Vancomycin - Predicted Trough Value - Level drawn early

This program can be used to determine if the current regimen is appropriate based on an early (supratherapeutic) vancomycin level which is used along with an estimated elimination rate constant to determine the level just before the next dose.

(Note: if a random supratherapeutic vancomcyin level is drawn and you need to determine when to give the next dose based on a desired target trough level - use the following program.   Overview: An estimated elimination rate constant is generated from the creatinine clearance which is then used to determine the timing of the next dose based on the target trough concentration.)
Estimated creatinine clearance (mL/min)
Current trough (early supratherapeutic value):   mg/ml
Number of hours trough was drawn PRIOR to next dose  hrs.
(Note: may use decimals e.g. 3.5 hrs.  This time will be used to calculate the estimated trough value just before the next dose is due.)


Determination of Vancomycin Ke:
Matzke GR, McGroy RW, Halstenson CE et al. Pharmacokinetics of vancomycin in patients with various degrees of renal function. Antimicrob Agents Chemother. 1984; 25:433-437.
Matzke (Ke) = 0.00083(CLcr) + 0.0044


All calculations must be confirmed before use. The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgement. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.   Read the disclaimer
more Career Center image description
Medical Calculators - A thru Z
Lab Values - A thru Z