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WARFARIN DOSE PREDICTION EQUATION

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Patient Parameters
Age:      Specify race:  
Height
:     Weight:
Target INR
Target INR
Concomitant conditions
Patient receiving amiodarone:  
Smoker     
DVT or PE present?
:

Equations  Used:

BSA

1]  (Weight) kg0.425 x   (Height) cm0.725 x  0.007184 = BSA in M2
    
Reference
: DuBois D, DuBois DF. A formula to estimate the approximate surface area if height and weight be known. Arch Int Med 1916;17:863-71.




Warfarin Dose Prediction

2]   exp [0.613 + (0.425 x BSA) - (0.0075 x age)  + (0.156 x African-American race)
            + (0.216  x target INR) - (0.257 x amiodarone) + (0.108  x smokes) 
                + 0.0784  x  DVT/PE ]

Reference:  Gage BF, Eby C, Johnson JA, Deych E, Rieder MJ, et al. Use of pharmacogenetic and clinical factors to predict the therapeutic dose of warfarin. Clin Pharmacol Ther. 2008 Sep;84(3):326-31. Epub 2008 Feb 27.


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Disclaimer

All calculations must be confirmed before use. The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.   Read the disclaimer
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