations/2/amount
      Historical; current review incomplete
      H51-AD47895B840E53ED325963D3catalog.json
      /records/44/preparations/2/reconstitution
      Historical; current review incomplete
      H51-EDEF60A813865A84C600A1F7catalog.json
      /records/44/preparations/2/diluent
      Historical; current review incomplete
      H51-601EDE570900603541A900F6catalog.json
      /records/44/preparations/2/final_volume
      Historical; current review incomplete
      H51-D5DA8133151CD58E842ABED3catalog.json
      /records/44/preparations/2/concentration
      Historical; current review incomplete
      H51-ECE5FA3C1FBE4FC567069270catalog.json
      /records/44/preparations/2/rate
      Historical; current review incomplete
      H51-78B34AAADA105C07ADD578F5catalog.json
      /records/44/preparations/2/stability
      Historical; current review incomplete
      H51-AF91120DDCF7608FD8CE947Ccatalog.json
      /records/44/preparations/2/notes
      Historical; current review incomplete
      H51-5A781E30EF29A81D8C9CA51Dcatalog.json
      /records/44/preparations/3
      Historical; current review incomplete
      H51-118E4D90656CE0087B5EF9F8catalog.json
      /records/44/preparations/3/population
      Historical; current review incomplete
      H51-AF9FA542E797464CD0F965A0catalog.json
      /records/44/preparations/3/amount
      Historical; current review incomplete
      H51-3BFDD781E1C80151429EF30Ecatalog.json
      /records/44/preparations/3/reconstitution
      Historical; current review incomplete
      H51-A9F1F8ADB56C2FBDE6F9575Fcatalog.json
      /records/44/preparations/3/diluent
      Historical; current review incomplete
      H51-463D1195D494F8CFF55AD072catalog.json
      /records/44/preparations/3/final_volume
      Historical; current review incomplete
      H51-003EFB8588AFAFED1C7AED18catalog.json
      /records/44/preparations/3/concentration
      Historical; current review incomplete
      H51-658ADF37E7D1B1CD3D5C060Fcatalog.json
      /records/44/preparations/3/rate
      Historical; current review incomplete
      H51-8EB0C35BDAAA191E65A89A73catalog.json
      /records/44/preparations/3/stability
      Historical; current review incomplete
      H51-69685019FDF3B28A42E07440catalog.json
      /records/44/preparations/3/notes
      Historical; current review incomplete
      H51-71509B7B7AB96E24A8868E07catalog.json
      /records/44/preparations/4
      Historical; current review incomplete
      H51-71931975FF12B9937AE12B9Ccatalog.json
      /records/44/preparations/4/population
      Historical; current review incomplete
      H51-8064DF2509C7433D74D6F9FDcatalog.json
      /records/44/preparations/4/amount
      Historical; current review incomplete
      H51-960E8CAE61D05AD7AFC11DF5catalog.json
      /records/44/preparations/4/reconstitution
      Historical; current review incomplete
      H51-F84C3311048C781F1B70F3F7catalog.json
      /records/44/preparations/4/diluent
      Historical; current review incomplete
      H51-A708E40BF88304F4FFD85C5Acatalog.json
      /records/44/preparations/4/final_volume
      Historical; current review incomplete
      H51-44E970161B71822BFBDB1424catalog.json
      /records/44/preparations/4/concentration
      Historical; current review incomplete
      H51-B401F472B75A687EEDEF2B2Ecatalog.json
      /records/44/preparations/4/rate
      Historical; current review incomplete
      H51-F1AC441C3F7FF6BD442D66D2catalog.json
      /records/44/preparations/4/stability
      Historical; current review incomplete
      H51-2A1310D3820699B3F3E708DCcatalog.json
      /records/44/preparations/4/notes
      Historical; current review incomplete
      H51-D14B7CE8053984F69442E4B2catalog.json
      /records/44/preparations/5
      Historical; current review incomplete
      H51-467E6F649E5ACFD85C63BCEBcatalog.json
      /records/44/preparations/5/population
      Historical; current review incomplete
      H51-D0D4C18BA42D6A13F64AB0ACcatalog.json
      /records/44/preparations/5/amount
      Historical; current review incomplete
      H51-200963F2DFE98D5A04C0C69Ccatalog.json
      /records/44/preparations/5/reconstitution
      Historical; current review incomplete
      H51-F2CC831D6E34FAA320732E1Dcatalog.json
      /records/44/preparations/5/diluent
      Historical; current review incomplete
      H51-6E5928D8F3DD8F063A82E168catalog.json
      /records/44/preparations/5/final_volume
      Historical; current review incomplete
      H51-6401275A7C5ADEE07DC0E700catalog.json
      /records/44/preparations/5/concentration
      Historical; current review incomplete
      H51-3246A90E56A1BB1BD4659755catalog.json
      /records/44/preparations/5/rate
      Historical; current review incomplete
      H51-3F7F4035F394FDCE871FD183catalog.json
      /records/44/preparations/5/stability
      Historical; current review incomplete
      H51-0C6BF4F33A4B9DE45550B77Bcatalog.json
      /records/44/preparations/5/notes
      Historical; current review incomplete
      H51-B755D14F53D6F4F096D2A14Bcatalog.json
      /records/44/preparations/6
      Historical; current review incomplete
      H51-038974CB4DC5BA78BF36B92Acatalog.json
      /records/44/preparations/6/population
      Historical; current review incomplete
      H51-2BF3A14659386DC6816C179Ecatalog.json
      /records/44/preparations/6/amount
      Historical; current review incomplete
      H51-5E8CC2C0D0D8FDCC864B1D85catalog.json
      /records/44/preparations/6/reconstitution
      Historical; current review incomplete
      H51-8250B696048EDF32FA2F18A1catalog.json
      /records/44/preparations/6/diluent
      Historical; current review incomplete
      H51-F37AB76B3842CD69FD7846EEcatalog.json
      /records/44/preparations/6/final_volume
      Historical; current review incomplete
      H51-CDF1AB822BAFADD7E8F71BFFcatalog.json
      /records/44/preparations/6/concentration
      Historical; current review incomplete
      H51-30B686C3E5C322087EF785A3catalog.json
      /records/44/preparations/6/rate
      Historical; current review incomplete
      H51-C81FA0392A89498C804A1395catalog.json
      /records/44/preparations/6/stability
      Historical; current review incomplete
      H51-7DBE25D53BA7F12CDE398DB6catalog.json
      /records/44/preparations/6/notes
      Historical; current review incomplete
      H51-7DF9490C480A14F96F409D7Ecatalog.json
      /records/44/warnings/0
      Historical; current review incomplete
      H51-7F4DB032BF46117AF82B5E0Dcatalog.json
      /records/44/warnings/1
      Historical; current review incomplete
      H51-57133BC4DDA6DCB04E3C3647catalog.json
      /records/44/warnings/2
      Historical; current review incomplete
      H51-1432350FD9333BA1FC2C6FC3catalog.json
      /records/44/warnings/3
      Historical; current review incomplete
      H51-F48DFDD8363DEE35C70FA32Dcatalog.json
      /records/44/warnings/4
      Historical; current review incomplete
      H51-32F65B0BC59FDE344C33E4D4catalog.json
      /records/44/monitoring/0
      Historical; current review incomplete
      H51-814AFE9A1FC4CE9AE110A46Acatalog.json
      /records/44/monitoring/1
      Historical; current review incomplete
      H51-4B3CDBDA465ED5BC6D04FC81catalog.json
      /records/44/monitoring/2
      Historical; current review incomplete
      H51-8C5DAD38A5A477195455EA9Ccatalog.json
      /records/44/monitoring/3
      Historical; current review incomplete
      H51-A3260A06EBBEA694C012581Acatalog.json
      /records/44/monitoring/4
      Historical; current review incomplete
      H51-45DC213DF6608B408724144Bcatalog.json
      /records/44/monitoring/5
      Historical; current review incomplete
      H51-96965FA7B79269B0AB0B9D1Bcatalog.json
      /records/44/compatibility/0
      Historical; current review incomplete
      H51-86E859AB54A41F0FA9D2B2D9catalog.json
      /records/44/compatibility/1
      Historical; current review incomplete
      H51-38FCE6F318CFE5B47D188029catalog.json
      /records/44/compatibility/2
      Historical; current review incomplete
      H51-DBF37CAEDE65827C83E6A26Acatalog.json
      /records/44/stability_notes/0
      Historical; current review incomplete
      H51-36BDAFA8839874363E813FD2catalog.json
      /records/44/stability_notes/1
      Historical; current review incomplete
      H51-2AE8020D9D22E7F36CF15E3Fcatalog.json
      /records/44/stability_notes/2
      Historical; current review incomplete
      H51-38C7E76A01BDFBE00180C95Ccatalog.json
      /records/44/stability_notes/3
      Historical; current review incomplete
      H51-7F5CDB53D1108B230D3FB162catalog.json
      /records/44/populations/0
      Historical; current review incomplete
      H51-8FFC8A2E617FCB175126954Ecatalog.json
      /records/44/populations/1
      Historical; current review incomplete
      H51-4AC8B9472D50CA3310616BB9catalog.json
      /records/44/populations/2
      Historical; current review incomplete
      H51-2B547F1549342AC7A7D57B52catalog.json
      /records/44/evidence_tier
      Historical; current review incomplete
      H51-84408EBF689BF7A3ADA4C819catalog.json
      /records/44/high_alert
      Historical; current review incomplete
      H51-9A333A437A202065F03C12F3catalog.json
      /records/44/hazardous
      Historical; current review incomplete
      H51-503D78AE9E06C6D722988E23catalog.json
      /records/44/status
      Historical; current review incomplete
      H51-EF29C28F5783A3FC581A29B6catalog.json
      /records/44/reviewed
      Historical; current review incomplete
      H51-7D956356D3881E7936A40292catalog.json
      /records/44/version_added
      Historical; current review incomplete
      H51-BCB71E9AE7A2A34B849E4D3Bcatalog.json
      /records/44/version_updated
      Historical; current review incomplete
      H51-A2D7B8C06B1869216F4C91B5catalog.json
      /records/44/sources/0
      Historical; current review incomplete
      H51-B2CB5FCD16AFF8B972A92E4Ecatalog.json
      /records/44/sources/0/label
      Historical; current review incomplete
      H51-2681BA71C13608180679EB27catalog.json
      /records/44/sources/0/url
      Historical; current review incomplete
      H51-D1F2D7965FA78F0A5280720Fcatalog.json
      /records/44/sources/0/kind
      Historical; current review incomplete
      H51-481400DAD7BF0F589D66013Dcatalog.json
      /records/44/sources/1
      Historical; current review incomplete
      H51-637E6C8DDFE7310661A2E558catalog.json
      /records/44/sources/1/label
      Historical; current review incomplete
      H51-E2EFE8603E158F813A3D63A8catalog.json
      /records/44/sources/1/url
      Historical; current review incomplete
      H51-BDBEB77E3400B2C1A44385E0catalog.json
      /records/44/sources/1/kind
      Historical; current review incomplete
      H51-FC77B96C8EC3E4538D0E1EC5catalog.json
      /records/44/legacy_title
      Historical; current review incomplete
      H51-6A812AAD7EE3BA9EB3CF0FC1catalog.json
      /records/44/clinical_release_verification/audit_version
      Historical; current review incomplete
      H51-4BCE6FA778EDFCFB8696DD0Bcatalog.json
      /records/44/clinical_release_verification/audited_on
      Historical; current review incomplete
      H51-D253CE70F551AFE9D13EBA4Dcatalog.json
      /records/44/clinical_release_verification/level
      Historical; current review incomplete
      H51-54A75AF25C67E4243E63403Fcatalog.json
      /records/44/clinical_release_verification/release_gate
      Historical; current review incomplete
      H51-13DC94D6086E9231D66FF494catalog.json
      /records/44/clinical_release_verification/exact_current_label_candidate
      Historical; current review incomplete
      H51-7FE269A0CC223AE9CB1A5A79catalog.json
      /records/44/clinical_release_verification/selected_setid
      Historical; current review incomplete
      H51-7BBF834C0D53A3CC5265BC6Ccatalog.json
      /records/44/clinical_release_verification/selected_label_title
      Historical; current review incomplete
      H51-299A7DCDAE97A236E428A2B8catalog.json
      /records/44/clinical_release_verification/numeric_support_ratio
      Historical; current review incomplete
      H51-BC20F6981681DA0C84FAE168catalog.json
      /records/44/clinical_release_verification/reference_url_count
      Historical; current review incomplete
      H51-653788941C60CFB1A72F78CBcatalog.json
      /records/44/clinical_release_verification/broken_reference_count
      Historical; current review incomplete
      H51-A22B0D9695A7D0A35373B7E0catalog.json
      /records/44/clinical_release_verification/point_of_use_confirmation_required
      Historical; current review incomplete
      H51-BC22D4166245BAFC309A0EE0catalog.json
      /records/44/clinical_release_verification/note
      Historical; current review incomplete
      H51-8DB15192071EF621568B0F93catalog.json
      /records/44/clinical_release_verification/dailymed_search_url
      Historical; current review incomplete
      H51-EECB65B75CE753EF7BA479B7dosing.json
      /records/44/id
      Historical; current review incomplete
      H51-59EBEE32D757C99BD17FC4F1dosing.json
      /records/44/generic_name
      Historical; current review incomplete
      H51-15F962620A951F2B578250F0dosing.json
      /records/44/coverage_status
      Historical; current review incomplete
      H51-98779493A7CA6A2403CE1042dosing.json
      /records/44/package_insert/query_name
      Historical; current review incomplete
      H51-9FE53F10FB19B7927DAFE488dosing.json
      /records/44/package_insert/preferred_setid
      Historical; current review incomplete
      H51-5A958FAFC7696605F738E368dosing.json
      /records/44/package_insert/product_and_route_must_match
      Historical; current review incomplete
      H51-C7B64CC3061AC0F95B8D81BEdosing.json
      /records/44/package_insert/live_current_label_enabled
      Historical; current review incomplete
      H51-38B18947FAE8F9DEA98A3445dosing.json
      /records/44/package_insert/source_priority
      Historical; current review incomplete
      H51-AA7A39D2E57BB7958F233654dosing.json
      /records/44/package_insert/direct_official_label_access_enabled
      Historical; current review incomplete
      H51-9EF3C5386C5616D7A71AD88Fdosing.json
      /records/44/package_insert/outbound_server_request_required
      Historical; current review incomplete
      H51-8B1AECADCDDFCE187B14467Adosing.json
      /records/44/package_insert/local_summary_status
      Historical; current review incomplete
      H51-F2B4BC28937F41F72A65090Cdosing.json
      /records/44/renal/classification
      Historical; current review incomplete
      H51-32879C3BA0FC61EE8487CA59dosing.json
      /records/44/renal/summary
      Historical; current review incomplete
      H51-D30DFAFD002C47EA1699E31Ddosing.json
      /records/44/renal/method_note
      Historical; current review incomplete
      H51-9F72130096C0AAA9E90B42B2dosing.json
      /records/44/existing_route_snapshots/0
      Historical; current review incomplete
      H51-8ACBC4CDCE4E8C82BC8D7009dosing.json
      /records/44/existing_route_snapshots/0/route
      Historical; current review incomplete
      H51-5316329AB1D3EDB832A9E400dosing.json
      /records/44/existing_route_snapshots/0/population
      Historical; current review incomplete
      H51-CE594B04A950C91026695A63dosing.json
      /records/44/existing_route_snapshots/0/indication
      Historical; current review incomplete
      H51-D54B38C2D5C23BB701E8D829dosing.json
      /records/44/existing_route_snapshots/0/dose
      Historical; current review incomplete
      H51-21B93F309C7015674A798A72dosing.json
      /records/44/existing_route_snapshots/0/interval
      Historical; current review incomplete
      H51-6CF2E535FA078ADDD0786B01dosing.json
      /records/44/existing_route_snapshots/0/duration
      Historical; current review incomplete
      H51-EE3EB8DA4B6F3207302E8DD4dosing.json
      /records/44/existing_route_snapshots/0/administration
      Historical; current review incomplete
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