Pentosan polysulfate sodium is a low molecular weight heparin-like
compound. It has anticoagulant and fibrinolytic effects. The mechanism
of action of pentosan polysulfate sodium in interstitial cystitis is not
INDICATIONS AND USAGE
ELMIRON® (pentosan polysulfate sodium) is indicated for the relief of
bladder pain or discomfort associated with interstitial cystitis.
ELMIRON® is contraindicated in patients with known hypersensitivity to
the drug, structurally related compounds, or excipients.
Adults: Oral: 100 mg 3
times/day taken with water 1 hour before or 2 hours after meals
Patients should be evaluated at 3 months and may be continued an
additional 3 months if there has been no improvement and if there are no
therapy-limiting side effects. The risks and benefits of continued use
beyond 6 months in patients who have not responded is not yet known .
Should be administered with water 1 hour before or 2 hours after meals.
Drug Category: Cholinergic Agonist.
Indication: Nonobstructive urinary retention and retention due
to neurogenic bladder.
Urinary retention, neurogenic bladder, and/or bladder atony:
Oral: Initial: 10-50 mg 2-4 times/day (some patients may
require dosages of 50-100 mg 4 times/day). To determine effective
dose, may initiate at a dose of 5-10 mg, with additional doses of 5-10
mg hourly until an effective cumulative dose is reached.
Cholinergic effects at higher oral dosages may be cumulative.
SubQ: Initial: 2.575 mg, may repeat in 15-30 minutes
(maximum cumulative initial dose: 10.3 mg); subsequent doses may be
given 3-4 times daily as needed (some patients may require more frequent
dosing at 2.5- to 3-hour intervals).
Chronic neurogenic atony may require doses of 7.5-10 mg every 4 hours.
Alum irrigation -BLADDER HEMORRHAGE
An astringent that induces hemostasis by precipitating protein over the
bleeding surface. Since it has low cell permeability, its action is
limited to the cell surface and interstitial spaces.
Proven efficacy - response rate
between 66% and 100% has been reported
Low incidence of side effects
Easy to administer
concentration: 1 percent alum bladder irrigation (base solution usually
saline or sterile water). Reserved for moderate to severe hematuria/bladder hemorrhage.
Average instillation rate: 250-300 ml/hour (2.5 - 3 grams/hour). In mild cases, saline
continuous bladder irrigation or suprahydration may be used.
National Institutes of Health, U.S. National Library of Medicine,
DailyMed Database. Provides access to the latest drug monographs submitted to the
Food and Drug Administration (FDA). Please review the latest applicable package insert for
additional information and possible updates. A local search
option of this data can be found here.
Listed dosages are for - Adult patients ONLY. PLEASE READ THE
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