NORVIR is administered orally in combination with other antiretroviral agents.
It is recommended that NORVIR be taken with meals if possible.
General Dosing Guidelines
Patients should be aware that frequently observed adverse events, such as mild
to moderate gastrointestinal disturbances and paraesthesias, may diminish as
therapy is continued.
Dose modification for NORVIR
Dose reduction of NORVIR is necessary when used with other protease inhibitors:
atazanavir, darunavir, fosamprenavir, saquinavir, and tipranavir.
Prescribers should consult the full prescribing information and clinical study
information of these protease inhibitors if they are co-administered with a
reduced dose of ritonavir.
Adult Patients Recommended Dosage for treatment of HIV-1
The recommended dosage of ritonavir is 600 mg twice daily by mouth. Use of a
dose titration schedule may help to reduce treatment-emergent adverse events
while maintaining appropriate ritonavir plasma levels. Ritonavir should be
started at no less than 300 mg twice daily and increased at 2 to 3 day intervals
by 100 mg twice daily. The maximum dose of 600 mg twice daily should not be
exceeded upon completion of the titration.
The recommended dosage of ritonavir in children greater than 1 month is 350 to
400 mg per m2 twice daily by mouth and should not exceed 600 mg twice
daily. Ritonavir should be started at 250 mg per m2 twice daily and
increased at 2 to 3 day intervals by 50 mg per m2 twice daily. If patients do not
tolerate 400 mg per m2 twice daily due to adverse events, the highest
tolerated dose may be used for maintenance therapy in combination with other
antiretroviral agents, however, alternative therapy should be considered. The
use of NORVIR oral solution is recommended for children greater than 1 month who
cannot swallow capsules. Please refer to the NORVIR oral solution full
prescribing information for pediatric dosage and administration.
No adjustment required.
Hemo: insufficient data. However, the need for adjustment is
National Institutes of Health, U.S. National Library of Medicine,
DailyMed Database. Provides access to the latest drug monographs submitted to the
Food and Drug Administration (FDA). Please review the latest applicable package insert for
additional information and possible updates. A local search
option of this data can be found here.
The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical
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