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TB

Tuberculosis - therapeutic agents

NEW MONOGRAPHS
Ethambutol Dosing: 15-25 mg/kg up to 2500 mg orally once daily.
Isoniazid Adults: 5mg/kg/day PO (maximum 300mg);or  15mg/kg (maximum 900mg) 2-3 times weekly.
Pyrazinamide Adults: 15 to 30 mg/kg/day (maximum of 2 grams daily). Alternative regimen:  50 to 70 mg/kg two or three times weekly (maximum 3 grams/dose).
rifabutin (Mycobutin):  300 mg orally once daily or 150 mg orally twice a day given with a meal.
Rifamate (INH 150mg + rifampin 300mg): Take 2 capsules orally once daily 1 hour before or 2 hours after a meal.  (2 capsules = 600 mg rifampin, 300 mg isoniazid)
Rifampin TB: 10-20 mg/kg up to 600 mg oral or IV once daily. 
Synergy gram (+): (900-1200 mg/day in 3 divided doses): Usual dose: 300 mg orally every 8 hours. Some recommend 600 mg orally once daily.
rifapentine (Priftin):  Cyclopentyl derivative of rifampin (longer duration of action and greater efficacy compared to rifampin). Dosing:  600 mg orally twice weekly x 2 months, then once weekly x 4 months. (Twice weekly if HIV).
Rifater ( INH50mg+rif 120mg +pyr300mg): Dosing: 6 tabs orally once daily (if > 55kg). 5 tabs orally once daily if < 55 kg.  (Take 1 hour before or 2 hours after a meal with a full glass of water.)

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References - Infectious Disease Section
Infectious Disease References

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