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Intravenous Dilution Guidelines

Streptokinase

The authors make no claims of the accuracy of the information contained herein; and these suggested doses and/or guidelines are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this document shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.    PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.

Usual Diluents

NS, D5W

Standard Dilutions   [Amount of drug] [Infusion volume] [Infusion rate]

 [250,000 u] [50 ml] [30 min]
[1,500,000 u] [50-250ml] [60 min]

Stability / Miscellaneous

Prepare just before use.
Avoid shaking to prevent foaming.

Acute MI: Give 1.5 million IU over 60 minutes.
PE: Loading dose: 250,000 iu over 30 minutes, followed by 100,000 iu/ hr x 24 hours. (x 72 hours for DVT).

Reconstitute the 250, 600, 750k with 5 ml NS. 1.5 mu with 10ml. Do not add more than 1.5 mu to an IV solution (limited stability).

Review contraindications - See Package Insert

Obtain baseline CBC, hct, platelet, PT/PTT, CPK, CPKmb, fibrinogen.
Source: [package insert]
Disclaimer
The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.  PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.
Medical Calculators - A thru Z
Lab Values - A thru Z