Tetracycline's - Medication List

Doxycycline (Vibramycin ®) Minocycline (Minocin ®)
Tetracycline (Achromycin ®)  

Doxycycline  (Vibramycin ®)  top of page icon

Use
Principally in the treatment of infections caused by susceptible Rickettsia , Chlamydia , and Mycoplasma ; alternative to mefloquine for malaria prophylaxis; treatment for syphilis, uncomplicated Neisseria gonorrhoeae , Listeria , Actinomyces israelii , and Clostridium infections in penicillin-allergic patients; used for community-acquired pneumonia and other common infections due to susceptible organisms; anthrax due to Bacillus anthracis, including inhalational anthrax (postexposure); treatment of infections caused by uncommon susceptible gram-negative and gram-positive organisms including Borrelia recurrentis , Ureaplasma urealyticum , Haemophilus ducreyi , Yersinia pestis , Francisella tularensis , Vibrio cholerae , Campylobacter fetus , Brucella spp, Bartonella bacilliformis , and Calymmatobacterium granulomatis

-------------------------------------------
Dosing:
Children >/= 8 years (<45 kg): Susceptible infections: Oral, I.V.: 2-5 mg/kg/day in 1-2 divided doses, not to exceed 200 mg/day
-------------------------
Children >8 years (>45 kg) and Adults: Susceptible infections: Oral, I.V.: 100-200 mg/day in 1-2 divided doses
-------------------------
Acute gonococcal infection (PID) in combination with another antibiotic: 100 mg every 12 hours until improved, followed by 100 mg orally twice daily to complete 14 days
-------------------------
Community-acquired pneumonia: 100 mg twice daily
-------------------------
Lyme disease: Oral: 100 mg twice daily for 14-21 days
-------------------------
Early syphilis: 200 mg/day in divided doses for 14 days
Late syphilis: 200 mg/day in divided doses for 28 days

-------------------------
Uncomplicated chlamydial infections: 100 mg twice daily for >/= 7 days
-------------------------
Endometritis, salpingitis, parametritis, or peritonitis: 100 mg I.V. twice daily with cefoxitin 2 g every 6 hours for 4 days and for >/= 48 hours after patient improves; then continue with oral therapy 100 mg twice daily to complete a 10- to 14-day course of therapy
-------------------------
Sclerosing agent for pleural effusion injection (unlabeled use): 500 mg as a single dose in 30-50 mL of NS or SWI
-------------------------
Periodontitis: Oral (Periostat®): 20 mg twice daily as an adjunct following scaling and root planing; may be administered for up to 9 months. Safety beyond 12 months of treatment and efficacy beyond 9 months of treatment have not been established.

-------------------------

Adults:
Anthrax:

Inhalational (postexposure prophylaxis): Oral, I.V. (use oral route when possible): 100 mg every 12 hours for 60 days ( MMWR , 2001, 50:889-93); Note: Preliminary recommendation, FDA review and update is anticipated.

Cutaneous (treatment): Oral: 100 mg every 12 hours for 60 days. Note: In the presence of systemic involvement, extensive edema, lesions on head/neck, refer to I.V. dosing for treatment of inhalational/gastrointestinal/oropharyngeal anthrax

-------------------------
Supplied:
Capsule, as hyclate: 50 mg, 100 mg
Capsule, as monohydrate (Monodox®): 50 mg, 100 mg
Capsule, coated pellets, as hyclate (Doryx®): 75 mg, 100 mg

Injection, powder for reconstitution, as hyclate (Doxy-100®): 100 mg
Powder for oral suspension, as monohydrate (Vibramycin®): 25 mg/5 mL (60 mL)
Syrup, as calcium (Vibramycin®): 50 mg/5 mL (480 mL)
Tablet, as hyclate: 100 mg
Periostat®: 20 mg
Vibra-Tabs®: 100 mg
Tablet, as monohydrate (Adoxa™): 50 mg, 75 mg, 100 mg

Minocycline (Minocin ®)  top of page icon

Use
Treatment of susceptible bacterial infections of both gram-negative and gram-positive organisms; treatment of anthrax (inhalational, cutaneous, and gastrointestinal); acne; meningococcal carrier state; Rickettsial diseases (including Rocky Mountain spotted fever, Q fever); nongonococcal urethritis, gonorrhea; acute intestinal amebiasis

Mechanism of Action
Inhibits bacterial protein synthesis by binding with the 30S and possibly the 50S ribosomal subunit(s) of susceptible bacteria; cell wall synthesis is not affected

Dosing:
Children >8 years: Oral, I.V.: Initial: 4 mg/kg followed by 2 mg/kg/dose every 12 hours

Adults:
Infection: Oral, I.V.: 200 mg stat, 100 mg every 12 hours not to exceed 400 mg/24 hours
Acne: Oral: 50 mg 1-3 times/day

May be taken with food or milk. Administer with adequate fluid to decrease the risk of esophageal irritation and ulceration.

Dosage adjustment in renal impairment: Consider decreasing dose or increasing dosing interval with renal impairment.

Supplied:
Capsule, as hydrochloride: 50 mg, 75 mg, 100 mg
Dynacin®: 50 mg, 75 mg, 100 mg
Capsule, pellet-filled, as hydrochloride (Minocin®): 50 mg, 100 mg
Injection, powder for reconstitution, as hydrochloride (Minocin®): 100 mg
Tablet, as hydrochloride (Dynacin®): 50 mg, 75 mg, 100 mg

Tetracycline  (Achromycin ®)  top of page icon

Use
Treatment of susceptible bacterial infections of both gram-positive and gram-negative organisms; also infections due to Mycoplasma , Chlamydia , and Rickettsia ; indicated for acne, exacerbations of chronic bronchitis, and treatment of gonorrhea and syphilis in patients that are allergic to penicillin; as part of a multidrug regimen for H. pylori eradication to reduce the risk of duodenal ulcer recurrence

Dosing:
Oral:
Children >8 years: 25-50 mg/kg/day in divided doses every 6 hours
----------------
Adults: 250-500 mg/dose every 6 hours

Helicobacter pylori eradication: 500 mg 2-4 times/day depending on regimen; requires combination therapy with at least one other antibiotic and an acid-suppressing agent (proton pump inhibitor or H2 blocker)
----------------
Dosing interval in renal impairment:
Clcr 50-80 mL/minute: Administer every 8-12 hours
Clcr 10-50 mL/minute: Administer every 12-24 hours
Clcr<10 mL/minute: Administer every 24 hours

Dialysis: Slightly dialyzable (5% to 20%) via hemo- and peritoneal dialysis or via continuous arteriovenous or venovenous hemofiltration; no supplemental dosage necessary

Dosing adjustment in hepatic impairment: Avoid use or maximum dose is 1 g/day
----------------
Administration
Should be administered on an empty stomach (ie, 1 hour prior to, or 2 hours after meals) to increase total absorption. Administer at least 1-2 hours prior to, or 4 hours after antacid because aluminum and magnesium cations may chelate with tetracycline and reduce its total absorption.

----------------
Supplied:
Capsule, as hydrochloride: 250 mg, 500 mg

Suspension, oral, as hydrochloride (Sumycin®): 125 mg/5 mL (480 mL) [contains sodium benzoate and sodium metabisulfite; fruit flavor]

Tablet, as hydrochloride (Sumycin®): 250 mg, 500 mg
top of page icon

Disclaimer

Listed dosages are for - Adult patients ONLY. PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER. GlobalRPH does not directly or indirectly practice medicine or provide medical services and therefore assumes no liability whatsoever of any kind for the information and data accessed through the Service or for any diagnosis or treatment made in reliance thereon.

David F. McAuley, Pharm.D., R.Ph.  GlobalRPh Inc.