:root{color-scheme:light;--iv-navy:#17233e;--iv-ink:#202b40;--iv-muted:#526179;--iv-violet:#5a57a0;--iv-line:#dce2ec;--iv-soft:#f1f3f9;--iv-blue:#ebf1fb}
*{box-sizing:border-box}
html{scroll-behavior:auto;scroll-padding-bottom:140px}
body{margin:0;background:#f3f5f9;color:var(--iv-ink);font-family:Arial,Helvetica,sans-serif;font-size:18px;line-height:1.58;padding-bottom:125px}
.iv-app{max-width:1240px;margin:0 auto;padding:0 28px;isolation:isolate;overflow-wrap:anywhere}
.iv-app h1,.iv-app h2,.iv-app h3,.iv-app p,.iv-app ul,.iv-app ol,.iv-app dl{margin-top:0}
.iv-app h1,.iv-app h2,.iv-app h3{font-family:Arial,Helvetica,sans-serif;color:var(--iv-navy);line-height:1.16}
.iv-app h2{font-size:31px;margin-bottom:18px;letter-spacing:-.5px}
.iv-app h3{font-size:23px;margin:32px 0 14px}
.iv-app p{margin-bottom:18px}
.iv-app a{color:#373d91;text-underline-offset:3px}
.iv-app a:hover{color:#1e2966}
.iv-app button,.iv-app input,.iv-app select{font:inherit}
.iv-app a:focus-visible,.iv-app button:focus-visible,.iv-app input:focus-visible,.iv-app select:focus-visible,.iv-app summary:focus-visible{outline:3px solid #d88a00;outline-offset:4px}
.iv-skip{position:absolute;left:20px;top:-70px;z-index:1000;padding:10px 20px;background:white;color:#15213d}
.iv-skip:focus{top:10px}
.iv-sr-only{position:absolute;width:1px;height:1px;clip:rect(0,0,0,0);overflow:hidden;white-space:nowrap}
.iv-brand{display:flex;justify-content:space-between;align-items:center;gap:20px;min-height:94px}
.iv-logo{display:flex;gap:12px;align-items:center;color:var(--iv-navy)!important;font-size:25px;font-weight:800;letter-spacing:-.6px;text-decoration:none}
.iv-logo-mark{display:grid;place-items:center;width:44px;height:44px;border-radius:12px;background:var(--iv-navy);color:white;font-size:30px}
.iv-logo small{display:block;color:var(--iv-muted);font-size:12px;line-height:1.2;letter-spacing:1px;font-weight:600;text-transform:uppercase}
.iv-backsite{font-size:15px;font-weight:700}
.iv-hero{display:grid;grid-template-columns:minmax(0,1fr) 250px;gap:36px;align-items:center;background:linear-gradient(120deg,#172540,#292b50 80%);padding:45px 48px;border-radius:20px;color:#f4f6ff;box-shadow:0 13px 35px #17233e14}
.iv-hero h1{font-size:58px;letter-spacing:-1.8px;line-height:1.04;color:#fff!important;margin:0 0 23px;font-weight:800}
.iv-hero .iv-kicker{color:#c6c9ef;font-size:13px;letter-spacing:2.2px;text-transform:uppercase;font-weight:700;margin-bottom:18px}
.iv-hero-intro{font-size:20px;max-width:700px;line-height:1.5;color:#e1e5f4}
.iv-hero-meta{display:flex;flex-wrap:wrap;gap:8px 18px;font-size:13px;color:#cbd1e6}
.iv-hero-art{display:flex;align-items:center;justify-content:center;flex-direction:column;color:#b7b9e8;border-left:1px solid #ffffff24;padding-left:28px}
.iv-hero-art svg{height:170px;width:160px}
.iv-hero-art span{font-weight:800;font-size:38px;line-height:1.3;color:white}
.iv-hero-art small{font-size:14px;letter-spacing:.2px}
.iv-ad{margin:20px auto;max-width:100%;text-align:center;position:relative;min-width:0;overflow:visible}
.iv-ad-label{display:block;font-size:10px;letter-spacing:1.3px;text-transform:uppercase;color:#7d8798;padding:2px 0 7px}
.iv-ad>div[data-aaad]{margin:0 auto;max-width:100%}
.iv-ad-leader{min-height:112px;width:970px}
.iv-ad-billboard{min-height:272px;width:970px}
.iv-ad-rectangle{min-height:272px;width:336px}
.iv-ad-sticky{min-height:112px;width:970px}
.iv-nav{display:flex;flex-wrap:wrap;gap:9px;border-bottom:1px solid var(--iv-line);padding:22px 0}
.iv-nav a{display:block;text-decoration:none;color:#37405d;font-size:16px;font-weight:700;padding:11px 16px;border:1px solid #d9dfeb;border-radius:9px;background:white;transition:background .16s}
.iv-nav a:hover{background:#ececf6}
.iv-nav a[aria-current="page"]{background:var(--iv-violet);border-color:var(--iv-violet);color:white}
.iv-panel{padding:34px;background:#fff;border:1px solid var(--iv-line);border-radius:15px;margin:24px 0;box-shadow:0 4px 16px #17233e05}
.iv-eyebrow{font-size:12px;letter-spacing:1.6px;text-transform:uppercase;font-weight:800;color:var(--iv-violet);margin-bottom:9px!important}
.iv-form-grid{display:grid;grid-template-columns:minmax(0,1.5fr) minmax(0,1fr);gap:20px}
.iv-form-grid-single{grid-template-columns:minmax(0,1fr);max-width:850px}
.iv-form-grid label{display:flex;flex-direction:column;gap:7px;font-size:16px;font-weight:700;min-width:0}
.iv-app input,.iv-app select{width:100%;min-width:0;padding:12px;border:1px solid #aeb8ca;border-radius:7px;background:white;color:var(--iv-ink);font-size:17px;line-height:1.4;min-height:49px}
.iv-app input::placeholder{color:#7a8495}
.iv-actions{display:flex;align-items:center;flex-wrap:wrap;gap:11px;margin:20px 0}
.iv-button{display:inline-flex;align-items:center;justify-content:center;padding:11px 18px;border:1px solid var(--iv-violet);border-radius:8px;background:var(--iv-violet);color:#fff!important;text-decoration:none;font-size:16px;font-weight:700;min-height:46px;line-height:1.4;cursor:pointer}
.iv-button:hover{background:#454387}
.iv-button-secondary{background:#f3f4fa;color:#363c77!important;border-color:#d4d9e7}
.iv-button-secondary:hover{background:#e4e7f2}
.iv-alphabet{display:flex;flex-wrap:wrap;gap:6px;margin-top:24px;padding-top:21px;border-top:1px solid var(--iv-line)}
.iv-alphabet a{display:grid;place-items:center;min-width:36px;min-height:38px;padding:3px 9px;text-decoration:none;background:#f4f5f9;border:1px solid #e1e5ee;border-radius:6px;font-size:15px;font-weight:700}
.iv-alphabet a[aria-current="true"]{background:var(--iv-navy);color:white}
.iv-results-head{display:flex;justify-content:space-between;align-items:baseline;gap:16px}
.iv-results-head p{font-size:15px;color:var(--iv-muted)}
.iv-drug-list{list-style:none;padding:0;margin:12px 0!important;display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:10px}
.iv-drug-card{display:flex;flex-direction:column;position:relative;padding:19px 42px 19px 19px;background:#fbfcfe;border:1px solid #e0e5ee;border-radius:9px;text-decoration:none;min-height:122px;height:100%;transition:border-color .15s,background .15s}
.iv-drug-card:hover{border-color:#8d91bb;background:#f4f4fb}
.iv-drug-card-name{font-weight:800;font-size:19px;color:var(--iv-navy);line-height:1.32}
.iv-drug-card-class{font-size:14px;color:var(--iv-muted);line-height:1.4;margin-top:6px}
.iv-drug-card-status{font-size:13px;color:#615d81;margin-top:9px}
.iv-card-arrow{position:absolute;right:17px;top:18px;color:#76799e;font-size:23px}
.iv-pagination{display:flex;align-items:center;justify-content:center;flex-wrap:wrap;gap:18px;margin:26px 0 20px}
.iv-pagination span{font-size:15px;color:var(--iv-muted)}
.iv-toplink{display:inline-block;margin-top:15px;font-size:15px}
.iv-notice{padding:22px 25px;background:#f4f3fb;border:1px solid #d9d7e9;border-left:5px solid #7672ad;border-radius:9px;margin:22px 0;font-size:17px}
.iv-notice p:last-child{margin-bottom:0}
.iv-notice strong{color:var(--iv-navy)}
.iv-notice p{margin:8px 0 10px}
.iv-drug-title{font-size:39px!important;margin-bottom:15px!important}
.iv-badge{display:inline-block;font-size:13px;font-weight:700;color:#4c487c;background:#eeedf7;border:1px solid #d8d6e9;border-radius:30px;padding:5px 12px;margin-bottom:4px}
.iv-muted{font-size:16px;color:var(--iv-muted);line-height:1.55}
.iv-link-note{max-width:900px}
.iv-safety-box{padding:23px 25px;border:1px solid #e7c896;border-left:5px solid #b78135;border-radius:8px;background:#fff9ef;margin:25px 0}
.iv-safety-box h3{margin-top:0}
.iv-safety-box ul{padding-left:23px}
.iv-safety-box p:last-child{margin-bottom:0}
.iv-claim{border:1px solid var(--iv-line);border-radius:11px;padding:24px;margin:16px 0;background:#fbfcff;break-inside:avoid}
.iv-claim-text{font-size:19px;font-weight:700;line-height:1.55}
.iv-claim-id{font-size:14px;color:#617084;margin-bottom:12px!important}
.iv-claim code{font-family:Consolas,monospace;font-size:14px;overflow-wrap:anywhere}
.iv-source-details,.iv-product-details{border:1px solid var(--iv-line);border-radius:8px;background:white;margin:16px 0;padding:0 18px}
.iv-source-details summary,.iv-product-details summary{padding:15px 0;font-weight:700;font-size:16px;cursor:pointer;color:#363d74}
.iv-source-list{list-style:none;padding:0 0 12px;margin:0!important;font-size:16px;line-height:1.65}
.iv-source-list li{padding:15px 0;border-top:1px solid var(--iv-line)}
.iv-source-list p{font-size:16px;margin:9px 0;line-height:1.65}
.iv-source-list .iv-source-number{font-size:14px;font-weight:700;color:#5a568b;margin:0 0 7px}
.iv-source-list .iv-source-title{font-weight:700;margin-top:0}
.iv-source-basis{margin:0 0 14px!important}
.iv-product-details>ul{font-size:16px;padding:0 15px 16px 23px}
.iv-product-details>p{font-size:16px}
.iv-data-list{display:grid;grid-template-columns:220px minmax(0,1fr);font-size:16px;margin:0 0 18px}
.iv-data-list dt,.iv-data-list dd{border-top:1px solid var(--iv-line);padding:12px 8px;margin:0}
.iv-data-list dt{font-weight:700;color:#3a4960}
.iv-data-list dd{overflow-wrap:anywhere}
.iv-legacy{margin-top:30px;padding-top:5px;border-top:1px solid var(--iv-line)}
.iv-empty{padding:20px;border:1px dashed #b8c2d2;border-radius:10px;background:#fafbfe;margin:26px 0}
.iv-empty h3{margin-top:0}
.iv-empty p:last-child{margin-bottom:0}
.iv-stats{display:grid;grid-template-columns:repeat(4,minmax(0,1fr));gap:12px;margin:25px 0}
.iv-stats>div{display:flex;flex-direction:column;padding:20px;background:#f4f5fa;border:1px solid #e0e4ec;border-radius:10px}
.iv-stats strong{font-size:33px;color:var(--iv-navy);line-height:1.3}
.iv-stats span{font-size:14px;color:var(--iv-muted);margin-top:8px}
.iv-table-wrap{position:relative;overflow-x:auto;max-width:100%;margin-bottom:24px}
.iv-app table{width:100%;border-collapse:collapse;font-size:16px}
.iv-app th,.iv-app td{text-align:left;vertical-align:top;padding:14px 12px;border-bottom:1px solid var(--iv-line);line-height:1.5}
.iv-app thead th{background:#eef0f7;color:var(--iv-navy);font-weight:700}
.iv-app tbody th{width:28%;font-weight:700}
.iv-app tbody td:nth-child(2){width:16%}
.iv-app tbody tr:nth-child(even){background:#fbfcfe}
.iv-footer{display:grid;grid-template-columns:minmax(0,1.8fr) minmax(0,1fr);gap:35px;border-top:1px solid #d1d8e4;padding:30px 0;color:var(--iv-muted);font-size:15px}
.iv-footer strong{color:var(--iv-navy)}
.iv-footer p{margin-top:9px;line-height:1.55}
.iv-footer-links{display:flex;flex-direction:column;gap:6px}
.iv-footer-links a{font-size:15px}
.iv-counter small{font-size:12px;display:block;margin-top:5px}
@media(max-width:800px){.iv-app{padding:0 19px}.iv-hero{grid-template-columns:minmax(0,1fr) 160px;gap:20px;padding:34px 30px}.iv-hero h1{font-size:46px}.iv-hero-art{padding-left:18px}.iv-hero-art svg{width:120px;height:140px}.iv-hero-art span{font-size:32px}.iv-panel{padding:26px}.iv-nav{gap:7px}.iv-nav a{font-size:15px;padding:10px 12px}.iv-stats{grid-template-columns:repeat(2,minmax(0,1fr))}.iv-data-list{grid-template-columns:170px minmax(0,1fr)}.iv-drug-list{grid-template-columns:1fr}.iv-ad-billboard{min-height:122px}.iv-footer{gap:25px}}
@media(max-width:550px){body{font-size:17px;padding-bottom:110px}.iv-app{padding:0 13px}.iv-brand{min-height:84px;gap:10px}.iv-logo{font-size:23px;gap:9px}.iv-logo-mark{height:38px;width:38px;border-radius:10px;font-size:26px}.iv-logo small{font-size:10px;letter-spacing:.6px}.iv-backsite{font-size:12px;max-width:102px;text-align:right}.iv-hero{display:block;padding:29px 24px;border-radius:14px}.iv-hero h1{font-size:42px;letter-spacing:-1.1px;line-height:1.06}.iv-hero .iv-kicker{font-size:11px;letter-spacing:1.4px}.iv-hero-intro{font-size:18px}.iv-hero-meta{font-size:12px;gap:7px 12px}.iv-hero-art{display:none}.iv-ad-leader{min-height:92px}.iv-ad-billboard{min-height:122px}.iv-ad-rectangle{min-height:272px}.iv-ad-sticky{min-height:112px}.iv-nav{padding:17px 0}.iv-nav a{font-size:14px;padding:10px 11px;flex-grow:1;text-align:center}.iv-panel{padding:23px 18px;border-radius:12px;margin:20px 0}.iv-app h2{font-size:27px}.iv-app h3{font-size:22px}.iv-form-grid{grid-template-columns:1fr;gap:17px}.iv-app input,.iv-app select{font-size:17px}.iv-button{font-size:16px;padding:10px 14px}.iv-actions{gap:9px}.iv-alphabet{gap:5px}.iv-alphabet a{min-width:36px;min-height:38px}.iv-results-head{display:block}.iv-results-head p{margin-top:-7px}.iv-drug-card{padding:16px 34px 16px 14px;min-height:115px}.iv-drug-card-name{font-size:18px}.iv-drug-card-class{font-size:14px}.iv-drug-card-status{font-size:13px}.iv-notice{padding:18px 17px;font-size:16.5px}.iv-drug-title{font-size:32px!important}.iv-claim{padding:20px 13px;margin:18px -3px}.iv-claim-text{font-size:19px;line-height:1.6}.iv-claim-id{font-size:14px}.iv-muted,.iv-source-list p,.iv-source-list,.iv-product-details>ul,.iv-product-details>p{font-size:16px}.iv-data-list{display:block;font-size:16px}.iv-data-list dt{padding:10px 2px 2px}.iv-data-list dd{padding:0 2px 12px;border-top:0}.iv-safety-box{padding:19px 16px}.iv-stats{gap:9px}.iv-stats>div{padding:15px 12px}.iv-stats strong{font-size:30px}.iv-stats span{font-size:13px}.iv-app table{font-size:16px;min-width:620px}.iv-footer{grid-template-columns:1fr;gap:16px;font-size:15.5px}.iv-footer-links a{font-size:15.5px}.iv-counter small{font-size:12px}.iv-source-details,.iv-product-details{padding:0 12px}.iv-source-list{padding-left:0}.iv-source-list li{padding:16px 0}.iv-source-details summary{line-height:1.5}.iv-source-details,.iv-product-details{overflow-wrap:anywhere}}
@media(prefers-reduced-motion:reduce){html{scroll-behavior:auto}*{transition:none!important}}
@media print{body{padding:0;background:#fff;font-size:12pt}.iv-app{padding:0;max-width:none}.iv-no-print,.iv-brand,.iv-hero-art,.iv-nav,.iv-ad,.iv-counter,.iv-footer-links{display:none!important}.iv-hero{background:white;color:#111;box-shadow:none;border:0;padding:0 0 14px;display:block}.iv-hero h1{color:#111!important;font-size:24pt}.iv-hero p{color:#333!important}.iv-kicker,.iv-hero-intro{display:none}.iv-hero-meta{color:#444}.iv-panel{border:0;box-shadow:none;padding:0}.iv-app h2{font-size:21pt}.iv-app h3{font-size:15pt;break-after:avoid}.iv-claim{background:white;break-inside:avoid;padding:10px}.iv-claim-text{font-size:12pt}.iv-source-details,.iv-product-details{display:block}.iv-source-details>*:not(summary),.iv-product-details>*:not(summary){display:block!important}.iv-data-list{display:block}.iv-data-list dt{font-weight:700;border:0;padding-bottom:0}.iv-data-list dd{border:0;padding-top:0}.iv-app a{color:#111}.iv-footer{display:block;font-size:10pt}.iv-app table{min-width:0;font-size:10pt}.iv-stats{grid-template-columns:repeat(4,1fr)}}

.iv-meta-provenance{font-size:16px;color:#5a6580;margin-top:8px}.iv-meta-provenance p{font-size:16px;margin:6px 0}.iv-meta-provenance code{font-size:14px}
.iv-ad iframe{max-width:100%!important}

/* Expose closed disclosures in print even when JavaScript is disabled. */
@media print {
  .iv-source-details::details-content,
  .iv-product-details::details-content,
  .iv-historical-id::details-content {
    display: block !important;
    content-visibility: visible !important;
    visibility: visible !important;
    block-size: auto !important;
    max-block-size: none !important;
  }
}

/* Restored reference workflows. */
.iv-app h4{font-size:20px;line-height:1.35;margin:25px 0 12px;color:var(--iv-navy)}
.iv-app h5{font-size:17px;line-height:1.4;margin:20px 0 10px;color:var(--iv-navy)}
.iv-section-nav{display:flex;flex-wrap:wrap;align-items:center;gap:9px 16px;padding:18px 0;margin:22px 0;border-top:1px solid var(--iv-line);border-bottom:1px solid var(--iv-line);font-size:16px}
.iv-history-provenance{background:#fff8ea;border:1px solid #decda9;border-left:5px solid #a97726;border-radius:9px;padding:22px 24px;margin:24px 0;font-size:17px;line-height:1.6}
.iv-history-provenance h3{margin-top:0}
.iv-history-provenance p:last-child{margin-bottom:0}
.iv-history-caption{font-size:16px;color:#775b2d;line-height:1.55;margin:0 0 20px}
.iv-historical-article{border-top:2px solid #d5dbea;margin:35px 0;padding:26px 0;min-width:0;max-width:100%}
.iv-history-heading h3{font-size:28px;margin-top:0}
.iv-history-body{font-size:18px;line-height:1.65;max-width:100%;min-width:0;overflow-wrap:anywhere}
.iv-history-body h1{font-size:30px}.iv-history-body h2{font-size:27px}.iv-history-body h3{font-size:24px}.iv-history-body h4{font-size:21px}
.iv-history-body p,.iv-history-body li,.iv-history-body td,.iv-history-body th,.iv-history-body font,.iv-history-body small{font-size:inherit;line-height:inherit}
.iv-history-body img{display:block;max-width:100%;height:auto;margin:20px auto}
.iv-history-body table{display:block;max-width:100%;overflow-x:auto;margin:20px 0;border-collapse:collapse}
.iv-history-body td,.iv-history-body th{min-width:130px;overflow-wrap:anywhere}
.iv-history-body .history-layout-table{display:block;width:100%;max-width:100%;min-width:0;margin:20px 0;overflow:visible;border:0}
.iv-history-body .history-layout-table>thead,.iv-history-body .history-layout-table>tbody,.iv-history-body .history-layout-table>tfoot,.iv-history-body .history-layout-table>tr,.iv-history-body .history-layout-table>thead>tr,.iv-history-body .history-layout-table>tbody>tr,.iv-history-body .history-layout-table>tfoot>tr{display:block;width:100%;max-width:100%;min-width:0}
.iv-history-body .history-layout-table>tr>td,.iv-history-body .history-layout-table>tr>th,.iv-history-body .history-layout-table>thead>tr>td,.iv-history-body .history-layout-table>thead>tr>th,.iv-history-body .history-layout-table>tbody>tr>td,.iv-history-body .history-layout-table>tbody>tr>th,.iv-history-body .history-layout-table>tfoot>tr>td,.iv-history-body .history-layout-table>tfoot>tr>th{display:block;width:100%;max-width:100%;min-width:0;padding:0;border:0}
.iv-history-body .history-table-scroll{display:block;width:100%;max-width:100%;min-width:0;margin:20px 0;overflow-x:auto;overscroll-behavior-x:contain;contain:inline-size}
.iv-history-body .history-table-scroll:focus-visible{outline:3px solid #d88a00;outline-offset:4px}
.iv-history-body .history-data-table{display:table;table-layout:auto;width:100%;max-width:none;min-width:620px;margin:0;overflow:visible}
.iv-print-source-url{display:none}
.iv-history-body pre{white-space:pre-wrap;max-width:100%;overflow-wrap:anywhere}
.iv-history-body iframe,.iv-history-body object,.iv-history-body embed{display:none!important}
.iv-history-body .history-safety-warning{font-size:17px}
.iv-historical-section{margin:34px 0;padding:26px 0;border-top:1px solid var(--iv-line);min-width:0;max-width:100%}
.iv-historical-section>h3{margin-top:0}
.iv-historical-section.iv-product-details{padding:0 18px}
.iv-historical-group{min-width:0;max-width:100%}
.iv-historical-list{padding-left:24px;margin:14px 0}
.iv-historical-list>li{padding:6px 0;min-width:0}
.iv-archive-fields{display:block;margin:0;font-size:17px;line-height:1.6}
.iv-archive-fields>div{display:grid;grid-template-columns:minmax(140px,210px) minmax(0,1fr);gap:14px;border-top:1px solid #e5e8ef;padding:13px 0;min-width:0}
.iv-archive-fields dt{font-weight:700;color:#34435b;min-width:0}
.iv-archive-fields dd{margin:0;min-width:0}
.iv-archive-fields .iv-archive-fields>div{grid-template-columns:1fr;gap:6px}
.iv-historical-value{overflow-wrap:anywhere}
.iv-historical-id{display:block;min-width:0;max-width:100%;font-size:15.5px;line-height:1.45;color:#526179;font-weight:400;margin:7px 0 3px}
.iv-historical-id>summary{font-size:15.5px;line-height:1.45;font-weight:400;padding:4px 0;color:#373d91;cursor:pointer}
.iv-historical-id>code{display:block;font-family:Consolas,monospace;font-size:15.5px;line-height:1.45;max-width:100%;white-space:normal;overflow-wrap:anywhere;margin:3px 0 6px}
.iv-archive-table{font-size:17px!important;line-height:1.6}
.iv-archive-table th,.iv-archive-table td{min-width:165px;max-width:390px;padding:15px 12px}
.iv-table-wrap[tabindex]:focus-visible{outline:3px solid #d88a00;outline-offset:4px}
.iv-safety-alert{background:#fff3ef;border-color:#e1b4a2;border-left-color:#a74728}
.iv-safety-alert h3{color:#6f2e21;margin-top:0;font-size:24px}
.iv-safety-alert .iv-eyebrow{color:#94482d}
.iv-alert-sources{padding-left:23px;margin-bottom:15px}
.iv-alert-sources li{padding:8px 0}
.iv-alert-sources p{font-size:16px;margin:8px 0}
.iv-filter-details{border:1px solid var(--iv-line);border-radius:9px;padding:0 18px;margin:22px 0;background:#fbfcff}
.iv-filter-details summary{padding:15px 0;font-size:16px;font-weight:700;cursor:pointer}
.iv-filter-grid,.iv-calculator-grid{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:20px}
.iv-filter-grid label,.iv-calculator-grid label,.iv-search-label{display:flex;flex-direction:column;gap:8px;font-size:16px;font-weight:700;min-width:0}
.iv-calculator-grid label small{font-size:14px;font-weight:400;line-height:1.5;color:var(--iv-muted)}
.iv-check-row{display:flex;flex-wrap:wrap;gap:16px 25px;padding:21px 0;font-size:16px}
.iv-check-row label{display:flex;gap:9px;align-items:flex-start;min-width:0}
.iv-app .iv-check-row input{width:18px;min-height:18px;flex:0 0 18px;margin:4px 0 0;padding:0}
.iv-class-grid{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:12px}
.iv-class-grid a{display:flex;flex-direction:column;gap:7px;background:#f6f7fc;border:1px solid var(--iv-line);border-radius:9px;padding:17px;text-decoration:none;font-size:17px}
.iv-class-grid span{color:var(--iv-muted);font-size:14px}
.iv-drug-card-history{font-size:13px;color:#6d654f;line-height:1.5;margin-top:7px}
.iv-calculation-result{padding:23px;border:1px solid #cdd7e6;border-radius:9px;background:#f2f6fc;margin-top:24px}
.iv-calculation-result h3{margin-top:0}
.iv-calculation-result output{font-size:22px;font-weight:700;color:#263359}
.iv-calculation-result[data-state="error"]{background:#fff5f2;border-color:#e2bbb0}
.iv-calculation-errors:empty{display:none}
.iv-calculation-errors{padding:20px;border:1px solid #dfb3a6;border-left:5px solid #ad4e30;background:#fff3ee;border-radius:8px;margin:22px 0}
.iv-calculation-errors ul{margin-bottom:0;padding-left:24px}
.iv-app input[aria-invalid="true"]{border:2px solid #ad4e30;background:#fffaf7}
.iv-bud-controlling{padding:18px;background:white;border-radius:7px}
.iv-archive-source-details h4{margin-top:22px}
@media(max-width:850px){.iv-filter-grid,.iv-calculator-grid{grid-template-columns:repeat(2,minmax(0,1fr))}.iv-class-grid{grid-template-columns:repeat(2,minmax(0,1fr))}.iv-archive-fields>div{grid-template-columns:170px minmax(0,1fr)}}
@media(max-width:550px){.iv-hero h1{font-size:37px}.iv-hero{padding:27px 21px}.iv-nav a{font-size:13px;flex:1 1 42%}.iv-section-nav{font-size:15px;gap:10px 13px}.iv-filter-grid,.iv-calculator-grid,.iv-class-grid{grid-template-columns:1fr}.iv-filter-details{padding:0 12px}.iv-check-row{display:grid;gap:15px}.iv-history-provenance{padding:18px 14px;font-size:17px}.iv-history-heading h3{font-size:25px}.iv-history-body{font-size:18px}.iv-history-body h1{font-size:28px}.iv-history-body h2{font-size:25px}.iv-history-body h3{font-size:23px}.iv-archive-fields>div{display:block;padding:12px 0}.iv-archive-fields dd{margin-top:7px}.iv-historical-list{padding-left:18px}.iv-archive-fields{font-size:17px}.iv-historical-section{margin:27px 0;padding:22px 0}.iv-historical-section.iv-product-details{padding:0 12px}.iv-archive-table th,.iv-archive-table td{min-width:160px}.iv-calculation-result{padding:18px 14px}.iv-safety-alert h3{font-size:23px}.iv-calculator-grid label{font-size:16px}}
@media print{
 .iv-section-nav,.iv-filter-details,.iv-search-form{display:none!important}
 .iv-history-provenance,.iv-safety-alert{background:#fff;border:1px solid #777;padding:12px}
 .iv-history-caption{color:#444}
 .iv-history-body{font-size:12pt}
 .iv-history-body table{display:table;width:100%;table-layout:fixed;min-width:0!important;overflow:visible}
 .iv-history-body .history-table-scroll{width:100%;max-width:none;overflow:visible;contain:none}
 .iv-history-body .history-data-table{width:100%;max-width:100%;min-width:0!important;table-layout:fixed}
 .iv-history-body .history-layout-table{display:block;min-width:0!important}
 .iv-print-source-url{display:block;font-size:10pt;line-height:1.4;overflow-wrap:anywhere;margin-top:5px}
 .iv-history-body td,.iv-history-body th{min-width:0;padding:6px;font-size:10pt;overflow-wrap:anywhere}
 .iv-history-body img{max-height:230mm;object-fit:contain}
 .iv-historical-section{break-inside:auto;margin:20px 0}
 .iv-archive-fields>div{display:block}
 .iv-archive-fields dt{font-weight:700}
 .iv-table-wrap{overflow:visible}
 .iv-archive-table,.iv-archive-table tbody,.iv-archive-table tr,.iv-archive-table td{display:block;min-width:0!important;max-width:none;width:auto}
 .iv-archive-table thead{display:none}
 .iv-archive-table tr{border:1px solid #aaa;padding:10px;margin:15px 0}
 .iv-archive-table td{padding:7px 0;border:0}
 .iv-archive-table td::before{content:attr(data-label);display:block;font-weight:700;font-size:11pt}
 .iv-historical-id,.iv-historical-id>summary,.iv-historical-id>code{font-size:9pt;white-space:normal;overflow:visible;max-width:none;text-overflow:clip}
 .iv-historical-id>*:not(summary){display:block!important}
 .iv-history-body details::details-content{display:block!important;content-visibility:visible!important;visibility:visible!important;block-size:auto!important;max-block-size:none!important}
}

/* Keep the monograph primary and supporting provenance compact. */
#iv-monograph,.iv-monograph [id]{scroll-margin-top:18px}
.iv-record-actions{margin:0 0 14px;gap:10px 20px;font-size:16px;line-height:1.5}
.iv-record-actions .iv-button{padding:7px 12px;font-size:16px;min-height:36px}
.iv-record-header .iv-eyebrow{margin:8px 0 5px;font-size:15.5px}
.iv-record-header .iv-drug-title{margin:0 0 10px}
.iv-record-status{display:flex;flex-wrap:wrap;align-items:center;gap:7px 12px;font-size:16.5px;line-height:1.5;margin-bottom:12px!important}
.iv-record-status .iv-badge{font-size:15.5px}
.iv-record-navigation{margin:8px 0 12px;border-top:1px solid var(--iv-line);border-bottom:1px solid var(--iv-line)}
.iv-record-navigation>summary{font-size:16.5px;font-weight:700;line-height:1.5;padding:9px 0;cursor:pointer;color:#373d91}
.iv-record-navigation .iv-section-nav{margin:0;padding:5px 0 12px;border:0;font-size:16px;gap:10px 18px}
.iv-record-resource-links{position:relative;display:flex;flex-wrap:wrap;gap:8px 20px;font-size:16px;line-height:1.5;margin:9px 0 12px}
.iv-record-resource-links:empty{display:none}
.iv-renal-resource{position:relative;min-width:0;max-width:100%;overflow-wrap:anywhere;line-height:1.5}
.iv-renal-master{background:#eef3fa;border:1px solid #c9d5e7;border-left:4px solid #576ba2;border-radius:7px;padding:12px 16px;margin:12px 0 18px;font-size:17px}
.iv-renal-master p{margin:0 0 5px!important}
.iv-renal-master p:last-child{margin-bottom:0!important;font-size:16px}
.iv-renal-master strong{margin-right:12px}
.iv-renal-context{display:block;background:#f2f5fa;border-left:3px solid #afbed6;border-radius:3px;padding:8px 11px;margin:10px 0;font-size:16px!important;font-weight:400}
.iv-history-body .iv-renal-context{font-size:16px!important;line-height:1.5}
.iv-primary-history>.iv-historical-article:first-child{margin-top:0;padding-top:0;border-top:0}
.iv-monograph>.iv-historical-article{margin-top:10px;padding-top:0;border-top:0}
.iv-history-provenance-compact{padding:12px 16px;margin:12px 0 18px;border-left-width:3px;border-radius:7px;font-size:17px;line-height:1.5}
.iv-history-provenance-compact .iv-history-caution{font-size:17px;line-height:1.5;margin:0 0 6px}
.iv-history-provenance-compact .iv-history-source-line{font-size:15.5px;line-height:1.5;margin:0}
.iv-history-provenance-details{background:transparent;border:0;border-top:1px solid #deceb0;border-radius:0;padding:0;margin:8px 0 0}
.iv-history-provenance-details>summary{padding:8px 0 2px;font-size:15.5px;font-weight:400;line-height:1.5}
.iv-history-provenance-details[open]>summary{padding-bottom:12px}
.iv-history-provenance-details .iv-data-list{margin-bottom:4px;font-size:16px}
.iv-history-scope{background:#fff4e9;border-left:4px solid #ae7b2e;border-radius:5px;padding:12px 16px;margin:12px 0;font-size:17px}
.iv-history-scope ul{margin:6px 0 0;padding-left:22px}
.iv-safety-alert{padding:18px 20px;margin:16px 0}
.iv-safety-alert .iv-eyebrow{margin-bottom:6px;font-size:15.5px}
.iv-safety-alert h3{margin:0 0 10px}
.iv-safety-alert>p:last-of-type{margin-bottom:12px}
.iv-safety-sources{background:transparent;border:0;border-top:1px solid #e1b4a2;border-radius:0;margin:10px 0 0;padding:0}
.iv-safety-sources>summary{padding:8px 0 0;font-size:15.5px;line-height:1.5}
.iv-safety-sources[open]>summary{padding-bottom:10px}
.iv-index-correction{padding:12px 16px;margin:14px 0}
.iv-index-correction>p{margin-bottom:8px}
.iv-index-correction>.iv-source-details{background:transparent;margin:0;border:0;padding:0}
.iv-index-correction>.iv-source-details>summary{padding:6px 0;font-size:15.5px}
.iv-availability-note{font-size:16.5px;line-height:1.55;color:#526179;margin:16px 0!important}
.iv-section-alias{scroll-margin-top:18px}
.iv-restoration-provenance,.iv-review-details,.iv-safety-resources{margin:18px 0}
.iv-original-link{font-size:16px;margin:22px 0!important}
@media(max-width:550px){
 .iv-record-actions{gap:9px 16px;font-size:16px;margin-bottom:12px}
 .iv-record-actions .iv-button{padding:7px 10px;font-size:16px}
 .iv-record-status{display:block;font-size:16.5px}
 .iv-record-status>.iv-badge{display:table;margin-bottom:6px}
 .iv-record-resource-links{font-size:16px;gap:8px 15px}
 .iv-renal-master{padding:11px 13px;font-size:16.5px;margin:10px 0 14px}
 .iv-renal-master strong{display:block;margin:0 0 4px}
 .iv-renal-master p:last-child{font-size:16px}
 .iv-history-provenance-compact{padding:11px 13px;margin:10px 0 15px;font-size:16.5px}
 .iv-history-provenance-compact .iv-history-caution{font-size:16.5px}
 .iv-history-provenance-compact .iv-history-source-line,.iv-history-provenance-details>summary{font-size:15.5px}
 .iv-history-scope,.iv-safety-alert{padding:14px;font-size:16.5px}
 .iv-historical-section{padding-top:18px;margin-top:22px}
}
@media print{
 #iv-monograph,.iv-monograph [id]{scroll-margin-top:0}
 .iv-record-status,.iv-record-status .iv-badge{font-size:10pt}
 .iv-history-provenance-compact,.iv-history-scope,.iv-renal-master{background:#fff;padding:8pt;border:1px solid #888;font-size:10pt}
 .iv-history-provenance-compact .iv-history-caution,.iv-history-provenance-compact .iv-history-source-line,.iv-history-provenance-details>summary{font-size:10pt}
 .iv-renal-master p:last-child,.iv-renal-context,.iv-history-body .iv-renal-context{font-size:9pt!important}
 .iv-renal-resource a::after{content:" (" attr(href) ")";font-size:9pt;overflow-wrap:anywhere}
 .iv-history-provenance-details,.iv-safety-sources{padding:0;margin-top:6pt}
 .iv-safety-alert{padding:8pt}
 .iv-safety-alert .iv-eyebrow,.iv-safety-sources>summary{font-size:10pt}
 .iv-availability-note,.iv-original-link{font-size:10pt}
}