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Valacyclovir - Valtrex ® - Renal Dosing

Usual Dosing (Adults)

Herpes zoster (shingles): 1000mg po tid x 7 days. 
Primary genital herpes: 1000mg po bid x 10 days. 
Recurrent genital: 500mg po bid x 5 days. 
Genital-chronic suppression: 500mg po qd. 
Herpes labialis (cold sores) 2 gm q12h x 1 day.

Renal Dosing

dialysis [CRCL >50]: No changes

[30-49]: Zoster: 1 gram q12h. H. Labialis: 1 gram q12h x 2 doses. Initial episode Genital herpes: 1 gram q12h. Recurrent: 500mg q12h. Suppressive: 0.5 – 1 gm qd.

[10-29]: Zoster: 1 gram q24h.   H. Labialis: 500mg q12h x 2 doses.  Initial episode Genital herpes: 1 gram q24h. Recurrent: 500mg q24h.  Suppressive: 500mg q24-48h.

[<10]: Zoster: 500mg q24h.  H. Labialis: 500mg x 1. Initial episode Genital herpes: 500mg q24h. Recurrent: 500mg q24h. Suppressive: 500mg q24-48h.

Hemodialysis

dialysis Hemo:
500 mg PO q24h (on dialysis days give dose after dialysis)

Reference(s)

National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
Provides access to the latest drug monographs submitted to the Food and Drug Administration (FDA). Please review the latest applicable package insert for additional information and possible updates.  A local search option of this data can be found here.

Disclaimer

The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.   Read the disclaimer
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