IV Dilution &
Medication Reference

Isoproterenol (Isuprel ®)

Usual Diluents

Standard Dilutions [Amount of drug] [Infusion volume] [Infusion rate]

[1 - 2 mg] [250-500 ml] [Titrate]

Stability / Miscellaneous

(B1/B2) agonist. IV infusion: 2 to 20 mcg/ min.
Usual initial rate: 5 mcg/min.
Titrate to HR/BP.
May give IV-push (must use 1:50,000 dilution).

Calculation of drip rate:
1 mg/250 ml (ml/hr) = 15 x mcg/min. eg: 5 mcg/min = 75 ml/hr

DOSAGE AND ADMINISTRATION
ISUPREL injection 1:5000 should generally be started at the lowest recommended dose and the rate of administration gradually increased if necessary while carefully monitoring the patient. The usual route of administration is by intravenous infusion or bolus intravenous injection. In dire emergencies, the drug may be administered by intracardiac injection. If time is not of the utmost importance, initial therapy by intramuscular or subcutaneous injection is preferred.

*Subsequent dosage and method of administration depend on the ventricular rate and the rapidity with which the cardiac pacemaker can take over when the drug is gradually withdrawn.

There are no well-controlled studies in children to establish appropriate dosing; however, the American Heart Association recommends an initial infusion rate of 0.1 mcg/kg/min, with the usual range being 0.1 mcg/kg/min to 1 mcg/kg/min.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Such solution should not be used.

HOW SUPPLIED
Ampul
0.2 mg (0.2 mg/mL)
1 mL
UNI-AMP® pak of 25

Ampul
1 mg (0.2 mg/mL)
5 mL
10 ampuls per carton

Protect from light. Keep in opaque container until used.
Store at controlled room temperature 20° to 25°C (68° to 77°F). [See USP.]
Do not use if the injection is pinkish or darker than slightly yellow or contains a precipitate.

©Hospira 2004
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HOSPIRA, INC., LAKE FOREST, IL 60045 USA
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