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Preparation. Administration. Evidence.

IV Dilution &
Medication Reference

Search 255 medications, read preserved historical references, and inspect separately reviewed preparation statements. Full monograph updates remain pending.

Version 6.4Release date 2026-11-04For healthcare professionals
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Medication reference

Aztreonam-avibactam

Monograph awaiting updateThis monograph will be updated in the future.

Jump to a section
Selected DailyMed label (opens in a new tab)

No original site article was mapped to this record. The available historical structured fields and official-source links are retained.

Historical first look: uses, mechanism, dosing context, and administration

Recovered v5.1 source content; historical, awaiting current review.

Id
aztreonam-avibactam
Source IDH51-A5A01B76C6D9AB1DB1C145AB
Generic name
Aztreonam-avibactam
Source IDH51-91BA4C704E7F2E2D638E0A86
Class
Antibacterial
Source IDH51-32F3B671D5650E9B2DEFE71A
Subclass
Monobactam plus beta-lactamase inhibitor
Source IDH51-2E06C58EA372AEC9A36526AD
Primary uses
  1. Complicated intra-abdominal infection in adults with limited or no alternative options, used with metronidazole
    Source IDH51-DF1EA00DAD62BDEDF49CB2E3
Mechanism
The beta-lactam component inhibits penicillin-binding proteins and cell-wall synthesis; its partner protects or enhances activity against selected resistance mechanisms.
Source IDH51-8FD20D26D30DB28D9A66FF3F
Mechanism level
class_level
Source IDH51-9A31ECB8CB5C33699965C6D5
Basic dosing orientation
Adult loading dose, CLcr greater than 50 mL/min | Existing preparation record; use current package insert for indication-specific selection | 2.67 g total (2 g aztreonam/0.67 g avibactam) | Not normalized in the preparation record | See current package insert and professional guidance | IV infusion; Adult maintenance, CLcr greater than 50 mL/min | Existing preparation record; use current package insert for indication-specific selection | 2 g total (1.5 g aztreonam/0.5 g avibactam) every 6 hours | Not normalized in the preparation record | See current package insert and professional guidance | IV infusion
Source IDH51-23D5BCC3224D0DD731BA5BB6
Administration orientation
Infuse over 3 hours
Source IDH51-230E2ACD75EAF7EDFA60FED8
Renal and population orientation
Separate renal reference: Open Renal Dosing Master (opens in a new tab)Renal dose adjustment or interval modification is commonly required; verify the selected product label and patient-specific renal method.
Source IDH51-5BF7244B7FF95BA415C0BECD
Key safety orientation
  1. Serious beta-lactam hypersensitivity can occur.
    Source IDH51-48AE9DA8D108BBD72BFEA727
  2. Renal function may change during therapy and changes both dose and interval.
    Source IDH51-908E7E87694D4E9462140587
  3. Do not mix with other drugs in the same solution.
    Source IDH51-397FC552BB53070847E2915D
Coverage path
structured_local_snapshot
Source IDH51-D681336243C5F5A275752B76
Coverage path label
Structured GlobalRPh route snapshot
Source IDH51-22FD6D8F86D820EE5872571D
Review note
First-look orientation only. Verify indication, patient population, weight basis, organ function, exact IV product, dose, concentration, compatibility, rate, and current labeling before use.
Source IDH51-75E6FB5D8B7B505CB9F386C2
Search text
Aztreonam-avibactam Antibacterial Monobactam plus beta-lactamase inhibitor Complicated intra-abdominal infection in adults with limited or no alternative options, used with metronidazole The beta-lactam component inhibits penicillin-binding proteins and cell-wall synthesis; its partner protects or enhances activity against selected resistance mechanisms. Adult loading dose, CLcr greater than 50 mL/min | Existing preparation record; use current package insert for indication-specific selection | 2.67 g total (2 g aztreonam/0.67 g avibactam) | Not normalized in the preparation record | See current package insert and professional guidance | IV infusion; Adult maintenance, CLcr greater than 50 mL/min | Existing preparation record; use current package insert for indication-specific selection | 2 g total (1.5 g aztreonam/0.5 g avibactam) every 6 hours | Not normalized in the preparation record | See current package insert and professional guidance | IV infusion Infuse over 3 hours Renal dose adjustment or interval modification is commonly required; verify the selected product label and patient-specific renal method. Serious beta-lactam hypersensitivity can occur. Renal function may change during therapy and changes both dose and interval. Do not mix with other drugs in the same solution. Structured GlobalRPh route snapshot
Source IDH51-23F831DEC92B7F5FDA3B9280
Official access mode
direct_label
Source IDH51-F14024DD4F7F8CDA9A0D73B2
Official access reason
A source-specific DailyMed label route is available.
Source IDH51-D23643CC0F870838D6EF83BD
Label snapshot available
true
Source IDH51-03B9EE4C9B46A0B167F7323A
Label snapshot setid
be1a6c99-d4b3-46d7-9e99-6e5f9fab556a
Source IDH51-B53A1E200C4CB593405267F5
Product identifiers and clinical review status

This monograph will be updated in the future. Historical material is available where present in the original sources; full current exact-product and claim-level review remains pending.

Exact formulation, concentration, container, manufacturer, regulatory identifiers, and a reproducible label snapshot have not all been reconciled.

What remains to be completed
  • A retrieved source document is available; clinical reconciliation and a second-source claim map remain incomplete
  • Clinically reviewed, individually identified statements with two exact source mappings
  • Exact formulation, strength, container, manufacturer/labeler, application and NDC reconciliation
  • Renal-function methods and dialysis/CRRT modality review where applicable
  • Mechanism provenance, clinical source disagreements and full medication-specific safety reconciliation

Supplemental historical fields

Restored-data provenance and review notes

Source release: 2026-08-31. Current clinical review is incomplete. Original uses of current, verified, or normalized describe the historical source. They do not inherit the status of separately reviewed statements. Product formulations and source dates can differ.

Current review annotations for historical renal, dialysis, mechanism, and product fieldsSeparate renal reference: Open Renal Dosing Master (opens in a new tab)
Renal
Status
not_locally_normalized
Original classification
adjustment_required
Entries
    General note
    Preserve the source-specific renal-function basis. An indexed CrCl table is not interchangeable with unindexed CrCl or eGFR. Generic advice to check a method does not identify the equation for a dose row.
    Dialysis
    Status
    no_local_structured_regimen
    Entries
      General note
      Named modality alone does not establish applicability. CRRT subtype, effluent rate, residual renal function, timing and interruptions require review. Historical absence is not evidence that no guidance exists.
      Mechanisms
      • Source kind
        first_look
        Local pointer
        /mechanism
        Original level
        class_level
        Provenance classification
        historical_class_level
        Label derived verified
        false
        Independently corroborated
        false
        Exact label section
        Not recorded
        Original source note
        Not recorded
        Review status
        historical_unverified
        Note
        Drug-specific wording in the old file is not proof of independent corroboration or an exact label locator. Consult separately published current mechanism claims where present.
      • Source kind
        label_snapshot
        Local pointer
        /mechanism_summary
        Original level
        class_level
        Provenance classification
        historical_class_level
        Label derived verified
        false
        Independently corroborated
        false
        Exact label section
        Not recorded
        Original source note
        Concise GlobalRPh summary reviewed against the selected DailyMed label clinical-pharmacology or microbiology content.
        Review status
        historical_unverified
        Note
        Drug-specific wording in the old file is not proof of independent corroboration or an exact label locator. Consult separately published current mechanism claims where present.
      Future update
      Status
      pending_review
      Message
      This monograph will be updated in the future as current exact-product and claim-level review is completed.
      Source unavailable
      false
      Reason
      The historical content is restored; comprehensive contemporary verification remains incomplete.

      No separate structured rows were bundled for IV push, continuous infusion, dialysis, CRRT. Historical article content and source links may cover these topics.

      Historical dilution and intermittent infusion preparation

      Recovered v5.1 source content; historical, awaiting current review.

      Separate renal reference: Open Renal Dosing Master (opens in a new tab)
      PopulationAmountReconstitutionDiluentFinal volumeConcentrationRateStabilityNotes
      Source IDH51-6FF813B8FA5DE1B91A2F2B03
      Adult loading dose, CLcr greater than 50 mL/min
      Source IDH51-9F36CACDEA2763BBBE0FF652
      		2.67 g total (2 g aztreonam/0.67 g avibactam)
      Source IDH51-177B64E7BB873F3B3145409E
      		Reconstitute each vial with 10 mL Sterile Water for Injection; approximately 12 mL final per vial.
      Source IDH51-86B01107B9F1D3050AA62E9C
      		NS, D5W, or LR
      Source IDH51-A0A273B5BC09BDFA0C4EFBB3
      		Dilute withdrawn volume to 50 to 250 mL
      Source IDH51-0500BCE871176AD78D5C1B90
      		Aztreonam 2.7 to 40 mg/mL and avibactam 0.9 to 13.3 mg/mL
      Source IDH51-224223C0AC08C6BC2571F65E
      		Infuse over 3 hours
      Source IDH51-6B948FD9AA241498C3206112
      		Reconstituted vial: up to 60 minutes at not more than 30 C. NS or LR bag: up to 24 hours refrigerated then 12 hours at not more than 30 C. D5W bag: up to 24 hours refrigerated then 4 hours at not more than 30 C.
      Source IDH51-7DA62158202717B775E72D64
      		Loading dose requires two vials.
      Source IDH51-49FCBED13B0605A5F24AC185
      Source IDH51-81B1AC9E8A587CC74360095C
      Adult maintenance, CLcr greater than 50 mL/min
      Source IDH51-C56D39AA85B6B4D63C7BFD5F
      		2 g total (1.5 g aztreonam/0.5 g avibactam) every 6 hours
      Source IDH51-741F5413343A744D7F26256B
      		Reconstitute one vial with 10 mL Sterile Water for Injection.
      Source IDH51-616CE3609A1DE390D484FBAC
      		NS, D5W, or LR
      Source IDH51-B0A162409D1C3E40AD048C33
      		50 to 250 mL
      Source IDH51-64A9AC7F2D0543856DF8E7F1
      		Within label range
      Source IDH51-C2307B2A75240EBA8A16D17F
      		Infuse over 3 hours
      Source IDH51-DF18DFB0D53FAB3EC33A9E3E
      		Use label-specific limits above and apply the shorter USP sterility-based ceiling.
      Source IDH51-FE3E3B16C61385B9ADEDC350
      		Renal adjustment is required at CLcr 50 mL/min or less.
      Source IDH51-4933981EFD447F4503709850

      Historical DailyMed label snapshot

      Recovered v5.1 source content; historical, awaiting current review.

      Id
      aztreonam-avibactam
      Source IDH51-92DF6BFF9D3B1851892D59E7
      Catalog name
      Aztreonam-avibactam
      Source IDH51-3D9A156AF433F7B5AB6175DA
      Selection status
      accepted_high_confidence
      Source IDH51-4C806F0657B3CD885EB404CB
      Confidence
      very_high
      Source IDH51-88DFAE9ED170616D58E79345
      Match path
      verified_direct_label
      Source IDH51-1BEC7ACE88CE276E51B81CDA
      Brand name
      EMBLAVEO
      Source IDH51-19C132FE7213289CE6D5AA46
      Label title
      EMBLAVEO (aztreonam and avibactam) powder for solution
      Source IDH51-9649E08C488A55E334D22326
      Setid
      be1a6c99-d4b3-46d7-9e99-6e5f9fab556a
      Source IDH51-577045A03D4516F698F9EA55
      Route
      Loading dose followed by extended intravenous infusions
      Source IDH51-055401EDED5B5DBA203BE5AC
      Dosage form
      Combination powder for reconstitution and further dilution
      Source IDH51-A1B600E36381088FCB2EFE6F
      Dosage administration summary
      Separate renal reference: Open Renal Dosing Master (opens in a new tab)
      1. Use the current indication- and renal-function-specific table. In adults with high renal function, the label uses a loading dose followed by maintenance doses infused over 3 hours.
        Source IDH51-B006A4E4EE67E27DE526FBC9
      2. Reconstitute the vial with the labeled volume and further dilute the calculated dose in a compatible 50 to 250 mL infusion container.
        Source IDH51-F31EEC8BA0336DDF90934A17
      3. Renal function changes both dose and interval; reassess frequently when renal function is changing.
        Source IDH51-DB6060CF7D4D90BAE3EC86AB
      Dosage forms strengths
      1. 2 g single-dose vial containing 1.5 g aztreonam and 0.5 g avibactam
        Source IDH51-63B633075FB00D87B0634D52
      Mechanism summary
      Aztreonam inhibits bacterial penicillin-binding proteins; avibactam inhibits selected beta-lactamases and protects aztreonam from hydrolysis.
      Source IDH51-7459A4B1F5499F4874171C83
      Scope note
      Selected EMBLAVEO combination label. Do not apply to aztreonam alone.
      Source IDH51-98DD676F8C95E1F2087F47CF
      Reviewed on
      2026-08-31
      Source IDH51-7D59700845DFD4B6D22C1886
      Mechanism source
      Concise GlobalRPh summary reviewed against the selected DailyMed label clinical-pharmacology or microbiology content.
      Source IDH51-214A4A458BAB8C269DBE18A2
      Source sections
      1. Dosage and Administration
        Source IDH51-169EA391AC12A06DE84FFC6C
      2. Dosage Forms and Strengths
        Source IDH51-84FA63A3AE3F38A138932C81
      3. Clinical Pharmacology or Microbiology as applicable
        Source IDH51-ED1EC425C7CB11818D31CAD6
      Retrieval method
      Manual build-time review of the current DailyMed full prescribing information for the selected Set ID; no live server retrieval is required during page use.
      Source IDH51-B435C64ECED02E8A56050BBE
      Label status
      current
      Source IDH51-00AE73A9ED9DC3C7974CDD5B
      Disclaimer
      Verify the exact formulation, strength, manufacturer, NDC, route, current label revision, patient-specific order, institutional policy, and monitoring before use.
      Source IDH51-94014A4DA36300744EBE55C3

      Historical indication and population dosing

      Recovered tables and source-separated snapshots; full clinical revalidation remains pending.

      Existing dose and route snapshots

      Separate renal reference: Open Renal Dosing Master (opens in a new tab)
      RoutePopulationIndicationDoseIntervalDurationAdministrationSource levelNotes
      Source IDH51-E4FE6BCC1B649F1210F7D895
      IV infusion
      Source IDH51-4A358937FAB394CC1B6459BC
      		Adult loading dose, CLcr greater than 50 mL/min
      Source IDH51-48385FB0B09AC369612DE979
      		Existing preparation record; use current package insert for indication-specific selection
      Source IDH51-648E67BE393858C983B7761E
      		2.67 g total (2 g aztreonam/0.67 g avibactam)
      Source IDH51-5431DE31292388B034F76E14
      		Not normalized in the preparation record
      Source IDH51-CDA7060E4A739B6AD8A794FD
      		See current package insert and professional guidance
      Source IDH51-B48DB1F2F29FC57D640ABC28
      		Infuse over 3 hours
      Source IDH51-38643E267A1D93AEBF609FA5
      		Existing GlobalRPh structured preparation snapshot
      Source IDH51-A0CCEF6F7BE5889FADC3AC98
      		Loading dose requires two vials.
      Source IDH51-84F7DCB3FD7DCDBAD3FAABB7
      Source IDH51-EA477F57B23E5DF9E81D87EC
      IV infusion
      Source IDH51-1D435928143AA3BCC5370CB8
      		Adult maintenance, CLcr greater than 50 mL/min
      Source IDH51-2A8A4AB53970F2AE830F790F
      		Existing preparation record; use current package insert for indication-specific selection
      Source IDH51-42BD3628B4B9882415F5C80F
      		2 g total (1.5 g aztreonam/0.5 g avibactam) every 6 hours
      Source IDH51-83B8621FC69CEEE045CDE5E5
      		Not normalized in the preparation record
      Source IDH51-06AD6F2E8E202482789D2624
      		See current package insert and professional guidance
      Source IDH51-A62F2A9D0CB9F55195F33C4A
      		Infuse over 3 hours
      Source IDH51-FE69DA9227DB880BC4DD3CE9
      		Existing GlobalRPh structured preparation snapshot
      Source IDH51-BACA9245ADA283B4364EE538
      		Renal adjustment is required at CLcr 50 mL/min or less.
      Source IDH51-A009D1B5C6167282DDAC46F3

      Historical renal-function guidance

      Recovered v5.1 source content; historical, awaiting current review.

      Separate renal reference: Open Renal Dosing Master (opens in a new tab)
      Classification
      adjustment_required
      Source IDH51-5B45761FF81BADBA0E6768AD
      Summary
      Renal dose adjustment or interval modification is commonly required; verify the selected product label and patient-specific renal method.
      Source IDH51-101E8067CF14CB16EEAC29DD
      Method note
      Use the renal function estimate and body-size convention specified by the selected label or institutional protocol. Do not interchange Cockcroft-Gault CrCl, indexed eGFR, and de-indexed eGFR without confirming the dosing source.
      Source IDH51-68183DA12EDFB436EEE1BD0E

      Historical Common IV uses

      Recovered v5.1 source content; historical, awaiting current review.

      1. Complicated intra-abdominal infection in adults with limited or no alternative options, used with metronidazole
        Source IDH51-360A35D1D40EA6C7D66D0516

      Historical Warnings and safeguards

      Recovered v5.1 source content; historical, awaiting current review.

      Separate renal reference: Open Renal Dosing Master (opens in a new tab)
      1. Serious beta-lactam hypersensitivity can occur.
        Source IDH51-6D618196D8F8BDD12928BE3C
      2. Renal function may change during therapy and changes both dose and interval.
        Source IDH51-F9C160DFC55A0752379801C8
      3. Do not mix with other drugs in the same solution.
        Source IDH51-175907033D0DA823E7D38BCA

      Historical Monitoring

      Recovered v5.1 source content; historical, awaiting current review.

      Separate renal reference: Open Renal Dosing Master (opens in a new tab)
      1. Renal function
        Source IDH51-9D08958FE6976CE64E4EB58C
      2. Hepatic tests
        Source IDH51-E4FED64C80211BBEF67CCE69
      3. Clinical and microbiologic response
        Source IDH51-212644BE82690970ED81B7A9

      Historical supplemental professional sources

      Recovered v5.1 source content; historical, awaiting current review.

      LabelUrlKind
      Source IDH51-F18AB587EBF9A0A7B6B877FC
      UCSF adult antimicrobial dosing, non-dialysis
      Source IDH51-97F4F7C000A1C5B49934BA32
      		https://idmp.ucsf.edu/adult-antimicrobial-dosing-non-dialysis (opens in a new tab)
      Source IDH51-89554F5190284F37FA307A3C
      		Professional institutional guidance
      Source IDH51-483686669521775532CBD223
      Source IDH51-ECC625F5C52FC66825785F7B
      UCSF antimicrobial dosing in intermittent and continuous hemodialysis
      Source IDH51-215A975FABE8A5804029BA7C
      		https://idmp.ucsf.edu/antimicrobial-dosing-intermittent-continuous-hemodialysis (opens in a new tab)
      Source IDH51-7BB3BD370CC12FCDF6E9A5B6
      		Professional institutional guidance
      Source IDH51-BDE405F25E19BB2DA5049F04
      Source IDH51-6EBA7DEA1A8ABDD97E368EA6
      UCSF pediatric antimicrobial dosing
      Source IDH51-ADDF409C5E4E1B714583E004
      		https://idmp.ucsf.edu/pediatric-antimicrobial-dosing-benioff-childrens-hospitals (opens in a new tab)
      Source IDH51-7B7590B227E5C242026660AE
      		Professional institutional guidance
      Source IDH51-B4DC3B4B3ECDD7D22E8D9A43
      Source IDH51-B26800CE76E9DCEE5D452D1D
      UCSF neonatal antimicrobial dosing
      Source IDH51-E0392A75B2E1BA5F83AED7EC
      		https://idmp.ucsf.edu/neonatal-antimicrobial-dosing-benioff-childrens-hospitals (opens in a new tab)
      Source IDH51-BFD0A8D7B7A5A272E0DB355C
      		Professional institutional guidance
      Source IDH51-E711866553C267FE26F9429B
      Other recovered source fields and original editorial metadata

      Original status words such as current, verified, or normalized describe the historical source release. They do not change the clinical review status of this release.

      Catalog source fields

      Id
      aztreonam-avibactam
      Source IDH51-938AF00A20DBFAED21A34863
      Generic name
      Aztreonam-avibactam
      Source IDH51-FF62CB7DFC42CCB0336705B7
      Brand names
      1. Emblaveo
        Source IDH51-6A6DE84988E1E23FA1B109FC
      Aliases
      1. aztreonam avibactam
        Source IDH51-0EAFFDD56A1DB2AAC5D1A77B
      Class
      Antibacterial
      Source IDH51-EE700F4CB949488F345F7907
      Subclass
      Monobactam plus beta-lactamase inhibitor
      Source IDH51-547C5FFC3009EED3B7ABA73F
      Summary
      Newer fixed 3:1 combination supplied as 1.5 g aztreonam plus 0.5 g avibactam per vial, with a loading dose followed by prolonged maintenance infusions.
      Source IDH51-F3ED5EA126C97CD423F257E7
      Populations
      1. Adult
        Source IDH51-50C089A9CF3C139D4678827C
      Evidence tier
      Current-label candidate - verify exact product
      Source IDH51-F12B6FF5615F9F72A71697AB
      High alert
      false
      Source IDH51-29C9F9580935E08366E11146
      Hazardous
      false
      Source IDH51-2BB019F31D0ECD4582131F30
      Status
      Active
      Source IDH51-F7B42EDED6D4F454F4502A8A
      Reviewed
      2026-08-29
      Source IDH51-516788AA09AE8DD29C7D0F24
      Version added
      1.2
      Source IDH51-6E61FC2C6D3A3807E3261192
      Sources
      LabelUrlKind
      Source IDH51-E390D847607A5857B606E024
      DailyMed EMBLAVEO prescribing information
      Source IDH51-7A18326CC37DC2844A0B4B07
      		https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=be1a6c99-d4b3-46d7-9e99-6e5f9fab556a (opens in a new tab)
      Source IDH51-774973EADD31B45C4F4E85A1
      		Primary
      Source IDH51-D97696143882A5FA760680A2
      Source IDH51-9EA5813F9E0238FE3435CE52
      GlobalRPh legacy IV dilution monograph
      Source IDH51-6074F9C3E041D91C9F7ADF95
      		legacy:auto
      Source IDH51-B9068BD615C754EE7018ACFF
      		Legacy
      Source IDH51-D8FFC5D5A93DAF6123D699F7
      Clinical release verification
      Audit version
      3.4
      Source IDH51-4A2D44AC6C87FCB0C43E8732
      Audited on
      2026-08-30
      Source IDH51-FFAD45EFB8E7638656DDF19D
      Level
      amber
      Source IDH51-F3EE38C54B4E0DFACF9B4D36
      Release gate
      trusted_professional_source_present_exact_label_unconfirmed
      Source IDH51-DE9AADA8B7DF89226CA1F430
      Exact current label candidate
      false
      Source IDH51-94A9DCC821708518746EAF35
      Selected setid
      be1a6c99-d4b3-46d7-9e99-6e5f9fab556a
      Source IDH51-5EDEE74702FE2DF0DD06BF8C
      Numeric support ratio
      0
      Source IDH51-571C76EBB33B28571CDD667B
      Reference url count
      5
      Source IDH51-0D32C1CC677634EFB295365E
      Broken reference count
      0
      Source IDH51-07F312CCEC1A4BAC229AE5C2
      Point of use confirmation required
      true
      Source IDH51-13AC7F70D051A7F835AD6D17
      Note
      Do not treat this record as a fully current product-specific monograph until the exact IV formulation and current sources are confirmed.
      Source IDH51-E4374D159155B8E87876A322

      Dosing source fields

      Id
      aztreonam-avibactam
      Source IDH51-B63AF989A332E2D57A40D61F
      Generic name
      Aztreonam-avibactam
      Source IDH51-86CCCA8BD094C9C4D2B3F7EE
      Coverage status
      direct_official_label_access_plus_local_snapshot
      Source IDH51-5DF5E1AF02B533108EF9A589
      Package insert
      Query name
      Aztreonam-avibactam
      Source IDH51-403041655876783D932A4131
      Preferred setid
      be1a6c99-d4b3-46d7-9e99-6e5f9fab556a
      Source IDH51-8F650CF0316079746B7B48E4
      Product and route must match
      true
      Source IDH51-53FAE84B322460614D39093E
      Live current label enabled
      false
      Source IDH51-1E4E51ADE2C3798CF72C578C
      Source priority
      Reviewed local summary when available, then a verified DailyMed label or product search when available, followed by professional references and institutional policy.
      Source IDH51-FB91303C4828F34C9795C948
      Direct official label access enabled
      true
      Source IDH51-3B2C8B3CDB81E37F8CBECAF2
      Outbound server request required
      false
      Source IDH51-B6A106F141570BAF7ECFC9F0
      Local summary status
      not_bundled
      Source IDH51-2C856525FBC7BF5785FB9EE4
      Clinical review
      Locally normalized
      false
      Source IDH51-45C7E90FFA7DEAA87D18F1C0
      Reviewed
      2026-08-29
      Source IDH51-86BA40EF81AD390F49571275
      Status
      Direct official package-insert access enabled; indication-specific local normalization pending.
      Source IDH51-5BA1BA02D354789CF3469B85
      Clinical release verification
      Audit version
      3.4
      Source IDH51-51E07DA5D1B2F771A089EDA3
      Audited on
      2026-08-30
      Source IDH51-DC045BC6D2B17DA7818B9AFA
      Level
      amber
      Source IDH51-CA77BFA6168E048C918984B5
      Release gate
      trusted_professional_source_present_exact_label_unconfirmed
      Source IDH51-1EB5BFEDEAE0FA3D09E5AD77
      Exact current label candidate
      false
      Source IDH51-C36644D0553C0C4FEBAFF797
      Selected setid
      be1a6c99-d4b3-46d7-9e99-6e5f9fab556a
      Source IDH51-6E45BEDF98B64205C17585DF
      Numeric support ratio
      0
      Source IDH51-36F015F073D3147EEA2F4B2D
      Reference url count
      5
      Source IDH51-9339434522490A28FE5C438F
      Broken reference count
      0
      Source IDH51-02F777E3DFF89942E3D8E2DF
      Point of use confirmation required
      true
      Source IDH51-6E450DE9B6EE9CFBDC59E71C
      Note
      Do not treat this record as a fully current product-specific monograph until the exact IV formulation and current sources are confirmed.
      Source IDH51-C96F9956D5BBCDB64A5093AD
      Historical preparation assessment

      Recovered v5.1 source content; historical, awaiting current review.

      Id
      aztreonam-avibactam
      Source IDH51-DA6B6D49ACF3A53AFEB4C07F
      Name
      Aztreonam-avibactam
      Source IDH51-29059C8850426CE5C71D223C
      Brands
      Emblaveo
      Source IDH51-2364EE1777C9D4B3D073370B
      Therapeutic class
      Antibacterial
      Source IDH51-D806F1896C6BDE6FC906D4DC
      Review version
      3.1
      Source IDH51-82E5C493CAB51F32F0120322
      Review date
      2026-08-30
      Source IDH51-F0C0BDD079D88AE4A8788CA1
      Release status
      structured_record_current_label_not_confirmed
      Source IDH51-195C978414E01D5025334D12
      Market status
      Status
      no_current_us_iv_spl_confirmed
      Source IDH51-15CAEA345C46768BD89BC03C
      Basis
      No high-confidence current IV SPL was automatically selected; legacy information is segregated
      Source IDH51-8D4BAE73DC380B9607A390EB
      Ten point assessment
      Exact formulation
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-48BC0ACA5B37726E23081432
      Reconstitution concentration
      Reconstitute each vial with 10 mL Sterile Water for Injection; approximately 12 mL final per vial. Reconstitute one vial with 10 mL Sterile Water for Injection.
      Source IDH51-8E3831FA3FF3B32D5AB5D41D
      Maximum or recommended final concentration
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-6BC6ACBBACF285BD0FE8C127
      Appropriate standardized containers
      Dilute withdrawn volume to 50 to 250 mL 50 to 250 mL
      Source IDH51-4974148E7AC6F7AD6000DD7A
      Adult dosing range
      2.67 g total (2 g aztreonam/0.67 g avibactam) 2 g total (1.5 g aztreonam/0.5 g avibactam) every 6 hours
      Source IDH51-3EC996A273B4053F34795CA7
      Pediatric dosing range
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-08EE8A45C6DDCD888FA125AB
      Neonatal dosing range
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-1974D02F6987DA83504D0081
      Infusion time
      Infuse over 3 hours
      Source IDH51-4A55BC0CCF1E16E45655C175
      Fluid restriction alternatives
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-1F67E799A779F269D5806B12
      Current manufacturer labeling
      Setid
      be1a6c99-d4b3-46d7-9e99-6e5f9fab556a
      Source IDH51-751ABA453954D76C0D80713C
      Match confidence
      unresolved
      Source IDH51-81AA99104FAA9D56C23C89B1
      Field provenance
      Exact formulation
      Primary
      not_found
      Source IDH51-CED7E69D02780598769CC189
      Reconstitution concentration
      Primary
      existing_structured_record
      Source IDH51-0AC4B622FE14DCAAB7419924
      Maximum or recommended final concentration
      Primary
      not_found
      Source IDH51-F06DE5159B46A03A9FB9BEEA
      Appropriate standardized containers
      Primary
      existing_structured_record
      Source IDH51-DB0E037E8FF966716FAB44A4
      Adult dosing range
      Primary
      existing_structured_record
      Source IDH51-7BB16751FF1180AB059C0D1A
      Pediatric dosing range
      Primary
      not_found
      Source IDH51-A058A11DC4B1C4D64C041D6E
      Neonatal dosing range
      Primary
      not_found
      Source IDH51-35FD67E3EDF1CAD3156D3EB1
      Infusion time
      Primary
      existing_structured_record
      Source IDH51-F0343470C87CE484367B0DD4
      Fluid restriction alternatives
      Primary
      not_found
      Source IDH51-6B642D510D3021CA20A29A79
      Current manufacturer labeling
      Primary
      DailyMed current-label gateway
      Source IDH51-B8278620FD238614E2CFF71B
      Population applicability
      Adult
      Applicability
      supported_or_source_present
      Source IDH51-3BFB82D1F2AFDD341C6F0DDA
      Guide generation allowed
      true
      Source IDH51-8EA8A7676CBB35AB34336856
      Pediatric
      Applicability
      supported_or_source_present
      Source IDH51-01E08233A526D4520EC4C377
      Guide generation allowed
      false
      Source IDH51-93E24CCA3751E62A6E954A30
      Neonatal
      Applicability
      supported_or_source_present
      Source IDH51-C76F2D0FB74AF05A0C8FC6C8
      Guide generation allowed
      false
      Source IDH51-5D412E91E605E8581DCFF36A
      Route presence
      Structured dilution
      true
      Source IDH51-9F283B05AE30598B453B4A75
      Iv push
      false
      Source IDH51-E49A5EF7593841698DE38128
      Continuous infusion
      false
      Source IDH51-8892B22256F155C9CBD73917
      Pediatric source
      true
      Source IDH51-657EB1F29D912CADD89916BB
      Neonatal source
      true
      Source IDH51-81DAEB99F6A5E5D17A5EC1AA
      Legacy reference
      Status
      not_available
      Source IDH51-668B28DF690090F4099B3A9B
      Label resolution
      Status
      build_environment_network_unavailable
      Source IDH51-A3760A7A9DB5FB90DB3F774E
      Existing setids
      1. be1a6c99-d4b3-46d7-9e99-6e5f9fab556a
        Source IDH51-17597A3AE0C8A4DE78A898D2
      Source files
      1. catalog.json
        Source IDH51-3F21567D1A964BCD744E6631
      2. dosing.json
        Source IDH51-C9D7E8EFAD7F140BBADD8082
      3. new-in-v1.2.json
        Source IDH51-CAE4CF033DBCEF10E6F2E69F
      Clinical release note
      Preparation instructions are released only at the evidence level shown. Legacy content remains visibly separate. Exact product, NDC, route, current labeling, and institutional policy must be confirmed.
      Source IDH51-9BA7C7CF8590FB55164A90B1
      Historical statement IDs and source locations

      These IDs identify recovered source units. They are not evidence-qualified clinical claims.

      Historical IDOriginal source locationStatus
      H51-938AF00A20DBFAED21A34863catalog.json
      /records/31/id      		Historical; current review incomplete
      H51-FF62CB7DFC42CCB0336705B7catalog.json
      /records/31/generic_name      		Historical; current review incomplete
      H51-6A6DE84988E1E23FA1B109FCcatalog.json
      /records/31/brand_names/0      		Historical; current review incomplete
      H51-0EAFFDD56A1DB2AAC5D1A77Bcatalog.json
      /records/31/aliases/0      		Historical; current review incomplete
      H51-EE700F4CB949488F345F7907catalog.json
      /records/31/class      		Historical; current review incomplete
      H51-547C5FFC3009EED3B7ABA73Fcatalog.json
      /records/31/subclass      		Historical; current review incomplete
      H51-F3ED5EA126C97CD423F257E7catalog.json
      /records/31/summary      		Historical; current review incomplete
      H51-360A35D1D40EA6C7D66D0516catalog.json
      /records/31/common_uses/0      		Historical; current review incomplete
      H51-6FF813B8FA5DE1B91A2F2B03catalog.json
      /records/31/preparations/0      		Historical; current review incomplete
      H51-9F36CACDEA2763BBBE0FF652catalog.json
      /records/31/preparations/0/population      		Historical; current review incomplete
      H51-177B64E7BB873F3B3145409Ecatalog.json
      /records/31/preparations/0/amount      		Historical; current review incomplete
      H51-86B01107B9F1D3050AA62E9Ccatalog.json
      /records/31/preparations/0/reconstitution      		Historical; current review incomplete
      H51-A0A273B5BC09BDFA0C4EFBB3catalog.json
      /records/31/preparations/0/diluent      		Historical; current review incomplete
      H51-0500BCE871176AD78D5C1B90catalog.json
      /records/31/preparations/0/final_volume      		Historical; current review incomplete
      H51-224223C0AC08C6BC2571F65Ecatalog.json
      /records/31/preparations/0/concentration      		Historical; current review incomplete
      H51-6B948FD9AA241498C3206112catalog.json
      /records/31/preparations/0/rate      		Historical; current review incomplete
      H51-7DA62158202717B775E72D64catalog.json
      /records/31/preparations/0/stability      		Historical; current review incomplete
      H51-49FCBED13B0605A5F24AC185catalog.json
      /records/31/preparations/0/notes      		Historical; current review incomplete
      H51-81B1AC9E8A587CC74360095Ccatalog.json
      /records/31/preparations/1      		Historical; current review incomplete
      H51-C56D39AA85B6B4D63C7BFD5Fcatalog.json
      /records/31/preparations/1/population      		Historical; current review incomplete
      H51-741F5413343A744D7F26256Bcatalog.json
      /records/31/preparations/1/amount      		Historical; current review incomplete
      H51-616CE3609A1DE390D484FBACcatalog.json
      /records/31/preparations/1/reconstitution      		Historical; current review incomplete
      H51-B0A162409D1C3E40AD048C33catalog.json
      /records/31/preparations/1/diluent      		Historical; current review incomplete
      H51-64A9AC7F2D0543856DF8E7F1catalog.json
      /records/31/preparations/1/final_volume      		Historical; current review incomplete
      H51-C2307B2A75240EBA8A16D17Fcatalog.json
      /records/31/preparations/1/concentration      		Historical; current review incomplete
      H51-DF18DFB0D53FAB3EC33A9E3Ecatalog.json
      /records/31/preparations/1/rate      		Historical; current review incomplete
      H51-FE3E3B16C61385B9ADEDC350catalog.json
      /records/31/preparations/1/stability      		Historical; current review incomplete
      H51-4933981EFD447F4503709850catalog.json
      /records/31/preparations/1/notes      		Historical; current review incomplete
      H51-6D618196D8F8BDD12928BE3Ccatalog.json
      /records/31/warnings/0      		Historical; current review incomplete
      H51-F9C160DFC55A0752379801C8catalog.json
      /records/31/warnings/1      		Historical; current review incomplete
      H51-175907033D0DA823E7D38BCAcatalog.json
      /records/31/warnings/2      		Historical; current review incomplete
      H51-9D08958FE6976CE64E4EB58Ccatalog.json
      /records/31/monitoring/0      		Historical; current review incomplete
      H51-E4FED64C80211BBEF67CCE69catalog.json
      /records/31/monitoring/1      		Historical; current review incomplete
      H51-212644BE82690970ED81B7A9catalog.json
      /records/31/monitoring/2      		Historical; current review incomplete
      H51-50C089A9CF3C139D4678827Ccatalog.json
      /records/31/populations/0      		Historical; current review incomplete
      H51-F12B6FF5615F9F72A71697ABcatalog.json
      /records/31/evidence_tier      		Historical; current review incomplete
      H51-29C9F9580935E08366E11146catalog.json
      /records/31/high_alert      		Historical; current review incomplete
      H51-2BB019F31D0ECD4582131F30catalog.json
      /records/31/hazardous      		Historical; current review incomplete
      H51-F7B42EDED6D4F454F4502A8Acatalog.json
      /records/31/status      		Historical; current review incomplete
      H51-516788AA09AE8DD29C7D0F24catalog.json
      /records/31/reviewed      		Historical; current review incomplete
      H51-6E61FC2C6D3A3807E3261192catalog.json
      /records/31/version_added      		Historical; current review incomplete
      H51-E390D847607A5857B606E024catalog.json
      /records/31/sources/0      		Historical; current review incomplete
      H51-7A18326CC37DC2844A0B4B07catalog.json
      /records/31/sources/0/label      		Historical; current review incomplete
      H51-774973EADD31B45C4F4E85A1catalog.json
      /records/31/sources/0/url      		Historical; current review incomplete
      H51-D97696143882A5FA760680A2catalog.json
      /records/31/sources/0/kind      		Historical; current review incomplete
      H51-9EA5813F9E0238FE3435CE52catalog.json
      /records/31/sources/1      		Historical; current review incomplete
      H51-6074F9C3E041D91C9F7ADF95catalog.json
      /records/31/sources/1/label      		Historical; current review incomplete
      H51-B9068BD615C754EE7018ACFFcatalog.json
      /records/31/sources/1/url      		Historical; current review incomplete
      H51-D8FFC5D5A93DAF6123D699F7catalog.json
      /records/31/sources/1/kind      		Historical; current review incomplete
      H51-14E1653D8053EA84A3792D2Ccatalog.json
      /records/31/legacy_title      		Historical; current review incomplete
      H51-4A2D44AC6C87FCB0C43E8732catalog.json
      /records/31/clinical_release_verification/audit_version      		Historical; current review incomplete
      H51-FFAD45EFB8E7638656DDF19Dcatalog.json
      /records/31/clinical_release_verification/audited_on      		Historical; current review incomplete
      H51-F3EE38C54B4E0DFACF9B4D36catalog.json
      /records/31/clinical_release_verification/level      		Historical; current review incomplete
      H51-DE9AADA8B7DF89226CA1F430catalog.json
      /records/31/clinical_release_verification/release_gate      		Historical; current review incomplete
      H51-94A9DCC821708518746EAF35catalog.json
      /records/31/clinical_release_verification/exact_current_label_candidate      		Historical; current review incomplete
      H51-5EDEE74702FE2DF0DD06BF8Ccatalog.json
      /records/31/clinical_release_verification/selected_setid      		Historical; current review incomplete
      H51-1EB657654E563471B0549CFEcatalog.json
      /records/31/clinical_release_verification/selected_label_title      		Historical; current review incomplete
      H51-571C76EBB33B28571CDD667Bcatalog.json
      /records/31/clinical_release_verification/numeric_support_ratio      		Historical; current review incomplete
      H51-0D32C1CC677634EFB295365Ecatalog.json
      /records/31/clinical_release_verification/reference_url_count      		Historical; current review incomplete
      H51-07F312CCEC1A4BAC229AE5C2catalog.json
      /records/31/clinical_release_verification/broken_reference_count      		Historical; current review incomplete
      H51-13AC7F70D051A7F835AD6D17catalog.json
      /records/31/clinical_release_verification/point_of_use_confirmation_required      		Historical; current review incomplete
      H51-E4374D159155B8E87876A322catalog.json
      /records/31/clinical_release_verification/note      		Historical; current review incomplete
      H51-99A656C751CDF5E35C6B8CC8catalog.json
      /records/31/clinical_release_verification/dailymed_search_url      		Historical; current review incomplete
      H51-92DF6BFF9D3B1851892D59E7dailymed-label-snapshots-v5.1.json
      /records/7/id      		Historical; current review incomplete
      H51-3D9A156AF433F7B5AB6175DAdailymed-label-snapshots-v5.1.json
      /records/7/catalog_name      		Historical; current review incomplete
      H51-4C806F0657B3CD885EB404CBdailymed-label-snapshots-v5.1.json
      /records/7/selection_status      		Historical; current review incomplete
      H51-88DFAE9ED170616D58E79345dailymed-label-snapshots-v5.1.json
      /records/7/confidence      		Historical; current review incomplete
      H51-1BEC7ACE88CE276E51B81CDAdailymed-label-snapshots-v5.1.json
      /records/7/match_path      		Historical; current review incomplete
      H51-19C132FE7213289CE6D5AA46dailymed-label-snapshots-v5.1.json
      /records/7/brand_name      		Historical; current review incomplete
      H51-9649E08C488A55E334D22326dailymed-label-snapshots-v5.1.json
      /records/7/label_title      		Historical; current review incomplete
      H51-577045A03D4516F698F9EA55dailymed-label-snapshots-v5.1.json
      /records/7/setid      		Historical; current review incomplete
      H51-055401EDED5B5DBA203BE5ACdailymed-label-snapshots-v5.1.json
      /records/7/route      		Historical; current review incomplete
      H51-A1B600E36381088FCB2EFE6Fdailymed-label-snapshots-v5.1.json
      /records/7/dosage_form      		Historical; current review incomplete
      H51-B006A4E4EE67E27DE526FBC9dailymed-label-snapshots-v5.1.json
      /records/7/dosage_administration_summary/0      		Historical; current review incomplete
      H51-F31EEC8BA0336DDF90934A17dailymed-label-snapshots-v5.1.json
      /records/7/dosage_administration_summary/1      		Historical; current review incomplete
      H51-DB6060CF7D4D90BAE3EC86ABdailymed-label-snapshots-v5.1.json
      /records/7/dosage_administration_summary/2      		Historical; current review incomplete
      H51-63B633075FB00D87B0634D52dailymed-label-snapshots-v5.1.json
      /records/7/dosage_forms_strengths/0      		Historical; current review incomplete
      H51-7459A4B1F5499F4874171C83dailymed-label-snapshots-v5.1.json
      /records/7/mechanism_summary      		Historical; current review incomplete
      H51-98DD676F8C95E1F2087F47CFdailymed-label-snapshots-v5.1.json
      /records/7/scope_note      		Historical; current review incomplete
      H51-64ED819676018E574EBB4004dailymed-label-snapshots-v5.1.json
      /records/7/labeler      		Historical; current review incomplete
      H51-51874F9BC9C2752BBC1AFC25dailymed-label-snapshots-v5.1.json
      /records/7/official_label_url      		Historical; current review incomplete
      H51-7D59700845DFD4B6D22C1886dailymed-label-snapshots-v5.1.json
      /records/7/reviewed_on      		Historical; current review incomplete
      H51-214A4A458BAB8C269DBE18A2dailymed-label-snapshots-v5.1.json
      /records/7/mechanism_source      		Historical; current review incomplete
      H51-169EA391AC12A06DE84FFC6Cdailymed-label-snapshots-v5.1.json
      /records/7/source_sections/0      		Historical; current review incomplete
      H51-84FA63A3AE3F38A138932C81dailymed-label-snapshots-v5.1.json
      /records/7/source_sections/1      		Historical; current review incomplete
      H51-ED1EC425C7CB11818D31CAD6dailymed-label-snapshots-v5.1.json
      /records/7/source_sections/2      		Historical; current review incomplete
      H51-B435C64ECED02E8A56050BBEdailymed-label-snapshots-v5.1.json
      /records/7/retrieval_method      		Historical; current review incomplete
      H51-00AE73A9ED9DC3C7974CDD5Bdailymed-label-snapshots-v5.1.json
      /records/7/label_status      		Historical; current review incomplete
      H51-94014A4DA36300744EBE55C3dailymed-label-snapshots-v5.1.json
      /records/7/disclaimer      		Historical; current review incomplete
      H51-B63AF989A332E2D57A40D61Fdosing.json
      /records/31/id      		Historical; current review incomplete
      H51-86CCCA8BD094C9C4D2B3F7EEdosing.json
      /records/31/generic_name      		Historical; current review incomplete
      H51-5DF5E1AF02B533108EF9A589dosing.json
      /records/31/coverage_status      		Historical; current review incomplete
      H51-403041655876783D932A4131dosing.json
      /records/31/package_insert/query_name      		Historical; current review incomplete
      H51-8F650CF0316079746B7B48E4dosing.json
      /records/31/package_insert/preferred_setid      		Historical; current review incomplete
      H51-53FAE84B322460614D39093Edosing.json
      /records/31/package_insert/product_and_route_must_match      		Historical; current review incomplete
      H51-1E4E51ADE2C3798CF72C578Cdosing.json
      /records/31/package_insert/live_current_label_enabled      		Historical; current review incomplete
      H51-FB91303C4828F34C9795C948dosing.json
      /records/31/package_insert/source_priority      		Historical; current review incomplete
      H51-3B2C8B3CDB81E37F8CBECAF2dosing.json
      /records/31/package_insert/direct_official_label_access_enabled      		Historical; current review incomplete
      H51-B6A106F141570BAF7ECFC9F0dosing.json
      /records/31/package_insert/outbound_server_request_required      		Historical; current review incomplete
      H51-2C856525FBC7BF5785FB9EE4dosing.json
      /records/31/package_insert/local_summary_status      		Historical; current review incomplete
      H51-5B45761FF81BADBA0E6768ADdosing.json
      /records/31/renal/classification      		Historical; current review incomplete
      H51-101E8067CF14CB16EEAC29DDdosing.json
      /records/31/renal/summary      		Historical; current review incomplete
      H51-68183DA12EDFB436EEE1BD0Edosing.json
      /records/31/renal/method_note      		Historical; current review incomplete
      H51-E4FE6BCC1B649F1210F7D895dosing.json
      /records/31/existing_route_snapshots/0      		Historical; current review incomplete
      H51-4A358937FAB394CC1B6459BCdosing.json
      /records/31/existing_route_snapshots/0/route      		Historical; current review incomplete
      H51-48385FB0B09AC369612DE979dosing.json
      /records/31/existing_route_snapshots/0/population      		Historical; current review incomplete
      H51-648E67BE393858C983B7761Edosing.json
      /records/31/existing_route_snapshots/0/indication      		Historical; current review incomplete
      H51-5431DE31292388B034F76E14dosing.json
      /records/31/existing_route_snapshots/0/dose      		Historical; current review incomplete
      H51-CDA7060E4A739B6AD8A794FDdosing.json
      /records/31/existing_route_snapshots/0/interval      		Historical; current review incomplete
      H51-B48DB1F2F29FC57D640ABC28dosing.json
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      H51-38643E267A1D93AEBF609FA5dosing.json
      /records/31/existing_route_snapshots/0/administration      		Historical; current review incomplete
      H51-A0CCEF6F7BE5889FADC3AC98dosing.json
      /records/31/existing_route_snapshots/0/source_level      		Historical; current review incomplete
      H51-84F7DCB3FD7DCDBAD3FAABB7dosing.json
      /records/31/existing_route_snapshots/0/notes      		Historical; current review incomplete
      H51-EA477F57B23E5DF9E81D87ECdosing.json
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      H51-1D435928143AA3BCC5370CB8dosing.json
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      H51-2A8A4AB53970F2AE830F790Fdosing.json
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      H51-42BD3628B4B9882415F5C80Fdosing.json
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      H51-83B8621FC69CEEE045CDE5E5dosing.json
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      H51-06AD6F2E8E202482789D2624dosing.json
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      H51-A62F2A9D0CB9F55195F33C4Adosing.json
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      H51-A009D1B5C6167282DDAC46F3dosing.json
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      H51-F18AB587EBF9A0A7B6B877FCdosing.json
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      H51-97F4F7C000A1C5B49934BA32dosing.json
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      H51-89554F5190284F37FA307A3Cdosing.json
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      H51-215A975FABE8A5804029BA7Cdosing.json
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      H51-DC045BC6D2B17DA7818B9AFAdosing.json
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      H51-6E450DE9B6EE9CFBDC59E71Cdosing.json
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      H51-C96F9956D5BBCDB64A5093ADdosing.json
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      H51-A5A01B76C6D9AB1DB1C145ABfirst-look-v5.1.json
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      /31/clinical_release_note      		Historical; current review incomplete
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