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Preparation. Administration. Evidence.

IV Dilution &
Medication Reference

Search 255 medications, read preserved historical references, and inspect separately reviewed preparation statements. Full monograph updates remain pending.

Version 6.4Release date 2026-11-04For healthcare professionals
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Medication reference

Alteplase

Monograph awaiting updateThis monograph will be updated in the future.

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Historical source. Current clinical review is incomplete. This monograph will be updated in the future.

Alteplase (opens in a new tab)Original source URL: https://globalrph.com/dilution/alteplase/ | Retrieved 2026-11-04

Source dates, location and integrity

This historical article is separate from the reviewed claim cards. Product formulations and source dates may differ.

Original source URL
https://globalrph.com/dilution/alteplase/ (opens in a new tab)
Source date
Not established in the retrieved source
Retrieved
2026-11-04T19:45:43.196726+00:00
Source location
div.post-content
Packaged content SHA-256
27d28687e4dc26a444883577951da999717023ec708424cd3d6beb94cb0aebbd
Original response SHA-256
633be7627fb8220f2cd2d923708f186acdb39d7789100199ace65c20937107c3
Source body SHA-256
e125b055de2aed4ad1a1cb49e15ad702dcda4e1f7712e348843d7d5b2b48a2d4

Alteplase - (ACTIVASE, TPA)

The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material. PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER. Read the disclaimer

Usual Diluents
NS, D5W

Standard Dilutions [Amount of drug] [Infusion volume] [Infusion rate]
Note: Sterile water without preservative
[50 mg vial] [50 ml - SW] [UD]
[100 mg vial] [100 ml - SW ] [UD]

Peripheral arterial occlusive disease: Continuous infusion of alteplase: 0.5 to 2 mg/hr x 6 to 72 hours depending on location. Preparation: Dilute alteplase with sterile water as above, then further dilute with NS to produce one of the following concentrations below:

Concentration (0.1 mg/ml)
[25 mg] [250ml]
[50 mg] [500 ml]

Concentration (0.2 mg/ml)
[50 mg] [250ml]

Alternatives:
-------------------------------------------
Concentration (0.025 mg/ml)
[12.5 mg] [500ml]

Concentration (0.05 mg/ml)
[25 mg] [500ml]

Stability / Miscellaneous
EXP: 8 hours (RT). Prepare just before use. Results in concentration of 1 mg/ml. May be infused at this concentration or may dilute further with equal volume of normal saline or D5W (0.5 mg/ml).

Stability data:
Drug Stability Refrigerated Stability Room Temp. Reconstituted Vial/Powder Notes P-Insert Updated
Alteplase Kit Store lyophilized Activase under refrigeration not to exceed (2-8°C/36-46°F). Protect the lyophilized material during extended storage from excessive exposure to light. If stored between 2-30°C (36-86°F), Activase may be used within 8 hours following reconstitution. Store lyophilized Activase at controlled room temperature not to exceed 30°C (86°F). Protect the lyophilized material during extended storage from excessive exposure to light. If stored between 2-30°C (36-86°F), Activase may be used within 8 hours following reconstitution. Kit Discard any unused solution after administration is complete. Do not use beyond the expiration date stamped on the vial. 02 24 15
Alteplase (TPA) Store lyophilized Cathflo Activase at refrigerated temperature (2-8°C/36-46°F). The solution may be used for intracatheter instillation within 8 hours following reconstitution when stored at 2-30°C (36-86°F). The solution may be used for intracatheter instillation within 8 hours following reconstitution when stored at 2-30°C (36-86°F). Powder Any unused solution should be discarded. Do not use beyond the expiration date on the vial. Protect the lyophilized material during extended storage from excessive exposure to light. 10 08 13

Dosing:
Acute MI: (2 protocols)- (1) (Preferred) Accelerated infusion: for patients > 65kg: 15 mg IV bolus f/b 50mg over next 30min, and the remaining 35mg (100mg total) infused over the next 60 min. Patients <65kg: 15 mg bolus, then 0.75 mg/kg (max 50 mg) over 30 minutes, then 0.5 mg/kg (max 35 mg) over next 60 minutes. (2) 3-hour infusion (may be less effective): In 1st hour, 60 mg is administered (of which 6-10mg is administered ivpush in first 1-2 minutes), followed by 20 mg/hr x 2 hours. (100mg total). For patients <65 kg: administer 1.25 mg/kg in the same manner over 3 hours.

Pulmonary embolism: 100 mg over 2 hours.
Stroke: (Give within first 3 hours): 0.9 mg/kg (max 90mg)-10% of dose given ivpush, followed by a continuous infusion over 1 hour.

Intracatheter: Cathflo® Activase® (Alteplase) is for instillation into the dysfunctional catheter at a concentration of 1 mg/mL.

DOSAGE AND ADMINISTRATION
• Patients weighing >/=30 kg: 2 mg in 2 mL.
• Patients weighing <30 kg: 110% of the internal lumen volume of the catheter, not to exceed 2 mg in 2 mL. If catheter function is not restored at 120 minutes after 1 dose of Cathflo Activase, a second dose may be instilled (see INSTRUCTIONS FOR ADMINISTRATION). There is no efficacy or safety information on dosing in excess of 2 mg per dose for this indication. Studies have not been performed with administration of total doses greater than 4 mg (two 2-mg doses). Package insert.

Instructions for Administration
Preparation of Solution: Reconstitute Cathflo Activase to a final concentration of 1 mg/mL: Aseptically withdraw 2.2 mL of Sterile Water for Injection, USP (diluent is not provided). Do not use Bacteriostatic Water for Injection. Inject the 2.2 mL of Sterile Water for Injection, USP, into the Cathflo Activase vial, directing the diluent stream into the powder. Slight foaming is not unusual; let the vial stand undisturbed to allow large bubbles to dissipate. Mix by gently swirling until the contents are completely dissolved. Complete dissolution should occur within 3 minutes. DO NOT SHAKE. The reconstituted preparation results in a colorless to pale yellow transparent solution containing 1 mg/mL Cathflo Activase at a pH of approximately 7.3. Cathflo Activase contains no antibacterial preservatives and should be reconstituted immediately before use. The solution may be used for intracatheter instillation within 8 hours following reconstitution when stored at 2-30°C (36-86°F). No other medication should be added to solutions containing Cathflo Activase.

Instillation of Solution into the Catheter Inspect the product prior to administration for foreign matter and discoloration. Withdraw 2 mL (2 mg) of solution from the reconstituted vial. Instill the appropriate dose of Cathflo Activase (see DOSAGE AND ADMINISTRATION) into the occluded catheter. After 30 minutes of dwell time, assess catheter function by attempting to aspirate blood. If the catheter is functional, go to Step 7. If the catheter is not functional, go to Step 5. After 120 minutes of dwell time, assess catheter function by attempting to aspirate blood and catheter contents. If the catheter is functional, go to Step 7. If the catheter is not functional, go to Step 6. If catheter function is not restored after one dose of Cathflo Activase, a second dose of equal amount may be instilled. Repeat the procedure beginning with Step 1 under Preparation of Solution. If catheter function has been restored, aspirate 4-5 mL of blood in patients >/=10 kg or 3 mL in patients <10 kg to remove Cathflo Activase and residual clot, and gently irrigate the catheter with 0.9% Sodium Chloride Injection, USP. Any unused solution should be discarded.

Stability and Storage Store lyophilized Cathflo Activase at refrigerated temperature (2-8°C/36-46°F). Do not use beyond the expiration date on the vial. Protect the lyophilized material during extended storage from excessive exposure to light.

HOW SUPPLIED Cathflo Activase (Alteplase) for injection is supplied as a sterile, lyophilized powder in 2 mg vials. Each Cathflo®Activase® carton contains one 2 mg vial of Cathflo® Activase® (Alteplase): NDC 50242-041-64.

Intra-arterial: Acute peripheral arterial occlusive disease (unlabeled use): 0.02-0.1 mg/kg/hour for up to 36 hours Advisory Panel to the Society for Cardiovascular and Interventional Radiology on Thrombolytic Therapy recommendation: </=2 mg/hour and subtherapeutic heparin (aPTT <1.5 times baseline) Additional info

Open this historical article on its own

Product identifiers and clinical review status

This monograph will be updated in the future. Historical material is available where present in the original sources; full current exact-product and claim-level review remains pending.

Exact formulation, concentration, container, manufacturer, regulatory identifiers, and a reproducible label snapshot have not all been reconciled.

What remains to be completed
  • Retrievable exact-product SPL XML with version, revision, retrieval date and reproducible hash
  • Clinically reviewed, individually identified statements with two exact source mappings
  • Exact formulation, strength, container, manufacturer/labeler, application and NDC reconciliation
  • Renal-function methods and dialysis/CRRT modality review where applicable
  • Mechanism provenance, clinical source disagreements and full medication-specific safety reconciliation

Supplemental historical fields

Restored-data provenance and review notes

Source release: 2026-08-31. Current clinical review is incomplete. Original uses of current, verified, or normalized describe the historical source. They do not inherit the status of separately reviewed statements. Product formulations and source dates can differ.

Current review annotations for historical renal, dialysis, mechanism, and product fieldsSeparate renal reference: Open Renal Dosing Master (opens in a new tab)
Renal
Status
not_locally_normalized
Original classification
current_label_review_required
Entries
    General note
    Preserve the source-specific renal-function basis. An indexed CrCl table is not interchangeable with unindexed CrCl or eGFR. Generic advice to check a method does not identify the equation for a dose row.
    Dialysis
    Status
    no_local_structured_regimen
    Entries
      General note
      Named modality alone does not establish applicability. CRRT subtype, effluent rate, residual renal function, timing and interruptions require review. Historical absence is not evidence that no guidance exists.
      Mechanisms
      • Source kind
        first_look
        Local pointer
        /mechanism
        Original level
        drug_specific
        Provenance classification
        historical_drug_specific_uncorroborated
        Label derived verified
        false
        Independently corroborated
        false
        Exact label section
        Not recorded
        Original source note
        Not recorded
        Review status
        historical_unverified
        Note
        Drug-specific wording in the old file is not proof of independent corroboration or an exact label locator. Consult separately published current mechanism claims where present.
      Future update
      Status
      pending_review
      Message
      This monograph will be updated in the future as current exact-product and claim-level review is completed.
      Source unavailable
      false
      Reason
      The historical content is restored; comprehensive contemporary verification remains incomplete.
      Historical first look: uses, mechanism, dosing context, and administration

      Recovered v5.1 source content; historical, awaiting current review.

      Id
      alteplase
      Source IDH51-FA05A85D5883D91EB9E1EB37
      Generic name
      Alteplase
      Source IDH51-E49EE48856283103459B4169
      Class
      Anticoagulation and hemostasis
      Source IDH51-C355969EF88FD7505012F726
      Subclass
      Thrombolytic
      Source IDH51-20CB072F1C71A367B50A9958
      Primary uses
      1. Acute ischemic stroke
        Source IDH51-248A258616F0B87A4CE8DE19
      2. Massive pulmonary embolism
        Source IDH51-BFF2CC067068035296080868
      3. Acute myocardial infarction
        Source IDH51-2D7C93093FE4A90E5DAA928A
      4. Occluded central venous catheter
        Source IDH51-C84ECF3C20FB3B1C01ED9421
      Mechanism
      Converts plasminogen to plasmin and promotes fibrin degradation and thrombus lysis.
      Source IDH51-9892712F1F1E40CB7E30DD8B
      Mechanism level
      drug_specific
      Source IDH51-FBECE48EC388983E4A2342E2
      Basic dosing orientation
      Adult systemic thrombolysis | Existing preparation record; use current package insert for indication-specific selection | Indication-specific weight-based or fixed dose | Not normalized in the preparation record | See current package insert and professional guidance | IV infusion; Adult stroke/MI protocols | Only the protocol-defined bolus fraction | Only the protocol-defined bolus fraction | Patient- and indication-specific | See current package insert | IV push
      Source IDH51-1C407C502A9743BA8ACCA392
      Administration orientation
      Bolus and infusion sequence depends entirely on indication; Bolus over approximately 1 minute when the indication regimen specifies; 1 mg/mL; Bolus over approximately 1 minute when the indication regimen specifies
      Source IDH51-296D4B8B35BF3CCA6EADB9C5
      Renal and population orientation
      Separate renal reference: Open Renal Dosing Master (opens in a new tab)Renal dosing status has not been locally normalized; use the current package insert before ordering or administration.
      Source IDH51-0C6AF2FC7A72F47588D0AB19
      Key safety orientation
      1. Fatal or disabling bleeding, including intracranial hemorrhage.
        Source IDH51-DB13F853D784EC452F3B5BB0
      2. Never use one indication regimen for another.
        Source IDH51-5BA2CEB922DCF6721D1892F4
      3. Avoid vigorous agitation.
        Source IDH51-E91243E127A65599E0D7BC4D
      Coverage path
      structured_local_snapshot
      Source IDH51-BA2F00721DD000D3BA96982B
      Coverage path label
      Structured GlobalRPh route snapshot
      Source IDH51-BE802919083001F289D342BE
      Legacy title
      Alteplase
      Source IDH51-E0CE31B14C5E610AAA3B8CA3
      Review note
      First-look orientation only. Verify indication, patient population, weight basis, organ function, exact IV product, dose, concentration, compatibility, rate, and current labeling before use.
      Source IDH51-96F0885071325B9A1EAA1782
      Search text
      Alteplase Anticoagulation and hemostasis Thrombolytic Acute ischemic stroke Massive pulmonary embolism Acute myocardial infarction Occluded central venous catheter Converts plasminogen to plasmin and promotes fibrin degradation and thrombus lysis. Adult systemic thrombolysis | Existing preparation record; use current package insert for indication-specific selection | Indication-specific weight-based or fixed dose | Not normalized in the preparation record | See current package insert and professional guidance | IV infusion; Adult stroke/MI protocols | Only the protocol-defined bolus fraction | Only the protocol-defined bolus fraction | Patient- and indication-specific | See current package insert | IV push Bolus and infusion sequence depends entirely on indication; Bolus over approximately 1 minute when the indication regimen specifies; 1 mg/mL; Bolus over approximately 1 minute when the indication regimen specifies Renal dosing status has not been locally normalized; use the current package insert before ordering or administration. Fatal or disabling bleeding, including intracranial hemorrhage. Never use one indication regimen for another. Avoid vigorous agitation. Structured GlobalRPh route snapshot
      Source IDH51-B60306A8DA07C8F634AC92CA
      Official access mode
      search
      Source IDH51-3A14CD625608C650BAD00345
      Official search query
      Alteplase
      Source IDH51-330D3D105FE55179E2A8C508
      Official access reason
      A source-backed DailyMed search is available; select and confirm the exact IV product.
      Source IDH51-1767003FF1BCA8FADE3610D5

      No separate structured rows were bundled for continuous infusion, dialysis, CRRT. Historical article content and source links may cover these topics.

      Historical dilution and intermittent infusion preparation

      Recovered v5.1 source content; historical, awaiting current review.

      PopulationAmountReconstitutionDiluentFinal volumeConcentrationRateStabilityNotes
      Source IDH51-1F14C0EC3A105A33BE1ACE49
      Adult systemic thrombolysis
      Source IDH51-761CAAB7FF7D3ADE0E59A85A
      		Indication-specific weight-based or fixed dose
      Source IDH51-A8A7F3BCE54A9FE72E46D44B
      		Reconstitute with supplied Sterile Water for Injection using transfer device; do not shake.
      Source IDH51-B2ADFE2850A2C91F63C13301
      		Reconstituted solution may be administered directly or diluted only as labeling permits
      Source IDH51-318631F56656BC93973CC04A
      		Vial or infusion container
      Source IDH51-F0B6F379F8C27BB541BDF261
      		Commonly 1 mg/mL after reconstitution
      Source IDH51-368D2F5FB4853B7CFA590D1D
      		Bolus and infusion sequence depends entirely on indication
      Source IDH51-E64C549890725A5D0664DF78
      		Use the shorter of current product labeling, validated stability data, and the applicable USP <797> sterility-based BUD ceiling.
      Source IDH51-004E4FF053B7FF4E48D1D91A
      		Stroke, PE, MI, and catheter-clearance doses are profoundly different.
      Source IDH51-8D62302B85A02AD0E1ED15B7

      Historical IV-push guidance

      Recovered v5.1 source content; historical, awaiting current review.

      PopulationDose scopeConcentrationRateStatus
      Source IDH51-D3BBA0673C3C4EC47625DA71
      Adult stroke/MI protocols
      Source IDH51-4CBB5707D25390E3132C76D1
      		Only the protocol-defined bolus fraction
      Source IDH51-E2C7281938B499DD48454B47
      		1 mg/mL
      Source IDH51-1446C6AFBF162EA0514D930F
      		Bolus over approximately 1 minute when the indication regimen specifies
      Source IDH51-D00D9ABEAD2F4CE03EA2E03C
      		Indication-specific thrombolysis protocol only
      Source IDH51-32C6604B89751601EBFB3BEF

      Historical indication and population dosing

      Recovered tables and source-separated snapshots; full clinical revalidation remains pending.

      Existing dose and route snapshots

      RoutePopulationIndicationDoseIntervalDurationAdministrationSource levelNotes
      Source IDH51-2DC12D186D5361EF933B2FB4
      IV infusion
      Source IDH51-CC3EF3447E29B00C9E40F15E
      		Adult systemic thrombolysis
      Source IDH51-4A4815EF2A36646674AE6902
      		Existing preparation record; use current package insert for indication-specific selection
      Source IDH51-7637C9A1BEA7D55346A35CFD
      		Indication-specific weight-based or fixed dose
      Source IDH51-8BC89A7DB96FC673081CC9C2
      		Not normalized in the preparation record
      Source IDH51-B9EE9B027E49410D2ADF9C65
      		See current package insert and professional guidance
      Source IDH51-25D8F83B14751B0EE3FDB5CC
      		Bolus and infusion sequence depends entirely on indication
      Source IDH51-C36AFB6B7CF1193092E0ACC1
      		Existing GlobalRPh structured preparation snapshot
      Source IDH51-14032B4CE1423B2B49E26BA8
      		Stroke, PE, MI, and catheter-clearance doses are profoundly different.
      Source IDH51-A6CB615722F5E641D736AF3E
      Source IDH51-CE46BC26677F35828FE24DA5
      IV push
      Source IDH51-DFBF1E8A48E0880F742E6628
      		Adult stroke/MI protocols
      Source IDH51-C777C46834866C0F8A6ACD65
      		Only the protocol-defined bolus fraction
      Source IDH51-3A7FAAC478861F83B37BA8C1
      		Only the protocol-defined bolus fraction
      Source IDH51-D6B7CBA3C3D019066CAF9A76
      		Patient- and indication-specific
      Source IDH51-17855D3471ECD459DD55EA1F
      		See current package insert
      Source IDH51-E5A2F9921524E67C154FBA0E
      		Bolus over approximately 1 minute when the indication regimen specifies
      Source IDH51-382F90CA207A388A87AFD5CE
      		Existing GlobalRPh IV push snapshot
      Source IDH51-EAB194303A6B5CD8232D7F39
      		Indication-specific thrombolysis protocol only
      Source IDH51-C3116886B7AE4B590C8D83AB

      Historical renal-function guidance

      Recovered v5.1 source content; historical, awaiting current review.

      Separate renal reference: Open Renal Dosing Master (opens in a new tab)
      Classification
      current_label_review_required
      Source IDH51-3A94E1F3F158622A94767045
      Summary
      Renal dosing status has not been locally normalized; use the current package insert before ordering or administration.
      Source IDH51-CBCED169C519244C5ED2C7D7
      Method note
      Use the renal function estimate and body-size convention specified by the selected label or institutional protocol. Do not interchange Cockcroft-Gault CrCl, indexed eGFR, and de-indexed eGFR without confirming the dosing source.
      Source IDH51-BAAF9CCF5A82BBDCB0FA2015

      Historical Common IV uses

      Recovered v5.1 source content; historical, awaiting current review.

      1. Acute ischemic stroke
        Source IDH51-91F87C4E5F15EEC4EDC360CC
      2. Massive pulmonary embolism
        Source IDH51-C37B85D6163EFF8B76693E68
      3. Acute myocardial infarction
        Source IDH51-53165C20DBB76AE92A76A067
      4. Occluded central venous catheter
        Source IDH51-1231342150A7143F2FC6FAFD

      Historical Warnings and safeguards

      Recovered v5.1 source content; historical, awaiting current review.

      1. Fatal or disabling bleeding, including intracranial hemorrhage.
        Source IDH51-CD63DD94F2FBB9A13C508CDA
      2. Never use one indication regimen for another.
        Source IDH51-0345285CC1393CF180BBC58E
      3. Avoid vigorous agitation.
        Source IDH51-040F8F1F6E3DBA9F6E43372A

      Historical Monitoring

      Recovered v5.1 source content; historical, awaiting current review.

      1. Neurologic status and bleeding
        Source IDH51-ED16188D64BA55212F5906FD
      2. Blood pressure
        Source IDH51-D4CFFE9D9AABCC1552AB4F29
      3. Protocol-specific antithrombotic timing and laboratory tests
        Source IDH51-54DB77DEAA8855E779768FF6
      Other recovered source fields and original editorial metadata

      Original status words such as current, verified, or normalized describe the historical source release. They do not change the clinical review status of this release.

      Catalog source fields

      Id
      alteplase
      Source IDH51-C791545B0A28964A9DE54DF3
      Generic name
      Alteplase
      Source IDH51-81FDBA72ECA7E264F3CB3167
      Brand names
      1. Activase
        Source IDH51-DD400448648F265739BA5474
      2. Cathflo
        Source IDH51-DFDAEEE26CA8792439494948
      Aliases
      1. tPA
        Source IDH51-900D7276D560E305C06BF583
      Class
      Anticoagulation and hemostasis
      Source IDH51-0D90F45E4533FA46050B8036
      Subclass
      Thrombolytic
      Source IDH51-B916B42D98F57A843BBCFA57
      Summary
      Fibrinolytic with indication-specific reconstitution, dose, bolus fraction, infusion duration, and maximum dose; regimens are not interchangeable.
      Source IDH51-5DC409FDFBE8D8EBD2ACB749
      Populations
      1. Adult
        Source IDH51-ACBDF362D74B618885CECDA5
      Evidence tier
      Core reference - verify current label
      Source IDH51-59565F498B78307F90F714F7
      High alert
      true
      Source IDH51-BBC28B85512A2BC85822756E
      Hazardous
      false
      Source IDH51-02DBF41B40E902A30412CF2C
      Status
      Active
      Source IDH51-A947FEA7B64D3986ECCF1E33
      Reviewed
      2026-08-29
      Source IDH51-26BAC59904471B412C7ECF19
      Version added
      1.0
      Source IDH51-958D55A079887680004C5B50
      Sources
      LabelUrlKind
      Source IDH51-209C8D4E8AB24F077C6E60BD
      DailyMed label search
      Source IDH51-6E979ADFE3BA364A0A767FFF
      		https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=Alteplase (opens in a new tab)
      Source IDH51-E3A5B01E0A528FEE90F08E92
      		Primary
      Source IDH51-48259C49EE39136C4AFBDC77
      Source IDH51-16E55D52599C5CDF8CC9CF01
      GlobalRPh legacy IV dilution monograph
      Source IDH51-43D3E691955BDBAFE68D0310
      		legacy:auto
      Source IDH51-C24DF6AE0653AE746B3E2952
      		Legacy
      Source IDH51-A93BE2A720D866CED1F59CB1
      Legacy title
      Alteplase
      Source IDH51-287EA06B63E1F1F63BEA8DCC
      Clinical release verification
      Audit version
      3.4
      Source IDH51-B81AB71CDD74B489FF7673D4
      Audited on
      2026-08-30
      Source IDH51-51DE959948DAB1CBC800ADC4
      Level
      amber
      Source IDH51-6EAB02D261DF54AFDFD0CBB8
      Release gate
      trusted_professional_source_present_exact_label_unconfirmed
      Source IDH51-AD5DEF92D3CE77B5377666E8
      Exact current label candidate
      false
      Source IDH51-E5E3DF06A6196AE796D7A75A
      Numeric support ratio
      0
      Source IDH51-187EB2C2E29BA9824E58DF47
      Reference url count
      1
      Source IDH51-E4C28A281C8D1BE085ADDD7A
      Broken reference count
      0
      Source IDH51-7B2B8BD8967ABEBDDECB6CC4
      Point of use confirmation required
      true
      Source IDH51-91308B815A2A42571D09AB80
      Note
      Do not treat this record as a fully current product-specific monograph until the exact IV formulation and current sources are confirmed.
      Source IDH51-3ADE13093A34A09BC21255EB

      Dosing source fields

      Id
      alteplase
      Source IDH51-724621E7ABD0AC8BD36E53F0
      Generic name
      Alteplase
      Source IDH51-B4B0C6A9CED738EBD0F459A6
      Coverage status
      direct_official_label_access_plus_local_snapshot
      Source IDH51-BE6EB72C90B2DA70CAFA0761
      Package insert
      Query name
      Alteplase
      Source IDH51-2185591DFB321F9A2948C491
      Product and route must match
      true
      Source IDH51-1334059350F69B5384A8545B
      Live current label enabled
      false
      Source IDH51-AEF537F214857B2AAD5A7C32
      Source priority
      Reviewed local summary when available, then a verified DailyMed label or product search when available, followed by professional references and institutional policy.
      Source IDH51-D57DD534C1112687ECCD636F
      Direct official label access enabled
      true
      Source IDH51-5A17826B90673903F51F1DA6
      Outbound server request required
      false
      Source IDH51-8284C93557E8E882D8330179
      Local summary status
      not_bundled
      Source IDH51-84FC5BC7521D61B16EA2EA3F
      Clinical review
      Locally normalized
      false
      Source IDH51-12DA143C9809043528F5019F
      Reviewed
      2026-08-29
      Source IDH51-77AD63B3E25275E40C9E603B
      Status
      Direct official package-insert access enabled; indication-specific local normalization pending.
      Source IDH51-AD398B717A4EEE053928390B
      Clinical release verification
      Audit version
      3.4
      Source IDH51-B854EB88123962F58680001C
      Audited on
      2026-08-30
      Source IDH51-8619852FDE017B1806D4EC87
      Level
      amber
      Source IDH51-06AA0DAB84CA2BD8EFE0FD1C
      Release gate
      trusted_professional_source_present_exact_label_unconfirmed
      Source IDH51-E0BDCCA9B60E9D6A06790BA5
      Exact current label candidate
      false
      Source IDH51-9C7554CF43901417949148E4
      Numeric support ratio
      0
      Source IDH51-A0DA80CE200E8322ADD6B77D
      Reference url count
      1
      Source IDH51-CA6171BA892BF804C1DFDB47
      Broken reference count
      0
      Source IDH51-72D50A20A2F4BF424116E869
      Point of use confirmation required
      true
      Source IDH51-95A358E98D83D24E76DAFE26
      Note
      Do not treat this record as a fully current product-specific monograph until the exact IV formulation and current sources are confirmed.
      Source IDH51-1D9B24CE58126890C3DFF7A9
      Historical preparation assessment

      Recovered v5.1 source content; historical, awaiting current review.

      Id
      alteplase
      Source IDH51-6A3994D08BFE4A147BF13FB1
      Name
      Alteplase
      Source IDH51-D4084FD10C9891A5F1F48B25
      Brands
      Activase | Cathflo
      Source IDH51-698746E1D87EE47BCD8A88E6
      Therapeutic class
      Anticoagulation and hemostasis
      Source IDH51-0EE79D8B6923F467C308F2B8
      Review version
      3.1
      Source IDH51-AF8963E7F0CDB8AAF9B99794
      Review date
      2026-08-30
      Source IDH51-C2275D590C0EB8ABAB1B8BD2
      Release status
      structured_record_current_label_not_confirmed
      Source IDH51-97A013ABACDA8C07A427FB07
      Market status
      Status
      no_current_us_iv_spl_confirmed
      Source IDH51-71FEAC5FBA9B63F1C22BC9A8
      Basis
      No high-confidence current IV SPL was automatically selected; legacy information is segregated
      Source IDH51-A7714B23D7F0FE03A10B774B
      Ten point assessment
      Exact formulation
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-5C60A686F8D20B09BE97D2B3
      Reconstitution concentration
      Reconstitute with supplied Sterile Water for Injection using transfer device; do not shake.
      Source IDH51-8EFBABE12772A6F06B4329ED
      Maximum or recommended final concentration
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-54D4E4A7C14661FB6D30FF76
      Appropriate standardized containers
      Vial or infusion container
      Source IDH51-0D1EAAE1979953321718B9B0
      Adult dosing range
      Indication-specific weight-based or fixed dose Only the protocol-defined bolus fraction Only the protocol-defined bolus fraction
      Source IDH51-6A8B44DD96E9D4D70E4EA500
      Pediatric dosing range
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-974D6C042303A234285FF07D
      Neonatal dosing range
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-4DC7D1E71A014666330D8C47
      Infusion time
      Bolus and infusion sequence depends entirely on indication Bolus over approximately 1 minute when the indication regimen specifies
      Source IDH51-E43814284B943A32B19A90BA
      Fluid restriction alternatives
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-59D77ED89F23CB1C25FC4048
      Current manufacturer labeling
      Match confidence
      unresolved
      Source IDH51-C113EEC5DF39A57041BC38F4
      Field provenance
      Exact formulation
      Primary
      not_found
      Source IDH51-485F5115ED38A82D4C19573C
      Reconstitution concentration
      Primary
      existing_structured_record
      Source IDH51-B73957794C6AA24602D73CD8
      Maximum or recommended final concentration
      Primary
      not_found
      Source IDH51-EA20B707FD3F6C335336B04E
      Appropriate standardized containers
      Primary
      existing_structured_record
      Source IDH51-774BA5005177A7C315E2318E
      Adult dosing range
      Primary
      existing_structured_record
      Source IDH51-962AC1B78FDC6558385A5190
      Pediatric dosing range
      Primary
      not_found
      Source IDH51-A4F99623966D7352111CCE88
      Neonatal dosing range
      Primary
      not_found
      Source IDH51-A05352402CC05A1D990A56E8
      Infusion time
      Primary
      existing_structured_record
      Source IDH51-CA25C81BC33A01023314C3EB
      Fluid restriction alternatives
      Primary
      not_found
      Source IDH51-315D7774CC8F3C82C21DF26C
      Current manufacturer labeling
      Primary
      DailyMed search gateway
      Source IDH51-7811FCA9F65A70FE9BE26C33
      Population applicability
      Adult
      Applicability
      supported_or_source_present
      Source IDH51-141B442D4AA414523A6D80C1
      Guide generation allowed
      true
      Source IDH51-E6E29EFE48443B480AE5CD68
      Pediatric
      Applicability
      not_established
      Source IDH51-F3A5DB6EC93AB5A0E7B6CE3F
      Guide generation allowed
      false
      Source IDH51-022DD741E60D4A5EE1039728
      Neonatal
      Applicability
      not_established
      Source IDH51-26A4DEE5312B4940034C6F97
      Guide generation allowed
      false
      Source IDH51-61FE6E206AF730D75B153FDF
      Route presence
      Structured dilution
      true
      Source IDH51-B31DCBAC601E7DC0E15689F1
      Iv push
      true
      Source IDH51-02087818AF77EC2A2E2CE018
      Continuous infusion
      false
      Source IDH51-92A62A62DD6723B99179DF02
      Pediatric source
      false
      Source IDH51-42804276F0DF8E9060D77961
      Neonatal source
      false
      Source IDH51-22388C5D17B1F24510CA217A
      Legacy reference
      Status
      not_available
      Source IDH51-26E57CC319678BC91CB2E371
      Label resolution
      Status
      build_environment_network_unavailable
      Source IDH51-BEC93D235C9387E0B5ACE516
      Source files
      1. catalog.json
        Source IDH51-4DA0C34D20CC31A4DCDDBC2C
      2. dosing.json
        Source IDH51-AC8D577763FE9D6B6421E476
      3. legacy-map.json
        Source IDH51-3082BE487C8CECDA0A3FE93C
      Clinical release note
      Preparation instructions are released only at the evidence level shown. Legacy content remains visibly separate. Exact product, NDC, route, current labeling, and institutional policy must be confirmed.
      Source IDH51-48C98B63EC9BB3173D9314E8
      Historical statement IDs and source locations

      These IDs identify recovered source units. They are not evidence-qualified clinical claims.

      Historical IDOriginal source locationStatus
      H51-C791545B0A28964A9DE54DF3catalog.json
      /records/10/id      		Historical; current review incomplete
      H51-81FDBA72ECA7E264F3CB3167catalog.json
      /records/10/generic_name      		Historical; current review incomplete
      H51-DD400448648F265739BA5474catalog.json
      /records/10/brand_names/0      		Historical; current review incomplete
      H51-DFDAEEE26CA8792439494948catalog.json
      /records/10/brand_names/1      		Historical; current review incomplete
      H51-900D7276D560E305C06BF583catalog.json
      /records/10/aliases/0      		Historical; current review incomplete
      H51-0D90F45E4533FA46050B8036catalog.json
      /records/10/class      		Historical; current review incomplete
      H51-B916B42D98F57A843BBCFA57catalog.json
      /records/10/subclass      		Historical; current review incomplete
      H51-5DC409FDFBE8D8EBD2ACB749catalog.json
      /records/10/summary      		Historical; current review incomplete
      H51-91F87C4E5F15EEC4EDC360CCcatalog.json
      /records/10/common_uses/0      		Historical; current review incomplete
      H51-C37B85D6163EFF8B76693E68catalog.json
      /records/10/common_uses/1      		Historical; current review incomplete
      H51-53165C20DBB76AE92A76A067catalog.json
      /records/10/common_uses/2      		Historical; current review incomplete
      H51-1231342150A7143F2FC6FAFDcatalog.json
      /records/10/common_uses/3      		Historical; current review incomplete
      H51-1F14C0EC3A105A33BE1ACE49catalog.json
      /records/10/preparations/0      		Historical; current review incomplete
      H51-761CAAB7FF7D3ADE0E59A85Acatalog.json
      /records/10/preparations/0/population      		Historical; current review incomplete
      H51-A8A7F3BCE54A9FE72E46D44Bcatalog.json
      /records/10/preparations/0/amount      		Historical; current review incomplete
      H51-B2ADFE2850A2C91F63C13301catalog.json
      /records/10/preparations/0/reconstitution      		Historical; current review incomplete
      H51-318631F56656BC93973CC04Acatalog.json
      /records/10/preparations/0/diluent      		Historical; current review incomplete
      H51-F0B6F379F8C27BB541BDF261catalog.json
      /records/10/preparations/0/final_volume      		Historical; current review incomplete
      H51-368D2F5FB4853B7CFA590D1Dcatalog.json
      /records/10/preparations/0/concentration      		Historical; current review incomplete
      H51-E64C549890725A5D0664DF78catalog.json
      /records/10/preparations/0/rate      		Historical; current review incomplete
      H51-004E4FF053B7FF4E48D1D91Acatalog.json
      /records/10/preparations/0/stability      		Historical; current review incomplete
      H51-8D62302B85A02AD0E1ED15B7catalog.json
      /records/10/preparations/0/notes      		Historical; current review incomplete
      H51-D3BBA0673C3C4EC47625DA71catalog.json
      /records/10/iv_push/0      		Historical; current review incomplete
      H51-4CBB5707D25390E3132C76D1catalog.json
      /records/10/iv_push/0/population      		Historical; current review incomplete
      H51-E2C7281938B499DD48454B47catalog.json
      /records/10/iv_push/0/dose_scope      		Historical; current review incomplete
      H51-1446C6AFBF162EA0514D930Fcatalog.json
      /records/10/iv_push/0/concentration      		Historical; current review incomplete
      H51-D00D9ABEAD2F4CE03EA2E03Ccatalog.json
      /records/10/iv_push/0/rate      		Historical; current review incomplete
      H51-32C6604B89751601EBFB3BEFcatalog.json
      /records/10/iv_push/0/status      		Historical; current review incomplete
      H51-C96BCB7242839611009316DAcatalog.json
      /records/10/iv_push/0/notes      		Historical; current review incomplete
      H51-CD63DD94F2FBB9A13C508CDAcatalog.json
      /records/10/warnings/0      		Historical; current review incomplete
      H51-0345285CC1393CF180BBC58Ecatalog.json
      /records/10/warnings/1      		Historical; current review incomplete
      H51-040F8F1F6E3DBA9F6E43372Acatalog.json
      /records/10/warnings/2      		Historical; current review incomplete
      H51-ED16188D64BA55212F5906FDcatalog.json
      /records/10/monitoring/0      		Historical; current review incomplete
      H51-D4CFFE9D9AABCC1552AB4F29catalog.json
      /records/10/monitoring/1      		Historical; current review incomplete
      H51-54DB77DEAA8855E779768FF6catalog.json
      /records/10/monitoring/2      		Historical; current review incomplete
      H51-ACBDF362D74B618885CECDA5catalog.json
      /records/10/populations/0      		Historical; current review incomplete
      H51-59565F498B78307F90F714F7catalog.json
      /records/10/evidence_tier      		Historical; current review incomplete
      H51-BBC28B85512A2BC85822756Ecatalog.json
      /records/10/high_alert      		Historical; current review incomplete
      H51-02DBF41B40E902A30412CF2Ccatalog.json
      /records/10/hazardous      		Historical; current review incomplete
      H51-A947FEA7B64D3986ECCF1E33catalog.json
      /records/10/status      		Historical; current review incomplete
      H51-26BAC59904471B412C7ECF19catalog.json
      /records/10/reviewed      		Historical; current review incomplete
      H51-958D55A079887680004C5B50catalog.json
      /records/10/version_added      		Historical; current review incomplete
      H51-209C8D4E8AB24F077C6E60BDcatalog.json
      /records/10/sources/0      		Historical; current review incomplete
      H51-6E979ADFE3BA364A0A767FFFcatalog.json
      /records/10/sources/0/label      		Historical; current review incomplete
      H51-E3A5B01E0A528FEE90F08E92catalog.json
      /records/10/sources/0/url      		Historical; current review incomplete
      H51-48259C49EE39136C4AFBDC77catalog.json
      /records/10/sources/0/kind      		Historical; current review incomplete
      H51-16E55D52599C5CDF8CC9CF01catalog.json
      /records/10/sources/1      		Historical; current review incomplete
      H51-43D3E691955BDBAFE68D0310catalog.json
      /records/10/sources/1/label      		Historical; current review incomplete
      H51-C24DF6AE0653AE746B3E2952catalog.json
      /records/10/sources/1/url      		Historical; current review incomplete
      H51-A93BE2A720D866CED1F59CB1catalog.json
      /records/10/sources/1/kind      		Historical; current review incomplete
      H51-287EA06B63E1F1F63BEA8DCCcatalog.json
      /records/10/legacy_title      		Historical; current review incomplete
      H51-B81AB71CDD74B489FF7673D4catalog.json
      /records/10/clinical_release_verification/audit_version      		Historical; current review incomplete
      H51-51DE959948DAB1CBC800ADC4catalog.json
      /records/10/clinical_release_verification/audited_on      		Historical; current review incomplete
      H51-6EAB02D261DF54AFDFD0CBB8catalog.json
      /records/10/clinical_release_verification/level      		Historical; current review incomplete
      H51-AD5DEF92D3CE77B5377666E8catalog.json
      /records/10/clinical_release_verification/release_gate      		Historical; current review incomplete
      H51-E5E3DF06A6196AE796D7A75Acatalog.json
      /records/10/clinical_release_verification/exact_current_label_candidate      		Historical; current review incomplete
      H51-12482CA494FC5A2160D8123Fcatalog.json
      /records/10/clinical_release_verification/selected_setid      		Historical; current review incomplete
      H51-B709865B92BCBDCA50C53819catalog.json
      /records/10/clinical_release_verification/selected_label_title      		Historical; current review incomplete
      H51-187EB2C2E29BA9824E58DF47catalog.json
      /records/10/clinical_release_verification/numeric_support_ratio      		Historical; current review incomplete
      H51-E4C28A281C8D1BE085ADDD7Acatalog.json
      /records/10/clinical_release_verification/reference_url_count      		Historical; current review incomplete
      H51-7B2B8BD8967ABEBDDECB6CC4catalog.json
      /records/10/clinical_release_verification/broken_reference_count      		Historical; current review incomplete
      H51-91308B815A2A42571D09AB80catalog.json
      /records/10/clinical_release_verification/point_of_use_confirmation_required      		Historical; current review incomplete
      H51-3ADE13093A34A09BC21255EBcatalog.json
      /records/10/clinical_release_verification/note      		Historical; current review incomplete
      H51-EAF9F29BBD8EBE3EE6748DEFcatalog.json
      /records/10/clinical_release_verification/dailymed_search_url      		Historical; current review incomplete
      H51-724621E7ABD0AC8BD36E53F0dosing.json
      /records/10/id      		Historical; current review incomplete
      H51-B4B0C6A9CED738EBD0F459A6dosing.json
      /records/10/generic_name      		Historical; current review incomplete
      H51-BE6EB72C90B2DA70CAFA0761dosing.json
      /records/10/coverage_status      		Historical; current review incomplete
      H51-2185591DFB321F9A2948C491dosing.json
      /records/10/package_insert/query_name      		Historical; current review incomplete
      H51-0188E25B7C1B62D69A4A89A8dosing.json
      /records/10/package_insert/preferred_setid      		Historical; current review incomplete
      H51-1334059350F69B5384A8545Bdosing.json
      /records/10/package_insert/product_and_route_must_match      		Historical; current review incomplete
      H51-AEF537F214857B2AAD5A7C32dosing.json
      /records/10/package_insert/live_current_label_enabled      		Historical; current review incomplete
      H51-D57DD534C1112687ECCD636Fdosing.json
      /records/10/package_insert/source_priority      		Historical; current review incomplete
      H51-5A17826B90673903F51F1DA6dosing.json
      /records/10/package_insert/direct_official_label_access_enabled      		Historical; current review incomplete
      H51-8284C93557E8E882D8330179dosing.json
      /records/10/package_insert/outbound_server_request_required      		Historical; current review incomplete
      H51-84FC5BC7521D61B16EA2EA3Fdosing.json
      /records/10/package_insert/local_summary_status      		Historical; current review incomplete
      H51-3A94E1F3F158622A94767045dosing.json
      /records/10/renal/classification      		Historical; current review incomplete
      H51-CBCED169C519244C5ED2C7D7dosing.json
      /records/10/renal/summary      		Historical; current review incomplete
      H51-BAAF9CCF5A82BBDCB0FA2015dosing.json
      /records/10/renal/method_note      		Historical; current review incomplete
      H51-2DC12D186D5361EF933B2FB4dosing.json
      /records/10/existing_route_snapshots/0      		Historical; current review incomplete
      H51-CC3EF3447E29B00C9E40F15Edosing.json
      /records/10/existing_route_snapshots/0/route      		Historical; current review incomplete
      H51-4A4815EF2A36646674AE6902dosing.json
      /records/10/existing_route_snapshots/0/population      		Historical; current review incomplete
      H51-7637C9A1BEA7D55346A35CFDdosing.json
      /records/10/existing_route_snapshots/0/indication      		Historical; current review incomplete
      H51-8BC89A7DB96FC673081CC9C2dosing.json
      /records/10/existing_route_snapshots/0/dose      		Historical; current review incomplete
      H51-B9EE9B027E49410D2ADF9C65dosing.json
      /records/10/existing_route_snapshots/0/interval      		Historical; current review incomplete
      H51-25D8F83B14751B0EE3FDB5CCdosing.json
      /records/10/existing_route_snapshots/0/duration      		Historical; current review incomplete
      H51-C36AFB6B7CF1193092E0ACC1dosing.json
      /records/10/existing_route_snapshots/0/administration      		Historical; current review incomplete
      H51-14032B4CE1423B2B49E26BA8dosing.json
      /records/10/existing_route_snapshots/0/source_level      		Historical; current review incomplete
      H51-A6CB615722F5E641D736AF3Edosing.json
      /records/10/existing_route_snapshots/0/notes      		Historical; current review incomplete
      H51-CE46BC26677F35828FE24DA5dosing.json
      /records/10/existing_route_snapshots/1      		Historical; current review incomplete
      H51-DFBF1E8A48E0880F742E6628dosing.json
      /records/10/existing_route_snapshots/1/route      		Historical; current review incomplete
      H51-C777C46834866C0F8A6ACD65dosing.json
      /records/10/existing_route_snapshots/1/population      		Historical; current review incomplete
      H51-3A7FAAC478861F83B37BA8C1dosing.json
      /records/10/existing_route_snapshots/1/indication      		Historical; current review incomplete
      H51-D6B7CBA3C3D019066CAF9A76dosing.json
      /records/10/existing_route_snapshots/1/dose      		Historical; current review incomplete
      H51-17855D3471ECD459DD55EA1Fdosing.json
      /records/10/existing_route_snapshots/1/interval      		Historical; current review incomplete
      H51-E5A2F9921524E67C154FBA0Edosing.json
      /records/10/existing_route_snapshots/1/duration      		Historical; current review incomplete
      H51-382F90CA207A388A87AFD5CEdosing.json
      /records/10/existing_route_snapshots/1/administration      		Historical; current review incomplete
      H51-EAB194303A6B5CD8232D7F39dosing.json
      /records/10/existing_route_snapshots/1/source_level      		Historical; current review incomplete
      H51-C3116886B7AE4B590C8D83ABdosing.json
      /records/10/existing_route_snapshots/1/notes      		Historical; current review incomplete
      H51-12DA143C9809043528F5019Fdosing.json
      /records/10/clinical_review/locally_normalized      		Historical; current review incomplete
      H51-77AD63B3E25275E40C9E603Bdosing.json
      /records/10/clinical_review/reviewed      		Historical; current review incomplete
      H51-AD398B717A4EEE053928390Bdosing.json
      /records/10/clinical_review/status      		Historical; current review incomplete
      H51-B854EB88123962F58680001Cdosing.json
      /records/10/clinical_release_verification/audit_version      		Historical; current review incomplete
      H51-8619852FDE017B1806D4EC87dosing.json
      /records/10/clinical_release_verification/audited_on      		Historical; current review incomplete
      H51-06AA0DAB84CA2BD8EFE0FD1Cdosing.json
      /records/10/clinical_release_verification/level      		Historical; current review incomplete
      H51-E0BDCCA9B60E9D6A06790BA5dosing.json
      /records/10/clinical_release_verification/release_gate      		Historical; current review incomplete
      H51-9C7554CF43901417949148E4dosing.json
      /records/10/clinical_release_verification/exact_current_label_candidate      		Historical; current review incomplete
      H51-948A565C136A6C1F0ECD9F89dosing.json
      /records/10/clinical_release_verification/selected_setid      		Historical; current review incomplete
      H51-6E56CC35D00C6183D1A6FC94dosing.json
      /records/10/clinical_release_verification/selected_label_title      		Historical; current review incomplete
      H51-A0DA80CE200E8322ADD6B77Ddosing.json
      /records/10/clinical_release_verification/numeric_support_ratio      		Historical; current review incomplete
      H51-CA6171BA892BF804C1DFDB47dosing.json
      /records/10/clinical_release_verification/reference_url_count      		Historical; current review incomplete
      H51-72D50A20A2F4BF424116E869dosing.json
      /records/10/clinical_release_verification/broken_reference_count      		Historical; current review incomplete
      H51-95A358E98D83D24E76DAFE26dosing.json
      /records/10/clinical_release_verification/point_of_use_confirmation_required      		Historical; current review incomplete
      H51-1D9B24CE58126890C3DFF7A9dosing.json
      /records/10/clinical_release_verification/note      		Historical; current review incomplete
      H51-864D395A92BC44C92919D1A8dosing.json
      /records/10/clinical_release_verification/dailymed_search_url      		Historical; current review incomplete
      H51-FA05A85D5883D91EB9E1EB37first-look-v5.1.json
      /records/10/id      		Historical; current review incomplete
      H51-E49EE48856283103459B4169first-look-v5.1.json
      /records/10/generic_name      		Historical; current review incomplete
      H51-C355969EF88FD7505012F726first-look-v5.1.json
      /records/10/class      		Historical; current review incomplete
      H51-20CB072F1C71A367B50A9958first-look-v5.1.json
      /records/10/subclass      		Historical; current review incomplete
      H51-248A258616F0B87A4CE8DE19first-look-v5.1.json
      /records/10/primary_uses/0      		Historical; current review incomplete
      H51-BFF2CC067068035296080868first-look-v5.1.json
      /records/10/primary_uses/1      		Historical; current review incomplete
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      H51-DB13F853D784EC452F3B5BB0first-look-v5.1.json
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      H51-6A3994D08BFE4A147BF13FB1preparation-assessments-v3.8.json
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      /10/clinical_release_note      		Historical; current review incomplete

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