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Intravenous Dilution Guidelines

STREPTOMYCIN

The authors make no claims of the accuracy of the information contained herein; and these suggested doses and/or guidelines are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this document shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.    PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.

Usual Diluents

NS, D5W

Standard Dilutions   [Amount of drug] [Infusion volume] [Infusion rate]

[Usual dose] [100 ml] [30-60 min]

(Not approved for IV use, however, has been used in patients with insufficient muscle mass.)

Stability / Miscellaneous

Label: Refrigerate
Dosing: (Tuberculosis): 15 mg/kg (Max=1 gram) IM once daily or 25-30 mg/kg administered twice weekly (maximum 1.5 grams/dose) or three times weekly (Maximum 1 gram/dose).

Streptomycin usually replaces ethambutol in the 4 drug regimen [INH, Rifampin, Pyrazinamide, streptomycin].

[CRCL: 10-50// q24-72h or 750mg 2 to 3x/week]
[CRCL < 10// q72-96hrs instead of once daily]

Serum level monitoring: Adjust dose to maintain a trough < 4 mcg/ml.

Source: [package insert]
Disclaimer
The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.  PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.
Medical Calculators - A thru Z
Lab Values - A thru Z