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Preparation. Administration. Evidence.

IV Dilution &
Medication Reference

Search 255 medications, read preserved historical references, and inspect separately reviewed preparation statements. Full monograph updates remain pending.

Version 6.4Release date 2026-11-04For healthcare professionals
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Medication reference

Flumazenil

Monograph awaiting updateThis monograph will be updated in the future.

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No original site article was mapped to this record. The available historical structured fields and official-source links are retained.

Historical first look: uses, mechanism, dosing context, and administration

Recovered v5.1 source content; historical, awaiting current review.

Id
flumazenil
Source IDH51-A59D80C3A1B063A2EC9EEECA
Generic name
Flumazenil
Source IDH51-DDECFC27E31115782F6CFF70
Class
Toxicology and reversal
Source IDH51-D6A1CD294D0EC4B229578E7C
Subclass
Benzodiazepine antagonist
Source IDH51-9E895B31D68D97806ABD0083
Primary uses
  1. Reversal of benzodiazepine sedation in selected patients
    Source IDH51-4BF0F6586649C415229B8253
Mechanism
Competitively blocks the benzodiazepine site on GABA-A receptors.
Source IDH51-AB34B9B59FE23AF31F4E2BF2
Mechanism level
drug_specific
Source IDH51-E4C937F68D91D789C1710116
Basic dosing orientation
Adult / Pediatric selected use | Initial adult 0.2 mg with titration per label; pediatric dose weight based in selected settings | Initial adult 0.2 mg with titration per label; pediatric dose weight based in selected settings | Patient- and indication-specific | See current package insert | IV push
Source IDH51-AE4A7467B35980DEE1FD01A4
Administration orientation
Initial 0.2 mg over 15 seconds; additional doses at label intervals; 0.1 mg/mL; Initial 0.2 mg over 15 seconds; additional doses at label intervals
Source IDH51-3E73CC4582F4B1A01D078C84
Renal and population orientation
Separate renal reference: Open Renal Dosing Master (opens in a new tab)Renal dosing status has not been locally normalized; use the current package insert before ordering or administration.
Source IDH51-B93439B713B0C7B05767FE65
Key safety orientation
  1. Seizures, acute withdrawal, resedation, and arrhythmia.
    Source IDH51-4991D317F8B2330B73F660F7
Coverage path
structured_local_snapshot
Source IDH51-9C14DCA6BA8B3616ED297AE4
Coverage path label
Structured GlobalRPh route snapshot
Source IDH51-34A748B4648A9AF9F843E885
Review note
First-look orientation only. Verify indication, patient population, weight basis, organ function, exact IV product, dose, concentration, compatibility, rate, and current labeling before use.
Source IDH51-D740C5A8C1398B729311B876
Search text
Flumazenil Toxicology and reversal Benzodiazepine antagonist Reversal of benzodiazepine sedation in selected patients Competitively blocks the benzodiazepine site on GABA-A receptors. Adult / Pediatric selected use | Initial adult 0.2 mg with titration per label; pediatric dose weight based in selected settings | Initial adult 0.2 mg with titration per label; pediatric dose weight based in selected settings | Patient- and indication-specific | See current package insert | IV push Initial 0.2 mg over 15 seconds; additional doses at label intervals; 0.1 mg/mL; Initial 0.2 mg over 15 seconds; additional doses at label intervals Renal dosing status has not been locally normalized; use the current package insert before ordering or administration. Seizures, acute withdrawal, resedation, and arrhythmia. Structured GlobalRPh route snapshot
Source IDH51-18CC0151E816377FA36F9E95
Official access mode
search
Source IDH51-5D08C0094553F4D78D2C61BF
Official search query
Flumazenil
Source IDH51-C942810809610F36A7510A56
Official access reason
A source-backed DailyMed search is available; select and confirm the exact IV product.
Source IDH51-6E722E705C10051089BFF78F
Product identifiers and clinical review status

This monograph will be updated in the future. Historical material is available where present in the original sources; full current exact-product and claim-level review remains pending.

Exact formulation, concentration, container, manufacturer, regulatory identifiers, and a reproducible label snapshot have not all been reconciled.

What remains to be completed
  • Retrievable exact-product SPL XML with version, revision, retrieval date and reproducible hash
  • Clinically reviewed, individually identified statements with two exact source mappings
  • Exact formulation, strength, container, manufacturer/labeler, application and NDC reconciliation
  • Renal-function methods and dialysis/CRRT modality review where applicable
  • Mechanism provenance, clinical source disagreements and full medication-specific safety reconciliation

Supplemental historical fields

Restored-data provenance and review notes

Source release: 2026-08-31. Current clinical review is incomplete. Original uses of current, verified, or normalized describe the historical source. They do not inherit the status of separately reviewed statements. Product formulations and source dates can differ.

Current review annotations for historical renal, dialysis, mechanism, and product fieldsSeparate renal reference: Open Renal Dosing Master (opens in a new tab)
Renal
Status
not_locally_normalized
Original classification
current_label_review_required
Entries
    General note
    Preserve the source-specific renal-function basis. An indexed CrCl table is not interchangeable with unindexed CrCl or eGFR. Generic advice to check a method does not identify the equation for a dose row.
    Dialysis
    Status
    no_local_structured_regimen
    Entries
      General note
      Named modality alone does not establish applicability. CRRT subtype, effluent rate, residual renal function, timing and interruptions require review. Historical absence is not evidence that no guidance exists.
      Mechanisms
      • Source kind
        first_look
        Local pointer
        /mechanism
        Original level
        drug_specific
        Provenance classification
        historical_drug_specific_uncorroborated
        Label derived verified
        false
        Independently corroborated
        false
        Exact label section
        Not recorded
        Original source note
        Not recorded
        Review status
        historical_unverified
        Note
        Drug-specific wording in the old file is not proof of independent corroboration or an exact label locator. Consult separately published current mechanism claims where present.
      Future update
      Status
      pending_review
      Message
      This monograph will be updated in the future as current exact-product and claim-level review is completed.
      Source unavailable
      false
      Reason
      The historical content is restored; comprehensive contemporary verification remains incomplete.

      No separate structured rows were bundled for preparation, continuous infusion, dialysis, CRRT. Historical article content and source links may cover these topics.

      Historical IV-push guidance

      Recovered v5.1 source content; historical, awaiting current review.

      PopulationDose scopeConcentrationRateStatusNotes
      Source IDH51-06AB2CDBD38FDDF260E4748F
      Adult / Pediatric selected use
      Source IDH51-BD3F5CCEC8D6392C811CDD33
      		Initial adult 0.2 mg with titration per label; pediatric dose weight based in selected settings
      Source IDH51-B62D2138B852F6C66DA04336
      		0.1 mg/mL
      Source IDH51-873AC67B3CE596D1EC0E61E2
      		Initial 0.2 mg over 15 seconds; additional doses at label intervals
      Source IDH51-ABBC086E4BD63E41807A6CC2
      		Use only when ordered and supported by current labeling or institutional policy
      Source IDH51-55A2057EFA3AA3A7F1FC1882
      		Avoid routine use in chronic benzodiazepine exposure, mixed proconvulsant overdose, or seizure disorders unless benefit clearly outweighs risk.
      Source IDH51-1515C3E886D6E75411DD271D

      Historical indication and population dosing

      Recovered tables and source-separated snapshots; full clinical revalidation remains pending.

      Existing dose and route snapshots

      RoutePopulationIndicationDoseIntervalDurationAdministrationSource levelNotes
      Source IDH51-E44A24055E48E5F646915402
      IV push
      Source IDH51-22BBCB3654AC8A8B57B33417
      		Adult / Pediatric selected use
      Source IDH51-7FB471E445E21D3B4FD344E9
      		Initial adult 0.2 mg with titration per label; pediatric dose weight based in selected settings
      Source IDH51-4CC46D9A169F1A2EA5CD8750
      		Initial adult 0.2 mg with titration per label; pediatric dose weight based in selected settings
      Source IDH51-9A1B6B314452D878A8E4F320
      		Patient- and indication-specific
      Source IDH51-BACD3BFD6344E02D8C9C8B09
      		See current package insert
      Source IDH51-B321E2C18E9894FA78CBE592
      		Initial 0.2 mg over 15 seconds; additional doses at label intervals
      Source IDH51-FF1EB77A6CA91F3E75516650
      		Existing GlobalRPh IV push snapshot
      Source IDH51-C0DE95C51320DAB3177E9D06
      		Use only when ordered and supported by current labeling or institutional policy Avoid routine use in chronic benzodiazepine exposure, mixed proconvulsant overdose, or seizure disorders unless benefit clearly outweighs risk.
      Source IDH51-F1BD0A10A0CF790E9ACC068F

      Historical renal-function guidance

      Recovered v5.1 source content; historical, awaiting current review.

      Separate renal reference: Open Renal Dosing Master (opens in a new tab)
      Classification
      current_label_review_required
      Source IDH51-CB91C2DB32BEAB2B4483B148
      Summary
      Renal dosing status has not been locally normalized; use the current package insert before ordering or administration.
      Source IDH51-18F6FB4EE1FB74B7A20D3DFB
      Method note
      Use the renal function estimate and body-size convention specified by the selected label or institutional protocol. Do not interchange Cockcroft-Gault CrCl, indexed eGFR, and de-indexed eGFR without confirming the dosing source.
      Source IDH51-9ECC91D1282D90789F3C1F29

      Historical Common IV uses

      Recovered v5.1 source content; historical, awaiting current review.

      1. Reversal of benzodiazepine sedation in selected patients
        Source IDH51-016A8DB5415B1F82FC38DA36

      Historical Warnings and safeguards

      Recovered v5.1 source content; historical, awaiting current review.

      1. Seizures, acute withdrawal, resedation, and arrhythmia.
        Source IDH51-EC851316D0F9CE146640B2FE

      Historical Monitoring

      Recovered v5.1 source content; historical, awaiting current review.

      1. Continuous respiratory and neurologic monitoring
        Source IDH51-C2A83520987D2FA9C00DDB1E
      2. Resedation
        Source IDH51-5B29D1B429243985A3A3E2B9
      Other recovered source fields and original editorial metadata

      Original status words such as current, verified, or normalized describe the historical source release. They do not change the clinical review status of this release.

      Catalog source fields

      Id
      flumazenil
      Source IDH51-B0CC3DD2B60CFD8E41C68934
      Generic name
      Flumazenil
      Source IDH51-1C163C3015365E6BE4C26BC4
      Brand names
      1. Romazicon
        Source IDH51-DC143F2B801B67DC0151B681
      Class
      Toxicology and reversal
      Source IDH51-D411902106074537674AD03C
      Subclass
      Benzodiazepine antagonist
      Source IDH51-60EBFD0BB660657B3E06F8CA
      Summary
      Benzodiazepine antagonist administered in small titrated boluses; can precipitate seizures and withdrawal.
      Source IDH51-3FB7CD49DF27B6566E568604
      Populations
      1. Adult
        Source IDH51-4BF36B8545661C1C150EA7F8
      2. Pediatric selected use
        Source IDH51-DD35A8A44B1DDFE22C6844C5
      Evidence tier
      IV push safety normalization - verify stocked product
      Source IDH51-4971129418C3D541D6005582
      High alert
      true
      Source IDH51-97495A9669B011929A344B7F
      Hazardous
      false
      Source IDH51-5993F1C581E0F9A2ADDB9EC3
      Status
      Active
      Source IDH51-A42614378976E3E55312DD53
      Reviewed
      2026-08-29
      Source IDH51-F2DBC72D459AB6BB2F8B030F
      Version added
      1.2
      Source IDH51-2E68DB2D3CA597C914A1492E
      Sources
      LabelUrlKind
      Source IDH51-B20F735E87ACF331C3C8B71F
      DailyMed label search
      Source IDH51-04DF916D7AC4CF656B550BEB
      		https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=Flumazenil (opens in a new tab)
      Source IDH51-1BDA6854570C3BE7EB86ED46
      		Primary
      Source IDH51-6189FAB664EAD22BE78E2D6C
      Source IDH51-5E50C93BD3AD4B5DECC10CD3
      GlobalRPh legacy IV dilution monograph
      Source IDH51-03ACFFB2B81FD0D7D80B7091
      		legacy:auto
      Source IDH51-C67E839090C0FA4615A02EA5
      		Legacy
      Source IDH51-A150084A672149CDCC4B1222
      Clinical release verification
      Audit version
      3.4
      Source IDH51-8D1FC1E39D80F63EB82F431E
      Audited on
      2026-08-30
      Source IDH51-19F0C40C0FA7BD6A7D46D8FC
      Level
      amber
      Source IDH51-B57389CC94D9F813A138A12F
      Release gate
      trusted_professional_source_present_exact_label_unconfirmed
      Source IDH51-65B7D1ED2D0357E08D939D1F
      Exact current label candidate
      false
      Source IDH51-9C7D755F55333C5606721021
      Numeric support ratio
      0
      Source IDH51-29480DEC6B49B8DE9614F025
      Reference url count
      1
      Source IDH51-F2FA073E21A31903D32342DD
      Broken reference count
      0
      Source IDH51-779801E33B323D303C0831DE
      Point of use confirmation required
      true
      Source IDH51-CE1F5EE6A5C0AAC8934894DB
      Note
      Do not treat this record as a fully current product-specific monograph until the exact IV formulation and current sources are confirmed.
      Source IDH51-636B0065BA47115D3FBF06DB

      Dosing source fields

      Id
      flumazenil
      Source IDH51-A5A8B5F596BD814A6677AF4E
      Generic name
      Flumazenil
      Source IDH51-59C1B5B1CC66C9E8F862F265
      Coverage status
      direct_official_label_access_plus_local_snapshot
      Source IDH51-5A1A7B17FF9B2C7A7182472D
      Package insert
      Query name
      Flumazenil
      Source IDH51-F18AB8CC812FB273B1B9A610
      Product and route must match
      true
      Source IDH51-7D70F1DB3049A938D1678F90
      Live current label enabled
      false
      Source IDH51-52BEC780B69E756D8DBD7247
      Source priority
      Reviewed local summary when available, then a verified DailyMed label or product search when available, followed by professional references and institutional policy.
      Source IDH51-97F0F1B0AEC5680BAC411176
      Direct official label access enabled
      true
      Source IDH51-FA08C8E867A021262619C0D5
      Outbound server request required
      false
      Source IDH51-3C1D93FE7C328AE4DDCAACD2
      Local summary status
      not_bundled
      Source IDH51-E579242C96C3A594A4484CDA
      Clinical review
      Locally normalized
      false
      Source IDH51-9463D2FC1DBFD36254C4FFED
      Reviewed
      2026-08-29
      Source IDH51-DBCD43F2EF07BD135306E363
      Status
      Direct official package-insert access enabled; indication-specific local normalization pending.
      Source IDH51-E7BC296FA4B017DF765A2B53
      Clinical release verification
      Audit version
      3.4
      Source IDH51-487C4E39774F3E5917685037
      Audited on
      2026-08-30
      Source IDH51-5DB12BBCF4C885022C37EFEB
      Level
      amber
      Source IDH51-A7528717B895FE36D26E64A5
      Release gate
      trusted_professional_source_present_exact_label_unconfirmed
      Source IDH51-8D3E68F86D9865427282C8EF
      Exact current label candidate
      false
      Source IDH51-FF98B2B2A4C46FB38802481A
      Numeric support ratio
      0
      Source IDH51-0273983B8EC80D1CEA0535CC
      Reference url count
      1
      Source IDH51-DADEF4F17A6456EB0C806033
      Broken reference count
      0
      Source IDH51-1D2D0C2F06AC527314642A9D
      Point of use confirmation required
      true
      Source IDH51-256C6F94A77CE0FCE94F9971
      Note
      Do not treat this record as a fully current product-specific monograph until the exact IV formulation and current sources are confirmed.
      Source IDH51-665CC2F64ECCC4515E896C46
      Historical preparation assessment

      Recovered v5.1 source content; historical, awaiting current review.

      Id
      flumazenil
      Source IDH51-F0468BDDD09549323F517F5F
      Name
      Flumazenil
      Source IDH51-6F62DAD0E538CCB804264A54
      Brands
      Romazicon
      Source IDH51-4258E0AA1B2E84077A7AE537
      Therapeutic class
      Toxicology and reversal
      Source IDH51-FFAACD71C3BBD09972F9CCE1
      Review version
      3.1
      Source IDH51-FF5F6008EAD21846B4F3C2F7
      Review date
      2026-08-30
      Source IDH51-ABB512320CE259F9506F0AA3
      Release status
      no_released_dilution_current_label_review_required
      Source IDH51-5EF4E9AFEE442A2FDEA80A04
      Market status
      Status
      no_current_us_iv_spl_confirmed
      Source IDH51-C82DABAAB52831B6F67A7057
      Basis
      No high-confidence current IV SPL was automatically selected; legacy information is segregated
      Source IDH51-3353BA8D1A3A387C7F840831
      Ten point assessment
      Exact formulation
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-9B1C653030FA4F6724E7247B
      Reconstitution concentration
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-A0C12D3858124A69E2F8486B
      Maximum or recommended final concentration
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-688057A34A0CB675826B929E
      Appropriate standardized containers
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-8690E1BDAA41D76598E1FE07
      Adult dosing range
      Initial adult 0.2 mg with titration per label; pediatric dose weight based in selected settings Initial adult 0.2 mg with titration per label; pediatric dose weight based in selected settings
      Source IDH51-A2808C26F84F0CFE8568DBA1
      Pediatric dosing range
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-E67745C374B9AD44A5BD86F4
      Neonatal dosing range
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-F4E539B93F3EEAA1F9DF2B09
      Infusion time
      Initial 0.2 mg over 15 seconds; additional doses at label intervals
      Source IDH51-BB1C5A567E68E0264CF32BF9
      Fluid restriction alternatives
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-8435466DCD5F7DB23AEA163C
      Current manufacturer labeling
      Match confidence
      unresolved
      Source IDH51-D7928D6AB939D2E784B983B4
      Field provenance
      Exact formulation
      Primary
      not_found
      Source IDH51-49415E3B1F53C9BFE3C0C0AA
      Reconstitution concentration
      Primary
      not_found
      Source IDH51-419FAC9FD09ADC4239127F5B
      Maximum or recommended final concentration
      Primary
      not_found
      Source IDH51-70E07A17C57CD81E1C148A06
      Appropriate standardized containers
      Primary
      not_found
      Source IDH51-C3DE0139040881F717A48B2E
      Adult dosing range
      Primary
      existing_structured_record
      Source IDH51-43CF71406BD473E8440B4992
      Pediatric dosing range
      Primary
      not_found
      Source IDH51-D884E8C33811494053E8F079
      Neonatal dosing range
      Primary
      not_found
      Source IDH51-4ED29EA006C12B2BB69DB61A
      Infusion time
      Primary
      existing_structured_record
      Source IDH51-7E5EFE725127E9E24EA5E5C9
      Fluid restriction alternatives
      Primary
      not_found
      Source IDH51-A7375FB1B2BAAA53BD597E6D
      Current manufacturer labeling
      Primary
      DailyMed search gateway
      Source IDH51-2E43D2639416275ED2E575DB
      Population applicability
      Adult
      Applicability
      supported_or_source_present
      Source IDH51-EC156498834F7D8FFB5899B6
      Guide generation allowed
      true
      Source IDH51-83E33D6D821FC7AE4C981917
      Pediatric
      Applicability
      supported_or_source_present
      Source IDH51-0A20A77C978303363ABA8430
      Guide generation allowed
      false
      Source IDH51-41EBB2F1AE5BFF897BA612E2
      Neonatal
      Applicability
      not_established
      Source IDH51-8641A0FA964068ED896A1835
      Guide generation allowed
      false
      Source IDH51-48238186974C9C7B082CDCC8
      Route presence
      Structured dilution
      false
      Source IDH51-49A331A1DF350A63BB237D3A
      Iv push
      true
      Source IDH51-624E5932FAFAE01B83E8359B
      Continuous infusion
      true
      Source IDH51-A9718D6869DB9977EC9AC7DD
      Pediatric source
      true
      Source IDH51-BEA49774EBCEFFAB53280FC1
      Neonatal source
      false
      Source IDH51-672EA922E2E0A7D73ACD8A04
      Legacy reference
      Status
      not_available
      Source IDH51-768095914F38CD91EC1E803F
      Label resolution
      Status
      build_environment_network_unavailable
      Source IDH51-B37B5AAF03F14BEBFD9B9F34
      Source files
      1. catalog.json
        Source IDH51-291DA3888478161960BEDD6A
      2. dosing.json
        Source IDH51-56E9C1C4CC3BDCB9AA95E771
      3. new-in-v1.2.json
        Source IDH51-AA3A9439969C7FD5DE97AC40
      Clinical release note
      Preparation instructions are released only at the evidence level shown. Legacy content remains visibly separate. Exact product, NDC, route, current labeling, and institutional policy must be confirmed.
      Source IDH51-E9715951279E61CA6020C32B
      Historical statement IDs and source locations

      These IDs identify recovered source units. They are not evidence-qualified clinical claims.

      Historical IDOriginal source locationStatus
      H51-B0CC3DD2B60CFD8E41C68934catalog.json
      /records/108/id      		Historical; current review incomplete
      H51-1C163C3015365E6BE4C26BC4catalog.json
      /records/108/generic_name      		Historical; current review incomplete
      H51-DC143F2B801B67DC0151B681catalog.json
      /records/108/brand_names/0      		Historical; current review incomplete
      H51-D411902106074537674AD03Ccatalog.json
      /records/108/class      		Historical; current review incomplete
      H51-60EBFD0BB660657B3E06F8CAcatalog.json
      /records/108/subclass      		Historical; current review incomplete
      H51-3FB7CD49DF27B6566E568604catalog.json
      /records/108/summary      		Historical; current review incomplete
      H51-016A8DB5415B1F82FC38DA36catalog.json
      /records/108/common_uses/0      		Historical; current review incomplete
      H51-06AB2CDBD38FDDF260E4748Fcatalog.json
      /records/108/iv_push/0      		Historical; current review incomplete
      H51-BD3F5CCEC8D6392C811CDD33catalog.json
      /records/108/iv_push/0/population      		Historical; current review incomplete
      H51-B62D2138B852F6C66DA04336catalog.json
      /records/108/iv_push/0/dose_scope      		Historical; current review incomplete
      H51-873AC67B3CE596D1EC0E61E2catalog.json
      /records/108/iv_push/0/concentration      		Historical; current review incomplete
      H51-ABBC086E4BD63E41807A6CC2catalog.json
      /records/108/iv_push/0/rate      		Historical; current review incomplete
      H51-55A2057EFA3AA3A7F1FC1882catalog.json
      /records/108/iv_push/0/status      		Historical; current review incomplete
      H51-1515C3E886D6E75411DD271Dcatalog.json
      /records/108/iv_push/0/notes      		Historical; current review incomplete
      H51-EC851316D0F9CE146640B2FEcatalog.json
      /records/108/warnings/0      		Historical; current review incomplete
      H51-C2A83520987D2FA9C00DDB1Ecatalog.json
      /records/108/monitoring/0      		Historical; current review incomplete
      H51-5B29D1B429243985A3A3E2B9catalog.json
      /records/108/monitoring/1      		Historical; current review incomplete
      H51-4BF36B8545661C1C150EA7F8catalog.json
      /records/108/populations/0      		Historical; current review incomplete
      H51-DD35A8A44B1DDFE22C6844C5catalog.json
      /records/108/populations/1      		Historical; current review incomplete
      H51-4971129418C3D541D6005582catalog.json
      /records/108/evidence_tier      		Historical; current review incomplete
      H51-97495A9669B011929A344B7Fcatalog.json
      /records/108/high_alert      		Historical; current review incomplete
      H51-5993F1C581E0F9A2ADDB9EC3catalog.json
      /records/108/hazardous      		Historical; current review incomplete
      H51-A42614378976E3E55312DD53catalog.json
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      H51-A5A8B5F596BD814A6677AF4Edosing.json
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