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Preparation. Administration. Evidence.

IV Dilution &
Medication Reference

Search 255 medications, read preserved historical references, and inspect separately reviewed preparation statements. Full monograph updates remain pending.

Version 6.4Release date 2026-11-04For healthcare professionals
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Medication reference

Four-factor prothrombin complex concentrate

Monograph awaiting updateThis monograph will be updated in the future.

Jump to a section

No original site article was mapped to this record. The available historical structured fields and official-source links are retained.

Historical first look: uses, mechanism, dosing context, and administration

Recovered v5.1 source content; historical, awaiting current review.

Id
four-factor-prothrombin-complex-concentrate
Source IDH51-702616060217903BB67F9E3A
Generic name
Four-factor prothrombin complex concentrate
Source IDH51-1B1B4DD4DBA720E317B6E6B9
Class
Anticoagulation and hemostasis
Source IDH51-43CF45B2A57E518F071E42B1
Subclass
Coagulation factor replacement
Source IDH51-31F541A596B329FD3C23B15C
Primary uses
  1. Urgent warfarin reversal for major bleeding or emergency surgery
    Source IDH51-F5EA098DDC76AA4AD6D2B912
Mechanism
Replaces vitamin K-dependent factors II, VII, IX, and X to restore thrombin generation.
Source IDH51-B1121BE029132655A648A071
Mechanism level
drug_specific
Source IDH51-ADA3546B7B7C843CEA98C0CA
Basic dosing orientation
Adult | Existing preparation record; use current package insert for indication-specific selection | Dose in factor IX units based on INR and weight; maximum dose applies | Not normalized in the preparation record | See current package insert and professional guidance | IV infusion
Source IDH51-26F3A1BE8EE0B865CC8E615D
Administration orientation
Infuse at the label-limited unit/kg/min rate
Source IDH51-52C2C7C11C5C5BCB82D96C82
Renal and population orientation
Separate renal reference: Open Renal Dosing Master (opens in a new tab)Renal dosing status has not been locally normalized; use the current package insert before ordering or administration.
Source IDH51-D98360E349E0E6040EDA756F
Key safety orientation
  1. Arterial and venous thromboembolic complications.
    Source IDH51-9D88B15808CD67B3681DCF8C
  2. Unit-based dose and vial potency must be verified independently.
    Source IDH51-0F0FF9F9EE429457E5165B89
Coverage path
structured_local_snapshot
Source IDH51-2D53EE9157A4B1EBC8F721B4
Coverage path label
Structured GlobalRPh route snapshot
Source IDH51-7A8F8F4FDEA0949EDA8702C6
Review note
First-look orientation only. Verify indication, patient population, weight basis, organ function, exact IV product, dose, concentration, compatibility, rate, and current labeling before use.
Source IDH51-C5C8D8F41D784F9BE8DACC23
Search text
Four-factor prothrombin complex concentrate Anticoagulation and hemostasis Coagulation factor replacement Urgent warfarin reversal for major bleeding or emergency surgery Replaces vitamin K-dependent factors II, VII, IX, and X to restore thrombin generation. Adult | Existing preparation record; use current package insert for indication-specific selection | Dose in factor IX units based on INR and weight; maximum dose applies | Not normalized in the preparation record | See current package insert and professional guidance | IV infusion Infuse at the label-limited unit/kg/min rate Renal dosing status has not been locally normalized; use the current package insert before ordering or administration. Arterial and venous thromboembolic complications. Unit-based dose and vial potency must be verified independently. Structured GlobalRPh route snapshot KCENTRA KCENTRA (prothrombin complex concentrate [human]) kit DailyMed label snapshot dosage administration dosage forms strengths mechanism
Source IDH51-25616A00CF0F13FD502E23CE
Official access mode
direct_label
Source IDH51-F7DF7991334D28D6577F03D7
Official search query
Four-factor prothrombin complex concentrate
Source IDH51-346E41CC8C509B4747F11E71
Official access reason
Very-high-confidence exact IV product label selected during the v5.1 build-time review. Open the current full DailyMed monograph and verify the stocked product before use.
Source IDH51-B3A995A2A5A7FA6083B4C2D1
Label snapshot available
true
Source IDH51-89A9F933E23BD55689CFFB6C
Label snapshot setid
eee1afb8-324c-42e4-8bf0-f0c9da5e6d42
Source IDH51-BEE4391C339E3549F2F0C119
Product identifiers and clinical review status

This monograph will be updated in the future. Historical material is available where present in the original sources; full current exact-product and claim-level review remains pending.

Exact formulation, concentration, container, manufacturer, regulatory identifiers, and a reproducible label snapshot have not all been reconciled.

What remains to be completed
  • A retrieved source document is available; clinical reconciliation and a second-source claim map remain incomplete
  • Clinically reviewed, individually identified statements with two exact source mappings
  • Exact formulation, strength, container, manufacturer/labeler, application and NDC reconciliation
  • Renal-function methods and dialysis/CRRT modality review where applicable
  • Mechanism provenance, clinical source disagreements and full medication-specific safety reconciliation

Supplemental historical fields

Restored-data provenance and review notes

Source release: 2026-08-31. Current clinical review is incomplete. Original uses of current, verified, or normalized describe the historical source. They do not inherit the status of separately reviewed statements. Product formulations and source dates can differ.

Current review annotations for historical renal, dialysis, mechanism, and product fieldsSeparate renal reference: Open Renal Dosing Master (opens in a new tab)
Renal
Status
not_locally_normalized
Original classification
current_label_review_required
Entries
    General note
    Preserve the source-specific renal-function basis. An indexed CrCl table is not interchangeable with unindexed CrCl or eGFR. Generic advice to check a method does not identify the equation for a dose row.
    Dialysis
    Status
    no_local_structured_regimen
    Entries
      General note
      Named modality alone does not establish applicability. CRRT subtype, effluent rate, residual renal function, timing and interruptions require review. Historical absence is not evidence that no guidance exists.
      Mechanisms
      • Source kind
        first_look
        Local pointer
        /mechanism
        Original level
        drug_specific
        Provenance classification
        historical_drug_specific_uncorroborated
        Label derived verified
        false
        Independently corroborated
        false
        Exact label section
        Not recorded
        Original source note
        Not recorded
        Review status
        historical_unverified
        Note
        Drug-specific wording in the old file is not proof of independent corroboration or an exact label locator. Consult separately published current mechanism claims where present.
      • Source kind
        label_snapshot
        Local pointer
        /mechanism_summary
        Original level
        drug_specific
        Provenance classification
        historical_drug_specific_uncorroborated
        Label derived verified
        false
        Independently corroborated
        false
        Exact label section
        Not recorded
        Original source note
        Concise GlobalRPh summary reviewed against the selected DailyMed label clinical-pharmacology or microbiology content.
        Review status
        historical_unverified
        Note
        Drug-specific wording in the old file is not proof of independent corroboration or an exact label locator. Consult separately published current mechanism claims where present.
      Future update
      Status
      pending_review
      Message
      This monograph will be updated in the future as current exact-product and claim-level review is completed.
      Source unavailable
      false
      Reason
      The historical content is restored; comprehensive contemporary verification remains incomplete.

      No separate structured rows were bundled for IV push, continuous infusion, dialysis, CRRT. Historical article content and source links may cover these topics.

      Historical dilution and intermittent infusion preparation

      Recovered v5.1 source content; historical, awaiting current review.

      PopulationAmountReconstitutionDiluentFinal volumeConcentrationRateStabilityNotes
      Source IDH51-831301C40AE94ABF75604FE1
      Adult
      Source IDH51-D6EAC45E6A8B53B0A98C3877
      Dose in factor IX units based on INR and weight; maximum dose applies
      Source IDH51-C283A8C5799698FF0771157B
      Reconstitute each vial using supplied diluent and transfer device; gently swirl.
      Source IDH51-ACDAE840F116DB64B01CE4A6
      Do not further dilute unless label permits
      Source IDH51-D3921820F8040008776110C2
      Vial-dependent
      Source IDH51-7FAE07AD959368F477E66D0A
      Product-specific units/mL
      Source IDH51-90EF33AE46DF2DC1BF724F77
      Infuse at the label-limited unit/kg/min rate
      Source IDH51-73B813765A3CED507C9F86C8
      Use the shorter of current product labeling, validated stability data, and the applicable USP <797> sterility-based BUD ceiling.
      Source IDH51-62CB78FADC3893B4B7232D50
      Administer vitamin K concurrently unless contraindicated or a temporary reversal is explicitly intended.
      Source IDH51-8A0603AD1C420DA081E3480E

      Historical DailyMed label snapshot

      Recovered v5.1 source content; historical, awaiting current review.

      Id
      four-factor-prothrombin-complex-concentrate
      Source IDH51-0288335BE05E1B3C45795C61
      Catalog name
      Four-factor prothrombin complex concentrate
      Source IDH51-4FCE61E09D915F90FB0839C5
      Selection status
      accepted_high_confidence
      Source IDH51-9B1F524E604A5D38C31FD694
      Confidence
      very_high
      Source IDH51-3253142570D70E2361374485
      Match path
      search_to_exact_label
      Source IDH51-D559B5693B7B4B6D15B4E7DD
      Brand name
      KCENTRA
      Source IDH51-79627398079954ABD04190A1
      Label title
      KCENTRA (prothrombin complex concentrate [human]) kit
      Source IDH51-46A74D8490432784E42974FA
      Setid
      eee1afb8-324c-42e4-8bf0-f0c9da5e6d42
      Source IDH51-152773B8C8CC1AD5B3DD07C9
      Route
      Intravenous infusion after reconstitution
      Source IDH51-A9763839F530F57963EBE497
      Dosage form
      Lyophilized coagulation-factor concentrate with diluent and transfer set
      Source IDH51-CA6AAA087E808CA30E99B739
      Dosage administration summary
      1. Dose is based on the pretreatment INR and actual body weight, subject to the product-specific maximum dose.
        Source IDH51-7105E88748BCC962E232D7DD
      2. Reconstitute with the supplied components, administer intravenously at the labeled rate, and give vitamin K concurrently when reversing vitamin K antagonist therapy.
        Source IDH51-4C567D10FDB6B1F52920E635
      3. Use the exact vial potency printed on the carton and vial label; factor IX units vary by lot.
        Source IDH51-804AC0266E66848036AB9378
      Dosage forms strengths
      1. Variable factor IX potency per vial; actual potency and calculated units are printed on each carton and vial
        Source IDH51-C9C283BFD41DDF94183CEDAF
      Mechanism summary
      KCENTRA replaces vitamin K-dependent coagulation factors II, VII, IX, and X and also contains proteins C and S.
      Source IDH51-A3EC82525CDEDAF8E7FDCA27
      Scope note
      Selected KCENTRA label for urgent vitamin K antagonist reversal. Thromboembolic risk and indication restrictions require the current monograph.
      Source IDH51-A82FCA694B888611918147D0
      Reviewed on
      2026-08-31
      Source IDH51-0F0B5D53A5A23B652C145FDD
      Mechanism source
      Concise GlobalRPh summary reviewed against the selected DailyMed label clinical-pharmacology or microbiology content.
      Source IDH51-51311DEC7664C0CD58517528
      Source sections
      1. Dosage and Administration
        Source IDH51-DAB0F127A8296AEFF5D7C552
      2. Dosage Forms and Strengths
        Source IDH51-A371DE469403E2F1D6F1AF23
      3. Clinical Pharmacology or Microbiology as applicable
        Source IDH51-FF4F61141A4681D30BD7856B
      Retrieval method
      Manual build-time review of the current DailyMed full prescribing information for the selected Set ID; no live server retrieval is required during page use.
      Source IDH51-0CC6EFF32F90E52CF6CD965C
      Label status
      current
      Source IDH51-F7D5C16A72AE1241365BC01B
      Disclaimer
      Verify the exact formulation, strength, manufacturer, NDC, route, current label revision, patient-specific order, institutional policy, and monitoring before use.
      Source IDH51-4D4B7F72E2862967ECC88589

      Historical indication and population dosing

      Recovered tables and source-separated snapshots; full clinical revalidation remains pending.

      Existing dose and route snapshots

      RoutePopulationIndicationDoseIntervalDurationAdministrationSource levelNotes
      Source IDH51-24C35588691222DE8F45D102
      IV infusion
      Source IDH51-23024161996B7DFC149E8284
      Adult
      Source IDH51-2BA321D753ECF9806D94F634
      Existing preparation record; use current package insert for indication-specific selection
      Source IDH51-6E6BBA960CA80A160B7CC88E
      Dose in factor IX units based on INR and weight; maximum dose applies
      Source IDH51-43943E0F991A3F8DB0F9672B
      Not normalized in the preparation record
      Source IDH51-FFED22B69F8BF1A32DFA3E61
      See current package insert and professional guidance
      Source IDH51-A4CBAEADED75CCFFE46D631A
      Infuse at the label-limited unit/kg/min rate
      Source IDH51-EF27C934B9A3CA6EF3DA3872
      Existing GlobalRPh structured preparation snapshot
      Source IDH51-F162D2136094CD5D620FCDFB
      Administer vitamin K concurrently unless contraindicated or a temporary reversal is explicitly intended.
      Source IDH51-ECFF30F45B5EF9373DA15140

      Historical renal-function guidance

      Recovered v5.1 source content; historical, awaiting current review.

      Separate renal reference: Open Renal Dosing Master (opens in a new tab)
      Classification
      current_label_review_required
      Source IDH51-D9CF7A2B61EEA25FA6CAB998
      Summary
      Renal dosing status has not been locally normalized; use the current package insert before ordering or administration.
      Source IDH51-BD2E97B49E729A6FC05A1D99
      Method note
      Use the renal function estimate and body-size convention specified by the selected label or institutional protocol. Do not interchange Cockcroft-Gault CrCl, indexed eGFR, and de-indexed eGFR without confirming the dosing source.
      Source IDH51-959689FB6083CBC0BD95794F

      Historical Common IV uses

      Recovered v5.1 source content; historical, awaiting current review.

      1. Urgent warfarin reversal for major bleeding or emergency surgery
        Source IDH51-0CC45D5BD64A2D7D9AA24B91

      Historical Warnings and safeguards

      Recovered v5.1 source content; historical, awaiting current review.

      1. Arterial and venous thromboembolic complications.
        Source IDH51-443648D01E19BC6B5C250571
      2. Unit-based dose and vial potency must be verified independently.
        Source IDH51-D0CA20D3E46648E3BB806258

      Historical Monitoring

      Recovered v5.1 source content; historical, awaiting current review.

      1. INR after administration
        Source IDH51-B193DAA8B2BB43ABF8527B20
      2. Hemostasis
        Source IDH51-EFF791761E8C9FED0DE3624D
      3. Thrombotic events
        Source IDH51-4902A099BABEE8E66F6BA600
      Other recovered source fields and original editorial metadata

      Original status words such as current, verified, or normalized describe the historical source release. They do not change the clinical review status of this release.

      Catalog source fields

      Id
      four-factor-prothrombin-complex-concentrate
      Source IDH51-3C4B3EB85C632C956AE0598E
      Generic name
      Four-factor prothrombin complex concentrate
      Source IDH51-294FBCA5B06F5AD005FF5AC7
      Brand names
      1. Kcentra
        Source IDH51-AC2BFF2C129F62C4141D5D42
      Aliases
      1. 4F-PCC
        Source IDH51-CFE908B0999F14B10F39B2A3
      2. PCC4
        Source IDH51-4A059BDF9A608DE8C4312EB9
      Class
      Anticoagulation and hemostasis
      Source IDH51-439D8164AFD2C8A57BC15C76
      Subclass
      Coagulation factor replacement
      Source IDH51-2CE5044689E52F67A04F4BB1
      Summary
      High-alert factor concentrate dosed in factor IX units by pretreatment INR and body weight for urgent vitamin K antagonist reversal.
      Source IDH51-C5DE7E160198E09C4B5D9CAB
      Populations
      1. Adult
        Source IDH51-4F6EF7694466146C1FD61493
      Evidence tier
      Core reference - verify current label
      Source IDH51-90274FD24288935C175C2447
      High alert
      true
      Source IDH51-89935180756A2A77F41F8F5C
      Hazardous
      false
      Source IDH51-01F906CA70A6A5CB76632B10
      Status
      Active
      Source IDH51-F72AD8814890090AF5D458C5
      Reviewed
      2026-08-29
      Source IDH51-D5F2B758C82F839A5A774D5A
      Version added
      1.2
      Source IDH51-E0E82A525D0ECC80E2C9C3AF
      Sources
      LabelUrlKind
      Source IDH51-209690F9842F77514FC7E7CF
      DailyMed label search
      Source IDH51-52E7128738B0176F7093C7DA
      https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=Four-factor+prothrombin+complex+concentrate (opens in a new tab)
      Source IDH51-5AA87D849E7EE7079F952FA4
      Primary
      Source IDH51-D732023C928ABCD82CB49D77
      Source IDH51-E281C8E8705158BAFD468D10
      GlobalRPh legacy IV dilution monograph
      Source IDH51-F19BD91ACB9CF540D992073F
      legacy:auto
      Source IDH51-EC719DFE72119CEDBFB3FD4D
      Legacy
      Source IDH51-256E5AE8A96C7F3F9E9D6CBF
      Clinical release verification
      Audit version
      3.4
      Source IDH51-8C30E4CA9E5F7AB32440E887
      Audited on
      2026-08-30
      Source IDH51-F9C1F476FE404A87EBD727C0
      Level
      amber
      Source IDH51-743A6D2ED6E7D7B0CC01EBC7
      Release gate
      trusted_professional_source_present_exact_label_unconfirmed
      Source IDH51-6C5F2580C2756233B56EFD43
      Exact current label candidate
      false
      Source IDH51-35F4DFEFA3E0DEF7A01E651E
      Reference url count
      1
      Source IDH51-47A99AE2A476C39D697AA03D
      Broken reference count
      0
      Source IDH51-BEB9BD506B69F748BA238112
      Point of use confirmation required
      true
      Source IDH51-D77CF0EAAA3EBE2783B6BEA3
      Note
      Do not treat this record as a fully current product-specific monograph until the exact IV formulation and current sources are confirmed.
      Source IDH51-01C09E442E3F03EC4B7A67E5
      Version updated
      5.1
      Source IDH51-833B80C602ED6C2C58F385E9

      Dosing source fields

      Id
      four-factor-prothrombin-complex-concentrate
      Source IDH51-F8F0611167F811DEAB66C253
      Generic name
      Four-factor prothrombin complex concentrate
      Source IDH51-02A60F2444A518BE2900348C
      Coverage status
      direct_official_label_access_plus_local_snapshot
      Source IDH51-C86BC44CCF73D345C777D8A7
      Package insert
      Query name
      Four-factor prothrombin complex concentrate
      Source IDH51-5F5150173DF2C0AD40B6353A
      Product and route must match
      true
      Source IDH51-2B3F4F136ED5D9EF4B8EB453
      Live current label enabled
      false
      Source IDH51-7BC21273A7E739E412A2394C
      Source priority
      Reviewed local summary when available, then a verified DailyMed label or product search when available, followed by professional references and institutional policy.
      Source IDH51-3D21421853B38CFC002145D0
      Direct official label access enabled
      true
      Source IDH51-33162C88CDD1DE5806605EE4
      Outbound server request required
      false
      Source IDH51-37CF11C1D1AD19730742749E
      Local summary status
      not_bundled
      Source IDH51-D24F7F6FBE4FC9936FBD4944
      Clinical review
      Locally normalized
      false
      Source IDH51-D83AA2CFB79FA660F2D4741E
      Reviewed
      2026-08-29
      Source IDH51-DE8C85BFF10DAB9EDBEFAE0E
      Status
      Direct official package-insert access enabled; indication-specific local normalization pending.
      Source IDH51-42D0B9530CF83151B529CA05
      Clinical release verification
      Audit version
      3.4
      Source IDH51-979C315C9BEEC8B40B27858B
      Audited on
      2026-08-30
      Source IDH51-2539A5722ED3258BF26ACBC1
      Level
      amber
      Source IDH51-98B412BE05FD88B3F3F2F676
      Release gate
      trusted_professional_source_present_exact_label_unconfirmed
      Source IDH51-07BEDC527A5FA68006400F86
      Exact current label candidate
      false
      Source IDH51-6E2F19FD9E0C2FB7563E47AF
      Reference url count
      1
      Source IDH51-9D48EA42E8F80EDFD5364D10
      Broken reference count
      0
      Source IDH51-E7CFAED965D9C5E328F028A3
      Point of use confirmation required
      true
      Source IDH51-892361D819C200A6141969D2
      Note
      Do not treat this record as a fully current product-specific monograph until the exact IV formulation and current sources are confirmed.
      Source IDH51-0AB3042D4DC3F8BB3C357A6C
      Historical preparation assessment

      Recovered v5.1 source content; historical, awaiting current review.

      Id
      four-factor-prothrombin-complex-concentrate
      Source IDH51-22D0091131ABD80CF380DCCE
      Name
      Four-factor prothrombin complex concentrate
      Source IDH51-771FF36A097C6306ED51DAF6
      Brands
      Kcentra
      Source IDH51-807BB2C7F7C2A18B6805B9D0
      Therapeutic class
      Anticoagulation and hemostasis
      Source IDH51-3AE7F8835F5052EF1D0120DB
      Review version
      3.1
      Source IDH51-C3B07DE286407385E5A56D64
      Review date
      2026-08-30
      Source IDH51-4B5F88F4EBCCD9A41142611D
      Release status
      structured_record_current_label_not_confirmed
      Source IDH51-8CDED852D9BD8CFAFDB97F8B
      Market status
      Status
      no_current_us_iv_spl_confirmed
      Source IDH51-84CEB1DBDCF03B95C061D96F
      Basis
      No high-confidence current IV SPL was automatically selected; legacy information is segregated
      Source IDH51-2C0347005B2B5F61F0835C6F
      Ten point assessment
      Exact formulation
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-AF7F9A2C23A9643677334BCB
      Reconstitution concentration
      Reconstitute each vial using supplied diluent and transfer device; gently swirl.
      Source IDH51-F038710626977D5549399C7E
      Maximum or recommended final concentration
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-FEF4B103121604E38D47B3DF
      Appropriate standardized containers
      Vial-dependent
      Source IDH51-18143A985FEA67ADD1BE1B64
      Adult dosing range
      Dose in factor IX units based on INR and weight; maximum dose applies
      Source IDH51-2883867F05A705476C54E12B
      Pediatric dosing range
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-0D102F8730BD2FF1821E151D
      Neonatal dosing range
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-98D65D682000EB25626AA2AE
      Infusion time
      Infuse at the label-limited unit/kg/min rate
      Source IDH51-347A613D7EAD13A7AF0DEA40
      Fluid restriction alternatives
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-6752D1CBA49260CC7E45D17C
      Current manufacturer labeling
      Match confidence
      unresolved
      Source IDH51-7E0BC749FBE7B5CBC1F43272
      Field provenance
      Exact formulation
      Primary
      not_found
      Source IDH51-D4376D387053411EBDFEE14E
      Reconstitution concentration
      Primary
      existing_structured_record
      Source IDH51-3F96CAC9F442F3163511D474
      Maximum or recommended final concentration
      Primary
      not_found
      Source IDH51-DCF3239D83DD992E83FADA03
      Appropriate standardized containers
      Primary
      existing_structured_record
      Source IDH51-359493FD704ED820412A9D6D
      Adult dosing range
      Primary
      existing_structured_record
      Source IDH51-8D28990B575F7836B7B1B3F0
      Pediatric dosing range
      Primary
      not_found
      Source IDH51-554D6A7DDAF2A7A90681B3C6
      Neonatal dosing range
      Primary
      not_found
      Source IDH51-1F763DC6EFB4F49955A91BF4
      Infusion time
      Primary
      existing_structured_record
      Source IDH51-6FACDDF803B4BC2036C8D18F
      Fluid restriction alternatives
      Primary
      not_found
      Source IDH51-EA7AD1BB842413E7E9A51F08
      Current manufacturer labeling
      Primary
      DailyMed search gateway
      Source IDH51-F48B40E17D54DB8AEF345E25
      Population applicability
      Adult
      Applicability
      supported_or_source_present
      Source IDH51-2AB15FA96E09C750C6FC095C
      Guide generation allowed
      true
      Source IDH51-8C58D0BA4984B1CA410C3584
      Pediatric
      Applicability
      not_established
      Source IDH51-9086FA2608E11C830683EB56
      Guide generation allowed
      false
      Source IDH51-CFCEC9767A6B394D7C712243
      Neonatal
      Applicability
      not_established
      Source IDH51-2FCD608EBFC08122F59D40F5
      Guide generation allowed
      false
      Source IDH51-3E676A15454C75AEE5BA97B7
      Route presence
      Structured dilution
      true
      Source IDH51-2EEA488B927057D905FD1201
      Iv push
      false
      Source IDH51-2C94B1CECD90EA1A87268085
      Continuous infusion
      false
      Source IDH51-21E692E0E1AD2D2F73BA62C4
      Pediatric source
      false
      Source IDH51-3C4E0ADB81EA444E96079170
      Neonatal source
      false
      Source IDH51-0E83EE10F5FDC07C5681C6F6
      Legacy reference
      Status
      not_available
      Source IDH51-14548EF5B918D73DC2BE8EDB
      Label resolution
      Status
      build_environment_network_unavailable
      Source IDH51-DA3D3D59494AA95197FA3E5D
      Source files
      1. catalog.json
        Source IDH51-45B05F78EFFC6737CF440691
      2. dosing.json
        Source IDH51-BCC5E94D3BCA54A63DD5315B
      3. new-in-v1.2.json
        Source IDH51-B2771CFA49471906E16C64BC
      Clinical release note
      Preparation instructions are released only at the evidence level shown. Legacy content remains visibly separate. Exact product, NDC, route, current labeling, and institutional policy must be confirmed.
      Source IDH51-5927645CDEFCE9C1AFFAC3EC
      Historical statement IDs and source locations

      These IDs identify recovered source units. They are not evidence-qualified clinical claims.

      Historical IDOriginal source locationStatus
      H51-3C4B3EB85C632C956AE0598Ecatalog.json
      /records/112/id
      Historical; current review incomplete
      H51-294FBCA5B06F5AD005FF5AC7catalog.json
      /records/112/generic_name
      Historical; current review incomplete
      H51-AC2BFF2C129F62C4141D5D42catalog.json
      /records/112/brand_names/0
      Historical; current review incomplete
      H51-CFE908B0999F14B10F39B2A3catalog.json
      /records/112/aliases/0
      Historical; current review incomplete
      H51-4A059BDF9A608DE8C4312EB9catalog.json
      /records/112/aliases/1
      Historical; current review incomplete
      H51-439D8164AFD2C8A57BC15C76catalog.json
      /records/112/class
      Historical; current review incomplete
      H51-2CE5044689E52F67A04F4BB1catalog.json
      /records/112/subclass
      Historical; current review incomplete
      H51-C5DE7E160198E09C4B5D9CABcatalog.json
      /records/112/summary
      Historical; current review incomplete
      H51-0CC45D5BD64A2D7D9AA24B91catalog.json
      /records/112/common_uses/0
      Historical; current review incomplete
      H51-831301C40AE94ABF75604FE1catalog.json
      /records/112/preparations/0
      Historical; current review incomplete
      H51-D6EAC45E6A8B53B0A98C3877catalog.json
      /records/112/preparations/0/population
      Historical; current review incomplete
      H51-C283A8C5799698FF0771157Bcatalog.json
      /records/112/preparations/0/amount
      Historical; current review incomplete
      H51-ACDAE840F116DB64B01CE4A6catalog.json
      /records/112/preparations/0/reconstitution
      Historical; current review incomplete
      H51-D3921820F8040008776110C2catalog.json
      /records/112/preparations/0/diluent
      Historical; current review incomplete
      H51-7FAE07AD959368F477E66D0Acatalog.json
      /records/112/preparations/0/final_volume
      Historical; current review incomplete
      H51-90EF33AE46DF2DC1BF724F77catalog.json
      /records/112/preparations/0/concentration
      Historical; current review incomplete
      H51-73B813765A3CED507C9F86C8catalog.json
      /records/112/preparations/0/rate
      Historical; current review incomplete
      H51-62CB78FADC3893B4B7232D50catalog.json
      /records/112/preparations/0/stability
      Historical; current review incomplete
      H51-8A0603AD1C420DA081E3480Ecatalog.json
      /records/112/preparations/0/notes
      Historical; current review incomplete
      H51-443648D01E19BC6B5C250571catalog.json
      /records/112/warnings/0
      Historical; current review incomplete
      H51-D0CA20D3E46648E3BB806258catalog.json
      /records/112/warnings/1
      Historical; current review incomplete
      H51-B193DAA8B2BB43ABF8527B20catalog.json
      /records/112/monitoring/0
      Historical; current review incomplete
      H51-EFF791761E8C9FED0DE3624Dcatalog.json
      /records/112/monitoring/1
      Historical; current review incomplete
      H51-4902A099BABEE8E66F6BA600catalog.json
      /records/112/monitoring/2
      Historical; current review incomplete
      H51-4F6EF7694466146C1FD61493catalog.json
      /records/112/populations/0
      Historical; current review incomplete
      H51-90274FD24288935C175C2447catalog.json
      /records/112/evidence_tier
      Historical; current review incomplete
      H51-89935180756A2A77F41F8F5Ccatalog.json
      /records/112/high_alert
      Historical; current review incomplete
      H51-01F906CA70A6A5CB76632B10catalog.json
      /records/112/hazardous
      Historical; current review incomplete
      H51-F72AD8814890090AF5D458C5catalog.json
      /records/112/status
      Historical; current review incomplete
      H51-D5F2B758C82F839A5A774D5Acatalog.json
      /records/112/reviewed
      Historical; current review incomplete
      H51-E0E82A525D0ECC80E2C9C3AFcatalog.json
      /records/112/version_added
      Historical; current review incomplete
      H51-209690F9842F77514FC7E7CFcatalog.json
      /records/112/sources/0
      Historical; current review incomplete
      H51-52E7128738B0176F7093C7DAcatalog.json
      /records/112/sources/0/label
      Historical; current review incomplete
      H51-5AA87D849E7EE7079F952FA4catalog.json
      /records/112/sources/0/url
      Historical; current review incomplete
      H51-D732023C928ABCD82CB49D77catalog.json
      /records/112/sources/0/kind
      Historical; current review incomplete
      H51-E281C8E8705158BAFD468D10catalog.json
      /records/112/sources/1
      Historical; current review incomplete
      H51-F19BD91ACB9CF540D992073Fcatalog.json
      /records/112/sources/1/label
      Historical; current review incomplete
      H51-EC719DFE72119CEDBFB3FD4Dcatalog.json
      /records/112/sources/1/url
      Historical; current review incomplete
      H51-256E5AE8A96C7F3F9E9D6CBFcatalog.json
      /records/112/sources/1/kind
      Historical; current review incomplete
      H51-8A22F6AA45D95CF17AEFBDF5catalog.json
      /records/112/legacy_title
      Historical; current review incomplete
      H51-8C30E4CA9E5F7AB32440E887catalog.json
      /records/112/clinical_release_verification/audit_version
      Historical; current review incomplete
      H51-F9C1F476FE404A87EBD727C0catalog.json
      /records/112/clinical_release_verification/audited_on
      Historical; current review incomplete
      H51-743A6D2ED6E7D7B0CC01EBC7catalog.json
      /records/112/clinical_release_verification/level
      Historical; current review incomplete
      H51-6C5F2580C2756233B56EFD43catalog.json
      /records/112/clinical_release_verification/release_gate
      Historical; current review incomplete
      H51-35F4DFEFA3E0DEF7A01E651Ecatalog.json
      /records/112/clinical_release_verification/exact_current_label_candidate
      Historical; current review incomplete
      H51-79C1C9770FEC70ED1C450070catalog.json
      /records/112/clinical_release_verification/selected_setid
      Historical; current review incomplete
      H51-91F305AE71CAB498702EC963catalog.json
      /records/112/clinical_release_verification/selected_label_title
      Historical; current review incomplete
      H51-3D8F2CC882EB677023D0EEACcatalog.json
      /records/112/clinical_release_verification/numeric_support_ratio
      Historical; current review incomplete
      H51-47A99AE2A476C39D697AA03Dcatalog.json
      /records/112/clinical_release_verification/reference_url_count
      Historical; current review incomplete
      H51-BEB9BD506B69F748BA238112catalog.json
      /records/112/clinical_release_verification/broken_reference_count
      Historical; current review incomplete
      H51-D77CF0EAAA3EBE2783B6BEA3catalog.json
      /records/112/clinical_release_verification/point_of_use_confirmation_required
      Historical; current review incomplete
      H51-01C09E442E3F03EC4B7A67E5catalog.json
      /records/112/clinical_release_verification/note
      Historical; current review incomplete
      H51-7B67E33AECBDEF27B50DF269catalog.json
      /records/112/clinical_release_verification/dailymed_search_url
      Historical; current review incomplete
      H51-833B80C602ED6C2C58F385E9catalog.json
      /records/112/version_updated
      Historical; current review incomplete
      H51-0288335BE05E1B3C45795C61dailymed-label-snapshots-v5.1.json
      /records/29/id
      Historical; current review incomplete
      H51-4FCE61E09D915F90FB0839C5dailymed-label-snapshots-v5.1.json
      /records/29/catalog_name
      Historical; current review incomplete
      H51-9B1F524E604A5D38C31FD694dailymed-label-snapshots-v5.1.json
      /records/29/selection_status
      Historical; current review incomplete
      H51-3253142570D70E2361374485dailymed-label-snapshots-v5.1.json
      /records/29/confidence
      Historical; current review incomplete
      H51-D559B5693B7B4B6D15B4E7DDdailymed-label-snapshots-v5.1.json
      /records/29/match_path
      Historical; current review incomplete
      H51-79627398079954ABD04190A1dailymed-label-snapshots-v5.1.json
      /records/29/brand_name
      Historical; current review incomplete
      H51-46A74D8490432784E42974FAdailymed-label-snapshots-v5.1.json
      /records/29/label_title
      Historical; current review incomplete
      H51-152773B8C8CC1AD5B3DD07C9dailymed-label-snapshots-v5.1.json
      /records/29/setid
      Historical; current review incomplete
      H51-A9763839F530F57963EBE497dailymed-label-snapshots-v5.1.json
      /records/29/route
      Historical; current review incomplete
      H51-CA6AAA087E808CA30E99B739dailymed-label-snapshots-v5.1.json
      /records/29/dosage_form
      Historical; current review incomplete
      H51-7105E88748BCC962E232D7DDdailymed-label-snapshots-v5.1.json
      /records/29/dosage_administration_summary/0
      Historical; current review incomplete
      H51-4C567D10FDB6B1F52920E635dailymed-label-snapshots-v5.1.json
      /records/29/dosage_administration_summary/1
      Historical; current review incomplete
      H51-804AC0266E66848036AB9378dailymed-label-snapshots-v5.1.json
      /records/29/dosage_administration_summary/2
      Historical; current review incomplete
      H51-C9C283BFD41DDF94183CEDAFdailymed-label-snapshots-v5.1.json
      /records/29/dosage_forms_strengths/0
      Historical; current review incomplete
      H51-A3EC82525CDEDAF8E7FDCA27dailymed-label-snapshots-v5.1.json
      /records/29/mechanism_summary
      Historical; current review incomplete
      H51-A82FCA694B888611918147D0dailymed-label-snapshots-v5.1.json
      /records/29/scope_note
      Historical; current review incomplete
      H51-ACED8154EBCEFE7CF600980Fdailymed-label-snapshots-v5.1.json
      /records/29/labeler
      Historical; current review incomplete
      H51-E423356A7920C4358B77272Ddailymed-label-snapshots-v5.1.json
      /records/29/official_label_url
      Historical; current review incomplete
      H51-0F0B5D53A5A23B652C145FDDdailymed-label-snapshots-v5.1.json
      /records/29/reviewed_on
      Historical; current review incomplete
      H51-51311DEC7664C0CD58517528dailymed-label-snapshots-v5.1.json
      /records/29/mechanism_source
      Historical; current review incomplete
      H51-DAB0F127A8296AEFF5D7C552dailymed-label-snapshots-v5.1.json
      /records/29/source_sections/0
      Historical; current review incomplete
      H51-A371DE469403E2F1D6F1AF23dailymed-label-snapshots-v5.1.json
      /records/29/source_sections/1
      Historical; current review incomplete
      H51-FF4F61141A4681D30BD7856Bdailymed-label-snapshots-v5.1.json
      /records/29/source_sections/2
      Historical; current review incomplete
      H51-0CC6EFF32F90E52CF6CD965Cdailymed-label-snapshots-v5.1.json
      /records/29/retrieval_method
      Historical; current review incomplete
      H51-F7D5C16A72AE1241365BC01Bdailymed-label-snapshots-v5.1.json
      /records/29/label_status
      Historical; current review incomplete
      H51-4D4B7F72E2862967ECC88589dailymed-label-snapshots-v5.1.json
      /records/29/disclaimer
      Historical; current review incomplete
      H51-F8F0611167F811DEAB66C253dosing.json
      /records/112/id
      Historical; current review incomplete
      H51-02A60F2444A518BE2900348Cdosing.json
      /records/112/generic_name
      Historical; current review incomplete
      H51-C86BC44CCF73D345C777D8A7dosing.json
      /records/112/coverage_status
      Historical; current review incomplete
      H51-5F5150173DF2C0AD40B6353Adosing.json
      /records/112/package_insert/query_name
      Historical; current review incomplete
      H51-AD0074711A949DDD51946791dosing.json
      /records/112/package_insert/preferred_setid
      Historical; current review incomplete
      H51-2B3F4F136ED5D9EF4B8EB453dosing.json
      /records/112/package_insert/product_and_route_must_match
      Historical; current review incomplete
      H51-7BC21273A7E739E412A2394Cdosing.json
      /records/112/package_insert/live_current_label_enabled
      Historical; current review incomplete
      H51-3D21421853B38CFC002145D0dosing.json
      /records/112/package_insert/source_priority
      Historical; current review incomplete
      H51-33162C88CDD1DE5806605EE4dosing.json
      /records/112/package_insert/direct_official_label_access_enabled
      Historical; current review incomplete
      H51-37CF11C1D1AD19730742749Edosing.json
      /records/112/package_insert/outbound_server_request_required
      Historical; current review incomplete
      H51-D24F7F6FBE4FC9936FBD4944dosing.json
      /records/112/package_insert/local_summary_status
      Historical; current review incomplete
      H51-D9CF7A2B61EEA25FA6CAB998dosing.json
      /records/112/renal/classification
      Historical; current review incomplete
      H51-BD2E97B49E729A6FC05A1D99dosing.json
      /records/112/renal/summary
      Historical; current review incomplete
      H51-959689FB6083CBC0BD95794Fdosing.json
      /records/112/renal/method_note
      Historical; current review incomplete
      H51-24C35588691222DE8F45D102dosing.json
      /records/112/existing_route_snapshots/0
      Historical; current review incomplete
      H51-23024161996B7DFC149E8284dosing.json
      /records/112/existing_route_snapshots/0/route
      Historical; current review incomplete
      H51-2BA321D753ECF9806D94F634dosing.json
      /records/112/existing_route_snapshots/0/population
      Historical; current review incomplete
      H51-6E6BBA960CA80A160B7CC88Edosing.json
      /records/112/existing_route_snapshots/0/indication
      Historical; current review incomplete
      H51-43943E0F991A3F8DB0F9672Bdosing.json
      /records/112/existing_route_snapshots/0/dose
      Historical; current review incomplete
      H51-FFED22B69F8BF1A32DFA3E61dosing.json
      /records/112/existing_route_snapshots/0/interval
      Historical; current review incomplete
      H51-A4CBAEADED75CCFFE46D631Adosing.json
      /records/112/existing_route_snapshots/0/duration
      Historical; current review incomplete
      H51-EF27C934B9A3CA6EF3DA3872dosing.json
      /records/112/existing_route_snapshots/0/administration
      Historical; current review incomplete
      H51-F162D2136094CD5D620FCDFBdosing.json
      /records/112/existing_route_snapshots/0/source_level
      Historical; current review incomplete
      H51-ECFF30F45B5EF9373DA15140dosing.json
      /records/112/existing_route_snapshots/0/notes
      Historical; current review incomplete
      H51-D83AA2CFB79FA660F2D4741Edosing.json
      /records/112/clinical_review/locally_normalized
      Historical; current review incomplete
      H51-DE8C85BFF10DAB9EDBEFAE0Edosing.json
      /records/112/clinical_review/reviewed
      Historical; current review incomplete
      H51-42D0B9530CF83151B529CA05dosing.json
      /records/112/clinical_review/status
      Historical; current review incomplete
      H51-979C315C9BEEC8B40B27858Bdosing.json
      /records/112/clinical_release_verification/audit_version
      Historical; current review incomplete
      H51-2539A5722ED3258BF26ACBC1dosing.json
      /records/112/clinical_release_verification/audited_on
      Historical; current review incomplete
      H51-98B412BE05FD88B3F3F2F676dosing.json
      /records/112/clinical_release_verification/level
      Historical; current review incomplete
      H51-07BEDC527A5FA68006400F86dosing.json
      /records/112/clinical_release_verification/release_gate
      Historical; current review incomplete
      H51-6E2F19FD9E0C2FB7563E47AFdosing.json
      /records/112/clinical_release_verification/exact_current_label_candidate
      Historical; current review incomplete
      H51-E7BC972B3E22BB80B8ACB40Adosing.json
      /records/112/clinical_release_verification/selected_setid
      Historical; current review incomplete
      H51-67BE09106B3F6028F35081B0dosing.json
      /records/112/clinical_release_verification/selected_label_title
      Historical; current review incomplete
      H51-119991537FE0011E4ECFCCD8dosing.json
      /records/112/clinical_release_verification/numeric_support_ratio
      Historical; current review incomplete
      H51-9D48EA42E8F80EDFD5364D10dosing.json
      /records/112/clinical_release_verification/reference_url_count
      Historical; current review incomplete
      H51-E7CFAED965D9C5E328F028A3dosing.json
      /records/112/clinical_release_verification/broken_reference_count
      Historical; current review incomplete
      H51-892361D819C200A6141969D2dosing.json
      /records/112/clinical_release_verification/point_of_use_confirmation_required
      Historical; current review incomplete
      H51-0AB3042D4DC3F8BB3C357A6Cdosing.json
      /records/112/clinical_release_verification/note
      Historical; current review incomplete
      H51-45A300E86B6D1533D7691259dosing.json
      /records/112/clinical_release_verification/dailymed_search_url
      Historical; current review incomplete
      H51-702616060217903BB67F9E3Afirst-look-v5.1.json
      /records/112/id
      Historical; current review incomplete
      H51-1B1B4DD4DBA720E317B6E6B9first-look-v5.1.json
      /records/112/generic_name
      Historical; current review incomplete
      H51-43CF45B2A57E518F071E42B1first-look-v5.1.json
      /records/112/class
      Historical; current review incomplete
      H51-31F541A596B329FD3C23B15Cfirst-look-v5.1.json
      /records/112/subclass
      Historical; current review incomplete
      H51-F5EA098DDC76AA4AD6D2B912first-look-v5.1.json
      /records/112/primary_uses/0
      Historical; current review incomplete
      H51-B1121BE029132655A648A071first-look-v5.1.json
      /records/112/mechanism
      Historical; current review incomplete
      H51-ADA3546B7B7C843CEA98C0CAfirst-look-v5.1.json
      /records/112/mechanism_level
      Historical; current review incomplete
      H51-26F3A1BE8EE0B865CC8E615Dfirst-look-v5.1.json
      /records/112/basic_dosing_orientation
      Historical; current review incomplete
      H51-52C2C7C11C5C5BCB82D96C82first-look-v5.1.json
      /records/112/administration_orientation
      Historical; current review incomplete
      H51-D98360E349E0E6040EDA756Ffirst-look-v5.1.json
      /records/112/renal_and_population_orientation
      Historical; current review incomplete
      H51-9D88B15808CD67B3681DCF8Cfirst-look-v5.1.json
      /records/112/key_safety_orientation/0
      Historical; current review incomplete
      H51-0F0FF9F9EE429457E5165B89first-look-v5.1.json
      /records/112/key_safety_orientation/1
      Historical; current review incomplete
      H51-2D53EE9157A4B1EBC8F721B4first-look-v5.1.json
      /records/112/coverage_path
      Historical; current review incomplete
      H51-7A8F8F4FDEA0949EDA8702C6first-look-v5.1.json
      /records/112/coverage_path_label
      Historical; current review incomplete
      H51-487837B0D3A900CF0F428F9Ffirst-look-v5.1.json
      /records/112/official_label_url
      Historical; current review incomplete
      H51-2AB1AD5095840E8A483ABF23first-look-v5.1.json
      /records/112/legacy_title
      Historical; current review incomplete
      H51-C5C8D8F41D784F9BE8DACC23first-look-v5.1.json
      /records/112/review_note
      Historical; current review incomplete
      H51-25616A00CF0F13FD502E23CEfirst-look-v5.1.json
      /records/112/search_text
      Historical; current review incomplete
      H51-69FF92B0F5EC9938CF2E4E4Bfirst-look-v5.1.json
      /records/112/official_search_url
      Historical; current review incomplete
      H51-F7DF7991334D28D6577F03D7first-look-v5.1.json
      /records/112/official_access_mode
      Historical; current review incomplete
      H51-2D71FC43C58BC7CFD5F06DA5first-look-v5.1.json
      /records/112/official_access_url
      Historical; current review incomplete
      H51-346E41CC8C509B4747F11E71first-look-v5.1.json
      /records/112/official_search_query
      Historical; current review incomplete
      H51-B3A995A2A5A7FA6083B4C2D1first-look-v5.1.json
      /records/112/official_access_reason
      Historical; current review incomplete
      H51-89A9F933E23BD55689CFFB6Cfirst-look-v5.1.json
      /records/112/label_snapshot_available
      Historical; current review incomplete
      H51-BEE4391C339E3549F2F0C119first-look-v5.1.json
      /records/112/label_snapshot_setid
      Historical; current review incomplete
      H51-22D0091131ABD80CF380DCCEpreparation-assessments-v3.8.json
      /112/id
      Historical; current review incomplete
      H51-771FF36A097C6306ED51DAF6preparation-assessments-v3.8.json
      /112/name
      Historical; current review incomplete
      H51-807BB2C7F7C2A18B6805B9D0preparation-assessments-v3.8.json
      /112/brands
      Historical; current review incomplete
      H51-3AE7F8835F5052EF1D0120DBpreparation-assessments-v3.8.json
      /112/therapeutic_class
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