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Rosuvastatin - Crestor® - Renal Dosing

Usual Dosing (Adults)

Usual initial dose: 10 mg once daily (range: 5 to 20 mg). Reserve higher initial dose for patients with severe hypercholesteremia or patients with homozygous familial hypercholesterolemia. May titrate dose after 2 weeks (increase by 5-10 mg once daily). Dosing range: 5-40 mg/day (maximum dose: 40 mg once daily).

Renal Dosing

dialysis [>30  mL/min/1.73 m2 ]: No changes.

[<30 mL/min/1.73 m2 - Not on hemodialysis]: Start at 5 mg qd. Do not exceed 10 mg qd.

Hemodialysis

dialysis Insufficient data. (Steady-state concentrations of rosuvastatin in patients on chronic hemodialysis were ~ 50% greater compared to healthy volunteer subjects with normal renal function).

Reference(s)

National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
Provides access to the latest drug monographs submitted to the Food and Drug Administration (FDA). Please review the latest applicable package insert for additional information and possible updates.  A local search option of this data can be found here.

Disclaimer

The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.   Read the disclaimer
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